MA47308A - Composés chimiques comme inhibiteurs de l'activité interleukine-1 - Google Patents
Composés chimiques comme inhibiteurs de l'activité interleukine-1Info
- Publication number
- MA47308A MA47308A MA047308A MA47308A MA47308A MA 47308 A MA47308 A MA 47308A MA 047308 A MA047308 A MA 047308A MA 47308 A MA47308 A MA 47308A MA 47308 A MA47308 A MA 47308A
- Authority
- MA
- Morocco
- Prior art keywords
- interleukin
- inhibitors
- activity
- chemical compounds
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- C—CHEMISTRY; METALLURGY
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Cardiology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
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- Tropical Medicine & Parasitology (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201762449431P | 2017-01-23 | 2017-01-23 | |
US201762492813P | 2017-05-01 | 2017-05-01 |
Publications (1)
Publication Number | Publication Date |
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MA47308A true MA47308A (fr) | 2019-11-27 |
Family
ID=61189525
Family Applications (2)
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MA055695A MA55695A (fr) | 2017-01-23 | 2018-01-22 | Composés chimiques comme inhibiteurs de l'activité interleukine-1 |
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EP (2) | EP3571187B1 (fr) |
JP (1) | JP7163293B2 (fr) |
KR (1) | KR20190111068A (fr) |
CN (1) | CN110366549A (fr) |
AU (1) | AU2018210525B2 (fr) |
BR (1) | BR112019014549A2 (fr) |
CA (1) | CA3047336A1 (fr) |
CL (1) | CL2019001988A1 (fr) |
CO (1) | CO2019009036A2 (fr) |
CR (1) | CR20190356A (fr) |
IL (1) | IL267961B2 (fr) |
MA (2) | MA55695A (fr) |
MX (1) | MX2019008592A (fr) |
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PE (1) | PE20191615A1 (fr) |
PH (1) | PH12019501611A1 (fr) |
SG (1) | SG11201906373VA (fr) |
TW (1) | TW201837021A (fr) |
UA (1) | UA126675C2 (fr) |
WO (1) | WO2018136890A1 (fr) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201837021A (zh) | 2017-01-23 | 2018-10-16 | 美商傑庫爾醫療股份有限公司 | 作為介白素-1活性抑制劑之化合物 |
CA3059458A1 (fr) | 2017-05-24 | 2018-11-29 | The University Of Queensland | Nouveaux composes et utilisations |
TWI789401B (zh) | 2017-07-07 | 2023-01-11 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
WO2019023147A1 (fr) | 2017-07-24 | 2019-01-31 | IFM Tre, Inc. | Composés et compositions destinés au traitement d'états pathologiques associés à une activité de nlrp |
WO2019034697A1 (fr) * | 2017-08-15 | 2019-02-21 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
EP3668862A1 (fr) * | 2017-08-15 | 2020-06-24 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
BR112020002906A2 (pt) | 2017-08-15 | 2020-08-04 | Inflazome Limited | novos compostos de sulfonamida-carboxamida |
WO2019034692A1 (fr) * | 2017-08-15 | 2019-02-21 | Inflazome Limited | Sulfonylurées et sulfonylthiourées en tant qu'inhibiteurs de nlrp3 |
EP3668843A1 (fr) * | 2017-08-15 | 2020-06-24 | Inflazome Limited | Sulfonylurées et sulfonylthiourées utilisés en tant qu'inhibiteurs de nlrp3 |
SG11202001166RA (en) * | 2017-08-15 | 2020-03-30 | Inflazome Ltd | Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors |
EP3707137A1 (fr) | 2017-11-09 | 2020-09-16 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
