LV5765B4 - Method for obtaining (S) - (-) - 1-propyl-2 ', 6'-pipecoloxylid hydrochloride monohydrate and its pharmaceutical preparation - Google Patents

Method for obtaining (S) - (-) - 1-propyl-2 ', 6'-pipecoloxylid hydrochloride monohydrate and its pharmaceutical preparation

Info

Publication number: LV5765B4
Authority: LV; Latvia
Prior art keywords: pipecoloxylid; propyl; obtaining; pharmaceutical preparation; hydrochloride monohydrate
Prior art date: 1986-01-03

Application number

LV960261A

Other languages

Latvian (lv)

Other versions

LV5765A4 (en

Inventor

Rune Verner Sandberg

Original Assignee

Astra Laekemedel Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-03

Filing date

1996-07-17

Publication date

1997-06-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20363001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV5765(B4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-07-17 Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab

1996-12-20 Publication of LV5765A4 publication Critical patent/LV5765A4/en

1997-06-20 Publication of LV5765B4 publication Critical patent/LV5765B4/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

LV960261A 1986-01-03 1996-07-17 Method for obtaining (S) - (-) - 1-propyl-2 ', 6'-pipecoloxylid hydrochloride monohydrate and its pharmaceutical preparation LV5765B4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8600017A SE451840B (en)	1986-01-03	1986-01-03	OPTICALLY PURE MONOHYDRATED OF S - (-) - 1-PROPYL-2 ', 6'-PIPECOLOXYLIDE HYDROCHLORIDE, SET TO PREPARE THIS AND PHARMACEUTICAL PREPARATIONS FOR LOCAL ANCHORING
EP86850440A EP0239710B1 (en)	1986-01-03	1986-12-15	(s)-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate, process for its preparation and pharmaceutical preparation containing it

Publications (2)

Publication Number	Publication Date
LV5765A4 LV5765A4 (en)	1996-12-20
LV5765B4 true LV5765B4 (en)	1997-06-20

Family

ID=20363001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LV960261A LV5765B4 (en)	1986-01-03	1996-07-17	Method for obtaining (S) - (-) - 1-propyl-2 ', 6'-pipecoloxylid hydrochloride monohydrate and its pharmaceutical preparation

Country Status (29)

Country	Link
US (1)	US4870086A (en)
EP (1)	EP0239710B1 (en)
JP (1)	JPH07598B2 (en)
KR (1)	KR940008302B1 (en)
AR (1)	AR242561A1 (en)
AT (1)	ATE56956T1 (en)
AU (1)	AU592392B2 (en)
BG (1)	BG62066B2 (en)
CA (1)	CA1276154C (en)
CY (1)	CY1680A (en)
DE (1)	DE3674582D1 (en)
DK (1)	DK171378B1 (en)
EG (1)	EG17867A (en)
ES (1)	ES2036179T3 (en)
FI (1)	FI83075C (en)
GR (1)	GR3002516T3 (en)
HK (1)	HK5493A (en)
IE (1)	IE59061B1 (en)
LU (1)	LU88843I2 (en)
LV (1)	LV5765B4 (en)
MY (1)	MY101132A (en)
NL (1)	NL960005I2 (en)
NO (2)	NO170330C (en)
NZ (1)	NZ218615A (en)
PH (1)	PH22924A (en)
PT (1)	PT84041B (en)
SE (1)	SE451840B (en)
SG (1)	SG117292G (en)
ZA (1)	ZA868600B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991018897A1 (en) *	1990-06-07	1991-12-12	The Wellcome Foundation Limited	Therapeutic heterocyclic compounds
ES2082703B1 (en) *	1993-11-04	1996-12-16	Inst Investigacion Desarrollo	NEW DERIVATIVES OF CYCLOPROPIL, PROCEDURES FOR ITS PREPARATION AND APPLICATIONS.
US5834490A (en) *	1993-11-04	1998-11-10	Instituto De Investigacion Y Desarrolo Quimico Biologico, S.A.	Cyclopropyl derivatives, preparation method there-of and applications
DE69525950T2 (en) *	1994-09-23	2002-09-19	Darwin Discovery Ltd., Cambridge	RACEMIZATION PROCESS IN THE PRODUCTION OF LEVOBUPIVACAINE AND ANALOGS
SE9501808D0 (en) *	1995-05-16	1995-05-16	Astra Ab	New process
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
SE9800139D0 (en)	1998-01-21	1998-01-21	Astra Ab	New use
BRPI0104491B8 (en) *	2001-10-10	2021-05-25	Cristalia Produtos Quim Farmaceuticos Ltda	n-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide; process of obtaining the enantiomers; non-racemic mixture of anantiomers and its process of obtaining and pharmaceutical composition.
US20060270708A1 (en) *	2005-05-25	2006-11-30	Navinta Llc	Novel process for preparation of isotonic aqueous injection of ropivacaine
US7683175B2 (en) *	2005-06-06	2010-03-23	Navinta, Llc	Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
US20090187024A1 (en) *	2006-04-25	2009-07-23	Dishman Pharmaceuticals And Chemicals Ltd.	Ropivacaine hydrochloride anhydrate and the preparation thereof
PT2234974E (en) *	2008-01-15	2012-05-29	Pharmathen Sa	Process for the preparation of (s)-1-alkyl-2`,6`-pipecoloxylidide compound
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
CN102093284B (en) *	2010-12-29	2013-05-08	宜昌人福药业有限责任公司	Method for enriching piperidine-2-formanilide optically active compound

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2248018A (en) *	1939-03-30	1941-07-01	Winthrop Chem Co Inc	4-aryl-piperidine-ketones and a process of preparing them
GB775749A (en) *	1955-04-06	1957-05-29	Bofors Ab	Method of preparing amides of n-alkyl piperidine monocarboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
GB775750A (en) *	1955-04-28	1957-05-29	Bofors Ab	Method of preparing amides of n-alkyl piperidine mono-carboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
US2799679A (en) *	1955-04-28	1957-07-16	Bofors Ab	Process of preparing amides of heterocyclic carboxylic acids
GB800565A (en) *	1956-01-23	1958-08-27	Bofors Ab	Method of producing n-alkyl-piperidine-ª‡-monocarboxylic acid amides and n-alkyl-pyrrolidine-ª‡-monocarboxylic acid amides
GB824542A (en) *	1957-05-15	1959-12-02	Bofors Ab	Method of producing n-alkyl-piperidine-alpha-monocarboxylic acid amides
GB869978A (en) *	1958-03-13	1961-06-07	Bofors Ab	Method of producing n-alkyl-and-cycloalkyl-piperidine carboxylic acid amides
GB949729A (en) *	1960-11-15	1964-02-19	Bofors Ab	Substituted-piperidine carboxylic acid amide salts and their preparation
SE341404B (en) *	1967-05-18	1971-12-27	Sterling Drug Inc
CH491915A (en) *	1967-06-28	1970-06-15	Geigy Ag J R	Process for the preparation of new piperidine derivatives
US3879382A (en) *	1971-08-27	1975-04-22	Teijin Ltd	Process for the recovery of D- or L-{60 -amino-{68 -caprolactam hydrochloride of enhanced optical purity from mixtures of D- and L-{60 -amino-{68 -caprolactam hydrochloride
SE7607114L (en) *	1976-06-22	1977-12-23	Bofors Ab	METHOD OF PREPARING THE HYDROCHLORIDE OF N-METHYLPIPERIDINE-2-CARBONIC ACID-2,6-XYLLIDIDE
SE431092B (en) *	1979-07-10	1984-01-16	Thuresson Af Ekenstam Bo	THERAPEUTICALLY ACTIVE, SUBSTITUTED PIPERIDINKARBOXIANILIDES
DE3379266D1 (en) *	1983-08-01	1989-04-06	Astra Laekemedel Ab	L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same

1986
- 1986-01-03 SE SE8600017A patent/SE451840B/en not_active IP Right Cessation
- 1986-11-12 ZA ZA868600A patent/ZA868600B/en unknown
- 1986-11-24 US US06/934,114 patent/US4870086A/en not_active Expired - Lifetime
- 1986-12-02 EG EG747/86A patent/EG17867A/en active
- 1986-12-03 NO NO864858A patent/NO170330C/en not_active IP Right Cessation
- 1986-12-12 AU AU66449/86A patent/AU592392B2/en not_active Expired
- 1986-12-12 NZ NZ218615A patent/NZ218615A/en unknown
- 1986-12-15 ES ES198686850440T patent/ES2036179T3/en not_active Expired - Lifetime
- 1986-12-15 EP EP86850440A patent/EP0239710B1/en not_active Expired - Lifetime
- 1986-12-15 AT AT86850440T patent/ATE56956T1/en active
- 1986-12-15 PH PH34593A patent/PH22924A/en unknown
- 1986-12-15 DE DE8686850440T patent/DE3674582D1/en not_active Expired - Lifetime
- 1986-12-26 JP JP61308983A patent/JPH07598B2/en not_active Expired - Lifetime
- 1986-12-30 MY MYPI86000260A patent/MY101132A/en unknown
- 1986-12-30 CA CA000526453A patent/CA1276154C/en not_active Expired - Lifetime
- 1986-12-31 KR KR1019860011720A patent/KR940008302B1/en not_active IP Right Cessation
- 1986-12-31 PT PT84041A patent/PT84041B/en unknown
1987
- 1987-01-02 FI FI870003A patent/FI83075C/en not_active IP Right Cessation
- 1987-01-02 IE IE487A patent/IE59061B1/en not_active IP Right Cessation
- 1987-01-02 DK DK000287A patent/DK171378B1/en not_active IP Right Cessation
1988
- 1988-12-17 AR AR88306211A patent/AR242561A1/en active
1990
- 1990-11-08 GR GR90400889T patent/GR3002516T3/en unknown
1992
- 1992-11-06 SG SG1172/92A patent/SG117292G/en unknown
1993
- 1993-01-21 HK HK54/93A patent/HK5493A/en not_active IP Right Cessation
- 1993-10-10 CY CY1680A patent/CY1680A/en unknown
1994
- 1994-02-18 BG BG098494A patent/BG62066B2/en unknown
1996
- 1996-03-26 NL NL960005C patent/NL960005I2/en unknown
- 1996-07-17 LV LV960261A patent/LV5765B4/en unknown
- 1996-11-27 LU LU88843C patent/LU88843I2/en unknown
1997
- 1997-07-31 NO NO1997009C patent/NO1997009I1/en unknown

Also Published As

Publication number	Publication date
EP0239710A1 (en)	1987-10-07
JPH07598B2 (en)	1995-01-11
FI83075C (en)	1991-05-27
NO1997009I1 (en)	1997-08-18
PT84041A (en)	1987-01-01
SE8600017L (en)	1987-07-04
SG117292G (en)	1993-01-29
LU88843I2 (en)	1997-03-14
FI83075B (en)	1991-02-15
NO170330B (en)	1992-06-29
KR940008302B1 (en)	1994-09-12
EG17867A (en)	1991-03-30
DK287A (en)	1987-07-04
DE3674582D1 (en)	1990-10-31
JPS62158251A (en)	1987-07-14
NL960005I1 (en)	1996-09-02
NO864858L (en)	1987-07-06
NO864858D0 (en)	1986-12-03
ATE56956T1 (en)	1990-10-15
FI870003A0 (en)	1987-01-02
NZ218615A (en)	1989-07-27
LV5765A4 (en)	1996-12-20
NO170330C (en)	1992-10-07
MY101132A (en)	1991-07-31
GR3002516T3 (en)	1993-01-25
FI870003A (en)	1987-07-04
CY1680A (en)	1993-10-10
ZA868600B (en)	1987-08-26
AU592392B2 (en)	1990-01-11
SE451840B (en)	1987-11-02
IE870004L (en)	1987-07-03
ES2036179T3 (en)	1993-05-16
PT84041B (en)	1989-09-14
DK287D0 (en)	1987-01-02
DK171378B1 (en)	1996-10-07
US4870086A (en)	1989-09-26
CA1276154C (en)	1990-11-13
BG62066B2 (en)	1999-01-29
KR870007118A (en)	1987-08-14
PH22924A (en)	1989-01-24
IE59061B1 (en)	1993-12-15
NL960005I2 (en)	1997-10-01
HK5493A (en)	1993-01-29
EP0239710B1 (en)	1990-09-26
SE8600017D0 (en)	1986-01-03
AU6644986A (en)	1987-07-09
AR242561A1 (en)	1993-04-30

