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MEP33108A - Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer - Google Patents

Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer

Info

Publication number
MEP33108A
MEP33108A MEP-331/08A MEP33108A MEP33108A ME P33108 A MEP33108 A ME P33108A ME P33108 A MEP33108 A ME P33108A ME P33108 A MEP33108 A ME P33108A
Authority
ME
Montenegro
Prior art keywords
cancer
treatment
production
bengamide derivatives
bengamide
Prior art date
Application number
MEP-331/08A
Other languages
Bosnian (bs)
Inventor
Holger Hoffmann
Sabine Haag-Richter
Michael Kurz
Heiko Tietgen
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of MEP33108A publication Critical patent/MEP33108A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Ovaj pronalazak obuhvata derivate bengamida, koji nastaju u toku fermentacije mikroorganizma Myxococcus virescens ST200611 (DSM 15898), njihovu primjenu za liječenje bolesti raka, ljekovi koji sadrže derivate bengamida, jedan postupak za proizvodnju bengamida formule (V), kao mikrooorganizam Myxococcus virescens ST200611 (DSM 15898).The present invention encompasses bengamide derivatives formed during the fermentation of the microorganism Myxococcus virescens ST200611 (DSM 15898), their use in the treatment of cancer, drugs containing bengamide derivatives, a process for the production of bengamides of formula (V), as the microorganism Myxococcus virescens ST2006 15898).

MEP-331/08A 2003-10-24 2004-10-08 Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer MEP33108A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349669A DE10349669B3 (en) 2003-10-24 2003-10-24 Bengamide derivatives, process for their preparation and their use
PCT/EP2004/011244 WO2005044803A1 (en) 2003-10-24 2004-10-08 Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer

Publications (1)

Publication Number Publication Date
MEP33108A true MEP33108A (en) 2010-10-10

Family

ID=34484998

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-331/08A MEP33108A (en) 2003-10-24 2004-10-08 Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer

Country Status (30)

Country Link
EP (2) EP1680405B1 (en)
JP (1) JP4769190B2 (en)
KR (1) KR20060120044A (en)
CN (2) CN101294173A (en)
AR (1) AR046553A1 (en)
AT (2) ATE477244T1 (en)
AU (1) AU2004287561B2 (en)
BR (1) BRPI0415529A (en)
CA (1) CA2543003A1 (en)
CL (1) CL2009000674A1 (en)
CY (1) CY1110458T1 (en)
DE (3) DE10349669B3 (en)
DK (1) DK1680405T3 (en)
ES (1) ES2320894T3 (en)
HK (1) HK1098131A1 (en)
HR (1) HRP20090187T1 (en)
IL (1) IL174524A (en)
MA (1) MA28213A1 (en)
ME (1) MEP33108A (en)
MX (1) MXPA06004084A (en)
NO (1) NO20062149L (en)
NZ (1) NZ546744A (en)
PL (1) PL1680405T3 (en)
PT (1) PT1680405E (en)
RS (1) RS20060263A (en)
RU (1) RU2357956C2 (en)
SI (1) SI1680405T1 (en)
UY (1) UY28574A1 (en)
WO (1) WO2005044803A1 (en)
ZA (1) ZA200602231B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878528B1 (en) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDES, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2878525B1 (en) * 2004-11-29 2007-02-23 Aventis Pharma Sa BENGAMIDES HAVING SUBSTITUTED CAPROLACTAM CYCLE, PREPARATION METHOD, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2901556A1 (en) 2006-05-24 2007-11-30 Sanofi Aventis Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE DERIVATIVES, THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2901555A1 (en) 2006-05-24 2007-11-30 Sanofi Aventis Sa 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZOTHIAZEPINE, THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR2901554B1 (en) 2006-05-24 2011-04-01 Sanofi Aventis 2-ALCOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZAZEPINE, PREPARATION THEREOF, COMPOSITIONS CONTAINING SAME AND USE THEREOF

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5140099A1 (en) * 1998-11-17 2002-03-22 Novartis Ag CERTAIN SUBSTITUTED CAPROLACTAMAS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND ITS USE IN TUMORS TREATMENT
ATE383341T1 (en) * 2000-05-11 2008-01-15 Novartis Pharma Gmbh SUBSTITUTED CAPROLACTAM CARBONATE AND ETHER AND THEIR USE AS ANTI-TUMOR ACTIVE INGREDIENTS
JP2004262793A (en) * 2003-02-28 2004-09-24 Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai Compound n-9011, its production method and use
CA2533335A1 (en) * 2003-07-25 2005-02-17 Novartis Ag Substituted lactams and their use as anti-cancer agents

Also Published As

Publication number Publication date
ZA200602231B (en) 2007-06-27
MXPA06004084A (en) 2006-06-27
RS20060263A (en) 2008-09-29
JP2007509084A (en) 2007-04-12
NO20062149L (en) 2006-07-11
IL174524A (en) 2012-08-30
CN101294173A (en) 2008-10-29
EP1873146A3 (en) 2008-05-21
AU2004287561B2 (en) 2011-06-02
RU2006117769A (en) 2007-11-27
CA2543003A1 (en) 2005-05-19
IL174524A0 (en) 2006-08-01
ATE477244T1 (en) 2010-08-15
HK1098131A1 (en) 2007-07-13
DK1680405T3 (en) 2009-05-04
PT1680405E (en) 2009-03-31
UY28574A1 (en) 2005-05-31
CY1110458T1 (en) 2015-04-29
SI1680405T1 (en) 2009-06-30
EP1873146A2 (en) 2008-01-02
RU2357956C2 (en) 2009-06-10
AU2004287561A1 (en) 2005-05-19
KR20060120044A (en) 2006-11-24
NZ546744A (en) 2009-03-31
CL2009000674A1 (en) 2009-08-07
DE10349669B3 (en) 2005-05-25
CN100398520C (en) 2008-07-02
DE502004008837D1 (en) 2009-02-26
CN1871217A (en) 2006-11-29
HRP20090187T1 (en) 2009-05-31
AR046553A1 (en) 2005-12-14
EP1680405B1 (en) 2009-01-07
MA28213A1 (en) 2006-10-02
ATE420074T1 (en) 2009-01-15
DE502004011536D1 (en) 2010-09-23
BRPI0415529A (en) 2006-12-26
EP1873146B1 (en) 2010-08-11
ES2320894T3 (en) 2009-05-29
JP4769190B2 (en) 2011-09-07
WO2005044803A1 (en) 2005-05-19
PL1680405T3 (en) 2009-06-30
EP1680405A1 (en) 2006-07-19

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