LU84089A1 - Composition analgesique a base de butorphanol et de zomepirac - Google Patents

Composition analgesique a base de butorphanol et de zomepirac Download PDF

Info

Publication number: LU84089A1
Authority: LU; Luxembourg
Prior art keywords: zomepirac; butorphanol; salt; analgesic; present
Prior art date: 1981-04-16

Application number

LU84089A

Other languages

English (en)

French (fr)

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-16

Filing date

1982-04-16

Publication date

1983-04-13

1982-04-16 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1983-04-13 Publication of LU84089A1 publication Critical patent/LU84089A1/fr

Links

239000000203 mixture Substances 0.000 title claims description 50
229960003414 zomepirac Drugs 0.000 title claims description 47
IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 title claims description 35
229960001113 butorphanol Drugs 0.000 title claims description 34
ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 title claims description 32
230000000202 analgesic effect Effects 0.000 title claims description 29
150000003839 salts Chemical class 0.000 claims description 18
150000001875 compounds Chemical class 0.000 claims description 11
241001465754 Metazoa Species 0.000 claims description 9
238000000034 method Methods 0.000 claims description 9
231100000252 nontoxic Toxicity 0.000 claims description 8
230000003000 nontoxic effect Effects 0.000 claims description 8
230000036592 analgesia Effects 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 4
239000002552 dosage form Substances 0.000 claims description 3
159000000000 sodium salts Chemical class 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 2
150000003892 tartrate salts Chemical class 0.000 claims 2
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 15
230000000694 effects Effects 0.000 description 12
230000002195 synergetic effect Effects 0.000 description 12
239000000730 antalgic agent Substances 0.000 description 9
239000003814 drug Substances 0.000 description 9
229940079593 drug Drugs 0.000 description 8
230000000996 additive effect Effects 0.000 description 7
241000699670 Mus sp. Species 0.000 description 6
238000002360 preparation method Methods 0.000 description 5
229960004492 suprofen Drugs 0.000 description 5
MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 4
208000002193 Pain Diseases 0.000 description 4
239000000654 additive Substances 0.000 description 4
239000002260 anti-inflammatory agent Substances 0.000 description 4
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 4
230000003993 interaction Effects 0.000 description 4
229940124641 pain reliever Drugs 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
241000282320 Panthera leo Species 0.000 description 3
229940035676 analgesics Drugs 0.000 description 3
229940121363 anti-inflammatory agent Drugs 0.000 description 3
230000036407 pain Effects 0.000 description 3
239000000243 solution Substances 0.000 description 3
229960000894 sulindac Drugs 0.000 description 3
RLQZIECDMISZHS-UHFFFAOYSA-N 2-phenylcyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C=CC(=O)C(C=2C=CC=CC=2)=C1 RLQZIECDMISZHS-UHFFFAOYSA-N 0.000 description 2
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 2
230000003042 antagnostic effect Effects 0.000 description 2
230000003110 anti-inflammatory effect Effects 0.000 description 2
GMTYREVWZXJPLF-AFHUBHILSA-N butorphanol D-tartrate Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O.N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 GMTYREVWZXJPLF-AFHUBHILSA-N 0.000 description 2
229960001590 butorphanol tartrate Drugs 0.000 description 2
239000002775 capsule Substances 0.000 description 2
229960004126 codeine Drugs 0.000 description 2
230000008602 contraction Effects 0.000 description 2
KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 2
229960001680 ibuprofen Drugs 0.000 description 2
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
229960002009 naproxen Drugs 0.000 description 2
CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 2
229960005489 paracetamol Drugs 0.000 description 2
229960002702 piroxicam Drugs 0.000 description 2
QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
230000004044 response Effects 0.000 description 2
MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 2
239000003826 tablet Substances 0.000 description 2
DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 description 1
BFNRPSUSOAQYNS-UHFFFAOYSA-N 2-[5-[(4-chlorophenyl)methyl]-1,4-dimethylpyrrol-2-yl]acetic acid Chemical compound C1=C(CC(O)=O)N(C)C(CC=2C=CC(Cl)=CC=2)=C1C BFNRPSUSOAQYNS-UHFFFAOYSA-N 0.000 description 1
208000004998 Abdominal Pain Diseases 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
208000002881 Colic Diseases 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
CGIGDMFJXJATDK-UHFFFAOYSA-N Indomethacin Natural products CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
206010022998 Irritability Diseases 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
208000007101 Muscle Cramp Diseases 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
206010028813 Nausea Diseases 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
206010047700 Vomiting Diseases 0.000 description 1
230000003187 abdominal effect Effects 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
230000009471 action Effects 0.000 description 1
208000005298 acute pain Diseases 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229940051880 analgesics and antipyretics pyrazolones Drugs 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000037396 body weight Effects 0.000 description 1
125000002843 carboxylic acid group Chemical group 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229960004415 codeine phosphate Drugs 0.000 description 1
238000004040 coloring Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000036461 convulsion Effects 0.000 description 1
239000013256 coordination polymer Substances 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
208000002173 dizziness Diseases 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
-1 elixirs Substances 0.000 description 1
230000004438 eyesight Effects 0.000 description 1
229960001395 fenbufen Drugs 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000012458 free base Substances 0.000 description 1
238000003304 gavage Methods 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000003979 granulating agent Substances 0.000 description 1
229960000905 indomethacin Drugs 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
229960000991 ketoprofen Drugs 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229940126601 medicinal product Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
229960005181 morphine Drugs 0.000 description 1
229960004715 morphine sulfate Drugs 0.000 description 1
GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 description 1
NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 description 1
229960000805 nalbuphine Drugs 0.000 description 1
239000004081 narcotic agent Substances 0.000 description 1
230000008693 nausea Effects 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
239000003921 oil Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000002304 perfume Substances 0.000 description 1
210000001428 peripheral nervous system Anatomy 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
230000010349 pulsation Effects 0.000 description 1
JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
150000003873 salicylate salts Chemical class 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
208000004371 toothache Diseases 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

