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MA40302A1 - Carbazole derivatives - Google Patents

Carbazole derivatives

Info

Publication number
MA40302A1
MA40302A1 MA40302A MA40302A MA40302A1 MA 40302 A1 MA40302 A1 MA 40302A1 MA 40302 A MA40302 A MA 40302A MA 40302 A MA40302 A MA 40302A MA 40302 A1 MA40302 A1 MA 40302A1
Authority
MA
Morocco
Prior art keywords
carbazole derivatives
carbazole
derivatives
salt
compounds
Prior art date
Application number
MA40302A
Other languages
French (fr)
Other versions
MA40302B1 (en
Inventor
Saleem Ahmad
Joseph A Tino
Qingjie Liu
Douglas G Batt
Scott Hunter Watterson
Satheesh Kesavan Nair
John E Macor
Tarun Kumar Maishal
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54427879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40302(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA40302A1 publication Critical patent/MA40302A1/en
Publication of MA40302B1 publication Critical patent/MA40302B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention concerne des composés de formule (i), ou un sel de ces composés, rThe invention relates to compounds of formula (i), or a salt thereof,

MA40302A 2014-10-24 2015-10-23 Carbazole derivatives MA40302B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462068234P 2014-10-24 2014-10-24
PCT/US2015/057077 WO2016065236A1 (en) 2014-10-24 2015-10-23 Carbazole derivatives

Publications (2)

Publication Number Publication Date
MA40302A1 true MA40302A1 (en) 2018-05-31
MA40302B1 MA40302B1 (en) 2018-10-31

Family

ID=54427879

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40302A MA40302B1 (en) 2014-10-24 2015-10-23 Carbazole derivatives

Country Status (34)

