MX2007000360A - Marcadores moleculares de pronostico. - Google Patents
Marcadores moleculares de pronostico.Info
- Publication number
- MX2007000360A MX2007000360A MX2007000360A MX2007000360A MX2007000360A MX 2007000360 A MX2007000360 A MX 2007000360A MX 2007000360 A MX2007000360 A MX 2007000360A MX 2007000360 A MX2007000360 A MX 2007000360A MX 2007000360 A MX2007000360 A MX 2007000360A
- Authority
- MX
- Mexico
- Prior art keywords
- patients
- ecteinascidin
- brca1
- cancer
- treatment
- Prior art date
Links
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 2
- 229960000977 trabectedin Drugs 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 102000036365 BRCA1 Human genes 0.000 abstract 1
- 108700020463 BRCA1 Proteins 0.000 abstract 1
- 101150072950 BRCA1 gene Proteins 0.000 abstract 1
- XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invencion se relaciona al uso de ceteinascidin 743 en pacientes que tienen ciertos niveles de marcadores moleculares, quienes pueden predecir el efecto de la quimioterapia, en particular en pacientes que tienen bajos niveles de expresion BRCA1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04076997 | 2004-07-09 | ||
PCT/EP2005/007605 WO2006005602A2 (en) | 2004-07-09 | 2005-07-11 | Use of ecteinascidin in the treatment of cancer in patients with low level of brca1 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007000360A true MX2007000360A (es) | 2007-06-12 |
Family
ID=35478393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007000360A MX2007000360A (es) | 2004-07-09 | 2005-07-11 | Marcadores moleculares de pronostico. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080293725A1 (es) |
EP (1) | EP1768671A2 (es) |
JP (1) | JP2008505862A (es) |
AU (1) | AU2005261860A1 (es) |
CA (1) | CA2573072A1 (es) |
MX (1) | MX2007000360A (es) |
NZ (1) | NZ552607A (es) |
WO (1) | WO2006005602A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
BR0115162A (pt) * | 2000-11-06 | 2003-10-21 | Pharma Mar Sa | Tratamentos antitumorais eficazes |
GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
CA2545054A1 (en) * | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
NZ554765A (en) * | 2004-10-26 | 2010-01-29 | Pharma Mar Sa | Pegylated Liposomal Doxorubicin In Combination With Ecteinescidin 743 |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
JP2011500046A (ja) * | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Et−743治療のための予後分子マーカー |
EP2093566A1 (en) * | 2008-02-21 | 2009-08-26 | Pangaea Biotech, S.A. | Method for the prognosis of non-small cell lung cancer |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5149804A (en) * | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
US5256663A (en) * | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
US5089273A (en) * | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
DE3635711A1 (de) * | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
US5478932A (en) * | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
US20040059112A1 (en) * | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
GB9508195D0 (en) * | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
US5908876A (en) * | 1996-04-19 | 1999-06-01 | Mitsui Chemicals, Inc. | Optical resin composition comprising a thiourethane prepolymer and use thereof |
US5721362A (en) * | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
US5985876A (en) * | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
DK1067933T3 (da) * | 1998-04-06 | 2007-12-27 | Univ Illinois | Semisyntetiske ecteinascidiner |
MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
US20020137663A1 (en) * | 2000-08-11 | 2002-09-26 | Forman Barry M. | The anti-neoplastic agent ET-743 inhibits trans activation by SXR |
BR0115162A (pt) * | 2000-11-06 | 2003-10-21 | Pharma Mar Sa | Tratamentos antitumorais eficazes |
WO2002064843A1 (en) * | 2001-02-09 | 2002-08-22 | The Regents Of The University Of California | Ecteinascidin family compounds: compositions and methods |
WO2003039571A1 (en) * | 2001-10-19 | 2003-05-15 | Pharmamar S.A. | Improved use of antitumoral compound in cancer therapy |
US20040019027A1 (en) * | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
GB0312407D0 (en) * | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
GB0324201D0 (en) * | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
-
2005
- 2005-07-11 CA CA002573072A patent/CA2573072A1/en not_active Abandoned
- 2005-07-11 AU AU2005261860A patent/AU2005261860A1/en not_active Abandoned
- 2005-07-11 EP EP05775117A patent/EP1768671A2/en not_active Withdrawn
- 2005-07-11 MX MX2007000360A patent/MX2007000360A/es not_active Application Discontinuation
- 2005-07-11 NZ NZ552607A patent/NZ552607A/en not_active IP Right Cessation
- 2005-07-11 US US11/571,589 patent/US20080293725A1/en not_active Abandoned
- 2005-07-11 JP JP2007519741A patent/JP2008505862A/ja not_active Withdrawn
- 2005-07-11 WO PCT/EP2005/007605 patent/WO2006005602A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CA2573072A1 (en) | 2006-01-19 |
US20080293725A1 (en) | 2008-11-27 |
WO2006005602A3 (en) | 2006-04-13 |
AU2005261860A1 (en) | 2006-01-19 |
JP2008505862A (ja) | 2008-02-28 |
EP1768671A2 (en) | 2007-04-04 |
NZ552607A (en) | 2009-07-31 |
WO2006005602A2 (en) | 2006-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2007002398A (es) | Nuevas composiciones farmaceuticas para el tratamiento de cancer. | |
SI1742644T1 (sl) | Terapevtski sestavek ki vsebuje vsaj en derivat pirolobenzodiazepina in fludarabin | |
SG164368A1 (en) | Treatment of cancer | |
MX361467B (es) | Compuestos de isoindolina para uso en el tratamiento de cancer. | |
PT1984357E (pt) | Compostos de 2,4-pirimidinadiamina para tratamento ou prevenção de doenças autoimunes | |
WO2006073457A3 (en) | Bioactive compounds and methods of uses thereof | |
DK1853250T3 (da) | Kombinationer og måder til indgivelse af terapeutiske midler og kombinationsterapi | |
TW200604192A (en) | Compounds and methods for inhibiting mitotic progression | |
MX2009003157A (es) | Pirazoliltienopiridinas terapeuticas. | |
IL182417A0 (en) | Mitotic kinesin inhibitors and methods of use thereof | |
TW200612918A (en) | Lonidamine analogs | |
UA85559C2 (en) | Aminobenzophenone compounds | |
WO2007101235A3 (en) | Improved antitumoral treatments | |
UA89226C2 (en) | Imidazole compounds | |
MX2008015775A (es) | Compuestos y composiciones para tratamiento de cancer. | |
UA91676C2 (ru) | Композиция, которая содержит ингибитор jnk и циклоспорин | |
MX2007000360A (es) | Marcadores moleculares de pronostico. | |
MY144632A (en) | Cytotoxic agents comprising new taxanes | |
GB0416508D0 (en) | Therapeutic agents | |
ZA200801332B (en) | Pentacyclic kinase inhibitors | |
WO2007130501A3 (en) | Combination therapy for treatment of cancer | |
ATE554753T1 (de) | 2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia | |
MXPA05011699A (es) | Inhibidores de la bomba de protones para el tratamiento de trastornos del abdomen inferior. | |
PL1838716T3 (pl) | Dihydrat embonianu olanzapiny | |
PL1965790T3 (pl) | Metabolity analogów wortmaniny i sposoby ich stosowania |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |