MA49841A - Carboxamides utilisées en tant qu'inhibiteurs de protéase spécifique de l'ubiquitine - Google Patents
Carboxamides utilisées en tant qu'inhibiteurs de protéase spécifique de l'ubiquitineInfo
- Publication number
- MA49841A MA49841A MA049841A MA49841A MA49841A MA 49841 A MA49841 A MA 49841A MA 049841 A MA049841 A MA 049841A MA 49841 A MA49841 A MA 49841A MA 49841 A MA49841 A MA 49841A
- Authority
- MA
- Morocco
- Prior art keywords
- ubiquitine
- protease inhibitors
- specific protease
- carboxamides used
- carboxamides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762544083P | 2017-08-11 | 2017-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA49841A true MA49841A (fr) | 2020-06-17 |
Family
ID=63405399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA049841A MA49841A (fr) | 2017-08-11 | 2018-08-09 | Carboxamides utilisées en tant qu'inhibiteurs de protéase spécifique de l'ubiquitine |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11524966B1 (fr) |
| EP (1) | EP3665169A1 (fr) |
| JP (1) | JP2020530469A (fr) |
| AR (1) | AR112468A1 (fr) |
| AU (1) | AU2018316254B2 (fr) |
| CA (1) | CA3072449A1 (fr) |
| MA (1) | MA49841A (fr) |
| TW (1) | TW201920157A (fr) |
| WO (1) | WO2019032863A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018316254B2 (en) | 2017-08-11 | 2022-07-14 | Valo Health, Inc. | Carboxamides as ubiquitin-specific protease inhibitors |
| BR112021002408A2 (pt) | 2018-08-09 | 2021-05-04 | Valo Early Discovery, Inc. | carboxamidas como inibidores da protease específica de ubiquitina |
| US12252490B2 (en) | 2018-08-09 | 2025-03-18 | Valo Health, Inc. | Inhibiting deubiquitinase USP25 and USP28 |
| CN111909181B (zh) * | 2019-05-09 | 2023-02-07 | 杭州普济远成生物医药科技有限公司 | 一类泛素化特异性蛋白酶抑制剂及其制备方法与应用 |
| CN111943879A (zh) * | 2020-08-03 | 2020-11-17 | 南通大学 | 一种（3s，4r）3-氨基-4（甲氧基甲基）吡咯烷-1-甲酸叔丁酯及其合成方法 |
| EP4516791A1 (fr) * | 2022-04-28 | 2025-03-05 | Chaser Therapeutics, Inc. | Inhibiteur de désubiquitinase et son utilisation |
| CN115974747A (zh) * | 2022-09-30 | 2023-04-18 | 上海北卡医药技术有限公司 | 一种3-（3-氯丙基）-4-氧代吡咯烷-1-羧酸乙酯的制备方法及用途 |
| WO2024114793A1 (fr) * | 2022-12-01 | 2024-06-06 | 杭州普济远成生物医药科技有限公司 | Forme saline et forme cristalline d'un inhibiteur de protéase spécifique de l'ubiquitination, leur procédé de préparation et leur utilisation |
| CN117916246A (zh) * | 2022-12-01 | 2024-04-19 | 杭州普济远成生物医药科技有限公司 | 泛素化特异性蛋白酶抑制剂盐型、晶型及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000078934A2 (fr) | 1999-06-22 | 2000-12-28 | School Of Pharmacy, University Of London | Diagnostic et traitement de la maladie d'alzheimer |
| EP1680431A1 (fr) * | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Compositions de benzothiazole et de thiazole'5,5-b!pyridine et leur utilisation comme inhibiteurs de l'ubiquitine ligase |
| SE0403171D0 (sv) | 2004-12-23 | 2004-12-23 | Astrazeneca Ab | New compounds |
| TW201040153A (en) * | 2009-02-13 | 2010-11-16 | Sanofi Aventis | Novel substituted tetrahydronaphthalenes, process for preparation thereof and use thereof as medicaments |
