LU83325A1 - Compose de platine,procede de preparation et compositions pharmaceutiques en contenant - Google Patents
Compose de platine,procede de preparation et compositions pharmaceutiques en contenant Download PDFInfo
- Publication number
- LU83325A1 LU83325A1 LU83325A LU83325A LU83325A1 LU 83325 A1 LU83325 A1 LU 83325A1 LU 83325 A LU83325 A LU 83325A LU 83325 A LU83325 A LU 83325A LU 83325 A1 LU83325 A1 LU 83325A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- platinum
- cis
- phic
- complex
- compound
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 4
- 150000003058 platinum compounds Chemical class 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 49
- 229910052697 platinum Inorganic materials 0.000 claims description 17
- 230000000259 anti-tumor effect Effects 0.000 claims description 9
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims description 8
- ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 claims description 7
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 claims description 5
- 238000001990 intravenous administration Methods 0.000 claims description 5
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims description 3
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 3
- HWMVXEKEEAIYGB-UHFFFAOYSA-K Isocitric acid, DL- Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C(O)C(C([O-])=O)CC([O-])=O HWMVXEKEEAIYGB-UHFFFAOYSA-K 0.000 claims description 2
- POQBJIOLWPDPJE-UHFFFAOYSA-N cyclohexane-1,2-diamine;platinum Chemical compound [Pt].NC1CCCCC1N POQBJIOLWPDPJE-UHFFFAOYSA-N 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910001961 silver nitrate Inorganic materials 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229920000833 poly(n-hexyl isocyanate) polymer Polymers 0.000 description 41
- 150000001875 compounds Chemical class 0.000 description 34
- 210000004027 cell Anatomy 0.000 description 20
- 238000007912 intraperitoneal administration Methods 0.000 description 20
- 241001465754 Metazoa Species 0.000 description 19
- 231100000419 toxicity Toxicity 0.000 description 17
- 230000001988 toxicity Effects 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 16
- 239000007924 injection Substances 0.000 description 15
- 238000002347 injection Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000003446 ligand Substances 0.000 description 7
- 231100000417 nephrotoxicity Toxicity 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 241001504519 Papio ursinus Species 0.000 description 6
- 230000036571 hydration Effects 0.000 description 6
- 238000006703 hydration reaction Methods 0.000 description 6
- 206010029155 Nephropathy toxic Diseases 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000007694 nephrotoxicity Effects 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 241000282520 Papio Species 0.000 description 4
- 208000006268 Sarcoma 180 Diseases 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000002440 hepatic effect Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 208000007093 Leukemia L1210 Diseases 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 150000003057 platinum Chemical class 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 231100000041 toxicology testing Toxicity 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010059024 Gastrointestinal toxicity Diseases 0.000 description 2
- 206010033109 Ototoxicity Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000007942 carboxylates Chemical group 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- SGLJYTWMWIAGEU-UHFFFAOYSA-N cyclohexane-1,2-diamine;platinum(2+) Chemical compound [Pt+2].NC1CCCCC1N SGLJYTWMWIAGEU-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 231100000414 gastrointestinal toxicity Toxicity 0.000 description 2
- 210000004276 hyalin Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 231100000262 ototoxicity Toxicity 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100001274 therapeutic index Toxicity 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- SSJXIUAHEKJCMH-OLQVQODUSA-N (1s,2r)-cyclohexane-1,2-diamine Chemical compound N[C@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-OLQVQODUSA-N 0.000 description 1
- TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 description 1
- 206010002536 Anisocytosis Diseases 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 108010077544 Chromatin Proteins 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 102100035861 Cytosolic 5'-nucleotidase 1A Human genes 0.000 description 1
- 241001331845 Equus asinus x caballus Species 0.000 description 1
- 206010061188 Haematotoxicity Diseases 0.000 description 1
- 101000802744 Homo sapiens Cytosolic 5'-nucleotidase 1A Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 101100465000 Mus musculus Prag1 gene Proteins 0.000 description 1
- 241000272868 Neochen jubata Species 0.000 description 1
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 1
- KUGRPPRAQNPSQD-UHFFFAOYSA-N OOOOO Chemical compound OOOOO KUGRPPRAQNPSQD-UHFFFAOYSA-N 0.000 description 1
- 241001670273 Ooia Species 0.000 description 1
- 235000016499 Oxalis corniculata Nutrition 0.000 description 1
- 240000007019 Oxalis corniculata Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- BSJGASKRWFKGMV-UHFFFAOYSA-L ammonia dichloroplatinum(2+) Chemical compound N.N.Cl[Pt+2]Cl BSJGASKRWFKGMV-UHFFFAOYSA-L 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000003321 atomic absorption spectrophotometry Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 210000003483 chromatin Anatomy 0.000 description 1
- 210000003477 cochlea Anatomy 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 231100000226 haematotoxicity Toxicity 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- -1 isocitrate ion Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000000110 microvilli Anatomy 0.000 description 1
- 230000003589 nefrotoxic effect Effects 0.000 description 1
- 230000021616 negative regulation of cell division Effects 0.000 description 1
- 210000000885 nephron Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 210000000633 nuclear envelope Anatomy 0.000 description 1
- 210000002985 organ of corti Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000002970 ototoxic effect Effects 0.000 description 1
- 231100001154 ototoxicity test Toxicity 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- FONYLINGKWPNNY-SMZBABNXSA-K trisodium (E)-prop-1-ene-1,2,3-tricarboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C\C(=C/C([O-])=O)C([O-])=O FONYLINGKWPNNY-SMZBABNXSA-K 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8014109 | 1980-04-29 | ||
| GB8014109 | 1980-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU83325A1 true LU83325A1 (fr) | 1981-07-24 |
Family
ID=10513074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU83325A LU83325A1 (fr) | 1980-04-29 | 1981-04-28 | Compose de platine,procede de preparation et compositions pharmaceutiques en contenant |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4452812A (el) |
| EP (1) | EP0039272B1 (el) |
| JP (1) | JPS595599B2 (el) |
| AR (1) | AR226354A1 (el) |
| AT (1) | AT372072B (el) |
| AU (1) | AU6978681A (el) |
| BE (1) | BE888367A (el) |
| CA (1) | CA1171425A (el) |
| DD (1) | DD158777A5 (el) |
| DE (1) | DE3163162D1 (el) |
| DK (1) | DK188481A (el) |
| ES (1) | ES8203324A1 (el) |
| FI (1) | FI811314L (el) |
| FR (1) | FR2481289B1 (el) |
| GB (1) | GB2077720B (el) |
| GR (1) | GR75598B (el) |
| IE (1) | IE51197B1 (el) |
| IL (1) | IL62615A0 (el) |
| IT (1) | IT1146749B (el) |
| JO (1) | JO1176B1 (el) |
| LU (1) | LU83325A1 (el) |
| MA (1) | MA19131A1 (el) |
| MC (1) | MC1391A1 (el) |
| NO (1) | NO811449L (el) |
| NZ (1) | NZ196803A (el) |
| OA (1) | OA06797A (el) |
| PL (1) | PL128539B1 (el) |
| PT (1) | PT72941B (el) |
| RO (1) | RO82032B (el) |
| YU (1) | YU102581A (el) |
| ZA (1) | ZA812474B (el) |
| ZW (1) | ZW8681A1 (el) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59112995A (ja) * | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | 新規グリコ−ル酸白金錯体 |
| US4565884A (en) * | 1983-05-10 | 1986-01-21 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
| JPS60501260A (ja) * | 1983-05-10 | 1985-08-08 | アンドルリス、リサ−チ、コ−ポレイション | 抗腫瘍剤としてのビス−白金錯塩 |
| US4720504A (en) * | 1983-05-10 | 1988-01-19 | Andrulis Research Corporation | Use of bis-platinum complexes as antitumor agents |
