MA41732B1 - Thiazolylbenzimidazole-derived molecules containing triazoles and their uses for the treatment of cancer - Google Patents
Thiazolylbenzimidazole-derived molecules containing triazoles and their uses for the treatment of cancerInfo
- Publication number
- MA41732B1 MA41732B1 MA41732A MA41732A MA41732B1 MA 41732 B1 MA41732 B1 MA 41732B1 MA 41732 A MA41732 A MA 41732A MA 41732 A MA41732 A MA 41732A MA 41732 B1 MA41732 B1 MA 41732B1
- Authority
- MA
- Morocco
- Prior art keywords
- thiazolylbenzimidazole
- synthesis
- cancer
- treatment
- 1hbenzo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne la synthèse d’unenouvelle classe des molécules poly hétérocycliques dérivés du thiazolylbenzimidazole contenant le motif triazolique via plusieurs étapes de synthèse, ainsi que l’utilisation de ces molécules dans le domaine de la santé pour le traitement du cancer. Premièrement, la synthèse de la 4-(1-(prop-2-yn-1-yl)-1hbenzo[d]imidazole-2-yl)thiazole(1) par uneréaction d’alkylation de thiazolylbenzimidazole dans les conditions de la catalyse par transfert de phase avec le bromure de propargyle, deuxièmement, préparation des azides avec l’azoture de sodium et le bromure d’alkyle et troisièmement, la synthèse de4-(1-((1-alkyl-1h-1,2,3-triazol-4-yl)méthyl)-1hbenzo[d]imidazol-2-yl)thiazole par une réaction de cycloaddition 1,3-dipolaire dans les conditions de la chimie clic. Quatrièmement, la quaternisation des cycloadduits avec iodométhane à reflux, à fin d’augmenter la solubilité de ces produits.The present invention relates to the synthesis of a new class of polyheterocyclic molecules derived from thiazolylbenzimidazole containing the triazole unit via several synthetic steps, as well as the use of these molecules in the field of health for the treatment of cancer. First, the synthesis of 4- (1- (prop-2-yn-1-yl) -1hbenzo [d] imidazol-2-yl) thiazole (1) by an alkylation reaction of thiazolylbenzimidazole under the conditions of catalysis by phase transfer with propargyl bromide, second, preparation of azides with sodium azide and alkyl bromide and third, synthesis of 4- (1 - ((1-alkyl-1h-1,2,3 -triazol-4-yl) methyl) -1hbenzo [d] imidazol-2-yl) thiazole by a 1,3-dipolar cycloaddition reaction under the conditions of click chemistry. Fourth, the quaternization of the cycloadducts with iodomethane at reflux, in order to increase the solubility of these products.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MA41732A MA41732B1 (en) | 2017-12-28 | 2017-12-28 | Thiazolylbenzimidazole-derived molecules containing triazoles and their uses for the treatment of cancer |
| PCT/MA2018/050019 WO2019132638A1 (en) | 2017-12-28 | 2018-12-28 | Molecules derived from thiazolylbenzimidazole containing triazoles and their uses for the treatment of cancer. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MA41732A MA41732B1 (en) | 2017-12-28 | 2017-12-28 | Thiazolylbenzimidazole-derived molecules containing triazoles and their uses for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA41732A1 MA41732A1 (en) | 2019-08-30 |
| MA41732B1 true MA41732B1 (en) | 2020-06-30 |
Family
ID=65352065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA41732A MA41732B1 (en) | 2017-12-28 | 2017-12-28 | Thiazolylbenzimidazole-derived molecules containing triazoles and their uses for the treatment of cancer |
Country Status (2)
| Country | Link |
|---|---|
| MA (1) | MA41732B1 (en) |
| WO (1) | WO2019132638A1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2408753A4 (en) * | 2009-03-20 | 2012-11-07 | Univ Brandeis | COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS |
| EP2698367A1 (en) * | 2012-08-14 | 2014-02-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Benzimidazoles for the treatment of cancer |
-
2017
- 2017-12-28 MA MA41732A patent/MA41732B1/en unknown
-
2018
- 2018-12-28 WO PCT/MA2018/050019 patent/WO2019132638A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| MA41732A1 (en) | 2019-08-30 |
| WO2019132638A1 (en) | 2019-07-04 |
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