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MX2007008614A - Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r). - Google Patents

Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r).

Info

Publication number
MX2007008614A
MX2007008614A MX2007008614A MX2007008614A MX2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A MX 2007008614 A MX2007008614 A MX 2007008614A
Authority
MX
Mexico
Prior art keywords
neuropeptide
receptor
peptides
agonist activity
obesity
Prior art date
Application number
MX2007008614A
Other languages
English (en)
Inventor
Waleed Danho
George Ehrlich
David C Fry
Wajiha Khan
Joseph Swistok
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2007008614A publication Critical patent/MX2007008614A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a agonistas del receptor del neuropeptido-2 de la formula (I): Y-R1-R2-X-R3--R4-R5-R6-R7-R8-R9- R10-R11-R12-R13-R14-NH2 (I) asi como sales farmaceuticamente aceptables, derivados y fragmentos de los mismos, donde los sustituyentes son como aquellos discutidos en la especificacion. Estos compuestos, y las composiciones farmaceuticas que las contienen, son utiles para el tratamiento de enfermedades como, por ejemplo, obesidad.
MX2007008614A 2005-01-18 2006-01-11 Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r). MX2007008614A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64484005P 2005-01-18 2005-01-18
PCT/EP2006/000161 WO2006077035A1 (en) 2005-01-18 2006-01-11 Peptides with neuropeptide-2 receptor (y2r) agonist activity

Publications (1)

Publication Number Publication Date
MX2007008614A true MX2007008614A (es) 2007-09-11

Family

ID=36118121

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007008614A MX2007008614A (es) 2005-01-18 2006-01-11 Peptidos con actividad agonista del receptor del neuropeptido-2 (y2r).

Country Status (22)

