[go: up one dir, main page]

MC2195A1 - Derives d'acides amines - Google Patents

Derives d'acides amines

Info

Publication number
MC2195A1
MC2195A1 MC902159A MC2159A MC2195A1 MC 2195 A1 MC2195 A1 MC 2195A1 MC 902159 A MC902159 A MC 902159A MC 2159 A MC2159 A MC 2159A MC 2195 A1 MC2195 A1 MC 2195A1
Authority
MC
Monaco
Prior art keywords
amino acid
acid derivatives
quinolylcarbonyl
prophylaxis
medicaments
Prior art date
Application number
MC902159A
Other languages
English (en)
Inventor
Armstrong Martin Joseph
Redshaw Sally
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC2195A1 publication Critical patent/MC2195A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Confectionery (AREA)
  • Cleaning Or Clearing Of The Surface Of Open Water (AREA)
  • Measurement Of Force In General (AREA)
MC902159A 1989-12-11 1990-12-04 Derives d'acides amines MC2195A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898927913A GB8927913D0 (en) 1989-12-11 1989-12-11 Amino acid derivatives
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Publications (1)

Publication Number Publication Date
MC2195A1 true MC2195A1 (fr) 1992-10-05

Family

ID=26296345

Family Applications (1)

Application Number Title Priority Date Filing Date
MC902159A MC2195A1 (fr) 1989-12-11 1990-12-04 Derives d'acides amines

Country Status (48)

