MD839F1 - Biologically active agent, method for its obtaining, preparation based on it and application process thereof - Google Patents
Biologically active agent, method for its obtaining, preparation based on it and application process thereofInfo
- Publication number
- MD839F1 MD839F1 MD95-0377A MD950377A MD839F1 MD 839 F1 MD839 F1 MD 839F1 MD 950377 A MD950377 A MD 950377A MD 839 F1 MD839 F1 MD 839F1
- Authority
- MD
- Moldova
- Prior art keywords
- hydrolysis
- products
- baa
- organic substances
- ingredients
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000013543 active substance Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 7
- 238000006460 hydrolysis reaction Methods 0.000 abstract 7
- 239000000047 product Substances 0.000 abstract 6
- 241001465754 Metazoa Species 0.000 abstract 5
- 239000004615 ingredient Substances 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000002994 raw material Substances 0.000 abstract 2
- 239000006228 supernatant Substances 0.000 abstract 2
- 229920002306 Glycocalyx Polymers 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000013020 embryo development Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 210000004517 glycocalyx Anatomy 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000010606 normalization Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000035790 physiological processes and functions Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A biologically active agent (BAA) is based on water-soluble products of hydrolysis of ingredients of disintegrated animal tissue which consist of organic substances, and has immunomodulating properties. The agent contains products of hydrolysis of morphoplasma components and of glycocalyx of cells (MCGC) modified during the processes of embryogenesis and/or proliferation and/or differentiation of cells, and/or during a pathology preceding or accompanying the process of regeneration and/or repatriation of the tissue. A method for obtaining BAA comprises disintegration of a washed raw material based on animal tissues, hydrolysis of the obtained ingredients with their subsequent centrifuging of the hydrolysis products or their filtration and separation of supernatant as desired product as the raw material animal tissues with modified MCGC are used. Before the hydrolysis the homogenization is carried out together with purification and elimination of non- disintegrated tissue elements and the supernatant is extracted containing ingredients with modified MCGC. A pharmaceutical preparation for normalization of physiological state of human beings and animals based on organic substances-products of hydrolysis of ingredients of animal tissue comprises, as active agent, BAA which contains among the hydrolysis products with modified MCGC organic substances at the following ratio in per cent by weight: polypeptides up to 26.0, peptides 10.0-23.0, amino acids 32.0-66.1, carbonhydrates 10.5-23.5, lipids, nucleotides and other organic substances 2.0-11.0 with the content of BAA in the preparation equal to 0.001-85.0 % by weight, the balance consisting of a solvent.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU5063049 RU2041715C1 (en) | 1992-07-21 | 1992-07-21 | Biologically active remedy, method for its producing, preparation containing the mentioned remedy and method for applying the preparation |
| UA93030288A UA2164C2 (en) | 1992-07-21 | 1992-12-17 | Biologically tool that possesses immunomodulating properties, the method of its receipt, drugs based on it AND METHOD FOR NORMALIZATION physiological state of the human body and animals in diseases generated MAINLY pathological AND / OR foreign body cells, microorganisms and / or products of their life, from the use of such THE DRUG |
| PCT/UA1993/000003 WO1994002104A1 (en) | 1992-07-21 | 1993-07-20 | Biologically active agent having immunomodulating properties, method for its obtaining and pharmaceutical preparation based on it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD839F1 true MD839F1 (en) | 1997-09-30 |
| MD839G2 MD839G2 (en) | 1998-05-31 |
Family
ID=26666279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0377A MD839G2 (en) | 1992-07-21 | 1993-07-20 | Biologically active agent having immunomodulating properties, method for its obtaining, preparation based on it and method for normalization of human and animal organism physiological state |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0673652B1 (en) |
| AT (1) | ATE214283T1 (en) |
| AU (1) | AU4767693A (en) |
| BG (1) | BG61680B1 (en) |
| CA (1) | CA2149146A1 (en) |
| DE (1) | DE69331704T2 (en) |
| HU (1) | HUT73378A (en) |
| MD (1) | MD839G2 (en) |
| PL (1) | PL173321B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116844160B (en) * | 2023-09-01 | 2023-11-28 | 武汉互创联合科技有限公司 | Embryo development quality assessment system based on main body identification |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU139404A1 (en) * | 1960-12-10 | 1961-11-30 | Н.Г. Беленький | Method for the production of tissue preparations |
| US4455302A (en) * | 1973-10-24 | 1984-06-19 | Robertson Harry J | Medical protein hydrolysate, process of making the same and processes of utilizing the protein hydrolysate to aid in healing traumatized areas |
| FR2413912A1 (en) * | 1978-01-10 | 1979-08-03 | Bontemps Raymond | Frozen biogenic foetal material in normal saline - for regeneration and re-organisation of cells |
| SU904707A1 (en) * | 1979-06-25 | 1982-02-15 | Ленинградский Ветеринарный Институт | Agent for increasing young stock organism resistancy and method of producing it |
| AU544136B2 (en) * | 1979-11-22 | 1985-05-16 | Cellena (Cell Engineering) A.G. | A water soluble fraction capable of controlling the immune reactions of a host against allogenic cells or tissue, the pharmaceutical compositions containing said fraction |
| ATE27913T1 (en) * | 1982-01-11 | 1987-07-15 | Theurer Karl Eugen | PRODUCTS FOR INTRAVASAL APPLICATION OF WATER-SOLUBLE OR EMULSABLE ANTIGEN ORGAN EXTRACTS. |
| US4468379A (en) * | 1982-05-06 | 1984-08-28 | Endeavor Corp. | Leukocyte extracts for affecting the immune system |
| ZA847349B (en) * | 1983-10-05 | 1985-04-24 | Solco Basel Ag | Process for the preparation of a biologically active extract |
| FR2599972B1 (en) * | 1986-06-12 | 1990-06-29 | Laumond Gerard | EMBRYONIC TISSUE EXTRACTS FROM ANIMAL ORGANS, INJECTABLE TO MAN |
-
1993
- 1993-07-20 CA CA002149146A patent/CA2149146A1/en not_active Abandoned
- 1993-07-20 MD MD95-0377A patent/MD839G2/en not_active IP Right Cessation
- 1993-07-20 AU AU47676/93A patent/AU4767693A/en not_active Abandoned
- 1993-07-20 DE DE69331704T patent/DE69331704T2/en not_active Expired - Lifetime
- 1993-07-20 AT AT94905611T patent/ATE214283T1/en active
- 1993-07-20 PL PL93308535A patent/PL173321B1/en not_active IP Right Cessation
- 1993-07-20 EP EP94905611A patent/EP0673652B1/en not_active Expired - Lifetime
- 1993-07-20 HU HU9500410A patent/HUT73378A/en unknown
-
1995
- 1995-02-20 BG BG99446A patent/BG61680B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG99446A (en) | 1996-03-29 |
| CA2149146A1 (en) | 1994-02-03 |
| HUT73378A (en) | 1996-07-29 |
| EP0673652A4 (en) | 1996-07-03 |
| ATE214283T1 (en) | 2002-03-15 |
| PL308535A1 (en) | 1995-08-21 |
| DE69331704D1 (en) | 2002-04-18 |
| EP0673652B1 (en) | 2002-03-13 |
| EP0673652A1 (en) | 1995-09-27 |
| MD839G2 (en) | 1998-05-31 |
| PL173321B1 (en) | 1998-02-27 |
| DE69331704T2 (en) | 2002-10-31 |
| BG61680B1 (en) | 1998-03-31 |
| HU9500410D0 (en) | 1995-04-28 |
| AU4767693A (en) | 1994-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Granted patent for invention | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20130720 |
|
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |