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LU88795I2 - Mycophenolate mofetil ou un sel pharmaceutiquement acceptable de celui-ci - Google Patents

Mycophenolate mofetil ou un sel pharmaceutiquement acceptable de celui-ci

Info

Publication number
LU88795I2
LU88795I2 LU88795C LU88795C LU88795I2 LU 88795 I2 LU88795 I2 LU 88795I2 LU 88795 C LU88795 C LU 88795C LU 88795 C LU88795 C LU 88795C LU 88795 I2 LU88795 I2 LU 88795I2
Authority
LU
Luxembourg
Prior art keywords
pharmaceutically acceptable
agents
acceptable salt
mycophenolate mofetil
chem
Prior art date
Application number
LU88795C
Other languages
English (en)
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21733252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU88795(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of LU88795I2 publication Critical patent/LU88795I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
LU88795C 1987-01-30 1987-12-15 Mycophenolate mofetil ou un sel pharmaceutiquement acceptable de celui-ci LU88795I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/008,717 US4753935A (en) 1987-01-30 1987-01-30 Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
LU88795I2 true LU88795I2 (fr) 1996-11-05

Family

ID=21733252

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88795C LU88795I2 (fr) 1987-01-30 1987-12-15 Mycophenolate mofetil ou un sel pharmaceutiquement acceptable de celui-ci

Country Status (26)

Country Link
US (7) US4753935A (fr)
EP (1) EP0281713B1 (fr)
JP (1) JPS63188672A (fr)
KR (1) KR940003758B1 (fr)
AT (1) ATE68180T1 (fr)
AU (1) AU599728B2 (fr)
CA (1) CA1333285C (fr)
DE (2) DE3773660D1 (fr)
DK (1) DK166675B1 (fr)
ES (1) ES2038190T3 (fr)
FI (1) FI85141C (fr)
GE (1) GEP20094816B (fr)
GR (1) GR3002866T3 (fr)
HK (1) HK125893A (fr)
HU (2) HU201927B (fr)
IE (1) IE60750B1 (fr)
IL (1) IL84833A (fr)
LU (1) LU88795I2 (fr)
LV (1) LV5748B4 (fr)
MX (1) MX9203163A (fr)
NL (1) NL960019I2 (fr)
NO (2) NO171680C (fr)
NZ (1) NZ222922A (fr)
PH (1) PH23819A (fr)
PT (1) PT86343B (fr)
ZA (1) ZA879414B (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
ATE186302T1 (de) * 1989-02-23 1999-11-15 Univ North Carolina Etoposidanaloge
US5219851A (en) * 1991-03-05 1993-06-15 Warner-Lambert Company Tetrahydroisoquinoline-type renin inhibiting peptides
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
WO1994012184A1 (fr) * 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Utilisation d'acide mycophenolique, de mofetile de mycophenolate ou d'un derive de ceux-ci pour inhiber la stenose
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
CA2165794A1 (fr) * 1993-06-25 1995-01-05 Brian Daunter Agent therapeutique
WO1995007902A1 (fr) * 1993-09-15 1995-03-23 Syntex (U.S.A.) Inc. Mofetil de mycophenolate anhydre cristallin et sa formulation intraveineuse
EP1475091A1 (fr) * 1993-10-01 2004-11-10 Roche Palo Alto LLC Suspensions de mycophénolate mofetile à dosage élevé et administration orale
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US6225073B1 (en) 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
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CA2348234A1 (fr) 1998-10-29 2000-05-11 Chunjian Liu Composes derives d'un noyau amine inhibiteurs de l'enzyme impdh
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
IN188985B (fr) 1998-12-09 2002-11-30 Biocon Ltd
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
JP2003531205A (ja) * 2000-04-24 2003-10-21 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素の阻害剤である複素環化合物
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7179791B2 (en) * 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
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JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
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WO2004100945A1 (fr) * 2003-05-14 2004-11-25 Dsm Ip Assets B.V. Utilisation de derives phtalides pour assurer le traitement et la prophylaxie du diabete sucre
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
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US7691420B2 (en) * 2003-09-23 2010-04-06 Dsm Ip Assets B.V. Compositions for the treatment and prevention of diabetes mellitus
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US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
EP1699773A2 (fr) * 2004-07-20 2006-09-13 Ceva Gyogyszergyar R Szv Nytarsasag Procede pour la preparation de mycophenolate sodique cristalline
CA2577169A1 (fr) * 2004-08-16 2006-02-23 The University Of Queensland Agents de modulation du metabolisme et utilisations associees
AU2006207789B2 (en) * 2005-01-20 2012-11-22 Apotex Fermentation Inc. An improved process for the preparation of mycophenolate mofetil
US20060235009A1 (en) * 2005-02-08 2006-10-19 Richard Glickman Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors
WO2006086500A2 (fr) * 2005-02-08 2006-08-17 Aspreva Pharmaceuticals Sa Compositions et methodes pour traiter des maladies vasculaires, auto-immunes et inflammatoires
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CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
EP1988890A1 (fr) * 2006-02-13 2008-11-12 Novartis AG Doses élevées d'acide mycophénolique (mpa)
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US20080188653A1 (en) * 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
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FI124873B (fi) 2009-10-06 2015-02-27 Maricap Oy Menetelmä ja laitteisto pneumaattisessa materiaalinsiirtojärjestelmässä
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CN102952105A (zh) * 2011-08-26 2013-03-06 中国科学院上海药物研究所 一类霉酚酸衍生物、其制备方法和用途
WO2013041205A1 (fr) 2011-09-19 2013-03-28 Pyxirion Pharma Gmbh Nouveaux concepts thérapeutiques pour le traitement de maladies vasculaires
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
DK2970101T3 (en) 2013-03-14 2018-08-20 Alkermes Pharma Ireland Ltd PRO-DRUGS OF FUMARATES AND THEIR USE IN TREATING DIFFERENT DISEASES
US10369133B2 (en) 2013-07-23 2019-08-06 The University Of Tennessee Research Foundation Immunosuppressive compounds and therapeutics
AU2015205151B2 (en) * 2014-01-10 2018-02-01 Fujifilm Corporation 5-hydroxy-1H-imidazole-4-carboxamide effective-dose/sensitivity prediction method and prediction device, xanthosine-monophosphate-amount measurement method, and myelodysplastic-syndrome treatment agent and treatment method
NZ723269A (en) 2014-02-24 2017-04-28 Alkermes Pharma Ireland Ltd Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2017210262A1 (fr) 2016-06-02 2017-12-07 Steven Baranowitz Prévention et traitement d'infections virales
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
US11918684B2 (en) 2017-03-13 2024-03-05 Liqmeds Worldwide Limited Pharmaceutical composition of oral suspension of immunosuppressive agents
US10835489B2 (en) * 2018-03-09 2020-11-17 University Of Saskatchewan Modified release formulations of mycophenolate mofetil
US20210308044A1 (en) 2018-08-18 2021-10-07 Ftf Pharma Private Limited Pharmaceutical suspension for oral dosage
CN110526885A (zh) * 2019-08-20 2019-12-03 上海英诺富成生物科技有限公司 麦考酚酸的前体药物及其制备方法
CN113549040B (zh) * 2020-04-23 2024-08-06 鲁南制药集团股份有限公司 一种吗替麦考酚酯杂质d的制备方法
CN112121173B (zh) * 2020-08-22 2022-05-06 浙江大学 脂肪酸修饰的免疫抑制剂mmf及fk506纳米制剂及其制备方法和应用
CN117177749A (zh) 2021-03-03 2023-12-05 萨那生物科技公司 与心肌细胞疗法一起使用的免疫抑制疗法以及相关的方法和组合物

