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MA26871A1 - Pyrimidinecarboxamides utiles comme inhibiteurs d'isozymes pde4. - Google Patents

Pyrimidinecarboxamides utiles comme inhibiteurs d'isozymes pde4.

Info

Publication number
MA26871A1
MA26871A1 MA26749A MA26749A MA26871A1 MA 26871 A1 MA26871 A1 MA 26871A1 MA 26749 A MA26749 A MA 26749A MA 26749 A MA26749 A MA 26749A MA 26871 A1 MA26871 A1 MA 26871A1
Authority
MA
Morocco
Prior art keywords
chronic
pyrimidinecarboxamides
useful
inhibitors
pde4
Prior art date
Application number
MA26749A
Other languages
English (en)
Inventor
Robert James Chambers
Thomas Victor Magee
Anthony Marfat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA26871A1 publication Critical patent/MA26871A1/fr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
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Abstract

DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 31 Janvier 2000 60/179,282 Voir en annexe le titre de l'invention et le texte de l'abrégé "Pyrimidinecarboxamides utiles comme inhibiteurs d'isozymes PDE4" Il est décrit des composés de formule (1.0.0.), ainsi que l'utilité d'une composition pharmaceutique pour le traitement de maladies et affections inflammatoires, respiratoires et allergiques, notamment de l'asthme ; d'une maladie pulmonaire obstructrice chronique (COPD), comprenant la bronchite chronique, l'emphysème et la bronchiectasie; de la rhinite chronique , et de la sinusite chronique.
MA26749A 2000-01-31 2002-07-29 Pyrimidinecarboxamides utiles comme inhibiteurs d'isozymes pde4. MA26871A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17928200P 2000-01-31 2000-01-31

Publications (1)

Publication Number Publication Date
MA26871A1 true MA26871A1 (fr) 2004-12-20

Family

ID=22655926

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26749A MA26871A1 (fr) 2000-01-31 2002-07-29 Pyrimidinecarboxamides utiles comme inhibiteurs d'isozymes pde4.

Country Status (44)

