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MD523G2 - New triazol pyrimidine derivatives, angiotension II antagonist, processes for preparation thereof, pharmaceutical compositions containg thereof - Google Patents

New triazol pyrimidine derivatives, angiotension II antagonist, processes for preparation thereof, pharmaceutical compositions containg thereof

Info

Publication number
MD523G2
MD523G2 MD95-0084A MD950084A MD523G2 MD 523 G2 MD523 G2 MD 523G2 MD 950084 A MD950084 A MD 950084A MD 523 G2 MD523 G2 MD 523G2
Authority
MD
Moldova
Prior art keywords
angiotension
antagonist
processes
preparation
pharmaceutical compositions
Prior art date
Application number
MD95-0084A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD523F1 (en
Inventor
Nicole Bru-Magniez
Eric Nicolai
Jean-Marie Teulon
Original Assignee
Laboratoires Upsa, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Upsa, S.A. filed Critical Laboratoires Upsa, S.A.
Publication of MD523F1 publication Critical patent/MD523F1/en
Publication of MD523G2 publication Critical patent/MD523G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to the derivatives of formula:(1)\tab\tab\tab\tab\taband to tautomers formula, as well as additive salts thereof, and using thereof in therapy, as well as for treatment and prevenzion of cardivascular diseases, particularly for hypertonic disease, cardiac insuficience, arterial wall disease, particularly, arteriosclerosis.Claims: 15
MD95-0084A 1991-07-05 1994-12-30 New triazol pyrimidine derivatives, angiotension II antagonist, processes for preparation thereof, pharmaceutical compositions containg thereof MD523G2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108486A FR2678618B1 (en) 1991-07-05 1991-07-05 NOVEL TRIAZOLO PYRIMIDINE DERIVATIVES ANTIAGONISTS OF ANGIOTENSIN II RECEPTORS; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Publications (2)

Publication Number Publication Date
MD523F1 MD523F1 (en) 1996-04-30
MD523G2 true MD523G2 (en) 1997-01-31

Family

ID=9414783

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0084A MD523G2 (en) 1991-07-05 1994-12-30 New triazol pyrimidine derivatives, angiotension II antagonist, processes for preparation thereof, pharmaceutical compositions containg thereof

Country Status (23)