Country Link
US (1) US5196438A (fr)
EP (1) EP0432695B1 (fr)
JP (1) JP2807093B2 (fr)
KR (1) KR970005912B1 (fr)
CN (2) CN1066329C (fr)
AT (1) ATE122661T1 (fr)
AU (1) AU634319B2 (fr)
BG (1) BG51452A3 (fr)
BR (1) BR9006264A (fr)
CA (1) CA2030433C (fr)
CU (1) CU22305A3 (fr)
CZ (1) CZ280558B6 (fr)
DE (2) DE69019481T2 (fr)
DK (1) DK0432695T3 (fr)
DZ (1) DZ1467A1 (fr)
EG (1) EG19722A (fr)
ES (1) ES2072959T3 (fr)
FI (2) FI973895A0 (fr)
GB (2) GB8927913D0 (fr)
GR (1) GR3017114T3 (fr)
HK (1) HK129093A (fr)
HR (1) HRP930341B1 (fr)
HU (2) HU207298B (fr)
ID (1) ID1018B (fr)
IE (1) IE67523B1 (fr)
IL (1) IL96550A (fr)
IN (1) IN172553B (fr)
IS (1) IS1803B (fr)
LT (1) LT3682B (fr)
LU (1) LU90014I2 (fr)
LV (1) LV5738B4 (fr)
MA (1) MA22014A1 (fr)
MC (1) MC2195A1 (fr)
MT (1) MTP1075B (fr)
MW (1) MW8890A1 (fr)
MX (1) MX173630B (fr)
NL (1) NL970013I2 (fr)
NO (1) NO176566C (fr)
OA (1) OA09334A (fr)
PL (1) PL165225B1 (fr)
PT (1) PT96145B (fr)
RO (1) RO107942B1 (fr)
RU (1) RU2071470C1 (fr)
SG (1) SG120493G (fr)
SI (1) SI9012315B (fr)
SK (1) SK576590A3 (fr)
ZA (1) ZA909743B (fr)
ZW (1) ZW17490A1 (fr)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) * 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US5614533A (en) * 1987-03-13 1997-03-25 Bio-Mega/Boehringer Ingelheim Research, Inc. Substituted pipecolinic acid derivatives as HIV protease inhibitors
USH1649H (en) 1987-07-31 1997-05-06 Barrish; Joel C. HIV protease inhibitor combinations
CA1340588C (fr) * 1988-06-13 1999-06-08 Balraj Krishan Handa Derive d'aminoacides
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
US5508407A (en) * 1991-07-10 1996-04-16 Eli Lilly And Company Retroviral protease inhibitors
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
WO1993008184A1 (fr) * 1991-10-23 1993-04-29 Merck & Co., Inc. Inhibiteurs de la protease du vih______________________
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
IL103613A (en) * 1991-11-08 1999-05-09 Merck & Co Inc Hiv protease inhibitors process and intermediats for their preparation and pharmaceutical compositions containing them
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
JPH07504654A (ja) 1992-03-11 1995-05-25 ナルヘックス　リミテッド オキソ及びヒドロキシ置換炭化水素のアミン誘導体
ES2066623T3 (es) * 1992-03-13 1995-03-01 Bio Mega Boehringer Ingelheim Derivados sustituidos del acido pipecolinico como inhibidores de la vih-proteasa.
WO1993023379A1 (fr) * 1992-05-21 1993-11-25 Monsanto Company Inhibiteurs de protease retrovirale
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
JP3657002B2 (ja) 1992-08-25 2005-06-08 ジー．ディー．サール アンド カンパニー レトロウイルスプロテアーゼ阻害剤として有用なα−およびβ−アミノ酸ヒドロキシエチルアミノスルホンアミド
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5783701A (en) * 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
TW372972B (en) * 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds
US5380849A (en) * 1992-11-09 1995-01-10 Merck & Co., Inc. Process for optically pure decahydroisoqiunolines
US5430150A (en) * 1992-12-16 1995-07-04 American Cyanamid Company Retroviral protease inhibitors
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5733906A (en) * 1993-10-12 1998-03-31 Eli Lilly And Company Inhibitors of HIV Protease useful for the treatment of Aids
US5846993A (en) * 1992-12-22 1998-12-08 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
MX9308025A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus dela inmunodeficiencia humana, procedimiento para supreparacion y formulacion farmaceutica que los contiene.
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.
US5491166A (en) * 1992-12-22 1996-02-13 Eli Lilly And Company Inhibitors of HIV protease useful for the treatment of AIDS
US5434265A (en) * 1992-12-22 1995-07-18 Eli Lilly And Company Inhibitors of HIV protease
US5693815A (en) * 1993-01-17 1997-12-02 Schering Corporation Peptides
US5939430A (en) * 1993-02-22 1999-08-17 Merrell Pharmaceuticals Inc. Combinations of retroviral inhibitors
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
EP0738724B1 (fr) 1993-07-15 1998-11-04 F. Hoffmann-La Roche Ag Procédé de préparation d'un dérivé N-terbutylamide
AU8074894A (en) * 1994-02-02 1995-08-21 Eli Lilly And Company Hiv protease inhibitors and intermediates
CA2183653A1 (fr) * 1994-03-07 1995-09-14 Roger Dennis Tung Derives de sulfamides en tant qu'inhibiteurs de protease d'aspartyle
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5470979A (en) * 1994-07-01 1995-11-28 American Cyanamid Company Asymmetric synthesis of bicyclic amino acid esters
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
US5591885A (en) 1994-09-23 1997-01-07 Hoffman-La Roche Inc. Process for the preparation of halogenated α-aminoketone compounds
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
DE69624354T2 (de) * 1995-06-06 2003-06-05 F. Hoffmann-La Roche Ag, Basel Pharmazeutische zusammensetzung enthaltend einen inhibitor von proteinase und einen monoglycerid
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
AU759386B2 (en) * 1995-06-29 2003-04-10 Abbvie Inc. Use of Ritonavir (ABT-538) for improving the pharmacokinetics of drugs metabolized by cytochrome P450 in a method of treating AIDS
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
DE69634959T2 (de) 1995-11-13 2006-05-24 Vitaleech Bioscience N.V. Antivirale isolate von blutegeln
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5883252A (en) * 1996-01-26 1999-03-16 Vertex Pharmaceuticals Incorporated Aspartyl protease inhibitors
US5587481A (en) * 1996-02-20 1996-12-24 The Monsanto Company Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide
US5914404A (en) * 1996-08-09 1999-06-22 Hoffmann-La Roche Inc. Process for the preparation of quinargine
EP0823424A1 (fr) * 1996-08-09 1998-02-11 F. Hoffmann-La Roche Ag Procédé pour la préparation de quinargine
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US5705647A (en) * 1996-09-05 1998-01-06 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US5925759A (en) 1996-09-05 1999-07-20 Agouron Pharmaceuticals, Inc. Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
EP0847994B1 (fr) 1996-12-11 2003-04-09 F. Hoffmann-La Roche Ag Procédé pour la préparation d'anhydrides mixtes
US6001851A (en) * 1997-03-13 1999-12-14 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6084107A (en) * 1997-09-05 2000-07-04 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US6143742A (en) * 1997-12-11 2000-11-07 Fuisz Technologies Ltd Treatment for necrotizing infections
US6436989B1 (en) * 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