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US (1) US6740655B2 (fr)
EP (1) EP1252157B1 (fr)
JP (1) JP2003522165A (fr)
KR (1) KR20020071029A (fr)
CN (1) CN1404480A (fr)
AP (1) AP2002002590A0 (fr)
AR (1) AR027336A1 (fr)
AT (1) ATE269860T1 (fr)
AU (1) AU2700301A (fr)
BG (1) BG106868A (fr)
BR (1) BR0107934A (fr)
CA (1) CA2396458C (fr)
CO (1) CO5271669A1 (fr)
CR (1) CR6714A (fr)
CZ (1) CZ20022413A3 (fr)
DE (1) DE60103976T2 (fr)
DK (1) DK1252157T3 (fr)
DZ (1) DZ3406A1 (fr)
EA (1) EA005028B1 (fr)
EE (1) EE200200426A (fr)
ES (1) ES2223772T3 (fr)
GE (1) GEP20043385B (fr)
GT (1) GT200100023A (fr)
HK (1) HK1054232A1 (fr)
HN (1) HN2001000018A (fr)
HU (1) HUP0204271A3 (fr)
IL (1) IL150486A0 (fr)
IS (1) IS6444A (fr)
MA (1) MA26871A1 (fr)
MX (1) MXPA02007465A (fr)
NO (1) NO20023614L (fr)
NZ (1) NZ519726A (fr)
OA (1) OA12170A (fr)
PA (1) PA8511301A1 (fr)
PE (1) PE20011059A1 (fr)
PL (1) PL357555A1 (fr)
PT (1) PT1252157E (fr)
SK (1) SK10342002A3 (fr)
SV (1) SV2001000298A (fr)
TN (1) TNSN01019A1 (fr)
TR (1) TR200402292T4 (fr)
UY (1) UY26570A1 (fr)
WO (1) WO2001057025A1 (fr)
ZA (1) ZA200206034B (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US20030032632A1 (en) * 1999-12-24 2003-02-13 Crispps Leslie Alan Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate
DE10110772A1 (de) * 2001-03-07 2002-09-12 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren
US7776315B2 (en) 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
YU39503A (sh) 2000-11-22 2006-05-25 F. Hoffmann-La Roche Ag. Derivati pirimidina
DE60203652T2 (de) * 2001-01-31 2005-09-08 Pfizer Products Inc., Groton Nikotinsäureamid-Derivate und ihre Mimetika als Inhibitoren von PDE4-Isozyme
NZ526531A (en) 2001-01-31 2005-02-25 Pfizer Prod Inc Ether derivatives useful as inhibitors of phosphodiesterase type IV (PDE4) isozymes
EA200300621A1 (ru) 2001-01-31 2003-12-25 Пфайзер Продактс Инк. Биарильные производные никотинамида, полезные в качестве ингибиторов изоферментов pde4
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
PL365443A1 (en) 2001-01-31 2005-01-10 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
ES2427930T3 (es) * 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
KR20040007596A (ko) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 골절 치료 촉진용 조성물
DE10142176A1 (de) * 2001-08-29 2003-03-27 Eucro Europe Contract Res Gmbh Verwendung einer Kombination aus ß-adrenergen Agonisten und NDMA-Antagonisten
DE10163991A1 (de) * 2001-12-24 2003-07-03 Merck Patent Gmbh Pyrrolo-pyrimidine
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US6951869B2 (en) * 2002-02-26 2005-10-04 Schlesinger Stephen L Use of leukotriene receptor antagonist for treatment of scarring
NZ553731A (en) * 2002-05-28 2007-07-27 Altana Pharma Ag Topically applicable pharmaceutical preparation of roflumilast and liquid paraffin
DE10224888A1 (de) 2002-06-05 2003-12-24 Merck Patent Gmbh Pyridazinderivate
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20040001895A1 (en) * 2002-06-17 2004-01-01 Pfizer Inc. Combination treatment for depression and anxiety
EP2319582A1 (fr) * 2002-08-29 2011-05-11 Cipla Ltd. Produits pharmaceutiques et compositions à base de formotérol, de budésonide et de tiotropium ou d'oxitropium
US9415102B2 (en) 2002-09-06 2016-08-16 Alexion Pharmaceuticals, Inc. High concentration formulations of anti-C5 antibodies
US20050271660A1 (en) 2002-09-06 2005-12-08 Alexion Pharmaceuticals, Inc. Nebulization of monoclonal antibodies for treating pulmonary diseases
JP4601426B2 (ja) * 2002-09-06 2010-12-22 アレクシオン ファーマシューティカルズ， インコーポレイテッド 補体成分ｃ５に対する抗体を使用する喘息の処置の方法
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
US7507531B2 (en) 2002-10-17 2009-03-24 Decode Genetics Chf. Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
EP2181704B1 (fr) 2002-12-30 2015-05-06 Angiotech International Ag Liberation de médicaments a partir d'une composition polymère à gélification rapide
AU2004232858B2 (en) 2003-04-23 2009-07-09 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
US7439241B2 (en) * 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
GB0317484D0 (en) 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317498D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Compounds
US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
US7132435B2 (en) 2003-07-25 2006-11-07 Pfizer Inc. Compounds
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
US20050020587A1 (en) * 2003-07-25 2005-01-27 Pfizer Inc Nicotinamide derivatives useful as PDE4 inhibitors
GB0317516D0 (en) 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
US20050059643A1 (en) * 2003-08-05 2005-03-17 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising a steroid and a betamimetic
WO2005014825A2 (fr) * 2003-08-08 2005-02-17 Arriva Pharmaceuticals, Inc. Procede de production de proteines dans une levure
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
SI1684719T1 (sl) * 2003-11-14 2012-07-31 Baxter Int Sestavki alfa antitripsina in postopki zdravljenja ob uporabi takih sestavkov
WO2006073413A1 (fr) * 2004-02-20 2006-07-13 The Board Of Trustees Of The University Of Illinois Reduction de la pression sanguine dans l'hypertension dependant du sel
EP1737499A4 (fr) * 2004-03-09 2009-07-22 Arriva Pharmaceuticals Inc Traitement de la bronchopneumopathie chronique obstructive par inhalation a faible dose d'inhibiteur de protease
ZA200609226B (en) * 2004-04-23 2008-06-25 Celgene Corp Methods of using and compositions comprising immuno-modulatory compounds for the treatment and management of pulmonary hypertension
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
ES2901955T3 (es) 2004-10-08 2022-03-24 Abbvie Inc Sal meglumínica y formas cristalinas de la misma de un farmaco (delafloxacina)
US20070105768A1 (en) * 2004-11-10 2007-05-10 Rajiv Nayar Dry recombinant human alpha 1-antitrypsin formulation
EP1891961B1 (fr) * 2005-03-17 2009-09-16 Proyecto de Biomedicina Cima, S.L. Emploi de 5'-methylthioadenosine (mta) dans la prevention et/ou le traitement de maladies auto-immunes et/ou du rejet de greffons
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
CA2620333A1 (fr) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenese par modulation du recepteur muscarinique
WO2007047978A2 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
EP2314289A1 (fr) 2005-10-31 2011-04-27 Braincells, Inc. Modulation de la neurogenese dont la médiation est assurée par récepteur gaba
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2982399B1 (fr) 2006-03-30 2017-12-06 Valeritas, Inc. Dispositif de distribution de fluide à plusieurs cartouches
CA2651813A1 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenese par modulation de l'angiotensine
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2068872A1 (fr) 2006-09-08 2009-06-17 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US8071596B2 (en) * 2007-01-12 2011-12-06 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
US8080549B2 (en) * 2007-01-12 2011-12-20 Concert Pharmaceuticals, Inc. Endothelin receptor antagonists
GB0706398D0 (en) * 2007-04-02 2007-05-09 Univ Hospital Of North Staford Improvements in and relating to copd determination
TW200902025A (en) * 2007-04-11 2009-01-16 Alcon Res Ltd Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
WO2009051822A1 (fr) * 2007-10-19 2009-04-23 Avila Therapeutics, Inc. Composés hétéroaryles et leurs utilisations
US7989465B2 (en) * 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
EP2100598A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
EP2100599A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
BRPI0910921B1 (pt) 2008-04-16 2022-06-21 Portola Pharmaceuticals, Inc Inibidores de proteína syk quinase, composição farmacêutica, kit e usos dos referidos inibidores
WO2010014117A1 (fr) * 2008-07-30 2010-02-04 Nitto Denko Corporation Vecteurs de médicament
EP2196465A1 (fr) 2008-12-15 2010-06-16 Almirall, S.A. Dérivés de (3-oxo)pyridazin-4-ylurée comme inhibiteurs de PDE4
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
EP2226323A1 (fr) 2009-02-27 2010-09-08 Almirall, S.A. Nouveaux dérivés de tétrahydropyrazolo [3,4-c]isoquinoléine-5-amine
EP2380890A1 (fr) 2010-04-23 2011-10-26 Almirall, S.A. Nouveaux dérivés de 7,8-dihydro-1,6-naphthyridin-5(6h)-one comme PDE4 inhibiteurs
EP2394998A1 (fr) 2010-05-31 2011-12-14 Almirall, S.A. Dérivés de 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl en tant qu'inhibiteurs de la PDE4
EP2692347B1 (fr) * 2011-03-31 2017-03-08 Maruho Co., Ltd. Onguent présentant une excellente stabilité de formulation
EP2510928A1 (fr) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium pour l'amélioration du sommeil des patients avec des maldadies respiratoires
CN102850321A (zh) * 2011-06-28 2013-01-02 中国科学院上海药物研究所 芳香氧基嘧啶甲酰胺或芳香氧基吡啶甲酰胺类化合物及其制备方法、药物组合物和用途
US9359308B2 (en) 2011-11-23 2016-06-07 Portola Pharmaceuticals, Inc. Pyrazine kinase inhibitors
WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
KR102006547B1 (ko) * 2017-11-16 2019-08-01 서울대학교산학협력단 벤즈아미드 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 염증질환의 치료 또는 예방용 약학적 조성물
WO2019139479A1 (fr) * 2018-01-11 2019-07-18 Rob Janssen Compositions et procédés pour le traitement d'un emphysème pulmonaire et d'autres formes de bpco
KR102200032B1 (ko) * 2019-03-13 2021-01-08 전남대학교산학협력단 호흡기 질환의 예방 또는 치료용 조성물
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861891A (en) * 1988-08-31 1989-08-29 Pfizer Inc. Antidepressant N-substituted nicotinamide compounds
TW429148B (en) 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
CN1254335A (zh) 1997-04-04 2000-05-24 辉瑞产品公司 烟酰胺衍生物
YU39503A (sh) * 2000-11-22 2006-05-25 F. Hoffmann-La Roche Ag. Derivati pirimidina

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