| BRPI1005828A2 (pt) | 2009-02-27 | 2017-07-18 | Siga Tech Inc | composição farmacêutica; método para o tratamento ou a profilaxia de uma infecção viral ou doença associada com a mesma; composto; método para a preparação de uma mistura de terc-butil(4e)-4-(hidroximetileno)-5-oxoazepano-1-carboxilato e terc-butil (3e)-3-(hidroximetileno)-4-oxoazepano-1-carboxilato; método para a preparação de uma mistura de terc-butil 3-ciano-2-tioxo-1,2,5,6,8,9-hexaidro-1h-pirido [2,3-d] azepina-7-carboxilato e terc-butil 3-ciano-2-tioxo-1,2,5,7,8,9-hexaidro-6h-pirido [3,2-c] azepina-6-carboxilato; método para a preparação de ácido 3-amino-7-terc-butiloxicarbonil-6,7,8,9-tetraidro-5h-1-tia-7,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4]tiazol-2-il)-amida; método para a preparação de ácido 3-amino-6,7,8,9-tetraidro-5h-1-tia-7,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida; método para a preparação de ácido 3-amino-6-tercbutiloxicarbonil-6,7,8,9-tetraidro-5h-1-tia-6,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida e método para a preparação de ácido 3-amino-6,7,8,9-tetraidro-5h-1-tia-6,10-diaza-ciclohepta [f] indeno-2-carboxílico (5-fenil-[1,3,4] tiadiazol-2-il)-amida |
| JP5852658B2 (ja) | 2010-09-24 | 2016-02-03 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | デユビキチナーゼ阻害剤およびその使用方法 |
| WO2014105952A2 (fr) | 2012-12-28 | 2014-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibiteurs du complexe usp1/uaf1 désubiquitinase et leurs utilisations |
| EP2948438A4 (fr) | 2013-01-23 | 2016-10-05 | Univ Chicago | Méthodes et compositions d'inhibition des protéines atox1 et ccs impliquées dans le transfert du cuivre |
| EP3414252B1 (fr) | 2016-02-12 | 2022-07-06 | Valo Health, Inc. | Thiénopyridine carboxamides utilisés comme inhibiteurs de protéase spécifique de l'ubiquitine |
| ES2763274T3 (es) | 2016-02-12 | 2020-05-27 | Forma Therapeutics Inc | Carboxamidas de tienopirazina como inhibidores de la proteasa específica de la ubiquitina |
| AU2018316254B2 (en) | 2017-08-11 | 2022-07-14 | Valo Health, Inc. | Carboxamides as ubiquitin-specific protease inhibitors |
-
2018
- 2018-08-09 AU AU2018316254A patent/AU2018316254B2/en active Active
- 2018-08-09 EP EP18760137.2A patent/EP3665169A1/fr active Pending
- 2018-08-09 US US16/637,692 patent/US11524966B1/en active Active
- 2018-08-09 AR ARP180102268 patent/AR112468A1/es unknown
- 2018-08-09 MA MA049841A patent/MA49841A/fr unknown
- 2018-08-09 JP JP2020507569A patent/JP2020530469A/ja active Pending
- 2018-08-09 WO PCT/US2018/046061 patent/WO2019032863A1/fr not_active Ceased
- 2018-08-09 CA CA3072449A patent/CA3072449A1/fr active Pending
- 2018-08-09 TW TW107127893A patent/TW201920157A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11524966B1 (en) | 2022-12-13 |
| WO2019032863A1 (fr) | 2019-02-14 |
| EP3665169A1 (fr) | 2020-06-17 |
| AU2018316254A1 (en) | 2020-02-20 |
| AU2018316254B2 (en) | 2022-07-14 |
| AR112468A1 (es) | 2019-10-30 |
| TW201920157A (zh) | 2019-06-01 |
| CA3072449A1 (fr) | 2019-02-14 |
| JP2020530469A (ja) | 2020-10-22 |
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