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MD4125C1 - Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită - Google Patents

Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită

Info

Publication number
MD4125C1
MD4125C1 MDA20100103A MD20100103A MD4125C1 MD 4125 C1 MD4125 C1 MD 4125C1 MD A20100103 A MDA20100103 A MD A20100103A MD 20100103 A MD20100103 A MD 20100103A MD 4125 C1 MD4125 C1 MD 4125C1
Authority
MD
Moldova
Prior art keywords
antituberculous
compounds
oxadiazole compounds
properties
containing monosubstituted
Prior art date
Application number
MDA20100103A
Other languages
English (en)
Russian (ru)
Other versions
MD4125B1 (ro
Inventor
Zinaida Ribkovskaia
Fliur MACAEV
Serghei Pogrebnoi
Original Assignee
Inst De Chimie Al Academiei De Stiinte A Moldovei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst De Chimie Al Academiei De Stiinte A Moldovei filed Critical Inst De Chimie Al Academiei De Stiinte A Moldovei
Priority to MDA20100103A priority Critical patent/MD4125C1/ro
Publication of MD4125B1 publication Critical patent/MD4125B1/ro
Publication of MD4125C1 publication Critical patent/MD4125C1/ro

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Invenţia se referă la compuşii 1,3,4-oxadiazolici, ce conţin tiouree monosubstituită, în special la derivaţii lor care manifestă proprietăţi antituberculoase.Compuşii, conform invenţiei, corespund formulei generale:unde:R = benzil (1a);R = 2,4-diclorfenacil (1b);R = alil (1c);R = piridin-4-ilmetil (1d).Sinteza include următoarele etape: hidrazinoliza p-aminobenzoatului de etil, ciclizarea-izotiocianarea-tiolarea hidrazidei obţinute cu disulfură de tetrametiltiuram în DMF, tioalchilarea şi, în final, amonoliza grupei izotiocianat cu soluţie apoasă de amoniac.Compuşii manifestă proprietăţi de inhibare a creşterii culturilor Mycobacterium tuberculosis.
MDA20100103A 2010-09-17 2010-09-17 Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită MD4125C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20100103A MD4125C1 (ro) 2010-09-17 2010-09-17 Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20100103A MD4125C1 (ro) 2010-09-17 2010-09-17 Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită

Publications (2)

Publication Number Publication Date
MD4125B1 MD4125B1 (ro) 2011-08-31
MD4125C1 true MD4125C1 (ro) 2012-03-31

Family

ID=45815251

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20100103A MD4125C1 (ro) 2010-09-17 2010-09-17 Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită

Country Status (1)

Country Link
MD (1) MD4125C1 (ro)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ306408B6 (cs) * 2014-12-11 2017-01-11 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Dinitrofenyloxadiazol nebo -triazol, jeho použití a farmaceutický přípravek ho obsahující
MD4404C1 (ro) * 2015-03-18 2016-09-30 Институт Химии Академии Наук Молдовы Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB729891A (en) * 1952-10-10 1955-05-11 Bayer Ag New 4,5-dihydro-1,3,4-oxadiazol-5-one derivatives
GB925911A (en) * 1960-07-28 1963-05-15 Ed Geistlich Sohne A G Antitubercular pharmaceutical compositions
JPH07258234A (ja) * 1994-03-17 1995-10-09 Shiratori Seiyaku Kk １，３，４−オキサジアゾール−２（３ｈ）−チオン類の製造法
MD613G2 (ro) * 1994-02-24 1997-06-30 Государственный Университет Молд0 Procedeu de obţinere a 2-mercapto-1,3,4-oxadiazolilor
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB729891A (en) * 1952-10-10 1955-05-11 Bayer Ag New 4,5-dihydro-1,3,4-oxadiazol-5-one derivatives
GB925911A (en) * 1960-07-28 1963-05-15 Ed Geistlich Sohne A G Antitubercular pharmaceutical compositions
MD613G2 (ro) * 1994-02-24 1997-06-30 Государственный Университет Молд0 Procedeu de obţinere a 2-mercapto-1,3,4-oxadiazolilor
JPH07258234A (ja) * 1994-03-17 1995-10-09 Shiratori Seiyaku Kk １，３，４−オキサジアゾール−２（３ｈ）−チオン類の製造法
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Chang Hoon Lee, Hyun In Cho, and Kee-Jung Lee. Bull. Korean Chem. oc. 2001, vol.22, No. 1153 (regăsit în Internet la 2011.05.12, url: http://pdf.easechem.com/pdf32/f0038874-65de-4d17-ad40-5ca8992fa8b7.pdf) *
Chang Hoon Lee, Hyun In Cho, and Kee-Jung Lee. Bull. Korean Chem. Soc. 2001, Vol. 22, No. 10 1153 (regăsit în Internet la 2011.05.12, url: http://pdf.easechem.com/pdf/32/f0038874-65de-4d17-ad40-5ca8992fa8b7.pdf ) *
Fliur Macaev, Ghenadie Rusu, Serghei Pogrebnoi, Alexandru Gudima, Eugenia Stingaci, Ludmila Vlad, Nathaly Shvets, Fatma Kandemirli, Anatholy Dimoglo, and Robert Reynolds. Bioorganic & Medicinal Chemistry, Volume 13, 2005, p. 4842-4850 *
Gabriel Navarrete-Vázquez, Gloria Marı´a Molina-Salinas, Zetel Vahi Duarte-Fajardo, Javier Vargas-Villarreal, Samuel Estrada-Soto, Francisco González-Salazar, Emanuel Hernández-Núñez, Salvador Said-Fernández. Bioorganic & Medicinal Chemistry, Volume 15, Issue 16, 15 August 2007, p. 5502-5508 *
Hamish S. Sutherland, Adrian Blaser, Iveta Kmentova, Scott G. Franzblau, Baojie Wan, Yuehong Wang, Zhenkun Ma, Brian D. Palmer, William A. Denny, and Andrew M. Thompson. J. Med. Chem. 2010, 53, pp. 855-866. *
Harish Rajak, Murli Dhar Khary and Pradeep Mishra. International Journal of Pharmaceutical Sciences and Nanotechnology. 2009, vol. 2, issue 1, p.390. (regăsit în Internet la 2011.05.12, url: http://ijpsnonline.com/Issues/310.pdf ) *
Harish Rajak, Murli Dhar Khary and Pradeep Mishra. International Journal of Pharmaceutical Sciences and Nanotechnology. 2009, vol. 2, issuie 1, p390. (Regăsit în Internet la 2011.05.12, url: http://ijpsnonline.com/Issues/310.pdf ) *
Rusu, G. G.; Gutu, E. E.; Barba, N. A. Russ. J. Org. Chem. 1995, vol. 31, p. 1721. *

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Publication number Publication date
MD4125B1 (ro) 2011-08-31

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees