LV10452B - A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles - Google Patents

A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles Download PDF

Info

Publication number: LV10452B
Authority: LV; Latvia
Prior art keywords: formula; compound; alkyl; cmecb; npn
Prior art date: 1987-06-01

Application number

LVP-92-233A

Other languages

English (en)

Latvian (lv)

Other versions

LV10452A (lv

Inventor

Alfons H M Raeymaekers

Eddy J E Freyne

Gelder Josephus L H Van

Marc G Venet

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-01

Filing date

1992-11-27

Publication date

1995-08-20

1992-11-27 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1995-02-20 Publication of LV10452A publication Critical patent/LV10452A/xx

1995-08-20 Publication of LV10452B publication Critical patent/LV10452B/lv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

LVP-92-233A 1987-06-01 1992-11-27 A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles LV10452B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5602187A	1987-06-01	1987-06-01

Publications (2)

Publication Number	Publication Date
LV10452A LV10452A (lv)	1995-02-20
LV10452B true LV10452B (en)	1995-08-20

Family

ID=22001654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-92-233A LV10452B (en)	1987-06-01	1992-11-27	A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles

Country Status (24)

Country	Link
EP (1)	EP0293978B1 (bg)
JP (1)	JPH0662612B2 (bg)
KR (1)	KR970000952B1 (bg)
CN (1)	CN1022184C (bg)
AU (1)	AU603446B2 (bg)
BG (2)	BG50278A3 (bg)
CA (1)	CA1307271C (bg)
CY (1)	CY1866A (bg)
DE (1)	DE3884055T2 (bg)
DK (1)	DK175218B1 (bg)
ES (1)	ES2059490T3 (bg)
FI (1)	FI90078C (bg)
HK (1)	HK114795A (bg)
HU (2)	HU201056B (bg)
IE (1)	IE61823B1 (bg)
IL (1)	IL86551A (bg)
LT (1)	LT3950B (bg)
LV (1)	LV10452B (bg)
NO (1)	NO169900C (bg)
NZ (1)	NZ224714A (bg)
PT (1)	PT87623B (bg)
RU (1)	RU1838308C (bg)
UA (1)	UA11192A (bg)
ZA (1)	ZA883861B (bg)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8827820D0 (en) *	1988-11-29	1988-12-29	Janssen Pharmaceutica Nv	(1h-azol-1-ylmethyl)substituted quinoline derivatives
CA2002859C (en) *	1988-11-29	1998-12-29	Jean P. F. Van Wauwe	Method of treating epithelial disorders
US5157046A (en) *	1988-11-29	1992-10-20	Janssen Pharmaceutica N.V.	Method of treating epithelial disorders
EP0408509B1 (de) *	1989-07-14	1996-03-06	Ciba-Geigy Ag	Substituierte Benzonitrile
US5066656A (en) *	1989-11-01	1991-11-19	Janssen Pharmaceutica N.V.	Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
CA2026792A1 (en) *	1989-11-01	1991-05-02	Michael N. Greco	(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
NZ236440A (en) *	1989-12-15	1993-07-27	Merck & Co Inc	Reversal of sexual phenotype in poultry using an inhibitor of steroid biotransformation and/or aromatase inhibitor, poultry produced by this process
AU7124691A (en) *	1990-02-27	1991-08-29	Ciba-Geigy Ag	Benzofurans
DE4010797A1 (de) *	1990-04-04	1991-10-10	Hoechst Ag	Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
EP0457716A1 (de) *	1990-04-20	1991-11-21	Ciba-Geigy Ag	Naphthalinderivate
TW224461B (bg) *	1990-09-18	1994-06-01	Ciba Geigy Ag
US5162337A (en) *	1990-10-05	1992-11-10	Merck & Co., Inc.	Animal growth promotion
TW210334B (bg) *	1990-12-12	1993-08-01	Ciba Geigy Ag
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
CA2116773C (en)	1991-09-02	2002-12-10	Minoru Okada	Triazolylated tertiary amine compound or salt thereof
US5635521A (en) *	1991-09-23	1997-06-03	Sandoz Ltd.	Imidazolylmethyl-pyridines
JP2700595B2 (ja) *	1992-05-21	1998-01-21	呉羽化学工業株式会社	アゾール誘導体を含有する抗アロマターゼ剤
CA2148489A1 (en) *	1992-11-10	1994-05-26	Albert Louis Anna Willemsens	Process for preparing enantiomerically pure 6-¬(4-chlorophenyl)(1h-1,2,4-triazol-1-yl) methyl\|-1-methyl-1h
CA2150326A1 (en) *	1994-05-27	1995-11-28	Kimihiro Murakami	Azolyl methyl phenyl derivatives having aromatase inhibitory activity
AU6821196A (en) *	1995-08-14	1997-03-12	Janssen Pharmaceutica N.V.	Transdermal administration of vorozole
IT1286866B1 (it) *	1996-10-28	1998-07-17	Menarini Farma Ind	Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
EP0949242A4 (en) *	1996-12-24	2004-09-08	Chugai Seiyakukabushiki Kaisha	AROMATIC AMINE DERIVATIVES HAVING AN INHIBITORY ACTION WITH RESPECT TO OUR
AU2001264223A1 (en) *	2000-06-28	2002-01-08	Ssp Co., Ltd.	Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts
CA2517517C (en) *	2003-03-03	2012-12-18	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
US7135575B2 (en)	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
US20090036435A1 (en)	2005-01-21	2009-02-05	Astex Therapeutics Limited	Pharmaceutical Compounds
JP5137816B2 (ja) *	2005-04-29	2013-02-06	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	カンナビノイド受容体アンタゴニストとしてのベンゾトリアゾール誘導体
US7572807B2 (en)	2005-06-09	2009-08-11	Bristol-Myers Squibb Company	Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
US8361996B2 (en)	2005-09-15	2013-01-29	Council Of Scientific And Industrial Research	Imidazolyl substituted steroidal and indan-1-one derivatives
BRPI0707401B8 (pt)	2006-01-31	2022-12-20	Array Biopharma Inc	compostos inibidores de cinase, composição farmacêutica, processo para a preparação e usos dos referidos compostos ou de um pró-fármaco de um composto
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
EP2073803B1 (en)	2006-10-12	2018-09-19	Astex Therapeutics Limited	Pharmaceutical combinations
WO2012052540A1 (en) *	2010-10-21	2012-04-26	Universitaet Des Saarlandes	Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR75101B (bg) *	1980-10-23	1984-07-13	Pfizer
US4659730A (en) *	1984-06-18	1987-04-21	Eli Lilly And Company	Aromatase inhibiting imidazole derivatives
US4609666A (en) *	1984-06-18	1986-09-02	Eli Lilly And Company	Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
US4801594A (en) *	1984-06-18	1989-01-31	Eli Lilly And Company	Aromatase inhibitors
US4602025A (en) *	1984-06-18	1986-07-22	Eli Lilly And Company	Aromatase inhibitors
EP0165781A1 (en) *	1984-06-18	1985-12-27	Eli Lilly And Company	Aromatase inhibiting N-substituted imidazole derivatives
DE3744589C1 (de)	1987-12-31	1988-12-29	Albrecht Josef Bohrfutter	Nachspannendes Bohrfutter

