[go: up one dir, main page]

MA27119A1 - Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine - Google Patents

Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine

Info

Publication number
MA27119A1
MA27119A1 MA27955A MA27955A MA27119A1 MA 27119 A1 MA27119 A1 MA 27119A1 MA 27955 A MA27955 A MA 27955A MA 27955 A MA27955 A MA 27955A MA 27119 A1 MA27119 A1 MA 27119A1
Authority
MA
Morocco
Prior art keywords
modulators
activity
receptor
tetrahydropyranyle
chimiokin
Prior art date
Application number
MA27955A
Other languages
English (en)
Inventor
Jiao Richard
Moyes Christopher
Yang Lihu
Morriello Gregori
Original Assignee
Merck Sharp & Dohme
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Merck & Co Inc filed Critical Merck Sharp & Dohme
Publication of MA27119A1 publication Critical patent/MA27119A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des composés de formule (I): (dans laquelle R3 et R4 sont définis ici) qui sont utiles comme modulateurs de l'activité d'un récepteur de chimiokine. En particulier, ces composés sont utiles comme modulateurs du récepteur de chimiokine CCR-2.
MA27955A 2002-04-29 2004-11-17 Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine MA27119A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37629102P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
MA27119A1 true MA27119A1 (fr) 2004-12-20

Family

ID=29401326

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27955A MA27119A1 (fr) 2002-04-29 2004-11-17 Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine

Country Status (22)

Country Link
US (1) US7786305B2 (fr)
KR (1) KR100754760B1 (fr)
CN (1) CN1310917C (fr)
AR (1) AR039489A1 (fr)
AU (1) AU2003234251A1 (fr)
BR (1) BR0309650A (fr)
DO (1) DOP2003000638A (fr)
EC (1) ECSP045392A (fr)
HR (1) HRP20041023A2 (fr)
IL (1) IL164909A (fr)
IS (1) IS7512A (fr)
JO (1) JO2479B1 (fr)
MA (1) MA27119A1 (fr)
MX (1) MXPA04010702A (fr)
MY (1) MY129850A (fr)
NO (1) NO20045235L (fr)
PE (1) PE20040598A1 (fr)
PL (1) PL373401A1 (fr)
RU (1) RU2285004C2 (fr)
TW (1) TWI262077B (fr)
UA (1) UA75828C2 (fr)
WO (1) WO2003093266A1 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI262077B (en) 2002-04-29 2006-09-21 Merck & Co Inc Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
DE60321333D1 (de) * 2002-04-29 2008-07-10 Merck Sharp & Dohme Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
MXPA05005660A (es) 2002-11-27 2005-10-18 Incyte Corp Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina.
CN1826334A (zh) * 2003-03-18 2006-08-30 麦克公司 趋化因子受体活性的四氢吡喃基环戊基杂环酰胺调节剂
WO2004110376A2 (fr) * 2003-06-06 2004-12-23 Merck & Co., Inc. Antagonistes de ccr-2 permettant de traiter une douleur neuropathique
EP1682135B1 (fr) * 2003-10-27 2011-07-27 Merck Sharp & Dohme Corp. sel d'un dérivé de tétrahydropyranyl cyclopentyl tétrahydropyridopyridine comme antagoniste de CCR-2
ES2439894T3 (es) 2003-12-18 2014-01-27 Incyte Corporation Derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimioquina
CN1897941A (zh) * 2004-01-02 2007-01-17 默克公司 趋化因子受体活性的烷基氨基、芳基氨基以及氨磺酰基环戊基酰胺调节剂
AU2005244207A1 (en) * 2004-04-26 2005-11-24 Merck Sharp & Dohme Corp. Tetrahydropyranyl cyclopentyl 1-substituted and 1,1-disubstituted tetrahydroisoquinoline modulators of chemokine receptor activity
CN101103027A (zh) * 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂
MXPA06013112A (es) 2004-05-11 2007-02-14 Incyte Corp 3-(4-heteroarilciclohexilamino)ciclopentanocarboxamidas como moduladores de receptores de quimiocinas.
CN102382088A (zh) 2004-06-28 2012-03-21 因赛特公司 作为趋化因子受体调节剂的3-氨基环戊烷甲酰胺类
MXPA06014672A (es) * 2004-06-28 2007-03-26 Incyte Corp 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas.
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
US7977358B2 (en) 2007-07-26 2011-07-12 Hoffmann-La Roche Inc. Pyrazol derivatives
SI2370442T1 (sl) * 2008-11-26 2013-06-28 Pfizer Inc. 3-aminociklopentankarboksiamidi kot modulatorji kemokinskega receptorja
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI471321B (zh) * 2009-06-08 2015-02-01 Abbott Gmbh & Co Kg Ｂｃｌ－２族群抑制劑之口服醫藥劑型
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
EP2515883A4 (fr) * 2009-12-22 2013-07-17 Abbvie Inc Capsule de abt-263
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
RU2598345C2 (ru) 2010-10-29 2016-09-20 Эббви Инк. Твердые дисперсии, содержащие средства, вызывающие апоптоз
DK2642999T3 (en) 2010-11-23 2017-01-09 Abbvie Ireland Unlimited Co METHODS OF TREATMENT FOR USING selectivity-VE BCL-2 INHIBITORS
RU2628560C2 (ru) 2010-11-23 2017-08-18 Эббви Инк. Соли и кристаллические формы индуцирующего апоптоз агента
WO2012125663A2 (fr) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Dérivés d'amino cyclopentane substitués par cyclohexane en tant qu'antagonistes utiles de ccr2
WO2012125893A1 (fr) 2011-03-17 2012-09-20 Bristol-Myers Squibb Company Inhibiteurs de jak3 de type pyrrolopyridazine et leur utilisation pour traiter les maladies inflammatoires et auto-immunes
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
JP6204983B2 (ja) 2012-07-19 2017-09-27 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２のオクタヒドロ−シクロペンタピロリル拮抗薬
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
MA42133A (fr) 2015-05-21 2021-06-02 Chemocentryx Inc Modulateurs du ccr2
JP7453139B2 (ja) 2017-09-25 2024-03-19 ケモセントリックス，インコーポレイティド ケモカイン受容体２（ｃｃｒ２）アンタゴニスト及びｐｄ－１／ｐｄ－ｌ１阻害剤を使用した併用療法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
WO2019136368A2 (fr) 2018-01-08 2019-07-11 Chemocentryx, Inc. Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647804A (en) 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
US3772308A (en) 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
CA2143143A1 (fr) 1994-03-08 1995-09-09 Toshihiko Tanaka Derives de la 3-phenylpyrrolidine
JPH09291034A (ja) 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
US6312689B1 (en) * 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US6500844B1 (en) 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2002013824A1 (fr) 2000-08-17 2002-02-21 Merck & Co., Inc. Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine
EP1368354A1 (fr) * 2001-03-07 2003-12-10 Pfizer Products Inc. Modulateurs de l'activite du recepteur de la chimiokine
DE60321333D1 (de) 2002-04-29 2008-07-10 Merck Sharp & Dohme Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität
TWI262077B (en) 2002-04-29 2006-09-21 Merck & Co Inc Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2003093231A2 (fr) 2002-04-29 2003-11-13 Merck & Co., Inc. Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline
EP1558243A4 (fr) 2002-10-30 2006-11-02 Merck & Co Inc Modulateurs de l'activite des recepteurs de la chimiokine a base de tetrahydropyranyl-cyclopentyl-benzylamide
EP1682135B1 (fr) 2003-10-27 2011-07-27 Merck Sharp & Dohme Corp. sel d'un dérivé de tétrahydropyranyl cyclopentyl tétrahydropyridopyridine comme antagoniste de CCR-2
CN101103027A (zh) 2004-04-28 2008-01-09 默克公司 3,3-二取代四氢吡喃基环戊基酰胺趋化因子受体活性调节剂

Also Published As

Publication number Publication date
IL164909A0 (en) 2005-12-18
RU2285004C2 (ru) 2006-10-10
IS7512A (is) 2004-10-18
US7786305B2 (en) 2010-08-31
IL164909A (en) 2010-04-15
TW200307543A (en) 2003-12-16
UA75828C2 (en) 2006-05-15
KR20050000413A (ko) 2005-01-03
AR039489A1 (es) 2005-02-23
ECSP045392A (es) 2005-01-03
NO20045235L (no) 2004-11-29
WO2003093266A1 (fr) 2003-11-13
JO2479B1 (en) 2009-01-20
AU2003234251A8 (en) 2003-11-17
DOP2003000638A (es) 2003-11-30
HRP20041023A2 (en) 2005-02-28
BR0309650A (pt) 2005-04-26
KR100754760B1 (ko) 2007-09-04
AU2003234251A1 (en) 2003-11-17
MXPA04010702A (es) 2005-02-17
US20050101628A1 (en) 2005-05-12
CN1310917C (zh) 2007-04-18
TWI262077B (en) 2006-09-21
PL373401A1 (en) 2005-08-22
MY129850A (en) 2007-05-31
CN1662532A (zh) 2005-08-31
PE20040598A1 (es) 2004-10-05
RU2004134604A (ru) 2005-05-27
HK1081967A1 (en) 2006-05-26

Similar Documents

Publication Publication Date Title
MA27119A1 (fr) Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine
MA28681B1 (fr) 3-aminocyclopentanecarboxamides utiles comme modulateurs de récepteurs de chimiokines
MA28680B1 (fr) 3-aminocyclopentanecarboxamides utiles comme modulateurs de récepteurs de chimiokines
WO2003092586A3 (fr) Modulateurs tetrahydropyranyl cyclopentyl tetrahydropyridopyridine de l'activite des recepteurs de chimiokine
MXPA02012712A (es) N-ureidoheterocicloalquil-piperidinas como moduladores de la actividad del receptor de quimiocinas.
DE69936998D1 (de) Pyrazolotriazinderivate als gaba-rezeptorliganden
ATE302005T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
WO2003093231A3 (fr) Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline
ATE302606T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
MA27452A1 (fr) Derives d'indole servant d'agonistes beta-2
AP2001002088A0 (en) 4,4-Biarylpiperidine derivatives with opiod receptor activity.
TNSN06188A1 (fr) Derives de 3-cycloalkylaminopyrrolidine utiles comme modulateurs de recepteurs de chimiokines
AU8334501A (en) Cyclopentyl modulators of chemokine receptor activity
BR0114045A (pt) Poliarilcarboxamidas úteis como agentes redutores de lipìdeos
WO2000059497A8 (fr) Modulateurs de pyrrolidine de l'activite du recepteur des chimiokines
TNSN04194A1 (fr) Derives de tropane servant de modulateurs de ccr5
MA27448A1 (fr) Derives de pyridine modulateurs du recepteur cb2
WO2004094371A3 (fr) Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine
MA28286A1 (fr) Dérivés de 1-N-phenyl-amino-1H-imidazole et compositions pharmaceutiques les contenant
MA27501A1 (fr) Derives d'imidazoquinoline en tant que ligands recepteurs de l'adenosine a3
PL367774A1 (en) Synthesis and intermediates
MY120237A (en) Method for the synthesis of quinoline derivatives
MA26721A1 (fr) Derives de 2-aminopyridine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
DE60031676D1 (en) N-cyclopentylmodulatoren der chemokine rezeptoraktivität
TNSN06444A1 (fr) 3-aminocyclopentanecarboxamides utiles comme modulateurs de recepteurs de chimiokines