RU2020115098A (ru) * | 2017-11-09 | 2021-12-10 | Инфлазоум Лимитед | Соединения новых сульфонамидкарбоксамидов |
US11834433B2 (en) | 2018-03-02 | 2023-12-05 | Inflazome Limited | Compounds |
WO2019166619A1 (fr) * | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
WO2019166633A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Dérivés de sulfonamide utilisés en tant qu'inhibiteurs de nlrp3 |
MX2020011501A (es) | 2018-05-04 | 2020-12-07 | Inflazome Ltd | Compuestos novedosos. |
CA3105521A1 (fr) * | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Composes de sulfonimidamide en tant qu'inhibiteurs de l'activite de l'interleukine 1 |
BR112021001012A2 (pt) | 2018-07-20 | 2021-04-20 | F. Hoffmann-La Roche Ag | compostos de sulfonilureia como inibidores da atividade de interleucina-1 |
GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
US12187702B2 (en) | 2018-08-15 | 2025-01-07 | Inflazome Limited | Sulfonamideurea compounds |
GB201817038D0 (en) * | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
JP2022505525A (ja) * | 2018-10-24 | 2022-01-14 | ノバルティス アーゲー | Nlrp活性に関連する状態を治療するための化合物及び組成物 |
WO2020086728A1 (fr) * | 2018-10-24 | 2020-04-30 | Novartis Inflammasome Research, Inc. | Composés et compositions pour traiter des états associés à l'activité d'un nlrp |
JP2022506898A (ja) | 2018-11-13 | 2022-01-17 | ノバルティス アーゲー | Nlrp活性に関連する状態を処置するための化合物及び組成物 |
GB201819083D0 (en) * | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
KR20210114967A (ko) | 2019-01-14 | 2021-09-24 | 카딜라 핼쓰캐어 리미티드 | 신규 치환된 설포닐우레아 유도체 |
US20220056043A1 (en) * | 2019-02-19 | 2022-02-24 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Nitrogen-containing fused cyclic compound, preparation method therefor and use thereof |
GB201905265D0 (en) | 2019-04-12 | 2019-05-29 | Inflazome Ltd | Inflammasome inhibition |
US20220378801A1 (en) | 2019-06-21 | 2022-12-01 | Ac Immune Sa | Novel compounds |
IL289885B1 (en) * | 2019-07-17 | 2024-12-01 | Zomagen Biosciences Ltd | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4,5,6,7-tetrahydrobenzofuran -2-sulfonamide derivatives and related compounds as nlpr3 modulators for the treatment of multiple sclerosis (ms) |
EP3999179A1 (fr) * | 2019-07-17 | 2022-05-25 | Zomagen Biosciences Ltd | Modulateurs de nlrp3 |
CN114401971A (zh) | 2019-08-16 | 2022-04-26 | 英夫拉索姆有限公司 | 用作nlrp3抑制剂的大环磺酰脲衍生物 |
EP4025565A1 (fr) | 2019-09-06 | 2022-07-13 | Inflazome Limited | Inhibiteurs de nlrp3 |
AU2020383646B2 (en) * | 2019-11-12 | 2023-10-12 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Amide derivative and preparation method therefore and use thereof in medicine |
CN115362152A (zh) | 2020-02-18 | 2022-11-18 | 英夫拉索姆有限公司 | 化合物 |
AR121573A1 (es) | 2020-03-16 | 2022-06-15 | Zomagen Biosciences Ltd | Moduladores de nlrp3 |
EP4168395A1 (fr) | 2020-06-19 | 2023-04-26 | AC Immune SA | Dérivés de dihydrooxazole et de thiourée modulant la voie inflammatoire nlrp3 |
CN114539256B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
CN114516878B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
CN115894478A (zh) * | 2021-09-30 | 2023-04-04 | 杭州民生药物研究院有限公司 | 一种新型吡啶并吡唑类杂环化合物及其应用 |
WO2023118521A1 (fr) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Composés dérivés de dihydro-oxazol |
TW202333678A (zh) * | 2021-12-22 | 2023-09-01 | 大陸商瑞石生物醫藥有限公司 | 一種磺醯脲類化合物 |
