MD20150073A2 - Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK) - Google Patents
Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK) Download PDFInfo
- Publication number
- MD20150073A2 MD20150073A2 MDA20150073A MD20150073A MD20150073A2 MD 20150073 A2 MD20150073 A2 MD 20150073A2 MD A20150073 A MDA20150073 A MD A20150073A MD 20150073 A MD20150073 A MD 20150073A MD 20150073 A2 MD20150073 A2 MD 20150073A2
- Authority
- MD
- Moldova
- Prior art keywords
- jak
- pyrrolo
- inhibitors
- janus
- pyrimidine derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title abstract 2
- 102000042838 JAK family Human genes 0.000 title 2
- 108091082332 JAK family Proteins 0.000 title 2
- 102000015617 Janus Kinases Human genes 0.000 abstract 2
- 108010024121 Janus Kinases Proteins 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
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- Biomedical Technology (AREA)
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- Diabetes (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
Abstract
Se revendică derivaţi ai pirolo[2,3-d]pirimidinei cu formula I, utilizarea lor în calitate de inhibitori de Janus-Kinaze (JAK) şi compoziţii farmaceutice care îi conţin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767947P | 2013-02-22 | 2013-02-22 | |
| PCT/IB2014/058889 WO2014128591A1 (en) | 2013-02-22 | 2014-02-11 | Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20150073A2 true MD20150073A2 (ro) | 2016-01-31 |
| MD4735B1 MD4735B1 (ro) | 2020-12-31 |
| MD4735C1 MD4735C1 (ro) | 2021-07-31 |
Family
ID=50151346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20150073A MD4735C1 (ro) | 2013-02-22 | 2014-02-11 | Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK) |
Country Status (47)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE054810T2 (hu) | 2010-08-18 | 2021-09-28 | Biosplice Therapeutics Inc | Diketonok és hidroxiketonok mint katenin-jelzõút aktivátorok |
| US10172789B2 (en) | 2013-01-24 | 2019-01-08 | Palvella Therapeutics Llc | Compositions for transdermal delivery of mTOR inhibitors |
| SG11201506592SA (en) | 2013-02-22 | 2015-09-29 | Samumed Llc | Gamma-diketones as wnt/beta -catenin signaling pathway activators |
| MD4735C1 (ro) | 2013-02-22 | 2021-07-31 | Pfizer Inc. | Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK) |
| WO2016024185A1 (en) * | 2014-08-12 | 2016-02-18 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
| RS59797B1 (sr) | 2014-08-20 | 2020-02-28 | Samumed Llc | Gama-diketoni za tretman i prevenciju starenja kože i bora |
| JP6564473B2 (ja) * | 2015-05-29 | 2019-08-21 | 无▲錫▼福祈制▲薬▼有限公司Ｗｕｘｉ Ｆｏｒｔｕｎｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ | Ｊａｎｕｓキナーゼ阻害剤 |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| SG10201913986YA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
| US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CN106831779B (zh) * | 2015-11-28 | 2019-07-19 | 南昌弘益药业有限公司 | 一类jak激酶抑制剂的新化合物 |
| US10973913B2 (en) | 2016-02-16 | 2021-04-13 | Washington University | JAK inhibitors and uses thereof |
| IL302385B2 (en) | 2017-01-06 | 2024-06-01 | Palvella Therapeutics Inc | Anhydrous compositions of mtor inhibitors and methods of use |
| CN108794480A (zh) * | 2017-04-28 | 2018-11-13 | 天津药物研究院有限公司 | 吡咯并嘧啶类化合物、其制备方法和用途 |
| HUE057970T2 (hu) | 2018-03-08 | 2022-06-28 | Incyte Corp | Aminopirazindiol-vegyületek mint PI3K-Y inhibitorok |
| EP3817743A4 (en) | 2018-07-02 | 2022-07-06 | Palvella Therapeutics, Inc. | ANHYDROUS COMPOSITIONS OF MTOR INHIBITORS AND METHODS OF USE |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| WO2020008391A1 (en) * | 2018-07-06 | 2020-01-09 | Pfizer Inc. | Manufacturing process and intermediates for a pyrrolo[2,3- d]pyrimidine compound and use thereof |
| EP3877389A4 (en) * | 2018-11-05 | 2022-07-13 | Avista Pharma Solutions, Inc. | Chemical compounds |
| EP3915989B1 (en) * | 2019-01-30 | 2023-06-28 | FelicaMed Biotechnology Co., Ltd | Jak inhibitor and preparation method therefor |
| WO2020165788A1 (en) | 2019-02-15 | 2020-08-20 | Pfizer Inc. | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
| KR102737181B1 (ko) | 2019-03-14 | 2024-12-02 | 상하이 시너지 파마슈티컬 사이언시스 코., 엘티디. | Jak 억제제 및 그 제조방법과 의약분야에서의 응용 |
| US20220259209A1 (en) * | 2019-06-27 | 2022-08-18 | Glenmark Life Sciences Limited | Process for the preparation of abrocitinib |
| CN114667148A (zh) * | 2019-09-11 | 2022-06-24 | 辉瑞公司 | 用jak抑制剂治疗汗腺炎 |
| WO2021198980A1 (en) | 2020-04-04 | 2021-10-07 | Pfizer Inc. | Methods of treating coronavirus disease 2019 |
| CN113637018A (zh) | 2020-04-27 | 2021-11-12 | 苏州晶云药物科技股份有限公司 | 磺酰胺类化合物的晶型及其制备方法 |
| BR112022021525A2 (pt) * | 2020-05-28 | 2022-12-13 | Pfizer | Derivados de pirrolo [2,3-d] pirimidina |
| TW202227434A (zh) * | 2020-09-08 | 2022-07-16 | 瑞士商葛德瑪控股公司 | 新穎jak抑制劑化合物、其合成方法及其用途 |
| JP2023544495A (ja) * | 2020-09-11 | 2023-10-24 | ガルデルマ ホールディング エスエー | 新規ｊａｋ阻害剤化合物、その合成方法、及びその使用 |
| US20250082638A1 (en) | 2021-02-02 | 2025-03-13 | Pfizer Inc. | Dosing Regime For Treatment of Chronic Hand Eczema |
| KR20230019801A (ko) * | 2021-08-02 | 2023-02-09 | 한국화학연구원 | 신규한 피롤로 피리미딘 유도체 화합물, 이의 제조방법, 및 이를 유효성분으로 포함하는 대사성 간질환의 예방 또는 치료용 약학적 조성물 |
| CN118255769A (zh) * | 2022-12-28 | 2024-06-28 | 格格巫（珠海）生物科技有限公司 | 一种立体异构体的制备方法及中间体 |
| ES2993658B2 (es) | 2023-06-27 | 2025-07-02 | Moehs Iberica Sl | (3-(metil(7h-pirrolo[2,3-d]pirimidin-4-il)amino)ciclobutilo)carbamato de bencilo o una sal del mismo, procedimiento para su preparacion y su uso en la sintesis de abrocitinib |
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| JPH08134068A (ja) | 1994-11-02 | 1996-05-28 | Teijin Ltd | ４―置換アルキルアミノ―ピロロ［２，３―ｄ］ピリミジン誘導体 |
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