MA51664B1 - Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-([5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino)-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide - Google Patents
Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-([5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino)-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amideInfo
- Publication number
- MA51664B1 MA51664B1 MA51664A MA51664A MA51664B1 MA 51664 B1 MA51664 B1 MA 51664B1 MA 51664 A MA51664 A MA 51664A MA 51664 A MA51664 A MA 51664A MA 51664 B1 MA51664 B1 MA 51664B1
- Authority
- MA
- Morocco
- Prior art keywords
- cyclopropylmethyl
- isoxazole
- pyrimidin
- difluoro
- cyclopropyl
- Prior art date
Links
- OBSRDFSSNGPUIY-UHFFFAOYSA-N 1-pyrimidin-2-ylcyclopropan-1-amine Chemical compound N=1C=CC=NC=1C1(N)CC1 OBSRDFSSNGPUIY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 102100022716 Atypical chemokine receptor 3 Human genes 0.000 title 1
- 101000678890 Homo sapiens Atypical chemokine receptor 3 Proteins 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des formes cristallines de l'acide (3s,4s)-1- cyclopropylméthyl-4-{[5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]- amino}-piperidine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)- amide ; des procédés pour leur préparation, et des compositions pharmaceutiques contenant de telles formes cristallines. Le composé agit en tant que modulateur du récepteur cxcr7 et est donc utile pour le traitement du cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2018051938 | 2018-01-26 | ||
| PCT/EP2019/051819 WO2019145460A1 (fr) | 2018-01-26 | 2019-01-25 | Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-{[5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino}-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA51664A MA51664A (fr) | 2021-05-05 |
| MA51664B1 true MA51664B1 (fr) | 2024-05-31 |
Family
ID=65139016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA51664A MA51664B1 (fr) | 2018-01-26 | 2019-01-25 | Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-([5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino)-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11339148B2 (fr) |
| EP (1) | EP3743422B1 (fr) |
| JP (1) | JP7076010B2 (fr) |
| KR (1) | KR102502046B1 (fr) |
| CN (1) | CN111683945B (fr) |
| AU (1) | AU2019212888B8 (fr) |
| BR (1) | BR112020015024A2 (fr) |
| CA (1) | CA3088478A1 (fr) |
| CL (1) | CL2020001928A1 (fr) |
| EA (1) | EA202091746A1 (fr) |
| ES (1) | ES2976567T3 (fr) |
| HR (1) | HRP20240552T1 (fr) |
| HU (1) | HUE066704T2 (fr) |
| IL (1) | IL276227B2 (fr) |
| MA (1) | MA51664B1 (fr) |
| MX (1) | MX2020007881A (fr) |
| PH (1) | PH12020551121A1 (fr) |
| PL (1) | PL3743422T3 (fr) |
| RS (1) | RS65594B1 (fr) |
| SG (1) | SG11202006943TA (fr) |
| TW (1) | TWI822724B (fr) |
| UA (1) | UA125327C2 (fr) |
| WO (1) | WO2019145460A1 (fr) |
| ZA (1) | ZA202005286B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12021552605A1 (en) | 2016-07-28 | 2023-01-23 | Idorsia Pharmaceuticals Ltd | Piperidine cxcr7 receptor modulators |
| AU2020372647A1 (en) | 2019-10-31 | 2022-06-16 | Idorsia Pharmaceuticals Ltd | Combination of a CXCR7 antagonist with an S1P1 receptor modulator |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL376925A1 (pl) | 2002-11-27 | 2006-01-09 | Incyte Corporation | Pochodne 3-aminopirolidyny jako modulatory receptorów chemokiny |
| TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| EP1670739A4 (fr) | 2003-10-08 | 2007-08-08 | Bristol Myers Squibb Co | Diamines cycliques et derives comme inhibiteurs du facteur xa |
| EP1853586B1 (fr) | 2005-02-18 | 2013-07-24 | AstraZeneca AB | Composés antibactériens dérivés de pipéridine |
| WO2009011850A2 (fr) * | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Nouveaux composés thérapeutiques |
| JP6094578B2 (ja) | 2011-06-09 | 2017-03-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝性障害の治療のためのｇｐｒ１１９モジュレーターとしての置換ピペリジン |
| WO2013084241A1 (fr) | 2011-12-09 | 2013-06-13 | Cadila Healthcare Limited | Composés inhibiteurs de rénine |
| AR091516A1 (es) | 2012-06-22 | 2015-02-11 | Actelion Pharmaceuticals Ltd | Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida |
| SG11201504212WA (en) | 2012-11-29 | 2015-06-29 | Chemocentryx Inc | Cxcr7 antagonists |
| UA118562C2 (uk) | 2013-05-30 | 2019-02-11 | Ідорсія Фармасьютікалз Лтд | Модулятори рецептора cxcr7 |
| KR102276644B1 (ko) | 2013-09-04 | 2021-07-13 | 브리스톨-마이어스 스큅 컴퍼니 | 면역조절제로서 유용한 화합물 |
| PL3041827T3 (pl) | 2013-09-06 | 2018-09-28 | Aurigene Discovery Tech Limited | Pochodne 1,2,4-oksadiazolu jako immunomodulatory |
| WO2015044900A1 (fr) | 2013-09-27 | 2015-04-02 | Aurigene Discovery Technologies Limited | Composés immunomodulateurs thérapeutiques |
| MX2017002986A (es) | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| AU2015315173A1 (en) * | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted pyrrolidine compounds |
| CA2963447A1 (fr) * | 2014-12-01 | 2016-06-09 | Actelion Pharmaceuticals Ltd | Modulateurs du recepteur cxcr7 |
| PH12021552605A1 (en) * | 2016-07-28 | 2023-01-23 | Idorsia Pharmaceuticals Ltd | Piperidine cxcr7 receptor modulators |
-
2019
- 2019-01-25 PL PL19701240.4T patent/PL3743422T3/pl unknown
- 2019-01-25 IL IL276227A patent/IL276227B2/en unknown
- 2019-01-25 KR KR1020207024352A patent/KR102502046B1/ko active Active
- 2019-01-25 SG SG11202006943TA patent/SG11202006943TA/en unknown
- 2019-01-25 TW TW108102825A patent/TWI822724B/zh active
- 2019-01-25 BR BR112020015024-0A patent/BR112020015024A2/pt unknown
- 2019-01-25 JP JP2020560586A patent/JP7076010B2/ja active Active
- 2019-01-25 MX MX2020007881A patent/MX2020007881A/es unknown
- 2019-01-25 ES ES19701240T patent/ES2976567T3/es active Active
- 2019-01-25 HU HUE19701240A patent/HUE066704T2/hu unknown
- 2019-01-25 MA MA51664A patent/MA51664B1/fr unknown
- 2019-01-25 RS RS20240646A patent/RS65594B1/sr unknown
- 2019-01-25 UA UAA202005451A patent/UA125327C2/uk unknown
- 2019-01-25 CA CA3088478A patent/CA3088478A1/fr active Pending
- 2019-01-25 WO PCT/EP2019/051819 patent/WO2019145460A1/fr active Application Filing
- 2019-01-25 US US16/964,885 patent/US11339148B2/en active Active
- 2019-01-25 HR HRP20240552TT patent/HRP20240552T1/hr unknown
- 2019-01-25 EP EP19701240.4A patent/EP3743422B1/fr active Active
- 2019-01-25 AU AU2019212888A patent/AU2019212888B8/en active Active
- 2019-01-25 CN CN201980010015.7A patent/CN111683945B/zh active Active
- 2019-01-25 EA EA202091746A patent/EA202091746A1/ru unknown
-
2020
- 2020-07-23 CL CL2020001928A patent/CL2020001928A1/es unknown
- 2020-07-24 PH PH12020551121A patent/PH12020551121A1/en unknown
- 2020-08-25 ZA ZA2020/05286A patent/ZA202005286B/en unknown
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