WO2023211929A1 (fr) * | 2022-04-25 | 2023-11-02 | Vanderbilt University | Sondes et méthodes de visualisation ciblée d'inflammasomes nlrp3 |
IL317984A (en) | 2022-07-14 | 2025-02-01 | Ac Immune Sa | History of Pyrrolotriazine and Imidazotriazine as Modulators of the NLRP3 Inflammasome Pathway |
US20240101563A1 (en) | 2022-07-28 | 2024-03-28 | Ac Immune Sa | Novel compounds |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5216026A (en) | 1990-07-17 | 1993-06-01 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
JP3573757B2 (ja) | 1997-01-29 | 2004-10-06 | ファイザー・インク | スルホニルウレア誘導体、およびインターロイキン−1の活性を制御する上でのスルホニルウレア誘導体の使用 |
CA2383026A1 (fr) | 1999-09-14 | 2001-03-22 | Pfizer Products Inc. | Traitement combine au moyen de il-1ra et de composes de diarylsulfonyluree |
EP1487457A1 (fr) | 2001-11-30 | 2004-12-22 | Pfizer Products Inc. | Combinaison d'un inhibiteur d'il-1/18 avec un inhibiteur de tnf pour le traitement d'inflammations |
CA3009937C (fr) | 2010-02-22 | 2020-12-15 | Askat Inc. | Utilisation d'antagonistes de recepteur ep4 dans le traitement de maladies mediees par il-23 |
EP2781216A4 (fr) | 2011-09-02 | 2015-05-27 | Kyowa Hakko Kirin Co Ltd | Régulateur d'activité de récepteur de chimiokine |
JP2016522831A (ja) * | 2013-05-21 | 2016-08-04 | ヴァージニア コモンウェルス ユニバーシティ | 炎症を予防および治療するためのクリオピリン阻害剤 |
MX2017010528A (es) | 2015-02-16 | 2018-11-12 | Univ Queensland | Sulfonilureas y compuestos relacionados y uso de estos. |
FR3046933B1 (fr) | 2016-01-25 | 2018-03-02 | Galderma Research & Development | Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires |
JP2019512009A (ja) | 2016-02-16 | 2019-05-09 | ザ・ユニバーシティ・オブ・クイーンズランド | スルホニルウレアおよび関連化合物ならびにこれらの利用 |
ES2927777T3 (es) | 2016-04-18 | 2022-11-10 | Novartis Ag | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de NLRP |
US11447460B2 (en) | 2016-04-18 | 2022-09-20 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
TW201837021A (zh) | 2017-01-23 | 2018-10-16 | 美商傑庫爾醫療股份有限公司 | 作為介白素-1活性抑制劑之化合物 |
CA3059458A1 (fr) | 2017-05-24 | 2018-11-29 | The University Of Queensland | Nouveaux composes et utilisations |
US11370776B2 (en) | 2017-07-07 | 2022-06-28 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
TWI789401B (zh) | 2017-07-07 | 2023-01-11 | 愛爾蘭商英弗雷佐姆有限公司 | 新穎化合物 |
WO2019034692A1 (fr) | 2017-08-15 | 2019-02-21 | Inflazome Limited | Sulfonylurées et sulfonylthiourées en tant qu'inhibiteurs de nlrp3 |
WO2019034697A1 (fr) | 2017-08-15 | 2019-02-21 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
BR112020002906A2 (pt) | 2017-08-15 | 2020-08-04 | Inflazome Limited | novos compostos de sulfonamida-carboxamida |
SG11202001166RA (en) * | 2017-08-15 | 2020-03-30 | Inflazome Ltd | Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors |
CA3071143A1 (fr) | 2017-08-15 | 2019-02-21 | Inflazome Limited | Nouveaux composes |
EP3668862A1 (fr) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
EP3668843A1 (fr) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Sulfonylurées et sulfonylthiourées utilisés en tant qu'inhibiteurs de nlrp3 |
WO2019043610A1 (fr) | 2017-08-31 | 2019-03-07 | Cadila Healthcare Limited | Nouveaux dérivés de sulfonylurées substitués |
EP3707137A1 (fr) | 2017-11-09 | 2020-09-16 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
