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MX2007012116A - Derivados de heteroaril urea utiles para inhibir chk1. - Google Patents

Derivados de heteroaril urea utiles para inhibir chk1.

Info

Publication number
MX2007012116A
MX2007012116A MX2007012116A MX2007012116A MX2007012116A MX 2007012116 A MX2007012116 A MX 2007012116A MX 2007012116 A MX2007012116 A MX 2007012116A MX 2007012116 A MX2007012116 A MX 2007012116A MX 2007012116 A MX2007012116 A MX 2007012116A
Authority
MX
Mexico
Prior art keywords
urea derivatives
derivatives useful
heteroaryl urea
inhibiting chkl
disclosed
Prior art date
Application number
MX2007012116A
Other languages
English (en)
Inventor
Frank Diaz
Francine S Farouz
Ryan Holcomb
Edward A Kesicki
Hua Chee Ooi
Alexander Rudolph
Frank Stappenbeck
Eugene Thorsett
John Joseph Gaudino
Kimba L Fisher
Adam Wade Cook
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of MX2007012116A publication Critical patent/MX2007012116A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Se describen compuestos de urea substituidos utiles en el tratamiento de enfermedades y condiciones relacionadas con dano al ADN o lesiones en replicacion de ADN. Tambien se describen metodos para hacer los compuestos, y sus usos como agentes terapeuticos, por ejemplo, para tratar cancer y otras enfermedades caracterizadas por defectos en replicacion de ADN, segregacion de cromosoma, o division de celula.
MX2007012116A 2005-03-29 2006-03-29 Derivados de heteroaril urea utiles para inhibir chk1. MX2007012116A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66602605P 2005-03-29 2005-03-29
PCT/US2006/011584 WO2006105262A1 (en) 2005-03-29 2006-03-29 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl

Publications (1)

Publication Number Publication Date
MX2007012116A true MX2007012116A (es) 2008-04-08

Family

ID=36677174

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007012116A MX2007012116A (es) 2005-03-29 2006-03-29 Derivados de heteroaril urea utiles para inhibir chk1.

Country Status (31)

Country Link
US (1) US8093244B2 (es)
EP (2) EP1869020B1 (es)
JP (2) JP5117374B2 (es)
KR (2) KR20090031459A (es)
CN (2) CN102219784A (es)
AR (1) AR056645A1 (es)
AT (1) ATE490248T1 (es)
AU (1) AU2006230337B2 (es)
BR (1) BRPI0609667A2 (es)
CA (1) CA2602199C (es)
CR (1) CR9395A (es)
CY (1) CY1111240T1 (es)
DE (1) DE602006018590D1 (es)
DK (1) DK1869020T3 (es)
EA (1) EA011287B1 (es)
ES (1) ES2356068T3 (es)
HR (1) HRP20100678T1 (es)
IL (1) IL185481A0 (es)
MA (1) MA29439B1 (es)
MX (1) MX2007012116A (es)
NO (1) NO20074944L (es)
NZ (1) NZ561458A (es)
PL (1) PL1869020T3 (es)
PT (1) PT1869020E (es)
RS (1) RS51616B (es)
SI (1) SI1869020T1 (es)
TN (1) TNSN07369A1 (es)
TW (1) TWI375559B (es)
UA (1) UA92164C2 (es)
WO (1) WO2006105262A1 (es)
ZA (1) ZA200707715B (es)

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US5221367A (en) 1988-08-03 1993-06-22 International Business Machines, Corp. Strained defect-free epitaxial mismatched heterostructures and method of fabrication
EA200900571A1 (ru) * 2006-10-20 2009-12-30 Айкос Корпорейшн Композиции chk1 ингибиторов
CN101200429B (zh) * 2006-12-13 2012-08-22 上海睿智化学研究有限公司 2-硝基-4,5-二卤代苯酚类和2-氨基-4,5-二卤代苯酚类及其盐及其合成方法
GB201008005D0 (en) 2010-05-13 2010-06-30 Sentinel Oncology Ltd Pharmaceutical compounds
US9993460B2 (en) 2013-07-26 2018-06-12 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
US11179394B2 (en) 2014-06-17 2021-11-23 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of Chk1 and ATR inhibitors
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
WO2017059357A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
HUE057976T2 (hu) 2016-02-04 2022-06-28 Pharmaengine Inc Chekpoint-kináz 1 (CHK1) inhibitorként alkalmazható 3,5-diszubsztituált pirazolok, elõállításuk és alkalmazásuk
IL261721B (en) 2016-03-15 2022-07-01 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
US20200108074A1 (en) * 2017-03-31 2020-04-09 Seattle Genetics, Inc. Combinations of chk1- and wee1- inhibitors
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
WO2021183973A1 (en) * 2020-03-13 2021-09-16 Research Development Foundation Methods for diagnosing and treating cancers

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US6218109B1 (en) 1997-09-05 2001-04-17 Baylor College Of Medicine Mammalian checkpoint genes and proteins
GB9718952D0 (en) 1997-09-05 1997-11-12 Medical Res Council Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods
WO1999017769A1 (en) 1997-10-06 1999-04-15 Basf Aktiengesellschaft INDENO[1,2-c]-, NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES
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Also Published As

Publication number Publication date
EP1869020B1 (en) 2010-12-01
ZA200707715B (en) 2009-09-30
HK1119670A1 (en) 2009-03-13
AR056645A1 (es) 2007-10-17
PT1869020E (pt) 2010-12-23
EA200702094A1 (ru) 2008-02-28
TNSN07369A1 (en) 2008-12-31
JP2008535830A (ja) 2008-09-04
CN102219784A (zh) 2011-10-19
KR20070107178A (ko) 2007-11-06
ATE490248T1 (de) 2010-12-15
AU2006230337B2 (en) 2011-10-27
SI1869020T1 (sl) 2011-02-28
CN101151259A (zh) 2008-03-26
JP2009227682A (ja) 2009-10-08
NZ561458A (en) 2011-03-31
CN101151259B (zh) 2011-06-15
EA011287B1 (ru) 2009-02-27
AU2006230337A1 (en) 2006-10-05
CR9395A (es) 2008-03-31
TW200722090A (en) 2007-06-16
US8093244B2 (en) 2012-01-10
KR100912998B1 (ko) 2009-08-20
HRP20100678T1 (hr) 2011-02-28
NO20074944L (no) 2007-10-24
ES2356068T3 (es) 2011-04-04
TWI375559B (en) 2012-11-01
MA29439B1 (fr) 2008-05-02
RS51616B (en) 2011-08-31
PL1869020T3 (pl) 2011-05-31
KR20090031459A (ko) 2009-03-25
DK1869020T3 (da) 2011-01-24
DE602006018590D1 (de) 2011-01-13
US20090143357A1 (en) 2009-06-04
EP1869020A1 (en) 2007-12-26
CA2602199A1 (en) 2006-10-05
IL185481A0 (en) 2008-01-06
BRPI0609667A2 (pt) 2010-04-20
WO2006105262A1 (en) 2006-10-05
UA92164C2 (ru) 2010-10-11
CY1111240T1 (el) 2015-06-11
EP2330105A1 (en) 2011-06-08
JP5117374B2 (ja) 2013-01-16
CA2602199C (en) 2013-09-10

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