[go: up one dir, main page]

MX2009000849A - Formas de dosificacion liofilizadasdisolvibles oralmente/desintegrables que contienen particulas protegidas. - Google Patents

Formas de dosificacion liofilizadasdisolvibles oralmente/desintegrables que contienen particulas protegidas.

Info

Publication number
MX2009000849A
MX2009000849A MX2009000849A MX2009000849A MX2009000849A MX 2009000849 A MX2009000849 A MX 2009000849A MX 2009000849 A MX2009000849 A MX 2009000849A MX 2009000849 A MX2009000849 A MX 2009000849A MX 2009000849 A MX2009000849 A MX 2009000849A
Authority
MX
Mexico
Prior art keywords
orally dissolvable
disintegrable
dosage forms
forms containing
lyophilized dosage
Prior art date
Application number
MX2009000849A
Other languages
English (en)
Inventor
Ehab Hamed
Lisa Hillman
Rajendra K Khankari
Derek Moe
Tam Nguyen
Vikas Agarwal
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06291198A external-priority patent/EP1891938A1/en
Priority claimed from EP06291458A external-priority patent/EP1905429A1/en
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Publication of MX2009000849A publication Critical patent/MX2009000849A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona una forma de dosificación disolvible/desintegrable oralmente, liofilizada, adaptada para dosificación oral directa, que incluye una partícula que contiene el ingrediente farmacéutico activo ("API") que es recubierta con un recubrimiento protector de solvente liofilizante, que protege la forma y/o atributo de la partícula y/o API y una matriz. También se proporciona un método para la fabricación de una forma de dosificación liofilizada disolvible/desintegrable oralmente de acuerdo con la presente invención y un método para el tratamiento de un paciente con una forma de dosificación de acuerdo con la presente invención.
MX2009000849A 2006-07-24 2007-07-24 Formas de dosificacion liofilizadasdisolvibles oralmente/desintegrables que contienen particulas protegidas. MX2009000849A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP06291198A EP1891938A1 (en) 2006-07-24 2006-07-24 High dose orally dissolvable/disintegrable lyophilized dosage form
EP06291458A EP1905429A1 (en) 2006-09-18 2006-09-18 Orally dissolvable/disintegrable lyophilized dosage forms containing protected particles
US11/880,503 US20080031947A1 (en) 2006-07-24 2007-07-23 Orally dissolvable/disintegrable lyophilized dosage forms containing protected
PCT/US2007/016690 WO2008013833A2 (en) 2006-07-24 2007-07-24 Orally dissolvable/disintegrable lyophilized dosage forms containing protected particles

Publications (1)

Publication Number Publication Date
MX2009000849A true MX2009000849A (es) 2009-06-30

Family

ID=39029455

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009000849A MX2009000849A (es) 2006-07-24 2007-07-24 Formas de dosificacion liofilizadasdisolvibles oralmente/desintegrables que contienen particulas protegidas.
MX2009000861A MX2009000861A (es) 2006-07-24 2007-07-24 Formas de dosis que oralmente se puede disolver/desintegrar de alta dosis.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2009000861A MX2009000861A (es) 2006-07-24 2007-07-24 Formas de dosis que oralmente se puede disolver/desintegrar de alta dosis.

Country Status (6)

Country Link
US (2) US20080031947A1 (es)
EP (2) EP2068826A2 (es)
JP (2) JP2009544706A (es)
CA (2) CA2658109A1 (es)
MX (2) MX2009000849A (es)
WO (2) WO2008013808A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080031947A1 (en) * 2006-07-24 2008-02-07 Cima Labs Inc. Orally dissolvable/disintegrable lyophilized dosage forms containing protected
MX2011001487A (es) * 2008-08-08 2011-03-30 Mcneil Ppc Inc Uso de sucralosa como agente granulante.
EP2359812A1 (en) * 2010-01-18 2011-08-24 Cephalon France Oral lyophilised compositions
EP2525783A1 (en) * 2010-01-18 2012-11-28 Cephalon France Improved oral lysophilisates containing pvp/va
EP2645943A1 (en) 2010-12-02 2013-10-09 Agile Endosurgery, Inc. Surgical tool
US9730885B2 (en) 2012-07-12 2017-08-15 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
US11058642B2 (en) * 2013-04-22 2021-07-13 Tower Laboratories Ltd Tablets with improved friability
US9650338B1 (en) 2016-07-29 2017-05-16 VDM Biochemicals, Inc. Opioid antagonist compounds and methods of making and using
US11638698B2 (en) 2017-04-20 2023-05-02 Zeenar Enterprises Pty Ltd Liquid crystalline dosage form for administering a statin
US20210015753A1 (en) * 2017-11-27 2021-01-21 Dsm Ip Assets B.V. Freeze-dried multiparticulate solid dosage form