Country Link
US (3) US10266491B2 (en)
EP (1) EP3209651B9 (en)
JP (1) JP6599983B2 (en)
KR (1) KR102514914B1 (en)
CN (1) CN107074804B (en)
AR (1) AR102427A1 (en)
AU (1) AU2015335703B2 (en)
BR (1) BR112017007545A2 (en)
CA (1) CA2965523A1 (en)
CL (1) CL2017001001A1 (en)
CO (1) CO2017004517A2 (en)
CY (1) CY1122549T1 (en)
DK (1) DK3209651T3 (en)
EA (1) EA032361B1 (en)
ES (1) ES2761903T3 (en)
HR (1) HRP20192197T2 (en)
HU (1) HUE048321T2 (en)
IL (1) IL251798B (en)
LT (1) LT3209651T (en)
MA (1) MA40302B1 (en)
ME (1) ME03754B (en)
MX (1) MX2017005255A (en)
MY (1) MY190568A (en)
PE (1) PE20171239A1 (en)
PH (1) PH12017500724B1 (en)
PL (1) PL3209651T3 (en)
PT (1) PT3209651T (en)
RS (1) RS59707B1 (en)
SG (2) SG11201703187PA (en)
SI (1) SI3209651T1 (en)
SM (1) SMT202000035T1 (en)
TN (1) TN2017000158A1 (en)
TW (1) TWI676618B (en)
WO (1) WO2016065236A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201702312UA (en) 2014-10-24 2017-05-30 Takeda Pharmaceuticals Co Heterocyclic compound
SG10201903621SA (en) * 2014-10-24 2019-05-30 Bristol Myers Squibb Co Tricyclic atropisomer compounds
KR102327917B1 (en) * 2016-07-07 2021-11-17 주식회사 대웅제약 NOVEL 4-AMINOPYRAZOLO[3,4-d]PYRIMIDINYLAZABICYCLO DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
GB201616627D0 (en) 2016-09-30 2016-11-16 Mission Therapeutics Limited Novel compounds
EP3694528A4 (en) 2017-10-13 2021-07-28 The Regents of the University of California MTORC1 MODULATORS
CN109053542A (en) * 2018-07-25 2018-12-21 南通大学 A kind of chemical synthesis process of the bromo- 5- hydroxyl 1-isoindolinone of 6-
US20240076280A1 (en) 2019-10-04 2024-03-07 Bristol-Myers Squibb Company Substituted carbazole compounds
CN110862396B (en) * 2019-11-29 2021-06-04 浙江工业大学 A kind of synthetic method of pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione compound
BR112022020342A2 (en) * 2020-04-10 2022-12-13 Gb005 Inc KINASE INHIBITORS
JP2023528421A (en) * 2020-06-02 2023-07-04 ジービー００５， インコーポレイテッド Kinase inhibitor
CN115232061B (en) * 2021-09-18 2024-01-30 山西紫罗蓝新材料科技有限公司 An extraction process for 3-nitro-9-ethylcarbazole crude product
WO2024010784A1 (en) * 2022-07-06 2024-01-11 Vividion Therapeutics, Inc. Pharmaceutical compositions comprising wrn helicase inhibitors
TW202430506A (en) * 2022-09-29 2024-08-01 美商維維迪昂醫療公司 Inhibitors and uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200750A (en) 1977-01-07 1980-04-29 Westwood Pharmaceuticals Inc. 4-Substituted imidazo [1,2-a]quinoxalines
CA2140722A1 (en) 1994-01-24 1995-07-25 Joseph A. Jakubowski Beta-carboline thromboxane synthase inhibitors
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
WO2005047290A2 (en) 2003-11-11 2005-05-26 Cellular Genomics Inc. Imidazo[1,2-a] pyrazin-8-ylamines as kinase inhibitors
DE602005023333D1 (en) 2004-10-15 2010-10-14 Takeda Pharmaceutical KINASE INHIBITORS
WO2006053121A2 (en) 2004-11-10 2006-05-18 Cgi Pharmaceuticals, Inc. Imidazo[1 , 2-a] pyrazin-8-ylamines useful as modulators of kinase activity
KR101317119B1 (en) 2004-12-17 2013-10-11 그렌마크 파머수티칼스 에스. 아. Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
US7723336B2 (en) 2005-09-22 2010-05-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
EP1954290B1 (en) * 2005-11-22 2012-07-25 Merck Sharp & Dohme Corp. Tricyclic compounds useful as inhibitors of kinases
NZ575389A (en) 2006-09-11 2012-03-30 Mylan Lab Ltd Dibenzofuran derivatives as inhibitors of pde-4 and pde-10
JP2010502751A (en) 2006-09-11 2010-01-28 シージーアイ ファーマシューティカルズ，インコーポレイティド Kinase inhibitors and methods of using and identifying kinase inhibitors
US20090062251A1 (en) 2007-08-17 2009-03-05 Astrazeneca Ab Novel Compounds 002
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
JP5489296B2 (en) * 2007-12-13 2014-05-14 メルク・シャープ・アンド・ドーム・コーポレーション JANUS kinase inhibitors
PT2247558T (en) 2008-02-14 2022-03-21 Lilly Co Eli Novel imaging agents for detecting neurological dysfunction
GB0809360D0 (en) 2008-05-22 2008-07-02 Isis Innovation Calcium modulation
WO2009153720A1 (en) 2008-06-18 2009-12-23 Pfizer Limited Nicotinamide derivatives
MX357627B (en) 2008-06-27 2018-07-17 Avila Therapeutics Inc Heteroaryl compounds and uses thereof.
EP2151441A1 (en) 2008-08-06 2010-02-10 Julius-Maximilians-Universität Würzburg Beta-carbolin-derivates as substrates for an enzyme
AU2009335821A1 (en) * 2008-12-19 2010-07-15 Bristol-Myers Squibb Company Carbazole carboxamide compounds useful as kinase inhibitors
CN101475571B (en) 2009-01-21 2011-06-22 中国药科大学 β-carboline cyclin-dependent kinase 2 inhibitors and uses thereof
EP2415184B1 (en) 2009-02-13 2019-04-10 Nextivity, Inc. Remote control for booster
EP2582668B1 (en) 2010-06-16 2016-01-13 Bristol-Myers Squibb Company Carboline carboxamide compounds useful as kinase inhibitors
EP2455378A1 (en) 2010-11-03 2012-05-23 Philip Morris Products S.A. Carbazole and carboline derivatives, and preparation and therapeutic applications thereof
CN105330675A (en) 2010-11-15 2016-02-17 Viiv保健英国有限公司 Inhibitors of HIV replication
MX345170B (en) 2011-05-17 2017-01-19 Hoffmann La Roche Inhibitors of bruton's tyrosine kinase.
AU2013207972B2 (en) 2012-01-10 2017-06-15 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
KR20150060839A (en) 2012-10-26 2015-06-03 에프. 호프만-라 로슈 아게 Inhibitors of bruton's tyrosine kinase
WO2014210087A1 (en) 2013-06-25 2014-12-31 Bristol-Myers Squibb Company Carbazole carboxamide compounds useful as kinase inhibitors
UY35625A (en) * 2013-06-25 2014-12-31 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware TETRAHYDROCARBAZOL AND CARBAZOL CARBOXAMIDA COMPOUNDS REPLACED AS QUINASA INHIBITORS
JP6517928B2 (en) 2014-10-24 2019-05-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Indolecarboxamides useful as kinase inhibitors
SG10201903621SA (en) * 2014-10-24 2019-05-30 Bristol Myers Squibb Co Tricyclic atropisomer compounds