Country Link
US (1) US5217973A (en)
EP (1) EP0521768B1 (en)
JP (1) JP3140566B2 (en)
KR (1) KR100243628B1 (en)
AT (1) ATE101153T1 (en)
AU (1) AU655288B2 (en)
CA (1) CA2072233C (en)
CZ (1) CZ284757B6 (en)
DE (1) DE69200045T2 (en)
DK (1) DK0521768T3 (en)
EE (1) EE03003B1 (en)
ES (1) ES2063570T3 (en)
FR (1) FR2678618B1 (en)
HU (2) HU220225B (en)
IE (1) IE65635B1 (en)
IL (1) IL102367A (en)
LV (1) LV10717B (en)
MD (1) MD523G2 (en)
NZ (1) NZ243443A (en)
RU (1) RU2103270C1 (en)
SK (1) SK279902B6 (en)
TW (1) TW221445B (en)
ZA (1) ZA924954B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358950A (en) * 1991-07-05 1994-10-25 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists
FR2687677B1 (en) * 1992-02-24 1996-10-11 Union Pharma Scient Appl NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST POLYAZAINDENES DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5389632A (en) * 1992-02-24 1995-02-14 Laboratoires Upsa Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
IT1263804B (en) * 1993-01-22 1996-09-03 Luso Farmaco Inst PYRIMIDINONIC DERIVATIVES MELT WITH NITROGEN HETEROCYCLES ACTIVATED IN II ANTAGONIST
US5358947A (en) * 1993-09-13 1994-10-25 American Cyanamid Company Angiotensin II receptor blocking 2,3-substituted pyrazolo[1,5-a]-1,3,5-triazin-4(3H)-ones
JP4195729B2 (en) * 1997-03-24 2008-12-10 協和醗酵工業株式会社 [1,2,4] Triazolo [1,5-c] pyrimidine derivatives
SE9903028D0 (en) 1999-08-27 1999-08-27 Astra Ab New use
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0719803D0 (en) * 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
WO2009158309A2 (en) * 2008-06-25 2009-12-30 Ligand Pharmaceuticals Inc. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
ES2624828T3 (en) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
CN118215664A (en) * 2021-10-19 2024-06-18 上海瑛派药业有限公司 Substituted triazoloheteroaryl compounds as USP1 inhibitors and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US269980A (en) * 1883-01-02 Horse power
GB897870A (en) * 1959-06-15 1962-05-30 Ici Ltd s-triazolo[2, 3-c]pyrimidine derivatives
EP0152841A1 (en) * 1984-02-03 1985-08-28 G.D. Searle & Co. 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazolo[1,5-c]pyrimidines
EP0435827A2 (en) * 1989-12-28 1991-07-03 Ciba-Geigy Ag Diaza compounds
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB859287A (en) * 1958-10-03 1961-01-18 Ici Ltd Triazolopyrimidine derivatives and their preparation
GB951652A (en) * 1960-06-28 1964-03-11 Wallace Broadbent Sulphamyl triazolopyrimidines and their preparation
US4269980A (en) * 1979-12-17 1981-05-26 American Cyanamid Company (Substituted-phenyl)-1,2,4-triazolo[4,3-c]pyrimidines and (substituted-phenyl)-1,2,4-triazolo[1,5-c]pyrimidines
US4572910A (en) * 1983-03-03 1986-02-25 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4528288A (en) * 1983-05-02 1985-07-09 Riker Laboratories, Inc. Substituted triazolo[1,5-c]pyrimidines
US4532242A (en) * 1983-05-02 1985-07-30 Riker Laboratories, Inc. Substituted triazolo[4,3-c]pyrimidines
US4728652A (en) * 1985-05-20 1988-03-01 E. R. Squibb & Sons, Inc. 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure
US5010195A (en) * 1988-05-25 1991-04-23 The Dow Chemical Company Herbicidal alkoxy-1,2,4-triazolo(1,5-c)primidine-2-sulfonamides
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5177206A (en) * 1991-10-08 1993-01-05 Dowelanco Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US269980A (en) * 1883-01-02 Horse power
GB897870A (en) * 1959-06-15 1962-05-30 Ici Ltd s-triazolo[2, 3-c]pyrimidine derivatives
EP0152841A1 (en) * 1984-02-03 1985-08-28 G.D. Searle & Co. 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazolo[1,5-c]pyrimidines
EP0435827A2 (en) * 1989-12-28 1991-07-03 Ciba-Geigy Ag Diaza compounds
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines

Also Published As

Publication number Publication date
EP0521768A1 (en) 1993-01-07
IL102367A0 (en) 1993-01-14
ES2063570T3 (en) 1995-01-01
IE922015A1 (en) 1993-01-13
LV10717A (en) 1995-06-20
IL102367A (en) 1997-06-10
FR2678618B1 (en) 1993-11-05
ZA924954B (en) 1993-04-28
HU9202227D0 (en) 1992-10-28
KR100243628B1 (en) 2000-03-02
MD523F1 (en) 1996-04-30
US5217973A (en) 1993-06-08
DK0521768T3 (en) 1994-08-15
HU220225B (en) 2001-11-28
EP0521768B1 (en) 1994-02-02
ATE101153T1 (en) 1994-02-15
HUT63422A (en) 1993-08-30
CZ284757B6 (en) 1999-02-17
AU655288B2 (en) 1994-12-15
CZ207892A3 (en) 1993-01-13
EE03003B1 (en) 1997-06-16
CA2072233C (en) 2003-11-18
TW221445B (en) 1994-03-01
CA2072233A1 (en) 1993-01-06
JPH06122685A (en) 1994-05-06
DE69200045D1 (en) 1994-03-17
IE65635B1 (en) 1995-11-01
NZ243443A (en) 1995-01-27
FR2678618A1 (en) 1993-01-08
HU211473A9 (en) 1995-11-28
SK207892A3 (en) 1995-08-09
LV10717B (en) 1995-12-20
KR930002349A (en) 1993-02-23
JP3140566B2 (en) 2001-03-05
RU2103270C1 (en) 1998-01-27
DE69200045T2 (en) 1994-05-19
SK279902B6 (en) 1999-05-07
AU1939692A (en) 1993-01-07

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20141230

MK4A Patent for invention expired