[go: up one dir, main page]

MA39583A1 - 6,7-Dihydropyrazolo [1,5-a] pyrazin-4 (5h) -one compounds and their use as mglur2-negative allosteric modulators - Google Patents

6,7-Dihydropyrazolo [1,5-a] pyrazin-4 (5h) -one compounds and their use as mglur2-negative allosteric modulators

Info

Publication number
MA39583A1
MA39583A1 MA39583A MA39583A MA39583A1 MA 39583 A1 MA39583 A1 MA 39583A1 MA 39583 A MA39583 A MA 39583A MA 39583 A MA39583 A MA 39583A MA 39583 A1 MA39583 A1 MA 39583A1
Authority
MA
Morocco
Prior art keywords
compounds
mglur2
dihydropyrazolo
pyrazin
allosteric modulators
Prior art date
Application number
MA39583A
Other languages
French (fr)
Inventor
Andrés Avelino Trabanco-Suárez
Diego Sergio-Alvar Alonso-De
Gool Michiel Luc Maria Van
Óscar Delgado-González
José Ignacio Andrés-Gil
María Luz Martín-Martín
Susana Conde-Ceide
Gary John Tresadern
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP2015/067572 external-priority patent/WO2016016395A1/en
Publication of MA39583A1 publication Critical patent/MA39583A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one utilisés comme modulateurs allostériques négatifs (nam) du sous-type 2 des récepteurs métabotropiques du glutamate ("mglur2"). Elle concerne aussi des compositions pharmaceutiques comprenant ces composés, des procédés de préparation de ces composés et compositions, et l'utilisation de ces composés et compositions pour la prévention ou le traitement de troubles dans lesquels intervient le sous-type mglur2 des récepteurs métabotropiques.The present invention relates to novel 6,7-dihydropyrazolo [1,5-a] pyrazin-4 (5h) -one derivatives as alloteric negative modulators (nam) of metabotropic glutamate receptor subtype 2 ("mglur2"). ). The invention also relates to pharmaceutical compositions comprising these compounds, processes for the preparation of these compounds and compositions, and the use of these compounds and compositions for the prevention or treatment of disorders in which the mglur2 subtype of the metabotropic receptors occurs.

MA39583A 2014-08-01 2015-07-30 6,7-Dihydropyrazolo [1,5-a] pyrazin-4 (5h) -one compounds and their use as mglur2-negative allosteric modulators MA39583A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179600 2014-08-01
PCT/EP2015/067572 WO2016016395A1 (en) 2014-08-01 2015-07-30 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

Publications (1)

Publication Number Publication Date
MA39583A1 true MA39583A1 (en) 2017-06-30

Family

ID=51257439

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39583A MA39583A1 (en) 2014-08-01 2015-07-30 6,7-Dihydropyrazolo [1,5-a] pyrazin-4 (5h) -one compounds and their use as mglur2-negative allosteric modulators

Country Status (2)

Country Link
AR (1) AR101394A1 (en)
MA (1) MA39583A1 (en)

Also Published As

Publication number Publication date
AR101394A1 (en) 2016-12-14

Similar Documents

Publication Publication Date Title
MA39582A1 (en) Compounds of 6,7-dihydropyrazolo [1,5-p] pyrazin-4 (5h) -one and their use as negative allosteric modulators of metabotropic glutamate receptors
PH12015502685A1 (en) 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PH12017500170A1 (en) 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors
MA41134A (en) 5-AMINO-6H-THIAZOLO [4,5-D] PYRIMIDINE-2,7-DIONE SUBSTITUTE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS
CA2883210C (en) Bicyclic aza compounds as muscarinic m1 receptor agonists
MX2017001453A (en) 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors.
MA42397B1 (en) Substituted 4-azaindoles and their use as modulators of the glun2b receptor
MA40875A (en) 2,4-DIAMINO-QUINOLEIN SUBSTITUTED AS NEW ANTI-CANCER AGENTS
PH12014501079A1 (en) 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions
MA41988B1 (en) Azabenzimidazoles and their use as ampa receptor modulators
MA43913A (en) POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC M1 RECEPTOR
PH12016500312A1 (en) 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
MA43250B1 (en) Oxadiazaspiro compounds for the treatment of drug abuse and dependence
MA39583A1 (en) 6,7-Dihydropyrazolo [1,5-a] pyrazin-4 (5h) -one compounds and their use as mglur2-negative allosteric modulators
MX2020004580A (en) Azabicyclo and diazepine derivatives for treating ocular disorders.
MA39446A1 (en) Pharmaceutical compositions for treating infectious diseases
FR3042191B1 (en) 1,4,8-TRIAZAPHENANTHRENE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
EA202192092A3 (en) TETRAHYDRO-PYRIDO[3,4-B]INDOL MODULATORS OF ESTROGEN RECEPTORS AND THEIR APPLICATION