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Also Published As

Publication number Publication date
EP0281713B1 (fr) 1991-10-09
MX9203163A (es) 1992-07-31
ES2038190T3 (es) 1993-07-16
NO875240L (no) 1988-08-01
LV5748B4 (lv) 1997-02-20
ATE68180T1 (de) 1991-10-15
US4948793A (en) 1990-08-14
HK125893A (en) 1993-11-19
EP0281713A1 (fr) 1988-09-14
AU8254087A (en) 1988-08-04
FI875502A (fi) 1988-07-31
KR880009016A (ko) 1988-09-13
DE19675020I2 (de) 2002-11-07
NO171680C (no) 1993-04-21
NO875240D0 (no) 1987-12-15
DE3773660D1 (de) 1991-11-14
FI85141C (fi) 1992-03-10
HU210350A9 (en) 1995-03-28
US4992467A (en) 1991-02-12
US4786637A (en) 1988-11-22
IL84833A (en) 1992-03-29
GEP20094816B (en) 2009-11-10
FI875502A0 (fi) 1987-12-15
PT86343B (pt) 1991-02-08
US4952579A (en) 1990-08-28
HU201927B (en) 1991-01-28
DK658787D0 (da) 1987-12-15
US4808592A (en) 1989-02-28
PT86343A (en) 1988-01-01
AU599728B2 (en) 1990-07-26
NZ222922A (en) 1990-09-26
DK166675B1 (da) 1993-06-28
NL960019I2 (nl) 1997-06-02
KR940003758B1 (ko) 1994-04-30
NL960019I1 (nl) 1996-10-01
JPH0571591B2 (fr) 1993-10-07
US4753935A (en) 1988-06-28
HUT47567A (en) 1989-03-28
JPS63188672A (ja) 1988-08-04
NO1997007I1 (no) 1997-07-01
IE873397L (en) 1988-07-30
IL84833A0 (en) 1988-06-30
IE60750B1 (en) 1994-08-10
PH23819A (en) 1989-11-23
CA1333285C (fr) 1994-11-29
LV5748A4 (lv) 1996-10-20
FI85141B (fi) 1991-11-29
US4868153A (en) 1989-09-19
ZA879414B (en) 1989-08-30
DK658787A (da) 1988-07-31
NO171680B (no) 1993-01-11
GR3002866T3 (en) 1993-01-25

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