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH528266A (fr) * 1969-11-26 1972-09-30 Orsymonde Procédé pour la préparation d'une composition lyophilisée à l'usage cosmétique ou hygiénique
GB1447988A (en) * 1973-04-03 1976-09-02 Orsymonde Pharmaceutical compositions
FR2539626B2 (fr) * 1983-01-25 1985-06-21 Lafon Labor Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede
FR2561916B1 (fr) * 1984-03-30 1987-12-11 Lafon Labor Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
GB8724763D0 (en) * 1987-10-22 1987-11-25 Aps Research Ltd Sustained-release formulations
DE3824399A1 (de) * 1988-07-19 1990-01-25 Ford Werke Ag Regelbares ringreibgetriebe
FR2634376B1 (fr) * 1988-07-21 1992-04-17 Farmalyoc Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation
US5223264A (en) * 1989-10-02 1993-06-29 Cima Labs, Inc. Pediatric effervescent dosage form
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5558880A (en) * 1989-12-22 1996-09-24 Janssen Pharmaceutica Inc. Pharmaceutical and other dosage forms
US5188825A (en) * 1989-12-28 1993-02-23 Iles Martin C Freeze-dried dosage forms and methods for preparing the same
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
CA2128821A1 (en) * 1993-07-27 1995-01-28 Dilip J. Gole Freeze-dried pharmaceutical dosage form and process for separation thereof
DK9500167U3 (da) * 1995-04-27 1996-01-12 Brdr Christensens Haner A S Afspærringsindretning af "double-block-and-bleed"-typen
US5599846A (en) * 1996-06-28 1997-02-04 Jame Fine Chemicals, Inc. Phenylephrine tannate compositions
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US5976577A (en) * 1997-07-11 1999-11-02 Rp Scherer Corporation Process for preparing fast dispersing solid oral dosage form
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
US6740341B1 (en) * 1998-11-25 2004-05-25 Cima Labs Inc. Taste masking rapid release coating system
ATE311227T1 (de) * 1999-12-01 2005-12-15 Natco Pharma Ltd Schnell-wirkende, gefrier-trocknete, orale, pharmazeutische formulierung für die behandlung von migräne
US6754511B1 (en) * 2000-02-04 2004-06-22 Harris Corporation Linear signal separation using polarization diversity
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
JP2003055197A (ja) * 2001-06-07 2003-02-26 Tanabe Seiyaku Co Ltd 機能性粒子含有口腔内速崩壊性製剤
US20040137061A1 (en) * 2001-06-07 2004-07-15 Takashi Ishibashi Functional grain-containing preparations quickly disintegrated in the oral cavity
US20030190343A1 (en) * 2002-03-05 2003-10-09 Pfizer Inc. Palatable pharmaceutical compositions for companion animals
AU2003224890A1 (en) * 2002-04-08 2003-10-27 Lavipharm Laboratories Inc. Drug-complex microparticles and methods of making/using same
BR0314036A (pt) * 2002-09-04 2005-07-12 Ranbaxy Lab Ltd Apresentações farmacêuticas com mascaramento de sabor e processo para sua preparação
WO2005020994A1 (en) * 2003-08-29 2005-03-10 Lifecycle Pharma A/S Solid dispersions comprising tacrolimus
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US7294347B2 (en) * 2004-06-21 2007-11-13 Council Of Scientific And Industrial Research Coating compositions for bitterness inhibition
US20060024370A1 (en) * 2004-07-29 2006-02-02 Cephalon France Modafinil oral lyophilizate
US8193211B2 (en) * 2004-09-30 2012-06-05 Supernus Pharmaceuticals, Inc. Controlled release compositions of gamma-hydroxybutyrate
US20080031947A1 (en) * 2006-07-24 2008-02-07 Cima Labs Inc. Orally dissolvable/disintegrable lyophilized dosage forms containing protected

