[go: up one dir, main page]

MA40737A - Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 - Google Patents

Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1

Info

Publication number
MA40737A
MA40737A MA040737A MA40737A MA40737A MA 40737 A MA40737 A MA 40737A MA 040737 A MA040737 A MA 040737A MA 40737 A MA40737 A MA 40737A MA 40737 A MA40737 A MA 40737A
Authority
MA
Morocco
Prior art keywords
determinants
immunotherapy
blocked
cancer response
cancer
Prior art date
Application number
MA040737A
Other languages
English (en)
Inventor
Timothy A Chan
Matthew D Hellman
Naiyer A Rizvi
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of MA40737A publication Critical patent/MA40737A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA040737A 2014-11-21 2015-11-22 Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 MA40737A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462083088P 2014-11-21 2014-11-21
US201562132381P 2015-03-12 2015-03-12

Publications (1)

Publication Number Publication Date
MA40737A true MA40737A (fr) 2017-07-04

Family

ID=56014697

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040737A MA40737A (fr) 2014-11-21 2015-11-22 Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1

Country Status (9)

Country Link
US (3) US20180291074A1 (fr)
EP (2) EP3220950A4 (fr)
JP (4) JP7173733B2 (fr)
CN (2) CN107206064B (fr)
AU (3) AU2015349644B2 (fr)
CA (1) CA2968059A1 (fr)
HK (1) HK1244440A1 (fr)
MA (1) MA40737A (fr)
WO (1) WO2016081947A2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX342591B (es) 2008-12-09 2016-10-05 Genentech Inc * Anticuerpos anti-pd-l1 y su uso para mejorar la función de células t.
JP6502959B2 (ja) 2013-12-12 2019-04-17 上海恒瑞医薬有限公司 Ｐｄ−１抗体、その抗原結合性断片及びそれらの医学的使用
KR102636539B1 (ko) 2014-10-29 2024-02-13 파이브 프라임 테라퓨틱스, 인크. 암에 대한 조합 요법
MA40737A (fr) 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
GB201516047D0 (en) 2015-09-10 2015-10-28 Cancer Rec Tech Ltd Method
SG11201804957VA (en) 2015-12-16 2018-07-30 Gritstone Oncology Inc Neoantigen identification, manufacture, and use
CA3008437A1 (fr) 2016-01-08 2017-07-13 Vaccibody As Vaccin therapeutique anticancereux a neoepitope
WO2017151502A1 (fr) * 2016-02-29 2017-09-08 Genentech, Inc. Méthodes thérapeutiques et de diagnostic du cancer
AU2017225869A1 (en) 2016-02-29 2018-09-06 Foundation Medicine, Inc. Methods of treating cancer
WO2017151727A1 (fr) * 2016-03-01 2017-09-08 North Carolina State University Immunothérapie anticancéreuse améliorée par le biais d'une administration par patch à micro-aiguilles
JP7147168B2 (ja) * 2016-03-02 2022-10-05 東レ株式会社 免疫誘導剤
KR102543118B1 (ko) 2016-05-27 2023-06-14 아게누스 인코포레이티드 항-tim-3 항체 및 이의 사용 방법
US11359017B2 (en) 2016-07-01 2022-06-14 Tohoku University Method of altering an antibody-related adverse event based on SCD163 and/or CXCL5 levels
KR20200003294A (ko) * 2016-08-25 2020-01-08 난토믹스, 엘엘씨 면역요법 마커들 및 그 용도들
TWI775781B (zh) 2016-10-06 2022-09-01 美商建南德克公司 癌症之治療性及診斷性方法
WO2018067937A1 (fr) 2016-10-07 2018-04-12 Omniseq, Inc. Procédés et systèmes pour déterminer des thérapies personnalisées
WO2018132753A1 (fr) * 2017-01-13 2018-07-19 Nantbio, Inc. Validation de traitement à base de néo-épitope
CA3050109A1 (fr) 2017-01-18 2018-07-26 Ichan School Of Medicine At Mount Sinai Neoantigenes et leurs utilisations dans le traitement du cancer
KR20190110612A (ko) 2017-02-01 2019-09-30 모더나티엑스, 인크. 활성화 종양유전자 돌연변이 펩티드를 인코드하는 면역조절 치료 mrna 조성물
WO2018145023A1 (fr) * 2017-02-06 2018-08-09 Novartis Ag Procédé de prédiction de la réponse à une immunothérapie
US20190360051A1 (en) * 2017-02-17 2019-11-28 Stichting Vumc Swarm intelligence-enhanced diagnosis and therapy selection for cancer using tumor- educated platelets
US10859566B2 (en) * 2017-03-20 2020-12-08 Genocea Biosciences, Inc. Treatment methods
MA50056A (fr) * 2017-03-31 2020-02-05 Bristol Myers Squibb Co Procédés de traitement de tumeur
GB201710815D0 (en) * 2017-07-05 2017-08-16 Francis Crick Inst Ltd Method