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EA032361B1 (en) 2019-05-31
CA2965523A1 (en) 2016-04-28
HRP20192197T1 (en) 2020-03-06
BR112017007545A2 (en) 2017-12-19
ES2761903T3 (en) 2020-05-21
KR20170075756A (en) 2017-07-03
US20170362176A1 (en) 2017-12-21
PL3209651T3 (en) 2020-03-31
TN2017000158A1 (en) 2018-10-19
IL251798B (en) 2020-08-31
AR102427A1 (en) 2017-03-01
HUE048321T2 (en) 2020-07-28
EP3209651B1 (en) 2019-10-23
LT3209651T (en) 2020-01-10
US10266491B2 (en) 2019-04-23
US20190225583A1 (en) 2019-07-25
EP3209651A1 (en) 2017-08-30
SI3209651T1 (en) 2019-12-31
US20200255377A1 (en) 2020-08-13
CN107074804A (en) 2017-08-18
HRP20192197T2 (en) 2020-11-13
HRP20192197T8 (en) 2020-04-03
CN107074804B (en) 2020-02-18
AU2015335703B2 (en) 2020-05-21
JP2017535536A (en) 2017-11-30
ME03754B (en) 2021-04-20
CO2017004517A2 (en) 2017-08-31
MY190568A (en) 2022-04-27
AU2015335703A1 (en) 2017-06-08
KR102514914B1 (en) 2023-03-27
MX2017005255A (en) 2017-08-18
US11053197B2 (en) 2021-07-06
SG10201903619YA (en) 2019-05-30
JP6599983B2 (en) 2019-10-30
SG11201703187PA (en) 2017-05-30
PE20171239A1 (en) 2017-08-24
EA201790745A1 (en) 2017-08-31
PH12017500724B1 (en) 2023-07-05
PT3209651T (en) 2019-12-30
PH12017500724A1 (en) 2017-10-09
CL2017001001A1 (en) 2017-11-24
SMT202000035T1 (en) 2020-03-13
IL251798A0 (en) 2017-06-29
CY1122549T1 (en) 2021-01-27
US10676434B2 (en) 2020-06-09
TWI676618B (en) 2019-11-11
DK3209651T3 (en) 2020-02-03
TW201629014A (en) 2016-08-16
EP3209651B9 (en) 2020-05-20
RS59707B1 (en) 2020-01-31
WO2016065236A1 (en) 2016-04-28
MA40302B1 (en) 2018-10-31

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