Country Link
US (1) US7410949B2 (es)
EP (1) EP1844070B1 (es)
JP (1) JP4633804B2 (es)
KR (1) KR100905380B1 (es)
CN (1) CN101107266A (es)
AR (1) AR051904A1 (es)
AT (1) ATE500268T1 (es)
AU (1) AU2006207659B2 (es)
BR (1) BRPI0606675A2 (es)
CA (1) CA2594423A1 (es)
DE (1) DE602006020407D1 (es)
DK (1) DK1844070T3 (es)
ES (1) ES2359850T3 (es)
IL (1) IL184428A0 (es)
MX (1) MX2007008614A (es)
NO (1) NO20073664L (es)
PL (1) PL1844070T3 (es)
PT (1) PT1844070E (es)
RU (1) RU2383553C2 (es)
TW (1) TWI309653B (es)
WO (1) WO2006077035A1 (es)
ZA (1) ZA200705674B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2381497T3 (es) * 2005-12-07 2012-05-28 F. Hoffmann-La Roche Ag Agonistas del receptor del neuropéptido-2
US8299023B2 (en) * 2008-09-17 2012-10-30 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists
JP2012507487A (ja) * 2008-11-05 2012-03-29 エフ．ホフマン−ラ ロシュ アーゲー 神経ペプチド２受容体（ｙ−２ｒ）アゴニスト及びその使用
JP5767582B2 (ja) * 2009-07-02 2015-08-19 武田薬品工業株式会社 ペプチド及びその用途
JP2013505221A (ja) * 2009-09-18 2013-02-14 ノヴォ ノルディスク アー／エス 長時間作用性ｙ２受容体アゴニスト
IN2012DN03042A (es) * 2009-10-13 2015-07-31 Hoffmann La Roche
KR101925620B1 (ko) 2010-12-16 2018-12-05 노보 노르디스크 에이/에스 Ｇｌｐ-1 아고니스트 및 ｎ-(8-(2-히드록시벤조일)아미노)카프릴산의 염을 포함하는 고체 조성물
RU2641198C3 (ru) 2012-03-22 2021-12-10 Ново Нордиск А/С Композиции glp-1 пептидов и их получение
WO2013186159A1 (en) 2012-06-13 2013-12-19 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
PE20150758A1 (es) 2012-09-25 2015-05-15 Hoffmann La Roche Nuevos derivados biciclicos
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
KR20210086717A (ko) 2013-05-02 2021-07-08 노보 노르디스크 에이/에스 Glp-1 화합물의 경구 투여
TWI661835B (zh) 2013-11-15 2019-06-11 丹麥商諾佛 儂迪克股份有限公司 選擇性ｐｙｙ化合物及其用途
EP3068795B1 (en) 2013-11-15 2019-03-06 Novo Nordisk A/S Hpyy(1-36) having a beta-homoarginine substitution at position 35
MY187449A (en) 2013-11-26 2021-09-22 Hoffmann La Roche New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl
ES2753549T3 (es) 2014-03-26 2020-04-13 Hoffmann La Roche Compuestos bicíclicos como inhibidores de la producción de autotaxina (ATX) y ácido lisofosfatídico (LPA)
CA2935612A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MA41898A (fr) * 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MA43205A (fr) 2015-06-12 2018-09-19 Novo Nordisk As Composés pyy sélectifs et leurs utilisations
WO2017037146A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
BR112018006034A2 (pt) 2015-09-24 2018-10-09 Hoffmann La Roche compostos bicíclicos como inibidores de atx
JP6877413B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重ａｔｘ／ｃａ阻害剤としての新規な二環式化合物
MX2017015034A (es) 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
CN115124538A (zh) 2015-09-24 2022-09-30 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
US20210171598A1 (en) 2017-12-01 2021-06-10 University Of Copenhagen Peptide hormone with one or more o-glycans
AR114353A1 (es) 2018-02-02 2020-08-26 Novo Nordisk As Composiciones sólidas que comprenden un agonista del glp-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico
EP3800195A1 (en) * 2019-10-03 2021-04-07 Universitat de Barcelona Peptide compounds for reducing side effects of cb1 receptor agonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
JPH08510205A (ja) 1993-03-29 1996-10-29 ユニバーシティ オブ シンシナティ Ｙｙペプチドのアナログとその用途
US6017879A (en) * 1998-04-03 2000-01-25 B.M.R.A. Corporation B.V. Template associated NPY Y2-receptor agonists
MXPA02000927A (es) * 1999-07-28 2003-07-14 Johnson & Johnson Amina y derivados de amida como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de obesidad y otros trastornos.
EP1583549A4 (en) * 2003-01-17 2006-10-04 Sod Conseils Rech Applic YY PEPTIDE ANALOGS
CA2545408A1 (en) * 2003-11-25 2005-06-16 Bayer Pharmaceuticals Corporation Selective neuropeptide y2 receptor agonists
WO2005077094A2 (en) * 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Pancreatic polypeptide family motifs and polypeptides comprising the same

Also Published As

Publication number Publication date
AU2006207659B2 (en) 2009-10-29
EP1844070B1 (en) 2011-03-02
ZA200705674B (en) 2009-08-26
DE602006020407D1 (de) 2011-04-14
RU2383553C2 (ru) 2010-03-10
JP4633804B2 (ja) 2011-02-16
US7410949B2 (en) 2008-08-12
AR051904A1 (es) 2007-02-14
NO20073664L (no) 2007-09-28
TWI309653B (en) 2009-05-11
PT1844070E (pt) 2011-05-04
ES2359850T3 (es) 2011-05-27
JP2008527017A (ja) 2008-07-24
EP1844070A1 (en) 2007-10-17
WO2006077035A1 (en) 2006-07-27
AU2006207659A1 (en) 2006-07-27
US20060160742A1 (en) 2006-07-20
RU2007131504A (ru) 2009-02-27
CN101107266A (zh) 2008-01-16
IL184428A0 (en) 2007-10-31
BRPI0606675A2 (pt) 2009-07-07
DK1844070T3 (da) 2011-06-14
CA2594423A1 (en) 2006-07-27
WO2006077035A9 (en) 2006-10-26
PL1844070T3 (pl) 2011-07-29
TW200637874A (en) 2006-11-01
KR100905380B1 (ko) 2009-06-30
ATE500268T1 (de) 2011-03-15
KR20070095422A (ko) 2007-09-28

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