Also Published As

Publication number Publication date
US20080031949A1 (en) 2008-02-07
EP2068826A2 (en) 2009-06-17
CA2658512A1 (en) 2008-01-31
US20080031947A1 (en) 2008-02-07
EP2068824A2 (en) 2009-06-17
WO2008013808A3 (en) 2008-05-15
JP2009544707A (ja) 2009-12-17
CA2658109A1 (en) 2008-01-31
WO2008013833A2 (en) 2008-01-31
JP2009544706A (ja) 2009-12-17
WO2008013808A2 (en) 2008-01-31
WO2008013833A3 (en) 2008-07-17
MX2009000861A (es) 2009-06-19

Similar Documents

Publication Publication Date Title
MX2009000849A (es) Formas de dosificacion liofilizadasdisolvibles oralmente/desintegrables que contienen particulas protegidas.
WO2005049091A3 (en) Antibody-targeted nanoparticulate active agent delivery
EA201400972A1 (ru) Лекарственные формы немедленного высвобождения с защитой от несанкционированного применения
NZ573555A (en) Nanoparticulate posaconazole formulations
IL173078A0 (en) Multiparticle pharmaceutical dosage form containing a mucoadhesively formulated peptide or protein active substances method for producing said pharmaceutical dosage form
EA200600877A1 (ru) Наночастицы для доставки лекарств
WO2010047765A8 (en) Nanostructures for drug delivery
EA200600696A1 (ru) Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств
EP1781257A4 (en) PHARMACEUTICAL FORMULATIONS WITH MICROPARTICLES OR NANOPARTICLES OF AN AGENT
MX2018012500A (es) Formas de dosificacion de liberacion modificada disuasivas de abuso.
WO2008033351A3 (en) Multimodal abuse resistant and extended release formulations
HUP0301887A2 (hu) Több részecskébżl álló gyógyszerforma, amely legalább két különbözżen bevont pelletformát tartalmaz
EA201591821A1 (ru) Защищенные от несанкционированного использования фармацевтические составы
UA101309C2 (ru) Антагонисты активина-actrii и их применение для повышения уровня эритроцитов
MX2009005727A (es) Nanoparticulas de entidad anfifilica.
MA34449B1 (fr) Formulation de poudre seche comprenant un inhibiteur de phosphodiesterase
ATE396712T1 (de) Pharmazeutische zubereitung zur modifizierten freisetzung
MX2010007462A (es) Metodos y composiciones para administracion oral de agentes terapeuticos de peptidos y proteinas.
MX2009004858A (es) Forma de dosificacion de imatinib procesada en fusion.
SI1765293T1 (sl) Farmacevtski sestavki za aplikacijo zdravil in postopki za zdravljenje ali preventivo stanj z njihovo uporabo
WO2005055955A3 (en) DOSING METHODS FOR ß-D-2’,3’-DIDEOXY-2’,3’-DIDEHYDRO-5-FLUOROCYTIDINE ANTIVIRAL THERAPY
EA200802350A2 (ru) Система доставки лекарств
WO2011151722A3 (en) Methods and compositions for oral pharmaceutical therapy
EA200600603A1 (ru) Оральная система доставки лекарственного препарата
AR061262A1 (es) Metodo para tratar trastornos respiratorios uso de un antibiotico enla fabricacion de un aerosol y composicion de antibiotico en aerosol

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration
GB Transfer or rights
PD Change of proprietorship

Owner name: CIMA LABS INC.