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MD663G2 - Erythromycin derivatives,method for their preparation and use thereof as drugs - Google Patents

Erythromycin derivatives,method for their preparation and use thereof as drugs

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
carbon atoms
hydrogen atom
heteroatoms
formula
saturated
Prior art date
Application number
MD95-0431A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD663F1 (en
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/en
Publication of MD663G2 publication Critical patent/MD663G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compounds of general formula (I),wherein R1, and R2 which are the same or different, are a hydrogen atom or a saturated or unsaturated hydrocarbon radical having up to 24 carbon atoms and being optionally interrupted by one or more heteroatoms provided with one or more functional groupings; or R1 and R2, taken together with the nitrogen atom to which they are attached, from a heterocyclic ring optionally containing one or more heteroatoms selected from nitrogen, oxigen and sulphur; or R1 and R2 taken together, forma radical (a) in which R'1 and R'2 which are the same or different, are hydrogen atom or saturated or unsaturated hydrocarbon radical, having up to 23 carbon atoms and being optinally interrupted by one or more heteroatoms and provided with one or more functional groupings, and Z is a hydrogen atom or a carboxylic acid residue having up to 18 carbon atoms; as well as acid addition salts there of formula (I) The compunds of formula (I) have valuable antibiotic properties.
MD95-0431A 1994-04-08 1995-04-06 Erythromycin derivatives,method for their preparation and use thereof as drugs MD663G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (en) 1994-04-08 1994-04-08 New erythromycin derivatives, their preparation process and their use as drugs.
PCT/FR1995/000441 WO1995027720A1 (en) 1994-04-08 1995-04-06 Novel erythromycin derivatives, method for preparing same and use thereof as drugs

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (en) 1997-01-31
MD663G2 true MD663G2 (en) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (en) 1994-04-08 1995-04-06 Erythromycin derivatives,method for their preparation and use thereof as drugs

Country Status (49)

Country Link
US (2) US5656607A (en)
EP (1) EP0676409B1 (en)
JP (1) JP3000023B2 (en)
KR (1) KR100317148B1 (en)
CN (1) CN1059445C (en)
AP (1) AP587A (en)
AT (1) ATE234853T1 (en)
AU (1) AU684939B2 (en)
BG (1) BG61916B1 (en)
BR (1) BR9506147A (en)
CA (1) CA2164638C (en)
CO (1) CO4370097A1 (en)
CZ (1) CZ296005B6 (en)
DE (1) DE69529934T2 (en)
DK (1) DK0676409T3 (en)
DZ (1) DZ1869A1 (en)
EE (1) EE04498B1 (en)
ES (1) ES2189820T3 (en)
FI (1) FI111264B (en)
FR (1) FR2718450B1 (en)
GB (1) GB2288174A (en)
GE (1) GEP19991836B (en)
HR (1) HRP950217B1 (en)
HU (1) HU215396B (en)
IL (1) IL112954A (en)
IS (1) IS1865B (en)
JO (1) JO1850B1 (en)
LV (1) LV11182B (en)
MA (1) MA23501A1 (en)
MD (1) MD663G2 (en)
MY (1) MY114672A (en)
NO (1) NO308361B1 (en)
NZ (1) NZ284498A (en)
OA (1) OA10200A (en)
PE (1) PE2896A1 (en)
PL (1) PL180837B1 (en)
PT (1) PT676409E (en)
RO (1) RO115634B1 (en)
RU (1) RU2141965C1 (en)
SA (1) SA97170757A (en)
SI (1) SI0676409T1 (en)
SK (1) SK284079B6 (en)
SV (1) SV1995000018A (en)
TN (1) TNSN95026A1 (en)
TW (1) TW316908B (en)
UA (1) UA44705C2 (en)
WO (1) WO1995027720A1 (en)
YU (1) YU49221B (en)
ZA (1) ZA952059B (en)

