MX2008011112A - Formulaciones farmaceuticas de latrunculina. - Google Patents
Formulaciones farmaceuticas de latrunculina.Info
- Publication number
- MX2008011112A MX2008011112A MX2008011112A MX2008011112A MX2008011112A MX 2008011112 A MX2008011112 A MX 2008011112A MX 2008011112 A MX2008011112 A MX 2008011112A MX 2008011112 A MX2008011112 A MX 2008011112A MX 2008011112 A MX2008011112 A MX 2008011112A
- Authority
- MX
- Mexico
- Prior art keywords
- formulation
- latrunculin
- present
- amount
- formulations
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- 229930193708 latrunculin Natural products 0.000 title abstract 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000012929 tonicity agent Substances 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una formulación farmacéutica acuosa que comprende cuando menos una latrunculina y la formulación no contiene una cantidad importante de sulfóxido de dimetilo. En una modalidad preferida, la presente invención está dirigida a una formulación farmacéutica acuosa que comprende cuando menos una latrunculina en una cantidad de 0.001-2% p/v, un agente tensoactivo no iónico en una cantidad de 0.01-2% p/v, y un agente de tonicidad para mantener una tonicidad de entre 200 y 400 mOsm/kG , a un pH de entre 4 y 8, en donde la latrunculina, el agente tensoactivo, y el agente de tonicidad son compatibles en la formulación, y la formulación no contiene una cantidad importante de sulfóxido de dimetilo. La formulación es estable durante cuando menos seis meses a temperatura de refrigeración. La presente invención además provee un método para reducir la presión intraocular, un método para tratar el glaucoma, un método para inhibir la curación de heridas después de la trabeculectomía, y un método para inhibir la angiogénesis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77927306P | 2006-03-02 | 2006-03-02 | |
| US11/680,893 US7785624B2 (en) | 2006-03-02 | 2007-03-01 | Pharmaceutical latrunculin formulations |
| PCT/US2007/063171 WO2007103782A2 (en) | 2006-03-02 | 2007-03-02 | Pharmaceutical latrunculin formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008011112A true MX2008011112A (es) | 2008-09-08 |
Family
ID=38475717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008011112A MX2008011112A (es) | 2006-03-02 | 2007-03-02 | Formulaciones farmaceuticas de latrunculina. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7785624B2 (es) |
| EP (1) | EP1993563A4 (es) |
| JP (1) | JP2009528390A (es) |
| KR (1) | KR20080098636A (es) |
| AU (1) | AU2007223378A1 (es) |
| BR (1) | BRPI0708483A2 (es) |
| CA (1) | CA2644198A1 (es) |
| MX (1) | MX2008011112A (es) |
| RU (1) | RU2434633C2 (es) |
| WO (1) | WO2007103782A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010014240A2 (en) * | 2008-07-29 | 2010-02-04 | The Regents Of The University Of California | Novel bioactive small molecules derived from sea sponges |
| CN109843266B (zh) * | 2016-08-02 | 2023-08-11 | 安巴知识产权有限公司 | 稳定的布洛芬注射组合物 |
| US20220047719A1 (en) * | 2020-08-17 | 2022-02-17 | Northwestern University | Enhancing subcutaneous injection and target tissue accumulation of nanoparticles via co-administration with macropinocytosis inhibitory nanoparticles (minp) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2052950A1 (en) | 1990-10-10 | 1992-04-11 | David P. Evitts | Aqueous ophthalmic microemulsions of tepoxalin |
| US5422116A (en) | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| US6586425B2 (en) | 1996-02-21 | 2003-07-01 | Wisconsin Alumni Research Foundation | Cytoskeletal active agents for glaucoma therapy |
| US5798380A (en) | 1996-02-21 | 1998-08-25 | Wisconsin Alumni Research Foundation | Cytoskeletal active agents for glaucoma therapy |
| JP3677421B2 (ja) * | 1999-12-27 | 2005-08-03 | 扶桑薬品工業株式会社 | 涙液分泌促進組成物 |
| US20030165545A1 (en) * | 2002-01-30 | 2003-09-04 | Allergan, Inc. | Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same |
| CN101160315A (zh) | 2005-03-25 | 2008-04-09 | 印斯拜尔药品股份有限公司 | 细胞骨架的活性化合物，组合物及用途 |
-
2007
- 2007-03-01 US US11/680,893 patent/US7785624B2/en not_active Expired - Fee Related
- 2007-03-02 AU AU2007223378A patent/AU2007223378A1/en not_active Abandoned
- 2007-03-02 KR KR1020087021403A patent/KR20080098636A/ko not_active Withdrawn
- 2007-03-02 MX MX2008011112A patent/MX2008011112A/es active IP Right Grant
- 2007-03-02 CA CA002644198A patent/CA2644198A1/en not_active Abandoned
- 2007-03-02 JP JP2008557515A patent/JP2009528390A/ja not_active Withdrawn
- 2007-03-02 WO PCT/US2007/063171 patent/WO2007103782A2/en active Application Filing
- 2007-03-02 BR BRPI0708483-8A patent/BRPI0708483A2/pt not_active IP Right Cessation
- 2007-03-02 RU RU2008139113/15A patent/RU2434633C2/ru not_active IP Right Cessation
- 2007-03-02 EP EP07757790A patent/EP1993563A4/en not_active Withdrawn
-
2010
- 2010-08-13 US US12/856,412 patent/US20100305175A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0708483A2 (pt) | 2011-05-31 |
| AU2007223378A1 (en) | 2007-09-13 |
| KR20080098636A (ko) | 2008-11-11 |
| US20070225343A1 (en) | 2007-09-27 |
| RU2434633C2 (ru) | 2011-11-27 |
| US7785624B2 (en) | 2010-08-31 |
| EP1993563A4 (en) | 2009-05-20 |
| JP2009528390A (ja) | 2009-08-06 |
| WO2007103782A2 (en) | 2007-09-13 |
| US20100305175A1 (en) | 2010-12-02 |
| CA2644198A1 (en) | 2007-09-13 |
| EP1993563A2 (en) | 2008-11-26 |
| RU2008139113A (ru) | 2010-04-10 |
| WO2007103782A3 (en) | 2008-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |