[go: up one dir, main page]

MA32009B1 - Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux - Google Patents

Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux

Info

Publication number
MA32009B1
MA32009B1 MA33007A MA33007A MA32009B1 MA 32009 B1 MA32009 B1 MA 32009B1 MA 33007 A MA33007 A MA 33007A MA 33007 A MA33007 A MA 33007A MA 32009 B1 MA32009 B1 MA 32009B1
Authority
MA
Morocco
Prior art keywords
pyrazolo
pyrimidine
anticancer agents
novel derivatives
human
Prior art date
Application number
MA33007A
Other languages
Arabic (ar)
English (en)
Inventor
Durga Prasad Konakanchi
Subba Rao Pula
Lakshmi Ananthaneni
Ramakrishna Pilli
Reddy Muddasani Pulla
Kali Satya Bhujanga Rao Adibhatla
Chowdary Nannapaneni Venkaiah
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of MA32009B1 publication Critical patent/MA32009B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés substitutes de pyrazolo [3,4-d] pyrimidine de formule (i), ou leurs sels pharmaceutiquement acceptables, qui possèdent une activité anti-proliférante telle qu'une activité anticancéreuse et sont donc utiles dans des procédés de traitement de l'organisme humain ou animal. L'invention concerne également des procédés de fabrication de dérivés substitués de pyrazolo [3,4-d] pyrimidine, des compositions pharmaceutiques contenant le composé et son utilisation dans la fabrication de médicaments pour la production d'un effet anti-proliférant dans un animal à sang chaud tel qu'un humain.
MA33007A 2008-01-11 2010-07-09 Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux MA32009B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN109CH2008 2008-01-11
PCT/IN2009/000037 WO2009098715A2 (fr) 2008-01-11 2009-01-12 Nouveaux dérivés de pyrazolo [3, 4 -d] pyrimidine en tant qu’agents anticancéreux

Publications (1)

Publication Number Publication Date
MA32009B1 true MA32009B1 (fr) 2011-01-03

Family

ID=40933862

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33007A MA32009B1 (fr) 2008-01-11 2010-07-09 Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux

Country Status (18)

Country Link
US (1) US8349847B2 (fr)
EP (1) EP2247596A2 (fr)
JP (1) JP2011509290A (fr)
KR (1) KR20100116607A (fr)
CN (1) CN101965350A (fr)
AP (1) AP2010005347A0 (fr)
AU (1) AU2009211004C1 (fr)
BR (1) BRPI0906475A2 (fr)
CA (1) CA2711777A1 (fr)
CO (1) CO6382174A2 (fr)
EA (1) EA201070841A1 (fr)
GE (1) GEP20135780B (fr)
IL (1) IL206811A0 (fr)
MA (1) MA32009B1 (fr)
MX (1) MX2010007523A (fr)
NZ (1) NZ586642A (fr)
WO (1) WO2009098715A2 (fr)
ZA (1) ZA201004823B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2448938T5 (en) 2009-06-29 2015-10-05 Incyte Corp Pyrimidinones AS PI3K inhibitors
WO2011075630A1 (fr) * 2009-12-18 2011-06-23 Incyte Corporation Dérivés substitués d'aryles et d'hétéroaryles fusionnés au titre d'inhibiteurs de pi3k
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
WO2012125629A1 (fr) 2011-03-14 2012-09-20 Incyte Corporation Dérivés diamino-pyrimidines et diamino-pyridines substituées en tant qu'inhibiteurs de pi3k
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
HRP20170285T1 (hr) 2011-09-02 2017-04-21 Incyte Holdings Corporation Heterociklilamini kao inhibitori pi3k
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CN102746307B (zh) * 2012-07-09 2013-07-31 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN102746309B (zh) * 2012-07-09 2013-06-05 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN103965202B (zh) * 2014-05-21 2016-01-20 邹宏丽 二环稠合杂环化合物、其制备方法及用途
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
MX373232B (es) 2015-02-27 2020-05-08 Incyte Holdings Corp Sales del inhibidor fosfoinositida 3-cinasa (pi3k) y procesos para su preparación.
WO2016183060A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Procédé de synthèse d'un inhibiteur de phospho-inositide 3-kinases
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
CN106008527B (zh) * 2016-06-29 2018-05-15 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
MX2020012826A (es) 2018-06-01 2021-03-09 Incyte Corp Regimen de dosificacion para el tratamiento de trastornos relacionados con fosfatidilinositol 3-cinasas (pi3k).
JP7794742B2 (ja) * 2019-12-23 2026-01-06 サンフォード バーナム プレビス メディカル ディスカバリー インスティテュート エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ１（ｅｎｐｐ１）モジュレーター及びその使用
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3000688A (en) 1961-09-19 Process for vatting of vat dyestuffs
US3551428A (en) 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
JPS5439096A (en) 1977-08-27 1979-03-24 Lion Dentifrice Co Ltd 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US5877178A (en) 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
CA2224435C (fr) 1995-07-06 2008-08-05 Novartis Ag Pyrrolopyrimidines et leurs procedes de preparation
ATE217873T1 (de) 1996-01-23 2002-06-15 Novartis Erfind Verwalt Gmbh Pyrrolopyrimidinen und verfahren zu deren herstellung
CH690773A5 (de) 1996-02-01 2001-01-15 Novartis Ag Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
US6537999B2 (en) 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
DE69738468T2 (de) 1996-08-23 2009-01-08 Novartis Ag Substituierte pyrrolopyrimidine und verfahren zu ihrer herstellung
DE19709488A1 (de) 1997-03-07 1998-09-10 Basf Ag Verfahren zur N-Alkylierung von Aminen
EA200000098A1 (ru) 1997-08-05 2000-08-28 Пфайзер Продактс Инк. 4-АМИНОПИРРОЛ(3,2-d)ПИРИМИДИНЫ В КАЧЕСТВЕ АНТАГОНИСТОВ РЕЦЕПТОРА НЕЙРОПЕПТИДА Y
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6423871B1 (en) 1999-02-26 2002-07-23 University Of South Florida Efficient synthesis of secondary amines by selective alkylation of primary amines
EP1183033B1 (fr) 1999-05-21 2006-03-01 Bristol-Myers Squibb Company Pyrrolotriazines inhibiteurs de kinases
ITMI992711A1 (it) 1999-12-27 2001-06-27 Novartis Ag Composti organici
AU2000240570A1 (en) 2000-03-29 2001-10-08 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
CN1263757C (zh) 2000-12-01 2006-07-12 Osi制药公司 特异于腺苷a1,a2a和a3受体的化合物及其应用
DE10060388A1 (de) 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
AR035885A1 (es) 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
WO2003000187A2 (fr) 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Nouvelles pyrazolo-pyrimidines et pyrrolo-pyrimidines et leur utilisation
GB0115393D0 (en) 2001-06-23 2001-08-15 Aventis Pharma Ltd Chemical compounds
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
KR20050067383A (ko) 2002-08-06 2005-07-01 아스트라제네카 아베 Ｔｉｅ2(ｔｅｋ) 활성을 갖는 축합 피리딘 및 피리미딘
US20040138238A1 (en) 2002-08-08 2004-07-15 Dhanoa Dale S. Substituted aminopyrimidine compounds as neurokinin antagonists

