MA54052A - Formulation d'anticorps - Google Patents
Formulation d'anticorpsInfo
- Publication number
- MA54052A MA54052A MA054052A MA54052A MA54052A MA 54052 A MA54052 A MA 54052A MA 054052 A MA054052 A MA 054052A MA 54052 A MA54052 A MA 54052A MA 54052 A MA54052 A MA 54052A
- Authority
- MA
- Morocco
- Prior art keywords
- antibody formulation
- antibody
- formulation
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Dermatology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18203104 | 2018-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA54052A true MA54052A (fr) | 2022-02-09 |
Family
ID=64082948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA054052A MA54052A (fr) | 2018-10-29 | 2019-10-25 | Formulation d'anticorps |
Country Status (19)
Country | Link |
---|---|
US (1) | US20210324062A1 (fr) |
EP (1) | EP3873519A1 (fr) |
JP (1) | JP6920393B2 (fr) |
KR (2) | KR102467349B1 (fr) |
CN (4) | CN119033685A (fr) |
AU (2) | AU2019370601B2 (fr) |
BR (1) | BR112021007946A2 (fr) |
CA (1) | CA3114728C (fr) |
CL (1) | CL2021001037A1 (fr) |
CR (1) | CR20210200A (fr) |
IL (1) | IL281717A (fr) |
MA (1) | MA54052A (fr) |
MX (1) | MX2021004774A (fr) |
MY (1) | MY195550A (fr) |
PE (1) | PE20211865A1 (fr) |
SG (1) | SG11202103064YA (fr) |
TW (1) | TWI734233B (fr) |
UA (1) | UA128258C2 (fr) |
WO (1) | WO2020089051A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CR20210435A (es) | 2019-02-18 | 2021-09-20 | Lilly Co Eli | Formulación de anticuerpos terapéuticos |
MX2023002496A (es) | 2020-09-04 | 2023-03-09 | Hoffmann La Roche | Anticuerpo que se une al factor de crecimiento endotelial vascular a (vegf-a) y a la angiopoyetina 2 (ang2) y metodos de uso. |
TW202221027A (zh) * | 2020-09-17 | 2022-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 特異性結合vegf和ang-2的雙特異性抗原結合分子 |
CN115581765A (zh) * | 2021-07-05 | 2023-01-10 | 山东新时代药业有限公司 | 一种重组人源化抗bcma/cd3双特异性抗体注射液 |
CN115569191A (zh) * | 2021-07-05 | 2023-01-06 | 山东新时代药业有限公司 | 一种重组人源化抗bcma/cd3双特异性抗体冻干制剂 |
WO2024085606A1 (fr) * | 2022-10-20 | 2024-04-25 | (주)니오테스바이오 | Anticorps bispécifique comprenant un premier site de liaison à l'antigène qui se lie de maniere spécifique à l'angiopoïétine-2 humaine et son utilisation |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
CA2288600C (fr) | 1997-05-02 | 2010-06-01 | Genentech, Inc. | Procede de preparation d'anticorps multispecifiques presentant des composants heteromultimeres |
JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
WO2007110205A2 (fr) | 2006-03-24 | 2007-10-04 | Merck Patent Gmbh | Domaines de proteine heterodimerique d'ingenierie |
JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー/エス | 二重特異性抗体の生産 |
US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
JP6157046B2 (ja) | 2008-01-07 | 2017-07-05 | アムジェン インコーポレイテッド | 静電的ステアリング(electrostaticsteering)効果を用いた抗体Fcヘテロ二量体分子を作製するための方法 |
US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
ES2708124T3 (es) | 2009-04-27 | 2019-04-08 | Oncomed Pharm Inc | Procedimiento para preparar moléculas heteromultiméricas |
ME02505B (fr) | 2009-12-29 | 2017-02-20 | Aptevo Res & Development Llc | Protéines de liaison hétérodimères et utilisations de celles-ci |
AR080794A1 (es) | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
AR080793A1 (es) * | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
EP2569337A1 (fr) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Protéines hétérodimériques et leurs procédés de production et de purification |
AU2011325833C1 (en) | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
AU2012355415B2 (en) | 2011-12-20 | 2017-07-06 | Medimmune, Llc | Modified polypeptides for bispecific antibody scaffolds |
CA2871068C (fr) | 2012-04-20 | 2022-06-14 | Merus B.V. | Procedes et moyens de production de molecules de type ig |
SI3495387T1 (sl) * | 2012-07-13 | 2021-12-31 | Roche Glycart Ag | Bispecifična protitelesa proti VEGF/proti ANG-2 in njihova uporaba pri zdravljenju bolezni očesnih žil |
KR20150063728A (ko) | 2013-12-02 | 2015-06-10 | 삼성전자주식회사 | 항 VEGF-C/항 Ang2 이중 특이 항체 |
CN105916880B (zh) * | 2014-01-15 | 2020-01-17 | 豪夫迈·罗氏有限公司 | 具有改善的蛋白A结合作用的Fc区变体 |
TWI761959B (zh) * | 2014-11-07 | 2022-04-21 | 瑞士商諾華公司 | 治療眼部疾病之方法 |
WO2016109822A1 (fr) * | 2014-12-31 | 2016-07-07 | Novelmed Therapeutics, Inc. | Formulation d'anticorps thérapeutiques aglycosylés |
KR101808234B1 (ko) * | 2015-06-23 | 2017-12-12 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제 |
KR20180083377A (ko) * | 2015-11-18 | 2018-07-20 | 포르미콘 아게 | Vegf 안타고니스트를 함유하는 사전충전형 플라스틱 주사기 |
JP6953433B2 (ja) * | 2016-01-26 | 2021-10-27 | フォーマイコン アーゲーFormycon Ag | Vegfアンタゴニストを含む液体医薬組成物および同医薬組成物を含有する充填済みシリンジ |
WO2017197199A1 (fr) | 2016-05-13 | 2017-11-16 | Askgene Pharma Inc. | Nouveaux antagonistes doubles d'angiopoïétine 2, vegf |
WO2018122053A1 (fr) * | 2016-12-29 | 2018-07-05 | F. Hoffmann-La Roche Ag | Formulation d'anticorps anti-angiopoïétine-2 |
CN112739323A (zh) * | 2018-05-10 | 2021-04-30 | 瑞泽恩制药公司 | 含有高浓度vegf受体融合蛋白的制剂 |
-
2019
- 2019-10-25 MX MX2021004774A patent/MX2021004774A/es unknown
- 2019-10-25 MA MA054052A patent/MA54052A/fr unknown
- 2019-10-25 CN CN202411176942.5A patent/CN119033685A/zh active Pending
- 2019-10-25 AU AU2019370601A patent/AU2019370601B2/en active Active
- 2019-10-25 KR KR1020217012818A patent/KR102467349B1/ko active IP Right Grant
- 2019-10-25 SG SG11202103064YA patent/SG11202103064YA/en unknown
- 2019-10-25 BR BR112021007946-7A patent/BR112021007946A2/pt unknown
- 2019-10-25 WO PCT/EP2019/079137 patent/WO2020089051A1/fr active Application Filing
- 2019-10-25 CR CR20210200A patent/CR20210200A/es unknown
- 2019-10-25 CN CN202411176182.8A patent/CN119033684A/zh active Pending
- 2019-10-25 EP EP19794983.7A patent/EP3873519A1/fr active Pending
- 2019-10-25 CN CN202411177017.4A patent/CN119033686A/zh active Pending
- 2019-10-25 UA UAA202102683A patent/UA128258C2/uk unknown
- 2019-10-25 CA CA3114728A patent/CA3114728C/fr active Active
- 2019-10-25 PE PE2021000547A patent/PE20211865A1/es unknown
- 2019-10-25 MY MYPI2021002306A patent/MY195550A/en unknown
- 2019-10-25 KR KR1020227032627A patent/KR102590359B1/ko active IP Right Grant
- 2019-10-25 CN CN201980071143.2A patent/CN112930194B/zh active Active
- 2019-10-28 TW TW108138766A patent/TWI734233B/zh active
- 2019-10-28 JP JP2019195009A patent/JP6920393B2/ja active Active
-
2021
- 2021-03-22 IL IL281717A patent/IL281717A/en unknown
- 2021-04-22 CL CL2021001037A patent/CL2021001037A1/es unknown
- 2021-04-28 US US17/242,667 patent/US20210324062A1/en active Pending
-
2024
- 2024-05-10 AU AU2024203126A patent/AU2024203126A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN119033684A (zh) | 2024-11-29 |
CA3114728A1 (fr) | 2020-05-07 |
BR112021007946A2 (pt) | 2021-08-03 |
UA128258C2 (uk) | 2024-05-22 |
AU2019370601B2 (en) | 2024-05-23 |
CN112930194B (zh) | 2024-08-09 |
US20210324062A1 (en) | 2021-10-21 |
AU2024203126A1 (en) | 2024-05-30 |
AU2019370601A1 (en) | 2021-05-27 |
KR102467349B1 (ko) | 2022-11-16 |
SG11202103064YA (en) | 2021-05-28 |
JP2020097567A (ja) | 2020-06-25 |
PE20211865A1 (es) | 2021-09-21 |
EP3873519A1 (fr) | 2021-09-08 |
IL281717A (en) | 2021-05-31 |
WO2020089051A1 (fr) | 2020-05-07 |
CN112930194A (zh) | 2021-06-08 |
TWI734233B (zh) | 2021-07-21 |
CN119033686A (zh) | 2024-11-29 |
KR20210069677A (ko) | 2021-06-11 |
CA3114728C (fr) | 2024-05-14 |
CN119033685A (zh) | 2024-11-29 |
KR20220136446A (ko) | 2022-10-07 |
JP6920393B2 (ja) | 2021-08-18 |
CL2021001037A1 (es) | 2021-09-24 |
MX2021004774A (es) | 2021-08-24 |
MY195550A (en) | 2023-01-31 |
TW202033180A (zh) | 2020-09-16 |
CR20210200A (es) | 2021-05-25 |
KR102590359B1 (ko) | 2023-10-16 |
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