1988
- 1988-05-19 NZ NZ224714A patent/NZ224714A/xx unknown
- 1988-05-20 RU SU884355784A patent/RU1838308C/ru active
- 1988-05-20 UA UA4355784A patent/UA11192A/uk unknown
- 1988-05-23 AU AU16537/88A patent/AU603446B2/en not_active Expired
- 1988-05-25 CA CA000567618A patent/CA1307271C/en not_active Expired - Lifetime
- 1988-05-26 CY CY186688A patent/CY1866A/xx unknown
- 1988-05-26 ES ES88201061T patent/ES2059490T3/es not_active Expired - Lifetime
- 1988-05-26 EP EP88201061A patent/EP0293978B1/en not_active Expired - Lifetime
- 1988-05-26 DE DE88201061T patent/DE3884055T2/de not_active Expired - Lifetime
- 1988-05-30 ZA ZA883861A patent/ZA883861B/xx unknown
- 1988-05-30 IL IL86551A patent/IL86551A/xx not_active IP Right Cessation
- 1988-05-31 IE IE164088A patent/IE61823B1/en not_active IP Right Cessation
- 1988-05-31 FI FI882552A patent/FI90078C/fi not_active IP Right Cessation
- 1988-05-31 DK DK198802952A patent/DK175218B1/da not_active IP Right Cessation
- 1988-05-31 BG BG084328A patent/BG50278A3/bg unknown
- 1988-05-31 NO NO882390A patent/NO169900C/no not_active IP Right Cessation
- 1988-05-31 PT PT87623A patent/PT87623B/pt not_active IP Right Cessation
- 1988-06-01 JP JP63132886A patent/JPH0662612B2/ja not_active Expired - Lifetime
- 1988-06-01 HU HU882783A patent/HU201056B/hu unknown
- 1988-06-01 KR KR1019880006557A patent/KR970000952B1/ko not_active IP Right Cessation
- 1988-06-01 CN CN88103408A patent/CN1022184C/zh not_active Expired - Lifetime
1992
- 1992-11-27 LV LVP-92-233A patent/LV10452B/lv unknown
1993
- 1993-10-18 BG BG098159A patent/BG60429B2/bg unknown
- 1993-12-16 LT LTIP1625A patent/LT3950B/lt not_active IP Right Cessation
1995
- 1995-06-29 HU HU95P/P00533P patent/HU211482A9/hu unknown
- 1995-07-13 HK HK114795A patent/HK114795A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
UA11192A (uk)	1996-12-25
DE3884055D1 (de)	1993-10-21
AU1653788A (en)	1988-12-01
DK175218B1 (da)	2004-07-12
IE881640L (en)	1988-12-01
NO169900C (no)	1992-08-19
BG60429B2 (bg)	1995-03-31
CN1022184C (zh)	1993-09-22
KR970000952B1 (ko)	1997-01-21
HU211482A9 (en)	1995-11-28
DK295288D0 (da)	1988-05-31
EP0293978B1 (en)	1993-09-15
CN88103408A (zh)	1988-12-14
PT87623B (pt)	1992-09-30
EP0293978A3 (en)	1990-06-13
PT87623A (pt)	1988-06-01
KR890000469A (ko)	1989-03-14
RU1838308C (ru)	1993-08-30
CA1307271C (en)	1992-09-08
NO882390D0 (no)	1988-05-31
FI882552A (fi)	1988-12-02
FI882552A0 (fi)	1988-05-31
LTIP1625A (en)	1995-07-25
NO882390L (no)	1988-12-02
IE61823B1 (en)	1994-11-30
HU201056B (en)	1990-09-28
DE3884055T2 (de)	1994-01-27
NO169900B (no)	1992-05-11
JPS63316775A (ja)	1988-12-26
LT3950B (en)	1996-05-27
NZ224714A (en)	1990-03-27
AU603446B2 (en)	1990-11-15
CY1866A (en)	1988-05-26
HK114795A (en)	1995-07-21
LV10452A (lv)	1995-02-20
FI90078B (fi)	1993-09-15
ES2059490T3 (es)	1994-11-16
HUT49132A (en)	1989-08-28
ZA883861B (en)	1990-01-31
IL86551A0 (en)	1988-11-15
IL86551A (en)	1992-07-15
EP0293978A2 (en)	1988-12-07
BG50278A3 (bg)	1992-06-15
JPH0662612B2 (ja)	1994-08-17
FI90078C (fi)	1993-12-27
DK295288A (da)	1988-12-02

Publication	Publication Date	Title
LV10452B (en)	1995-08-20	A process for the preparation of (1h-azolo-1-ylmethyl)-substituted derivatives of benzotriazoles
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JP4944954B2 (ja)	2012-06-06	ホスファチジルイノシトール３−キナーゼ阻害剤としてのチアゾリルウレア誘導体
RU97119064A (ru)	1999-09-10	Применение альфа(il)-агонистов для лечения недержания мочи
JP2008512490A5 (bg)	2008-10-30
KR20020062298A (ko)	2002-07-25	Ｎ-치환된 카바모일옥시알킬-아졸리움 유도체
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