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FR2732023B1 (en) * 1995-03-22 1997-04-30 Roussel Uclaf NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2742757B1 (en) * 1995-12-22 1998-01-30 Roussel Uclaf NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2745289B1 (en) * 1996-02-28 1998-05-29 Roussel Uclaf NOVEL DERIVATIVES OF CARBOXYLIC ACID 1 (2H) QUINOLEIN, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION TO THE SYNTHESIS OF PRODUCTS WITH ANTIBIOTIC PROPERTIES
KR20000011071A (en) * 1996-05-07 2000-02-25 스티븐 에프. 웨인스톡 3-descladinos-2,3-anhydroerythromycin derivative
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (en) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc NEW PROCESS FOR ISOMERIZATION OF RADICAL METHYL IN 10 FROM ERYTHROMYCIN DERIVATIVES
FR2751656B1 (en) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
PT1291353E (en) * 1996-09-04 2005-10-31 Abbott Lab 6-O-SUBSTITUTED CETOLIDES HAVING ANTIBACTERIAL ACTIVITY
UA51730C2 (en) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-0-substituted ketolides having antibacterial activity
FR2757168B1 (en) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2760017B1 (en) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc NOVEL ERYTROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
WO1998040392A1 (en) * 1997-03-10 1998-09-17 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
ID24529A (en) * 1997-06-11 2000-07-20 Pfizer Prod Inc 9-OKSIMA ERITROMICIN DESIGNS
FR2771008B1 (en) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc USE OF KETOLIDES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR PREVENTING ARTERIAL THROMBOTIC COMPLICATIONS LINKED TO ATHEROSCLEROSIS
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AU5299499A (en) * 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (en) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
DE69933897T2 (en) 1998-12-10 2007-03-15 Pfizer Products Inc., Groton Carbamate and carbazate ketolide antibiotics
FR2789392B1 (en) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
CA2370743A1 (en) 1999-04-16 2000-10-26 Dennis Hlasta Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
ES2272273T3 (en) * 1999-04-16 2007-05-01 Kosan Biosciences, Inc. MACROLID ANTI-INFECTIVE AGENTS.
CZ20013733A3 (en) * 1999-05-24 2002-11-13 Pfizer Products Inc. 13-Methyl erythromycin derivatives
CA2451391A1 (en) 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
EP1576106B1 (en) 2002-07-01 2016-06-22 Arkion Life Sciences LLC Process and materials for production of glucosamine and n-acetylglucosamine
CA2529817C (en) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
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CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
CN101917850B (en) * 2007-10-25 2016-01-13 森普拉制药公司 Macrolide antibacterial agent and its preparation method
CN102223794B (en) 2008-10-24 2017-12-22 森普拉制药公司 Use the method for the macrolide therapy resistance disease containing triazole
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (en) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド Method for treating malaria, tuberculosis and MAC disease
BR112012023950A2 (en) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc crystalline forms of a macrolide, and uses thereof
ES2636948T3 (en) 2010-05-20 2017-10-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates for them
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc Hydrogen bond forming fluoro ketolides for treating diseases
RU2658050C2 (en) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
RU2015138797A (en) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. CONVERGENT METHODS FOR PRODUCING MACROLIDE ANTIBACTERIAL AGENTS
BR112015025159A2 (en) 2013-04-04 2017-07-18 Harvard College macrolides and methods for their preparation and use
WO2016057798A1 (en) 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
US10640528B2 (en) 2015-03-25 2020-05-05 President And Fellows Of Havard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (en) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Process for treating planting material of flowers before planting
JP7199722B2 (en) 2019-12-25 2023-01-06 旭精工株式会社 Coin transport sorting mechanism and coin identification transport device provided with the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (en) * 1992-11-05 1994-05-11 Roussel Uclaf Erythromycin derivatives, their process of preparation and their application as medicaments

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US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (en) * 1978-09-30 1980-04-10 Merck Patent Gmbh BASIC AETHER, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
FR2692579B1 (en) * 1992-06-19 1995-06-02 Roussel Uclaf New picromycin derivatives, their preparation process and their use as medicines.
FR2697524B1 (en) * 1992-11-05 1994-12-23 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (en) * 1993-03-09 1995-04-28 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.

Patent Citations (1)

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Also Published As

Publication number Publication date
JO1850B1 (en) 1995-12-27
EE04498B1 (en) 2005-06-15
DZ1869A1 (en) 2002-02-17
SI0676409T1 (en) 2003-06-30
GB9506856D0 (en) 1995-05-24
CN1126997A (en) 1996-07-17
HU215396B (en) 1998-12-28
OA10200A (en) 1996-12-18
AP587A (en) 1997-04-29
MD663F1 (en) 1997-01-31
HRP950217A2 (en) 1997-08-31
IS1865B (en) 2003-05-02
LV11182B (en) 1997-04-20
NZ284498A (en) 1997-07-27
ZA952059B (en) 1996-03-13
BR9506147A (en) 1996-04-16
NO308361B1 (en) 2000-09-04
WO1995027720A1 (en) 1995-10-19
BG100150A (en) 1996-06-28
YU49221B (en) 2004-11-25
GEP19991836B (en) 1999-11-05
NO954942D0 (en) 1995-12-06
LV11182A (en) 1996-04-20
FI111264B (en) 2003-06-30
RU2141965C1 (en) 1999-11-27
PL180837B1 (en) 2001-04-30
US5656607A (en) 1997-08-12
FR2718450A1 (en) 1995-10-13
US5760233A (en) 1998-06-02
RO115634B1 (en) 2000-04-28
SK284079B6 (en) 2004-09-08
IS4309A (en) 1995-11-17
HU9503505D0 (en) 1996-02-28
TW316908B (en) 1997-10-01
AU684939B2 (en) 1998-01-08
GB2288174A (en) 1995-10-11
FI955913A0 (en) 1995-12-08
KR100317148B1 (en) 2002-06-22
MA23501A1 (en) 1995-12-31
CN1059445C (en) 2000-12-13
DK0676409T3 (en) 2003-06-23
EE9500080A (en) 1996-12-16
SK154695A3 (en) 1996-10-02
JP3000023B2 (en) 2000-01-17
JPH07278177A (en) 1995-10-24
CO4370097A1 (en) 1996-10-07
DE69529934D1 (en) 2003-04-24
MY114672A (en) 2002-12-31
BG61916B1 (en) 1998-09-30
HRP950217B1 (en) 2004-06-30
PT676409E (en) 2003-08-29
AP9500743A0 (en) 1995-07-31
UA44705C2 (en) 2002-03-15
CZ296005B6 (en) 2005-12-14
FI955913A (en) 1995-12-08
YU21695A (en) 1997-12-05
EP0676409A1 (en) 1995-10-11
PE2896A1 (en) 1996-02-12
CA2164638A1 (en) 1995-10-19
CA2164638C (en) 2003-12-30
NO954942L (en) 1996-02-07
SV1995000018A (en) 1997-10-24
CZ322395A3 (en) 1996-08-14
FR2718450B1 (en) 1997-01-10
ATE234853T1 (en) 2003-04-15
HUT73772A (en) 1996-09-30
TNSN95026A1 (en) 1996-02-06
PL311871A1 (en) 1996-03-18
IL112954A (en) 2000-07-16
ES2189820T3 (en) 2003-07-16
AU2310795A (en) 1995-10-30
EP0676409B1 (en) 2003-03-19
DE69529934T2 (en) 2003-09-04
SA97170757A (en) 2005-12-03
IL112954A0 (en) 1995-06-29

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees