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MD776C2 - Inclusion complexes of 3-morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic desease - Google Patents

Inclusion complexes of 3-morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic desease

Info

Publication number
MD776C2
MD776C2 MD94-0334A MD940334A MD776C2 MD 776 C2 MD776 C2 MD 776C2 MD 940334 A MD940334 A MD 940334A MD 776 C2 MD776 C2 MD 776C2
Authority
MD
Moldova
Prior art keywords
preparation
morpholinesydnonimine
derivatives
cyclodextrine
salts
Prior art date
Application number
MD94-0334A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD940334A (en
MD776B2 (en
Inventor
Andrasne Vikmon
Jozsef Szejtli
Lajos Szente
Jozsef Gaal
Istvan Hermecz
Agnes Horvath
Katalin Marmarosi
Gabor Horvath
Iren Munkacsi
Original Assignee
Therabel Industries S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therabel Industries S.A. filed Critical Therabel Industries S.A.
Publication of MD940334A publication Critical patent/MD940334A/en
Publication of MD776B2 publication Critical patent/MD776B2/en
Publication of MD776C2 publication Critical patent/MD776C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention relates to the inclusion complexes of 3-morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, containing their pharmaceutical compositions, method for preparation thereof and for treatment of stenocardia or ishemic desease.Inclusion complexes of 3-morpholinesydnonimine or its salts with cyclodextrine or its derivatives are prepared:a) by 3-morpholinesydnonimine or its salts interaction in the aqueous medium with cyclodextrine or its derivatives and by the further isolation of complexes from the solution by dehydrotation, orb) there is carried out the intensive grounding 3-morpholinesydnonimine or its salts with cyclodextrine or its derivatives.The technical result of the invention consists in the stabilisation of 3-morpholinesydnonimine and its derivatives with cyclodextrines.
MD94-0334A 1990-03-28 1991-03-28 Inclusion complexes of 3-morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic desease MD776C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU901869A HU212730B (en) 1990-03-28 1990-03-28 Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them
PCT/HU1991/000013 WO1991014681A1 (en) 1990-03-28 1991-03-28 Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same

Publications (3)

Publication Number Publication Date
MD940334A MD940334A (en) 1996-10-31
MD776B2 MD776B2 (en) 1997-07-31
MD776C2 true MD776C2 (en) 1998-05-31

Family

ID=10956597

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0334A MD776C2 (en) 1990-03-28 1991-03-28 Inclusion complexes of 3-morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic desease

Country Status (33)

Country Link
US (1) US5298496A (en)
EP (1) EP0478732B1 (en)
JP (1) JP2549961B2 (en)
KR (1) KR950004706B1 (en)
CN (1) CN1051081C (en)
AT (1) ATE170849T1 (en)
AU (1) AU635835B2 (en)
BG (1) BG61812B1 (en)
BR (1) BR9105137A (en)
CA (1) CA2054213C (en)
CZ (1) CZ285695B6 (en)
DE (1) DE69130146T2 (en)
DK (1) DK0478732T3 (en)
ES (1) ES2121780T3 (en)
FI (1) FI104882B (en)
GE (1) GEP19991743B (en)
HK (1) HK1011688A1 (en)
HR (1) HRP920560B1 (en)
HU (2) HU211648A9 (en)
LT (1) LT3257B (en)
LV (1) LV10087B (en)
MC (1) MC2186A1 (en)
MD (1) MD776C2 (en)
MW (1) MW6891A1 (en)
NO (1) NO303634B1 (en)
OA (1) OA09522A (en)
PL (1) PL165866B1 (en)
RO (1) RO109336B1 (en)
RU (1) RU2107695C1 (en)
SI (1) SI9110909B (en)
TJ (1) TJ189R3 (en)
UA (1) UA27242C2 (en)
WO (1) WO1991014681A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3119C2 (en) * 2000-02-24 2007-04-30 Therabel Pharmaceuticals Limited Drug form for oral use with prolonged release of molsidomine

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210921B (en) * 1990-03-28 1995-09-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
DE4117249C2 (en) * 1991-05-27 1998-05-14 Christian Dr Stief Linsidomine used to treat erectile dysfunction
HU213200B (en) 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
HU218280B (en) * 1994-04-26 2000-07-28 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
ATE319480T1 (en) * 2000-05-11 2006-03-15 Eastman Chem Co ACYLATED CYCLODEXTRIN GUEST INCLUSION COMPLEXES

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346638A1 (en) * 1983-12-23 1985-07-04 Cassella Ag, 6000 Frankfurt PHOTOSTABILIZATION OF MOLSIDOMIN
EP0206219A1 (en) * 1985-06-21 1986-12-30 CASSELLA Aktiengesellschaft Photostabilising of sydnonimines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1496056A (en) * 1964-06-08 1967-09-29 Takeda Chemical Industries Ltd New chemical compounds of the sydnonimine type
DE3221425A1 (en) * 1982-06-07 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim HYDROLYSIS-SENSITIVE ACTIVE SUBSTANCE CONTAINING STORAGE TABLET
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (en) * 1986-12-26 1996-02-28 日清製粉株式会社 Sustained-release pharmaceutical preparation
IT1204725B (en) * 1987-06-17 1989-03-10 Edmond Pharma Srl DIPYRIDAMOL INCLUSION COMPLEXES WITH CYCLODESTRINE
SE8904296D0 (en) * 1989-12-21 1989-12-21 Pharmacia Ab TRANSDERMAL SYSTEM
WO1991015346A1 (en) * 1990-04-06 1991-10-17 Gerhard Blatt Installation for conditioning concrete blocks

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346638A1 (en) * 1983-12-23 1985-07-04 Cassella Ag, 6000 Frankfurt PHOTOSTABILIZATION OF MOLSIDOMIN
EP0206219A1 (en) * 1985-06-21 1986-12-30 CASSELLA Aktiengesellschaft Photostabilising of sydnonimines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Cyclodextrin Technology", 1988, Kluwer, Derdrecht, p. 211-217. *
Chem. Pharm Bull vol.19, nr.6, 1971 p. 1079. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3119C2 (en) * 2000-02-24 2007-04-30 Therabel Pharmaceuticals Limited Drug form for oral use with prolonged release of molsidomine

Also Published As

Publication number Publication date
MD940334A (en) 1996-10-31
DE69130146T2 (en) 1999-04-01
MC2186A1 (en) 1992-09-16
CZ85291A3 (en) 1993-11-17
ES2121780T3 (en) 1998-12-16
JPH04506221A (en) 1992-10-29
FI915570A0 (en) 1991-11-26
NO303634B1 (en) 1998-08-10
NO914650D0 (en) 1991-11-27
US5298496A (en) 1994-03-29
DE69130146D1 (en) 1998-10-15
RU2107695C1 (en) 1998-03-27
PL165866B1 (en) 1995-02-28
BR9105137A (en) 1992-08-04
HU211648A9 (en) 1995-12-28
RO109336B1 (en) 1995-01-30
MW6891A1 (en) 1993-07-14
CA2054213C (en) 1998-12-01
SI9110909A (en) 1998-06-30
UA27242C2 (en) 2000-08-15
AU635835B2 (en) 1993-04-01
HRP920560B1 (en) 1999-12-31
DK0478732T3 (en) 1999-06-07
FI104882B (en) 2000-04-28
TJ189R3 (en) 1998-10-28
LV10087B (en) 1995-02-20
HK1011688A1 (en) 1999-07-16
KR920701183A (en) 1992-08-11
HU901869D0 (en) 1990-07-28
CN1051081C (en) 2000-04-05
EP0478732A1 (en) 1992-04-08
NO914650L (en) 1991-11-27
JP2549961B2 (en) 1996-10-30
HRP920560A2 (en) 1994-04-30
HU212730B (en) 1996-10-28
GEP19991743B (en) 1999-09-10
OA09522A (en) 1992-11-15
CN1055928A (en) 1991-11-06
KR950004706B1 (en) 1995-05-04
PL293020A1 (en) 1992-12-28
CZ285695B6 (en) 1999-10-13
WO1991014681A1 (en) 1991-10-03
SI9110909B (en) 1999-02-28
ATE170849T1 (en) 1998-09-15
BG61812B1 (en) 1998-06-30
HUT58110A (en) 1992-01-28
EP0478732B1 (en) 1998-09-09
LTIP387A (en) 1994-09-25
BG95530A (en) 1993-12-24
CA2054213A1 (en) 1991-09-29
LV10087A (en) 1994-05-10
LT3257B (en) 1995-05-25
MD776B2 (en) 1997-07-31
AU7549391A (en) 1991-10-21

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20110328