US11674962B2 (en) 2017-07-21 2023-06-13 Genentech, Inc. Therapeutic and diagnostic methods for cancer
EP3658914A1 (fr) * 2017-07-28 2020-06-03 Bristol-Myers Squibb Company Biomarqueur sanguin périphérique prédictif pour inhibiteurs de points de contrôle
MX2020002301A (es) * 2017-09-13 2020-07-13 Five Prime Therapeutics Inc Terapia de combinacion de anticuerpos anti receptor del factor estimulante de colonias 1 (csf1r) y anti proteina de muerte programada 1 (pd-1) combinados para cancer pancreatico.
WO2019055860A1 (fr) * 2017-09-15 2019-03-21 The Texas A&M University System Méthodes d'amélioration de l'immunothérapie dans le traitement du cancer
WO2019060894A2 (fr) 2017-09-25 2019-03-28 Memorial Sloan Kettering Cancer Center Charge de mutation de tumorale
CA3076918A1 (fr) * 2017-10-02 2019-04-11 Curematch, Inc. Procede de prediction de l'antigenicite et/ou de l'immunogenicite d'un neo-peptide derive d'une tumeur, a l'aide de motifs de signature mutationnelle
AU2018348165A1 (en) 2017-10-10 2020-05-21 Gritstone Bio, Inc. Neoantigen identification using hotspots
AU2018348249A1 (en) * 2017-10-12 2020-04-16 Nantomics, Llc Cancer score for assessment and response prediction from biological fluids
CN111247169A (zh) * 2017-10-15 2020-06-05 百时美施贵宝公司 治疗肿瘤的方法
EP3704268B1 (fr) 2017-11-03 2025-01-22 Guardant Health, Inc. Normalisation de la charge de mutation tumorale
AU2018367925A1 (en) * 2017-11-17 2020-07-02 Gmdx Co Pty Ltd Systems and methods for predicting the efficacy of cancer therapy
IL274799B1 (en) 2017-11-22 2025-01-01 Gritstone Bio Inc Reducing epitope binding presentation for neoantigens
CN110770838B (zh) * 2017-12-01 2023-12-19 Illumina公司 用于确定体细胞突变克隆性的方法和系统
EP3788173B1 (fr) 2018-05-03 2023-11-29 F. Hoffmann-La Roche AG Marqueur de substitution et procédé de mesure de charge de mutation de tumeur
WO2019211489A1 (fr) * 2018-05-04 2019-11-07 Merck Patent Gmbh INHIBITION COMBINÉE DE PD-1/PD-L1, DE TGFβ ET D'ADN-PK POUR LE TRAITEMENT DU CANCER
KR20210038577A (ko) 2018-07-23 2021-04-07 가던트 헬쓰, 인크. 종양 분율 및 커버리지에 의해 종양 돌연변이 부담을 조정하기 위한 방법 및 시스템
WO2020021119A1 (fr) 2018-07-27 2020-01-30 F. Hoffmann-La Roche Ag Procédé de surveillance de l'efficacité d'immunothérapie de patients atteints d'un cancer
WO2020045479A1 (fr) * 2018-08-29 2020-03-05 公益財団法人東京都医学総合研究所 Agent antitumoral ciblant un substrat de tyrosine kinase régulée par hgf (hgs)
AU2019328344A1 (en) 2018-08-31 2021-04-08 Guardant Health, Inc. Microsatellite instability detection in cell-free DNA
WO2020102674A1 (fr) * 2018-11-15 2020-05-22 Personal Genome Diagnostics Inc. Procédé d'amélioration de la prédiction de la réponse pour des patients cancéreux traités par immunothérapie
CN113194995A (zh) * 2018-12-12 2021-07-30 免疫医疗有限责任公司 基于血液的肿瘤突变负荷预测非小细胞肺癌的总存活
WO2020252456A1 (fr) * 2019-06-14 2020-12-17 The Trustees Of Columbia University In The City Of New York Inhibiteurs de nt5c2 pour le traitement de la leucémie lymphoblastique aiguë résistante à la chimiothérapie
GB202003669D0 (en) * 2020-03-13 2020-04-29 Univ Oxford Innovation Ltd Method for identifying neo-antigens
JP2023523450A (ja) 2020-04-28 2023-06-05 ジェネンテック， インコーポレイテッド 非小細胞肺がん免疫療法のための方法及び組成物
CN112309502B (zh) * 2020-10-14 2024-09-20 深圳市新合生物医疗科技有限公司 一种计算肿瘤新抗原负荷的方法及系统
CA3200667A1 (fr) * 2020-11-06 2022-05-12 The General Hospital Corporation Procedes pour caracteriser des echantillons biologiques
WO2022235482A1 (fr) * 2021-05-03 2022-11-10 Rutgers, The State University Of New Jersey Immunothérapie pour une maladie intestinale inflammatoire et/ou un cancer
CN113030475B (zh) * 2021-05-25 2021-08-10 泛肽生物科技(浙江)有限公司 一种基于细胞线粒体质量评估的t细胞pd-1检测方法
CN113355424B (zh) * 2021-07-14 2022-03-25 江苏先声医学诊断有限公司 Pcdh11x突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用
WO2024216165A1 (fr) 2023-04-12 2024-10-17 Icahn School Of Medicine At Mount Sinai Procédés de calcul pour sélectionner des vaccins à néo-antigènes personnalisés