Publication	Publication Date	Title
LV5760B4 (en)	1997-06-20	New pharmaceutical preparation for oral use
LV5765A4 (en)	1996-12-20	Method for obtaining (S) - (-) - 1-propyl-2 ', 6'-pipecoloxylid hydrochloride monohydrate and its pharmaceutical preparation
KR880005932A (en)	1988-07-21	Pharmaceutical composition for reducing neurotoxicity damage
DK52787D0 (en)	1987-02-02	PHARMACEUTICAL PREPARATION WITH PROTRAACTED EFFECTS AND PROCEDURES FOR PREPARING IT
FI891338A (en)	1989-09-25	Improvement of the process for the preparation of 2 ', 3'-dideoxy-2', 3'-didehydronucleosides
PH24749A (en)	1990-10-01	Piperidine compounds, pharmaceutical composition and method of use thereof
IT8922164A0 (en)	1989-10-27	PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR ITS PREPARATION
IT8767057A0 (en)	1987-01-29	LONG-RELEASE PHARMACEUTICAL COMPOSITIONS, RELATIVE DOSAGE FORMS AND PROCEDURE FOR THEIR PREPARATION
FI894546A (en)	1990-03-28	Process for the preparation of new 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyladenosine derivatives
DK559288D0 (en)	1988-10-06	PHARMACEUTICAL PREPARATION FOR PIPERIDINOAL CHANNEL DERIVATIVES
IT8722264A0 (en)	1987-10-14	PROCEDURE FOR THE PREPARATION OF SOLUBLE AND/OR DIVISIBLE TABLETS AND TABLETS OBTAINED SO.
IT1196499B (en)	1988-11-16	PROCESS PERFECTED FOR THE PREPARATION OF BORICA DIOXIDE
IT1196528B (en)	1988-11-16	AZOLYL DERIVATIVES FOR ANTI-Fungal activity
HUT47849A (en)	1989-04-28	Process for producing new pharmaceutical with analgetic and hypertonicity-relaxing effect
DK624587D0 (en)	1987-11-27	PHARMACEUTICAL PREPARATION CONTAINING IMIDAZOLD DERIVATIVES
GB2195082B (en)	1990-03-28	Pharmaceutical preparation for veterinary use
DK173287D0 (en)	1987-04-03	PERHYDROTHIAZEPINE AND PERHYDROAZEPINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
IT1216894B (en)	1990-03-14	PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR ITS PREPARATION.
LV5752A4 (en)	1996-12-20	Pharmaceutical preparation and method for its production
IT1222591B (en)	1990-09-05	1,4-DIHYDROPYRIDINS 2-ALCHIL- AND ALCHENYL-SUBSTITUTED, METHOD FOR THEIR PHARMACEUTICAL PREPARATION AND COMPOSITION CONTAINING THEM
IT1201174B (en)	1989-01-27	PHARMACEUTICAL SOLUTION INCLUDING L-3,4-DIHYDROXYPHENYL-ALPHA-METHYLALANINE CHELATES AND PROCEDURE FOR ITS PREPARATION
PT84557A (en)	1987-04-01	Process for the preparation of alkylaminofuranone derivatives and pharmaceutically acceptable salts thereof
SE8602975D0 (en)	1986-07-04	PHARMACEUTICAL PREPARATION
LV5818A4 (en)	1997-04-20	N, n-bis- (4-Fluorophenyl) carbamoylacethydroxamic acid and pharmaceutical composition thereof
PH22996A (en)	1989-02-24	Dichloroaniline derivatives, pharmaceutical composition containing said compound and method of use thereof