FR2779653B1 (fr) * 1998-06-11 2002-12-20 Inst Nat Sante Rech Med Utilisation de composes modulateurs du proteasome en therapie
ATE285396T1 (de) 1998-06-19 2005-01-15 Vertex Pharma Sulfonamide als aspartyl-protease-inhibitoren
AU756479B2 (en) * 1998-10-21 2003-01-16 Astellas Pharma Inc. Vitreous form of known bradykinin antagonist
KR100277723B1 (ko) 1998-12-14 2001-01-15 남창우 광학적으로 순수한 데카하이드로이소퀴놀린카르복사미드의 연속제조공정
US7635690B2 (en) * 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7115584B2 (en) * 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
ATE429224T1 (de) * 1999-06-04 2009-05-15 Abbott Lab Arzneizubereitungen enthaltend mindestens einen hiv preoteaseinhibitor
US6589962B1 (en) 1999-07-20 2003-07-08 Merck & Co., Inc. Alpha-hydroxy-gamma-[[(carbocyclic-or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives and uses thereof
AU6109500A (en) * 1999-07-20 2001-02-05 Merck & Co., Inc. Alpha-hydroxy-gamma-(((carbocyclic-or heterocyclic-substituted)amino)carbonyl)alkanamide derivatives and uses thereof
US6642237B1 (en) 1999-11-24 2003-11-04 Merck & Co., Inc. Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides and uses thereof
IT1313682B1 (it) * 1999-11-25 2002-09-09 Archimica Spa Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
DK1248600T3 (da) 2000-01-19 2008-09-08 Abbott Lab Forbedrede farmaceutiske formuleringer
AU2001259817A1 (en) * 2000-05-04 2001-11-12 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Methods of and compounds for inhibiting calpains
IT1318986B1 (it) * 2000-10-09 2003-09-19 Archimica S P A Ora Clariant L Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
GB0028483D0 (en) 2000-11-22 2001-01-10 Hoffmann La Roche Hydroxyethylamine HIV protease inhibitors
US20030191121A1 (en) * 2001-08-09 2003-10-09 Miller Ross A. Piperazine carboxamide intermediates of HIV protease inhibitors and processes for their preparation
EP1463807A4 (fr) 2001-12-19 2006-04-12 Bristol Myers Squibb Co Pichia pastoris formate deshydrogenase et ses utilisations
US20040067216A1 (en) * 2002-02-22 2004-04-08 Karki Shyam B. Hiv protease inhibitors supported on cation exchange resins for oral administration
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
WO2003106405A1 (fr) * 2002-06-01 2003-12-24 Sunesis Pharmaceuticals, Inc. Inhibiteurs de l'aspartyl-protease
US7115652B2 (en) * 2002-06-17 2006-10-03 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
AU2004255436B2 (en) * 2003-07-11 2006-11-30 F. Hoffmann-La Roche Ag Saquinavir mesylate oral dosage form
EP1604662A1 (fr) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft Derivés de la benzyl amine du acide carboxylique (2R) de la 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine et composés similaires pour l'utilisation comme inhibiteurs de la peptidase dipeptidyl IV (DPP-IV) pour le traitement de la diabetes mellitus de type 2
HUE043207T2 (hu) 2004-07-27 2019-08-28 Gilead Sciences Inc HIV-gátló vegyületek foszfonát analógjai
WO2006134612A1 (fr) * 2005-06-16 2006-12-21 Hetero Drugs Limited Procédé de préparation du saquinavir à l’aide d’un nouvel intermédiaire
KR101518079B1 (ko) 2007-03-12 2015-05-06 넥타르 테라퓨틱스 올리고머-프로테아제 억제제 컨주게이트
WO2009006199A1 (fr) * 2007-06-29 2009-01-08 Gilead Sciences, Inc. Compositions thérapeutiques et leur utilisation
EA200971096A1 (ru) * 2007-06-29 2010-08-30 Джилид Сайэнс, Инк. Терапевтические композиции и их применение
US20100093811A1 (en) * 2007-09-25 2010-04-15 Coburn Craig A Hiv protease inhibitors
US9095620B2 (en) * 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EA021377B9 (ru) 2008-12-09 2015-09-30 Джилид Сайэнс, Инк. Модуляторы толл-подобных рецепторов
EP2671888A1 (fr) 2008-12-23 2013-12-11 Gilead Pharmasset LLC Analogues de nucléoside phosphates 3',5'-cycliques
US8551973B2 (en) * 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
EP2435037B1 (fr) 2009-05-27 2014-11-12 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase du vih
WO2010144869A2 (fr) 2009-06-12 2010-12-16 Nektar Therapeutics Inhibiteurs de protéase
DE102010004957A1 (de) 2010-01-14 2011-07-21 Universitätsklinikum Jena, 07743 Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
WO2011123645A2 (fr) 2010-03-31 2011-10-06 Pharmasset, Inc. Phosphoramidates de nucléosides
WO2012055031A1 (fr) 2010-10-28 2012-05-03 Merck Canada Inc. Inhibiteurs de la protéase du vih
EP2392926A1 (fr) 2011-02-09 2011-12-07 Roche Diagnostics GmbH Biomarqueurs urinaires chez des sujets infectés par le VIH
EP2771332B1 (fr) 2011-10-26 2016-06-29 Merck Canada Inc. Dérivés sulfonamides de thiophen et thiazol en tant qu'inhibiteurs de la protease du HIV pour le traitement du SIDA
WO2013105118A1 (fr) 2012-01-10 2013-07-18 Council Of Scientific & Industrial Research Procédé pour la synthèse d' azido-époxyde synthétique et son utilisation en tant qu'intermédiaire de la synthèse d'amprénavir et de saquinavir
RU2015113091A (ru) 2012-09-11 2016-11-10 Мерк Шарп И Доум Корп. Ингибиторы протеазы вич
CA2889903C (fr) 2012-10-29 2021-03-09 Manjinder Singh Phull Analogues de phosphonate antiviraux et leur procede de preparation
WO2015013835A1 (fr) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Dérivés de pipérazine utilisés en tant qu'inhibiteurs de la protéase du vih
EP3082822B1 (fr) 2013-12-19 2020-01-15 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase du vih
EP3083609B1 (fr) 2013-12-19 2018-08-15 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase du vih
US9994587B2 (en) 2014-03-06 2018-06-12 Merck Sharp & Dohme Corp. HIV protease inhibitors
WO2015138220A1 (fr) 2014-03-10 2015-09-17 Merck Sharp & Dohme Corp. Dérivés de pipérazine utilisés en tant qu'inhibiteurs de la protéase du vih
WO2016001907A1 (fr) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv et mogroside v utilisables en tant qu'agonistes/stimulateurs/agents de déblocage des récepteurs toll 4 et adjuvant destiné à être utilisé dans un vaccin humain/animal et pour stimuler l'immunité contre des agents pathologiques
ES2930667T3 (es) 2014-07-11 2022-12-21 Gilead Sciences Inc Moduladores de receptores de tipo Toll para el tratamiento de VIH
WO2016069955A1 (fr) 2014-10-29 2016-05-06 Wisconsin Alumni Research Foundation Inhibiteurs de protéase de vih à base d'acide borique
WO2017048727A1 (fr) 2015-09-15 2017-03-23 Gilead Sciences, Inc. Modulateurs de récepteurs de type toll pour le traitement du vih
WO2021209563A1 (fr) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Composés destinés à être utilisés dans le traitement d'infections virales par un coronavirus associé au syndrome respiratoire