LU84089A 1981-04-16 1982-04-16 Composition analgesique a base de butorphanol et de zomepirac LU84089A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25482181		1981-04-16
US06/254,821 US4322427A (en)	1981-04-16	1981-04-16	Analgetic compositions and methods of use

Publications (1)

Publication Number	Publication Date
LU84089A1 true LU84089A1 (fr)	1983-04-13

Family

ID=22965711

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU84089A LU84089A1 (fr)	1981-04-16	1982-04-16	Composition analgesique a base de butorphanol et de zomepirac

Country Status (18)

Country	Link
US (1)	US4322427A (fi)
JP (1)	JPS57179117A (fi)
AT (1)	ATA148982A (fi)
AU (1)	AU8258282A (fi)
BE (1)	BE892884A (fi)
CA (1)	CA1173362A (fi)
CH (1)	CH652596A5 (fi)
DE (1)	DE3213788A1 (fi)
DK (1)	DK161482A (fi)
FI (1)	FI821287L (fi)
FR (1)	FR2504007A1 (fi)
GB (1)	GB2096894A (fi)
GR (1)	GR75549B (fi)
IT (1)	IT1147843B (fi)
LU (1)	LU84089A1 (fi)
NL (1)	NL8201544A (fi)
SE (1)	SE8202380L (fi)
ZA (1)	ZA822487B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4407805A (en) *	1982-06-30	1983-10-04	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and zomepirac
AU565634B2 (en) *	1982-06-30	1987-09-24	E.I. Du Pont De Nemours And Company	Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
US4656177A (en) *	1982-07-22	1987-04-07	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
WO1984000488A1 (en) *	1982-07-22	1984-02-16	Richardson Vicks Inc	Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4777174A (en) *	1982-07-22	1988-10-11	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4683243A (en) *	1984-02-08	1987-07-28	Richardson-Vicks, Inc.	Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4985459A (en) *	1984-02-08	1991-01-15	Richardson-Vicks, Inc.	Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4906625A (en) *	1984-02-08	1990-03-06	Richardson-Vicks, Inc.	Analgesic and anti-inflammatory compositions comprising diphenhydramine and metyhods of using same
US4755532A (en) *	1984-02-08	1988-07-05	Richardson-Vicks, Inc.	Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4522826A (en) *	1984-02-08	1985-06-11	Richardson-Vicks Inc.	Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4552899A (en) *	1984-04-09	1985-11-12	Analgesic Associates	Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4840962A (en) *	1984-04-09	1989-06-20	Analgesic Associates	Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4569937A (en) *	1985-02-11	1986-02-11	E. I. Du Pont De Nemours And Company	Analgesic mixture of oxycodone and ibuprofen
DE69226624T3 (de) *	1991-09-06	2009-11-05	Ortho-Mcneil Pharmaceutical, Inc.	Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung
US5558876A (en) *	1995-03-29	1996-09-24	Alcon Laboratories, Inc.	Topical ophthalmic acidic drug formulations
US5648358A (en) *	1996-03-05	1997-07-15	Mitra; Sekhar	Compositions and methods for treating respiratory disorders
RS49982B (sr) *	1997-09-17	2008-09-29	Euro-Celtique S.A.,	Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
EP1056443B1 (en)	1998-02-25	2004-05-06	Abbott Laboratories	Butorphanol sustained release formulations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3752826A (en) *	1970-01-26	1973-08-14	Mcneilab Inc	Aroyl substituted pyrroles
BE788478A (fr) *	1971-09-08	1973-03-06	Bristol Myers Co	Procede de preparation de composes analgesiques
DE2861595D1 (en) *	1978-07-10	1982-03-11	Mcneilab Inc	Pharmaceutical composition comprising a 5-aroyl-1-c1-5 alkyl-pyrrole-2-acetic acid compound and acetaminophen or acetylsalicylic acid
US4234601A (en) *	1978-12-18	1980-11-18	Mcneilab, Inc.	Analgesic potentiation
US4233316A (en) *	1978-12-18	1980-11-11	Mcneilab, Inc.	Analgesic potentiation
US4233314A (en) *	1978-12-18	1980-11-11	Mcneilab, Inc.	Analgesic potentiation
US4233317A (en) *	1978-12-18	1980-11-11	Mcneilab, Inc.	Analgesic potentiation
US4233315A (en) *	1978-12-18	1980-11-11	Mcneilab, Inc.	Analgesic potentiation
US4242353A (en) *	1978-12-18	1980-12-30	Mcneilab, Inc.	Analgesic potentiation
US4207340A (en) *	1978-12-18	1980-06-10	Mcneilab, Inc.	Analgesic potentiation
US4243673A (en) *	1978-12-20	1981-01-06	Ortho Pharmaceutical Corporation	Analgesic compositions and methods of use
US4237140A (en) *	1979-05-18	1980-12-02	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and acetaminophen
US4338324A (en) *	1981-03-17	1982-07-06	Mcneilab, Inc.	Analgesic potentiation

1981
- 1981-04-16 US US06/254,821 patent/US4322427A/en not_active Expired - Fee Related
1982
- 1982-03-31 CA CA000400089A patent/CA1173362A/en not_active Expired
- 1982-04-06 GR GR67822A patent/GR75549B/el unknown
- 1982-04-07 DK DK161482A patent/DK161482A/da not_active IP Right Cessation
- 1982-04-13 NL NL8201544A patent/NL8201544A/nl not_active Application Discontinuation
- 1982-04-13 ZA ZA822487A patent/ZA822487B/xx unknown
- 1982-04-13 FR FR8206332A patent/FR2504007A1/fr active Pending
- 1982-04-13 FI FI821287A patent/FI821287L/fi not_active Application Discontinuation
- 1982-04-14 JP JP57061189A patent/JPS57179117A/ja active Granted
- 1982-04-14 AU AU82582/82A patent/AU8258282A/en not_active Abandoned
- 1982-04-14 IT IT48227/82A patent/IT1147843B/it active
- 1982-04-15 SE SE8202380A patent/SE8202380L/ not_active Application Discontinuation
- 1982-04-15 DE DE19823213788 patent/DE3213788A1/de not_active Withdrawn
- 1982-04-16 CH CH2335/82A patent/CH652596A5/fr not_active IP Right Cessation
- 1982-04-16 AT AT0148982A patent/ATA148982A/de not_active IP Right Cessation
- 1982-04-16 BE BE0/207857A patent/BE892884A/fr not_active IP Right Cessation
- 1982-04-16 GB GB8211058A patent/GB2096894A/en not_active Withdrawn
- 1982-04-16 LU LU84089A patent/LU84089A1/fr unknown

Also Published As

Publication number	Publication date
JPH0157093B2 (fi)	1989-12-04
FR2504007A1 (fr)	1982-10-22
FI821287A0 (fi)	1982-04-13
CH652596A5 (fr)	1985-11-29
FI821287L (fi)	1982-10-17
IT8248227A0 (it)	1982-04-14
DK161482A (da)	1982-10-17
DE3213788A1 (de)	1982-11-04
AU8258282A (en)	1982-10-21
IT1147843B (it)	1986-11-26
ATA148982A (de)	1986-09-15
GB2096894A (en)	1982-10-27
US4322427A (en)	1982-03-30
CA1173362A (en)	1984-08-28
NL8201544A (nl)	1982-11-16
JPS57179117A (en)	1982-11-04
ZA822487B (en)	1982-11-24
BE892884A (fr)	1982-10-18
SE8202380L (sv)	1982-10-17
GR75549B (fi)	1984-07-27

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FR2607006A1 (fr)	1988-05-27	Composition pharmaceutique a base d'euphorbia pilulifera et/ou hirta, utilisee notamment comme cicatrisant et/ou desinfectant intestinal
FR3052066B1 (fr)	2019-09-13	Formulation pharmaceutique de cineol et d'amoxicilline
FR2669821A1 (fr)	1992-06-05	Utilisation de phenylethanolaminotetralines pour la preparation de medicaments destines au traitement de la depression.
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BE635642A (fi)