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MA30780B1 - Composes et procedes associes a des agents etiquetes 18f - Google Patents

Composes et procedes associes a des agents etiquetes 18f

Info

Publication number
MA30780B1
MA30780B1 MA31764A MA31764A MA30780B1 MA 30780 B1 MA30780 B1 MA 30780B1 MA 31764 A MA31764 A MA 31764A MA 31764 A MA31764 A MA 31764A MA 30780 B1 MA30780 B1 MA 30780B1
Authority
MA
Morocco
Prior art keywords
compounds
methods associated
label agents
label
agents
Prior art date
Application number
MA31764A
Other languages
English (en)
Inventor
Lutz Lehmann
Ananth Srinivasan
Thomas Brumby
Detlev Suelzle
Timo Stellfeld
Keith Graham
Mylene Karramkam
Simon Ametamey
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06090166A external-priority patent/EP1897885A1/fr
Priority claimed from EP07090079A external-priority patent/EP1985624A3/fr
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA30780B1 publication Critical patent/MA30780B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DE NOUVEAUX COMPOSÉS ADAPTÉS POUR ÊTRE RADIO-ÉTIQUETÉS 18F OU DÉJÀ RADIO-ÉTIQUETÉS 18F, DES PROCÉDÉS DE FABRICATION DESDITS COMPOSÉS ET L'UTILISATION DESDITS COMPOSÉS DANS L'IMAGERIE DE DIAGNOSTIC. LESDITS COMPOSÉS ÉTIQUETÉS SE CARACTÉRISENT PAR LA FORMULE II DANS LAQUELLE LES SUBSTITUANTS G, Q, L, Y ET U SONT TELS QUE DÉFINIS DANS LES SPÉCIFICATIONS ET LES REVENDICATIONS.
MA31764A 2006-09-08 2009-04-06 Composes et procedes associes a des agents etiquetes 18f MA30780B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06090166A EP1897885A1 (fr) 2006-09-08 2006-09-08 Composés marqués au fluor et méthode pour la production
EP07090079A EP1985624A3 (fr) 2007-04-23 2007-04-23 Procédé simple de radiofluorination de composés actifs biologiquement ou de biomolécules

Publications (1)

Publication Number Publication Date
MA30780B1 true MA30780B1 (fr) 2009-10-01

Family

ID=39031005

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31764A MA30780B1 (fr) 2006-09-08 2009-04-06 Composes et procedes associes a des agents etiquetes 18f

Country Status (20)

Country Link
US (1) US8557776B2 (fr)
EP (5) EP2455105B1 (fr)
JP (2) JP5603074B2 (fr)
KR (1) KR20090058553A (fr)
AR (1) AR062726A1 (fr)
AU (1) AU2007294124A1 (fr)
BR (1) BRPI0716554A2 (fr)
CA (2) CA2858907A1 (fr)
CL (1) CL2007002620A1 (fr)
CO (1) CO6150196A2 (fr)
CR (1) CR10654A (fr)
IL (4) IL197363A0 (fr)
MA (1) MA30780B1 (fr)
MX (1) MX2009002492A (fr)
NO (1) NO20091428L (fr)
PE (1) PE20080850A1 (fr)
RU (1) RU2009112716A (fr)
TN (1) TN2009000063A1 (fr)
TW (1) TW200829277A (fr)
WO (1) WO2008028688A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2858907A1 (fr) 2006-09-08 2008-03-13 Bayer Schering Pharma Aktiengesellschaft Composes et procedes associes a des agents etiquetes 18f
EA200901142A1 (ru) * 2007-03-01 2010-04-30 Байер Шеринг Фарма Акциенгезельшафт 18f фторбензоильные меченые биологически активные соединения в качестве диагностических визуализирующих средств, а также бензотриазол-1-илоксибензоильные, 2,5-(диоксопирролидин-1-илокси)бензоильные и триметиламмониобензоильные предшественники
GB201013808D0 (en) 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
WO2012094334A1 (fr) * 2011-01-04 2012-07-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Marquage au 18f en une seule étape de substrats biologiques et utilisations desdits substrats biologiques marqués au 18f
WO2012170602A1 (fr) * 2011-06-09 2012-12-13 Ge Healthcare Limited Dispositif et procédé de distillation
CN108558939B (zh) * 2013-03-15 2021-08-24 癌靶技术有限责任公司 18f-标记的靶向psma的pet成像剂
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
US11518754B2 (en) 2017-02-17 2022-12-06 Yale University Radiolabeled pharmaceuticals and methods of making and using same
TWI821192B (zh) 2017-07-11 2023-11-11 美商新索思股份有限公司 非天然核苷酸之導入及其方法
SG11202000939PA (en) 2017-08-03 2020-02-27 Synthorx Inc Cytokine conjugates for the treatment of proliferative and infectious diseases
WO2019204808A1 (fr) * 2018-04-20 2019-10-24 The General Hospital Corporation Promédicaments acétylés pour administration à travers la barrière hémato-encéphalique
JP2022519271A (ja) 2019-02-06 2022-03-22 シンソークス， インコーポレイテッド Ｉｌ－２コンジュゲートおよびその使用方法
WO2022246118A2 (fr) * 2021-05-20 2022-11-24 The Regents Of The University Of California Traceurs d'imagerie pet

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2795449B2 (ja) * 1987-09-24 1998-09-10 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 治療用ペプチド
US5084555A (en) * 1989-08-21 1992-01-28 The Administrators Of The Tulane Educational Fund An octapeptide bombesin analog
US5723578A (en) * 1987-09-24 1998-03-03 The Administrators Of Tulane Educational Fund Peptide analogs of bombesin
WO1990003980A1 (fr) * 1988-10-14 1990-04-19 Administrators Of The Tulane Educational Fund Peptides therapeutiques
CA2056449A1 (fr) * 1989-06-02 1990-12-03 Stanley J. Podlasek Methode de detection des anticorps antistreptokinase
US6232071B1 (en) 1990-06-11 2001-05-15 Gilead Sciences, Inc. Tenascin-C nucleic acid ligands
US5244883A (en) * 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists
TW432073B (en) * 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
SK9672000A3 (en) 1997-12-24 2001-04-09 Vertex Pharmaceuticals Inc Ver Prodrugs of aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6639076B1 (en) * 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6855715B1 (en) * 1999-06-14 2005-02-15 Eli Lilly And Company Serine protease inhibitors
AU2002228725A1 (en) * 2000-11-30 2002-06-11 Advanced Research And Technology Institute, Inc. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0206750D0 (en) 2002-03-22 2002-05-01 Amersham Plc Radiofluorination methods
ES2266798T3 (es) * 2002-04-09 2007-03-01 Eli Lilly And Company Secretagodos de hormona de crecimiento.
EP1527086B1 (fr) * 2002-08-09 2008-01-09 Astellas Pharma Europe B.V. Composes se liant a la p-selectine
US20080063599A1 (en) 2002-11-18 2008-03-13 Jorge Setoain Quinquer Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils
EP1597270A2 (fr) * 2003-02-20 2005-11-23 University of South Florida Inhibiteurs peptidomimetiques de l'activite de stat3 et utilisations medicales de ceux-ci
GB0305704D0 (en) 2003-03-13 2003-04-16 Amersham Plc Radiofluorination methods
WO2006083424A2 (fr) 2004-12-28 2006-08-10 The Trustees Of Columbia University In The City Of New York Composes radiomarques et utilisations de ceux-ci
JP2009505962A (ja) 2005-07-29 2009-02-12 バイエル・ヘルスケア・エルエルシー 肥満を治療するためのビフェニルアミノ酸誘導体の製造および使用
US20080029548A1 (en) 2006-05-05 2008-02-07 Ann De Wree Fabric treatment dispensing package
CA2858907A1 (fr) 2006-09-08 2008-03-13 Bayer Schering Pharma Aktiengesellschaft Composes et procedes associes a des agents etiquetes 18f

Also Published As

Publication number Publication date
EP2279759A2 (fr) 2011-02-02
BRPI0716554A2 (pt) 2013-09-24
JP5722966B2 (ja) 2015-05-27
EP2289564A2 (fr) 2011-03-02
JP2014028813A (ja) 2014-02-13
CO6150196A2 (es) 2010-04-20
AR062726A1 (es) 2008-11-26
TN2009000063A1 (en) 2010-08-19
KR20090058553A (ko) 2009-06-09
CR10654A (es) 2009-04-14
EP3056509A1 (fr) 2016-08-17
IL211526A0 (en) 2011-05-31
CA2662449A1 (fr) 2008-03-13
US8557776B2 (en) 2013-10-15
EP2455105B1 (fr) 2016-02-17
IL197363A0 (en) 2011-08-01
EP2455105A3 (fr) 2012-09-05
US20080292548A1 (en) 2008-11-27
JP2010503618A (ja) 2010-02-04
CL2007002620A1 (es) 2008-05-30
EP2289564A3 (fr) 2012-11-14
WO2008028688A3 (fr) 2008-11-13
JP5603074B2 (ja) 2014-10-08
EP2455105A2 (fr) 2012-05-23
AU2007294124A1 (en) 2008-03-13
IL211033A0 (en) 2011-04-28
PE20080850A1 (es) 2008-09-02
CA2858907A1 (fr) 2008-03-13
EP2279759A3 (fr) 2013-04-17
WO2008028688A2 (fr) 2008-03-13
EP2063918A2 (fr) 2009-06-03
MX2009002492A (es) 2009-08-28
NO20091428L (no) 2009-06-03
RU2009112716A (ru) 2010-10-20
IL211527A0 (en) 2011-05-31
TW200829277A (en) 2008-07-16
EP2063918B1 (fr) 2014-02-26

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