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933968A (en) * 1960-10-26 1963-08-14 May & Baker Ltd New phthalimide derivatives
US4123543A (en) * 1971-09-16 1978-10-31 Ab Kabi Derivatives of substituted indoline lactans with effect on the central nervous system
US3901897A (en) * 1972-10-05 1975-08-26 Squibb & Sons Inc 1,2,3,4,4a,5,6,7-octahydro-7-aryl-isoquinolines and derivatives thereof
US4329473A (en) * 1979-06-01 1982-05-11 Almquist Ronald G Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme
SE421551B (sv) * 1980-03-26 1982-01-04 Sandvik Ab Borrverktyg for rotations- och/eller slagborrning
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4812442A (en) * 1984-05-29 1989-03-14 Merck & Co., Inc. Tripeptide renin inhibitors
FR2575753B1 (fr) * 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AT383762B (de) * 1985-12-23 1987-08-25 Plansee Metallwerk Verfahren zur herstellung mehrkomponentiger, kongruent erschmelzender lotmaterialien
CA1286989C (fr) * 1985-12-26 1991-07-30 A. Arthur Gottlieb Immunoamplificateurs et composes apparentes
WO1988000939A1 (fr) * 1986-07-25 1988-02-11 Banyu Pharmaceutical Co., Ltd. Derives d'amino-alcools optiquement actifs et procede pour leur preparation
EP0264106B1 (fr) * 1986-10-14 1994-03-16 Banyu Pharmaceutical Co., Ltd. Dérivés 5-substitués de l'acide amino-4-hydroxy-pentanoique et leur emploi
US4863905A (en) * 1987-02-04 1989-09-05 Warner-Lambert Company Renin inhibitors II
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
DE3733296A1 (de) * 1987-10-02 1989-04-20 Merck Patent Gmbh Aminosaeurederivate
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
CA1340588C (fr) * 1988-06-13 1999-06-08 Balraj Krishan Handa Derive d'aminoacides
DE4033062A1 (de) * 1990-10-18 1992-04-23 Merck Patent Gmbh Aminosaeurederivate
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols