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033497A1 (en) 2002-08-13 2004-02-19 Alarcon-Riquelme Marta E. Polymorphisms of PD-1
TWI477602B (zh) 2006-02-09 2015-03-21 Educational Foundation Jichi Medical Univ Novel viral vector
US20110118298A1 (en) * 2009-11-13 2011-05-19 Infinity Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
CN103154034B (zh) * 2010-04-13 2016-06-08 塞尔德克斯医疗公司 结合人cd27的抗体及其用途
HUE049886T2 (hu) * 2010-05-14 2020-10-28 Massachusetts Gen Hospital Tumorspecifikus neoantigéneket tartalmazó készítmények, tumorok kezelésében történõ alkalmazásra
SG11201406592QA (en) 2012-05-04 2014-11-27 Pfizer Prostate-associated antigens and vaccine-based immunotherapy regimens
EP2901341B1 (fr) * 2012-09-28 2019-04-10 The University of Connecticut Identification d'épitopes protecteurs de tumeur pour le traitement de cancers
SG10201805674YA (en) * 2014-01-02 2018-08-30 Memorial Sloan Kettering Cancer Center Determinants of cancer response to immunotherapy
KR20230030022A (ko) * 2014-11-13 2023-03-03 더 존스 홉킨스 유니버시티 관문 차단 및 미소부수체 불안정성
MA40737A (fr) 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
WO2019060894A2 (fr) * 2017-09-25 2019-03-28 Memorial Sloan Kettering Cancer Center Charge de mutation de tumorale

Also Published As

Publication number Publication date
EP4393546A3 (fr) 2024-12-11
US20200040049A1 (en) 2020-02-06
CA2968059A1 (fr) 2016-05-26
EP4393546A2 (fr) 2024-07-03
JP2018502828A (ja) 2018-02-01
US10993998B2 (en) 2021-05-04
WO2016081947A4 (fr) 2016-09-09
AU2024278364A1 (en) 2025-02-13
AU2021215099A1 (en) 2021-08-26
CN107206064A (zh) 2017-09-26
CN114672559A (zh) 2022-06-28
JP2024125234A (ja) 2024-09-13
US20180291074A1 (en) 2018-10-11
EP3220950A2 (fr) 2017-09-27
WO2016081947A2 (fr) 2016-05-26
JP7173733B2 (ja) 2022-11-16
JP2023055625A (ja) 2023-04-18
JP7550193B2 (ja) 2024-09-19
WO2016081947A3 (fr) 2016-07-07
AU2015349644A1 (en) 2017-06-15
JP2020196732A (ja) 2020-12-10
EP3220950A4 (fr) 2018-08-29
CN107206064B (zh) 2021-12-21
HK1244440A1 (zh) 2018-08-10
AU2015349644B2 (en) 2021-08-19
US20210308241A1 (en) 2021-10-07

Similar Documents

Publication Publication Date Title
MA40737A (fr) Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
IL269810A (en) Combinatorial cancer immunotherapy
EP3624810A4 (fr) Immunothérapie anticancéreuse nano-activée
SG11201605432RA (en) Determinants of cancer response to immunotherapy
LT3240801T (lt) Kombinuota navikų imunoterapija
IL251890A0 (en) Combination immunotherapy approach for treatment of cancer
PL3283527T3 (pl) Leczenie skojarzone nowotworów
DK3204417T3 (da) Cd73-blokering
HUE059694T2 (hu) Készítmény rák kezelésére
LT3097119T (lt) Žmogaus antikūnai prieš pd-1
EP3330034A4 (fr) Procédé d'assemblage par friction
DK3186244T3 (da) Dioxolananaloger af uridin til behandling af cancer
IL247300A0 (en) Biomarker directed multi-target immunotherapy
DK3175012T3 (da) Forbedret aktivering af selvpassiverende metaller
EP3347334A4 (fr) Déshydrohalogénation d'hydrochlorofluorocarbones
DK3201559T3 (da) Patronhylster
EP3310915A4 (fr) Immunothérapie tumorale
HK1250719A1 (zh) 脫氧糖胺的合成
PL3390450T3 (pl) Humanizowane przeciwciało anty-cd28 formułowane do podawania ludziom
DK3253407T3 (da) Brug af hla-b27-homodimere til kræftbehandling
HK1258143A1 (zh) 和厚朴酚的改進的合成
IL256612B (en) Cyclopropanation of substituted alkenes
PT3384052T (pt) Correlatos clínicos de eficácia de imunoterapia
EP3387469A4 (fr) Détermination d'électrofaciès
KR20180084983A (ko) 암의 치료를 위한 피리미도-피리미다지논의 용도