RU2020115098A (ru) | 2017-11-09 | 2021-12-10 | Инфлазоум Лимитед | Соединения новых сульфонамидкарбоксамидов |
WO2019092172A1 (fr) | 2017-11-09 | 2019-05-16 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
GB201721185D0 (en) | 2017-12-18 | 2018-01-31 | Nodthera Ltd | Sulphonyl urea derivatives |
GB201803394D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
WO2019166619A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
GB201803393D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
GB201806578D0 (en) | 2018-04-23 | 2018-06-06 | Inflazome Ltd | Novel compound |
EP3817817A1 (fr) | 2018-07-03 | 2021-05-12 | Novartis AG | Modulateurs de nlrp |
BR112021001012A2 (pt) | 2018-07-20 | 2021-04-20 | F. Hoffmann-La Roche Ag | compostos de sulfonilureia como inibidores da atividade de interleucina-1 |
CA3105521A1 (fr) | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Composes de sulfonimidamide en tant qu'inhibiteurs de l'activite de l'interleukine 1 |
US12187702B2 (en) | 2018-08-15 | 2025-01-07 | Inflazome Limited | Sulfonamideurea compounds |
GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
GB201817038D0 (en) | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
JP2022505525A (ja) | 2018-10-24 | 2022-01-14 | ノバルティス アーゲー | Nlrp活性に関連する状態を治療するための化合物及び組成物 |
GB201819083D0 (en) | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
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2018
- 2018-01-22 TW TW107102246A patent/TW201837021A/zh unknown
- 2018-01-22 KR KR1020197024262A patent/KR20190111068A/ko active IP Right Grant
- 2018-01-22 UA UAA201907805A patent/UA126675C2/uk unknown
- 2018-01-22 WO PCT/US2018/014728 patent/WO2018136890A1/fr active Application Filing
- 2018-01-22 PE PE2019001474A patent/PE20191615A1/es unknown
- 2018-01-22 BR BR112019014549-4A patent/BR112019014549A2/pt not_active IP Right Cessation
- 2018-01-22 EP EP18704341.9A patent/EP3571187B1/fr active Active
- 2018-01-22 MA MA055695A patent/MA55695A/fr unknown
- 2018-01-22 MA MA047308A patent/MA47308A/fr unknown
- 2018-01-22 MY MYPI2019004010A patent/MY197636A/en unknown
- 2018-01-22 AU AU2018210525A patent/AU2018210525B2/en not_active Ceased
- 2018-01-22 SG SG11201906373VA patent/SG11201906373VA/en unknown
- 2018-01-22 CR CR20190356A patent/CR20190356A/es unknown
- 2018-01-22 CA CA3047336A patent/CA3047336A1/fr active Pending
- 2018-01-22 MX MX2019008592A patent/MX2019008592A/es unknown
- 2018-01-22 CN CN201880014694.0A patent/CN110366549A/zh active Pending
- 2018-01-22 EP EP20212018.4A patent/EP3851434A1/fr not_active Withdrawn
- 2018-01-22 JP JP2019539814A patent/JP7163293B2/ja active Active
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2019
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- 2019-07-10 IL IL267961A patent/IL267961B2/en unknown
- 2019-07-15 CL CL2019001988A patent/CL2019001988A1/es unknown
- 2019-07-16 US US16/513,621 patent/US11040985B2/en active Active
- 2019-08-21 CO CONC2019/0009036A patent/CO2019009036A2/es unknown
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2021
- 2021-01-25 US US17/157,749 patent/US20210395268A1/en not_active Abandoned
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2022
- 2022-03-03 US US17/686,183 patent/US11702428B2/en active Active
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