Also Published As

Publication number Publication date
JP2011509290A (ja) 2011-03-24
KR20100116607A (ko) 2010-11-01
BRPI0906475A2 (pt) 2015-07-14
US8349847B2 (en) 2013-01-08
WO2009098715A2 (fr) 2009-08-13
IL206811A0 (en) 2010-12-30
ZA201004823B (en) 2011-09-28
CO6382174A2 (es) 2012-02-15
WO2009098715A3 (fr) 2009-10-15
AP2010005347A0 (en) 2010-08-31
AU2009211004A1 (en) 2009-08-13
CN101965350A (zh) 2011-02-02
GEP20135780B (en) 2013-03-11
NZ586642A (en) 2012-04-27
AU2009211004C1 (en) 2013-08-01
EP2247596A2 (fr) 2010-11-10
MX2010007523A (es) 2010-08-18
EA201070841A1 (ru) 2011-02-28
AU2009211004A2 (en) 2011-01-27
WO2009098715A4 (fr) 2009-12-10
CA2711777A1 (fr) 2009-08-13
US20100298351A1 (en) 2010-11-25
AU2009211004B2 (en) 2011-09-01

Similar Documents

Publication Publication Date Title
MA32009B1 (fr) Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux
MA29926B1 (fr) Derives de pyrazine
TNSN07022A1 (fr) Derives de pyridine
WO2005004818A3 (fr) Composes heterocycliques et leur utilisation comme agents anticancereux
ATE437872T1 (de) Proteinkinaseinhibitoren
MA27389A1 (fr) Derives de benzimidazole nouveaux utiles comme agents antiproliferatifs.
UA86614C2 (ru) Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата
TN2009000450A1 (fr) Derives de pyridine
MA38380A1 (fr) Inhibiteurs quinazoline de l'activation des formes mutantes du récepteur de croissance épidermique (egfr)
MA31466B1 (fr) Derives de benzimidazole
MA33239B1 (fr) 3h-imidazo [4,5-c] pyridine-6-carboxamides en tant qu'anti-inflammatoires
WO2006067445A3 (fr) Composes chimiques
NO20090025L (no) Pyrrolotriazinkinaseinhibitorer
MA28270A1 (fr) Pyrido [2, 3-D] pyrimidine-2, 4-diamines servant d'inhibiteurs de PDE 2
SG148177A1 (en) Novel cis-imidazolines
MA31919B1 (fr) Composés inhibiteurs de la dipeptidyl peptidase-iv, leurs procédés de préparation, et compositions pharmaceutiques contenant ces composés comme agent actif
TN2009000428A1 (fr) Derives de sulfonylamides destines au traitement d'une croissance cellulaire anormale
MA29713B1 (fr) Derives de tetrahydroindolone et de tetrahydroindazolone
MXPA03011484A (es) Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades.
NO20070656L (no) 2,4,6-Trisubstituerte pyrimidiner som fosfotidylinositol-(PI)-3-kinaseinhibitorer og disses anvendelse ved behandling av kreft
MA29480B1 (fr) Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation
MA30075B1 (fr) Derives de pyrimidine pour le traitement d'une croissance cellulaire anormale
MX2022013946A (es) Antagonistas del receptor de adenosina a2a.
EA200701296A1 (ru) 3,5-дизамещенные и 3,5,7-тризамещенные 3h-оксазоло- и 3h-тиазоло[4,5-d] пиримидин-2-оны и их пролекарства
MA29411B1 (fr) 1h-quinazoline -2,4-diones et leur utilisation en tant que ligands du recepteur ampa