Also Published As

Publication number Publication date
PL288201A1 (en) 1991-09-09
EG19722A (en) 1996-01-31
FI905983L (fi) 1991-06-12
MX23619A (es) 1993-10-01
ES2072959T3 (es) 1995-08-01
RU2071470C1 (ru) 1997-01-10
IL96550A (en) 1995-03-15
RO107942B1 (ro) 1994-01-31
CN1052482A (zh) 1991-06-26
IE904453A1 (en) 1991-06-19
EP0432695A2 (fr) 1991-06-19
PT96145B (pt) 1998-04-30
OA09334A (fr) 1992-09-15
CA2030433C (fr) 1997-10-21
FI973895L (fi) 1997-10-06
IN172553B (fr) 1993-09-25
JPH03255076A (ja) 1991-11-13
LU90014I2 (fr) 1997-01-31
DE69019481T2 (de) 1995-11-09
DE69019481D1 (de) 1995-06-22
US5196438A (en) 1993-03-23
KR970005912B1 (en) 1997-04-22
AU634319B2 (en) 1993-02-18
ID1018B (id) 1996-10-18
NL970013I1 (nl) 1997-05-01
PT96145A (pt) 1991-09-30
HU211342A9 (en) 1995-11-28
LV5738B4 (lv) 1996-12-20
CZ280558B6 (cs) 1996-02-14
SG120493G (en) 1994-01-21
CN1066329C (zh) 2001-05-30
LT3682B (en) 1996-01-25
DE19675051I2 (de) 2001-04-12
DK0432695T3 (da) 1995-09-11
GR3017114T3 (en) 1995-11-30
GB8927913D0 (en) 1990-02-14
FI973895A7 (fi) 1997-10-06
CN1034805C (zh) 1997-05-07
ZA909743B (en) 1991-08-28
SI9012315A (en) 1997-10-31
BG51452A3 (bg) 1993-05-14
IS1803B (is) 2002-02-26
CN1138983A (zh) 1997-01-01
CA2030433A1 (fr) 1991-06-12
IL96550A0 (en) 1991-09-16
SK280249B6 (sk) 1999-10-08
CU22305A3 (es) 1995-01-31
FI905983A0 (fi) 1990-12-04
LTIP862A (en) 1995-03-27
NO176566B (no) 1995-01-16
EP0432695A3 (en) 1991-12-18
MX173630B (es) 1994-03-18
ZW17490A1 (en) 1992-06-17
AU6787690A (en) 1991-06-13
HU207298B (en) 1993-03-29
HRP930341B1 (en) 1998-12-31
IE67523B1 (en) 1996-04-03
SI9012315B (sl) 1998-06-30
FI100883B (fi) 1998-03-13
CZ576590A3 (en) 1995-11-15
FI973895A0 (fi) 1997-10-06
NL970013I2 (nl) 1997-09-01
ATE122661T1 (de) 1995-06-15
HRP930341A2 (en) 1994-10-31
SK576590A3 (en) 1999-10-08
MW8890A1 (en) 1991-03-13
GB2239016A (en) 1991-06-19
MA22014A1 (fr) 1991-07-01
HU908076D0 (en) 1991-06-28
MTP1075B (en) 1991-07-31
PL165225B1 (pl) 1994-11-30
EP0432695B1 (fr) 1995-05-17
DZ1467A1 (fr) 2004-09-13
NO905322D0 (no) 1990-12-10
IS3651A7 (is) 1991-06-12
BR9006264A (pt) 1991-09-24
HUT56073A (en) 1991-07-29
GB9026776D0 (en) 1991-01-30
HK129093A (en) 1993-12-03
NO176566C (no) 1995-04-26
GB2239016B (en) 1993-08-04
NO905322L (no) 1991-06-12
LV5738A4 (lv) 1996-08-20
KR910011894A (ko) 1991-08-07
JP2807093B2 (ja) 1998-09-30

Similar Documents

Publication Publication Date Title
MC2195A1 (fr) Derives d'acides amines
NO934719D0 (no) Hemmere av HIV-protease som er nyttige for behandling av AIDS
DK163581C (da) Kondenserede pyrazol-3-oxo-propannitrilderivater og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne
MY111630A (en) Amino acid derivatives.
ECSP900707A (es) Derivados de aminoacidos