MX2008008589A - Formulaciones farmaceuticas de fenofibrato que tienen biodisponibilidad mejorada. - Google Patents

Formulaciones farmaceuticas de fenofibrato que tienen biodisponibilidad mejorada.

Info

Publication number: MX2008008589A
Authority: MX; Mexico
Prior art keywords: fenofibrate; dosage form; weight; oral dosage; solid oral
Prior art date: 2005-12-28

Application number

MX2008008589A

Other languages

English (en)

Spanish (es)

Inventor

Moshe Flashner-Barak

E Itzhak Lerner

Naomi Moldavski

Vered Rosenberger

Anna Drabkin

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-28

Filing date

2005-12-28

Publication date

2009-02-25

2005-12-28 Application filed by Teva Pharma filed Critical Teva Pharma

2009-02-25 Publication of MX2008008589A publication Critical patent/MX2008008589A/es

Links

YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 title claims abstract description 108
229960002297 fenofibrate Drugs 0.000 title claims abstract description 102
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 48
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 28
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 24
229920001451 polypropylene glycol Polymers 0.000 claims abstract description 24
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 14
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 14
229940041616 menthol Drugs 0.000 claims abstract description 14
239000002552 dosage form Substances 0.000 claims abstract description 13
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 41
239000007787 solid Substances 0.000 claims description 38
239000006186 oral dosage form Substances 0.000 claims description 37
239000002245 particle Substances 0.000 claims description 37
239000011859 microparticle Substances 0.000 claims description 31
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239000006104 solid solution Substances 0.000 claims description 27
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WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 13
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FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 9
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 9
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
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Classifications

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- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
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MX2008008589A 2005-12-28 2005-12-28 Formulaciones farmaceuticas de fenofibrato que tienen biodisponibilidad mejorada. MX2008008589A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2005/047346 WO2007075171A1 (en)	2005-12-28	2005-12-28	Pharmaceutical formulations of fenofibrate having improved bioavailability

Publications (1)

Publication Number	Publication Date
MX2008008589A true MX2008008589A (es)	2009-02-25

Family

ID=36499668

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX2008008589A MX2008008589A (es)	2005-12-28	2005-12-28	Formulaciones farmaceuticas de fenofibrato que tienen biodisponibilidad mejorada.

Country Status (7)

Country	Link
JP (1)	JP2009522258A (ja)
CN (1)	CN101351191A (ja)
BR (1)	BRPI0520821A2 (ja)
CA (1)	CA2634094A1 (ja)
IL (1)	IL192230A0 (ja)
MX (1)	MX2008008589A (ja)
WO (1)	WO2007075171A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20120225946A1 (en) *	2009-09-09	2012-09-06	Bernard Charles Sherman	Choline fenofibrate delayed release compositions
PL2968529T3 (pl)	2013-03-14	2021-04-19	Aimmune Therapeutics, Inc.	Wytwarzanie formulacji orzeszków ziemnych do doustnego odczulania
US9492535B2 (en)	2013-03-14	2016-11-15	Aimmune Therapeutics, Inc.	Peanut formulations and uses thereof
KR101850119B1 (ko)	2015-11-11	2018-04-20	제이투에이치바이오텍 (주)	생체이용률이 향상된 신규한 페노피브르산 전구약물
WO2020132341A1 (en)	2018-12-20	2020-06-25	Aimmune Therapeutics, Inc.	Peanut oral immunotherapy dosing schedule for missed doses
CN113966229A (zh)	2019-05-10	2022-01-21	爱沐疗法公司	用于改善花生过敏患者的生活质量的方法
CN112618511A (zh) *	2020-12-31	2021-04-09	辰欣药业股份有限公司	一种非诺贝特胶囊的处方组成及制备工艺

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FR2627696B1 (fr) *	1988-02-26	1991-09-13	Fournier Innovation Synergie	Nouvelle forme galenique du fenofibrate
FR2758459B1 (fr) *	1997-01-17	1999-05-07	Pharma Pass	Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
US6368622B2 (en) *	1999-01-29	2002-04-09	Abbott Laboratories	Process for preparing solid formulations of lipid regulating agents with enhanced dissolution and absorption
ATE367802T1 (de) *	2000-09-20	2007-08-15	Jagotec Ag	Verfahren zur sprühtrocknung von zusammensetzungen enthaltend fenofibrat
DK1487416T3 (da) *	2002-03-26	2010-03-29	Teva Pharma	Lægemiddelmikropartikler
WO2005034908A2 (en) *	2003-10-10	2005-04-21	Lifecycle Pharma A/S	A solid dosage form comprising a fibrate and a statin
WO2005034920A1 (en) *	2003-10-10	2005-04-21	Lifecycle Pharma A/S	A solid dosage form comprising a fibrate

2005
- 2005-12-28 JP JP2008548479A patent/JP2009522258A/ja active Pending
- 2005-12-28 MX MX2008008589A patent/MX2008008589A/es not_active Application Discontinuation
- 2005-12-28 CN CNA2005800524449A patent/CN101351191A/zh active Pending
- 2005-12-28 WO PCT/US2005/047346 patent/WO2007075171A1/en active Application Filing
- 2005-12-28 CA CA002634094A patent/CA2634094A1/en not_active Abandoned
- 2005-12-28 BR BRPI0520821-1A patent/BRPI0520821A2/pt not_active IP Right Cessation
2008
- 2008-06-16 IL IL192230A patent/IL192230A0/en unknown

Also Published As

Publication number	Publication date
WO2007075171A1 (en)	2007-07-05
JP2009522258A (ja)	2009-06-11
IL192230A0 (en)	2008-12-29
CA2634094A1 (en)	2007-07-05
BRPI0520821A2 (pt)	2009-06-30
CN101351191A (zh)	2009-01-21

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JP4022269B2 (ja)	2007-12-12	医薬組成物
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Legal Events

Date	Code	Title	Description
2017-06-30	FA	Abandonment or withdrawal