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MA56551A - Procédés et intermédiaires pour la production de composés de diazaspiro-lactame - Google Patents

Procédés et intermédiaires pour la production de composés de diazaspiro-lactame

Info

Publication number
MA56551A
MA56551A MA056551A MA56551A MA56551A MA 56551 A MA56551 A MA 56551A MA 056551 A MA056551 A MA 056551A MA 56551 A MA56551 A MA 56551A MA 56551 A MA56551 A MA 56551A
Authority
MA
Morocco
Prior art keywords
diazaspirolactam
intermediates
compounds
production
methods
Prior art date
Application number
MA056551A
Other languages
English (en)
Inventor
Khalid Diker
Danny T Dinh
William R Perrault
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of MA56551A publication Critical patent/MA56551A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA056551A 2019-06-24 2020-06-23 Procédés et intermédiaires pour la production de composés de diazaspiro-lactame MA56551A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962865840P 2019-06-24 2019-06-24

Publications (1)

Publication Number Publication Date
MA56551A true MA56551A (fr) 2022-04-27

Family

ID=74060351

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056551A MA56551A (fr) 2019-06-24 2020-06-23 Procédés et intermédiaires pour la production de composés de diazaspiro-lactame

Country Status (7)

Country Link
US (1) US12215114B2 (fr)
EP (2) EP3986400B1 (fr)
CN (1) CN114269338B (fr)
ES (1) ES2991258T3 (fr)
MA (1) MA56551A (fr)
TW (1) TW202110852A (fr)
WO (1) WO2020263848A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020263848A1 (fr) 2019-06-24 2020-12-30 Naurex Inc. Procédés et intermédiaires pour la production de composés de diazaspiro-lactame
JP7617043B2 (ja) 2019-06-24 2025-01-17 ノーレックス インコーポレイテッド tert-ブチル(S)-2-((2S,3R)-1-アミノ-3-ヒドロキシ-1-オキソブタン-2-イル)-1-オキソ-2,5-ジアザスピロ[3.4]オクタン-5-カルボキシレートの固体形態およびそれらを調製する方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688787A (en) 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
CA2740628C (fr) * 2008-09-18 2018-05-01 Naurex, Inc. Modulateurs de recepteur nmda et leurs utilisations
SG11201505937SA (en) * 2013-01-29 2015-09-29 Naurex Inc Spiro-lactam nmda receptor modulators and uses thereof
LT3514158T (lt) 2013-01-29 2023-02-10 Aptinyx Inc. Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas
BR112015018092A2 (pt) * 2013-01-29 2017-07-18 Naurex Inc moduladores de receptor de nmda de espiro-lactama e usos dos mesmos
US20140238699A1 (en) 2013-02-22 2014-08-28 Vetco Gray Inc. Wellhead annulus seal having a wickered surface
CA3024606C (fr) * 2016-05-19 2019-09-03 Aptinyx Inc. Modulateurs de recepteurs nmda de spiro-lactame et utilisations associees
WO2017201285A1 (fr) * 2016-05-19 2017-11-23 Aptinyx Inc. Modulateurs spirolactames des récepteurs nmda et leurs utilisations
WO2019152696A1 (fr) 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactame modulateur de récepteurs nmda et leurs utilisations
WO2020263848A1 (fr) 2019-06-24 2020-12-30 Naurex Inc. Procédés et intermédiaires pour la production de composés de diazaspiro-lactame
JP7617043B2 (ja) * 2019-06-24 2025-01-17 ノーレックス インコーポレイテッド tert-ブチル(S)-2-((2S,3R)-1-アミノ-3-ヒドロキシ-1-オキソブタン-2-イル)-1-オキソ-2,5-ジアザスピロ[3.4]オクタン-5-カルボキシレートの固体形態およびそれらを調製する方法

Also Published As

Publication number Publication date
EP3986400A1 (fr) 2022-04-27
EP3986400B1 (fr) 2024-08-21
EP3986400C0 (fr) 2024-08-21
US20220259217A1 (en) 2022-08-18
EP3986400A4 (fr) 2023-05-17
US12215114B2 (en) 2025-02-04
EP4484431A3 (fr) 2025-03-26
WO2020263848A1 (fr) 2020-12-30
CN114269338B (zh) 2025-02-18
ES2991258T3 (es) 2024-12-03
TW202110852A (zh) 2021-03-16
CN114269338A (zh) 2022-04-01
EP4484431A2 (fr) 2025-01-01

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