| US4758588A (en) * | 1983-06-20 | 1988-07-19 | Research Corporation Technologies | Diaminocyclohexane platinum complexes |
| US4661516A (en) * | 1983-06-20 | 1987-04-28 | Research Corporation | Diaminocyclohexane platinum complexes |
| JPS6013795A (ja) * | 1983-06-20 | 1985-01-24 | リサ−チ・コ−ポレイシヨン | ジアミノシクロヘキサン白金錯体 |
| US4562275A (en) * | 1984-03-23 | 1985-12-31 | Bristol-Myers Co. | Antitumor platinum complexes |
| EP0169645A1 (en) * | 1984-06-27 | 1986-01-29 | Johnson Matthey Public Limited Company | Platinum co-ordination compounds |
| ATE49214T1 (de) * | 1984-12-17 | 1990-01-15 | American Cyanamid Co | Platinkomplexe von aliphatischen tricarbonsaeuren. |
| US5011959A (en) * | 1986-11-17 | 1991-04-30 | The Board Of Regents, The University Of Texas System | 1,2-diaminocyclohexane-platinum complexes with antitumor activity |
| EP0281463A3 (en) * | 1987-03-06 | 1989-01-25 | Sumitomo Pharmaceuticals Company, Limited | Platinum complex, process for its preparation and pharmaceutical composition including such a complex |
| US5393909A (en) * | 1988-11-22 | 1995-02-28 | Board Of Regents, The University Of Texas System | Diamine platinum complexes as antitumor agents |
| DE69028844T2 (de) * | 1989-12-12 | 1997-02-13 | Toray Industries, Inc., Tokio/Tokyo | Neuer platin(ii)komplex und mittel für die behandlung von bösartigen tumoren |
| JP3154399B2 (ja) * | 1996-07-04 | 2001-04-09 | デビオファーム エス．アー． | 白金化合物の製造方法 |
| US6689928B2 (en) * | 2000-04-04 | 2004-02-10 | Exxonmobil Research And Engineering Company | Transition metal complexes and oligomers therefrom |
| DE10206648A1 (de) * | 2002-02-15 | 2003-09-11 | November Ag Molekulare Medizin | Wirkstoff zur Herstellung eines Stoffs zur Beeinflussung der Koagulationsbereitschaft des Bluts |
| WO2005056641A1 (ja) * | 2003-12-10 | 2005-06-23 | Toudai Tlo, Ltd. | ジアミノシクロヘキサン白金(ii)とポリ(カルボン酸)セグメント含有ブロック共重合体との配位錯体、その抗腫瘍剤 |
| DE102004005906B3 (de) * | 2004-02-05 | 2005-09-29 | W.C. Heraeus Gmbh | Verfahren zur Herstellung von 1,2-Diaminocylohexan-Platin(II)-Komplexen |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| WO2006098496A1 (ja) * | 2005-03-18 | 2006-09-21 | The University Of Tokyo | ジアミノシクロヘキサン白金(ii)とブロック共重合体との配位化合物及びそれを含有する抗がん剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH588505A5 (el) * | 1972-06-08 | 1977-06-15 | Research Corp | |
| US4115418A (en) * | 1976-09-02 | 1978-09-19 | Government Of The United States Of America | 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity |
| JPS6041077B2 (ja) * | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| US4206226A (en) * | 1977-08-29 | 1980-06-03 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Use of 4-carboxy-phthalato-(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof in alleviating L1210 murine leukemia |
| JPS5829957B2 (ja) * | 1977-09-12 | 1983-06-25 | 喜徳 喜谷 | 新規な白金錯体 |
| SE447902B (sv) * | 1977-10-19 | 1986-12-22 | Johnson Matthey Co Ltd | Cis-koordinationsforening av platina och komposition innehallande foreningen |
| US4203912A (en) * | 1977-10-19 | 1980-05-20 | Johnson, Matthey & Co., Limited | Compositions containing platinum |
| SE7903359L (sv) * | 1978-04-20 | 1979-10-21 | Johnson Matthey Co Ltd | Kompositioner innehallande platina |
| US4284579A (en) * | 1979-07-17 | 1981-08-18 | The United States Of America As Represented By The Of The Department Of Health & Human Services | (N-Phosphonacetyl-L-aspartato)(1,2-diaminocyclchexane)platinum(II) or alkali metal salt |
-
1981
- 1981-03-31 GR GR64535A patent/GR75598B/el unknown
- 1981-04-09 IL IL62615A patent/IL62615A0/xx unknown
- 1981-04-10 BE BE0/204441A patent/BE888367A/fr not_active IP Right Cessation
- 1981-04-13 NZ NZ196803A patent/NZ196803A/xx unknown
- 1981-04-14 ZA ZA00812474A patent/ZA812474B/xx unknown
- 1981-04-15 DE DE8181400602T patent/DE3163162D1/de not_active Expired
- 1981-04-15 FR FR8107535A patent/FR2481289B1/fr not_active Expired
- 1981-04-15 EP EP81400602A patent/EP0039272B1/fr not_active Expired
- 1981-04-15 ZW ZW86/81A patent/ZW8681A1/xx unknown
- 1981-04-20 YU YU01025/81A patent/YU102581A/xx unknown
- 1981-04-20 AR AR285005A patent/AR226354A1/es active
- 1981-04-22 MC MC811512A patent/MC1391A1/xx unknown
- 1981-04-23 IT IT67555/81A patent/IT1146749B/it active
- 1981-04-23 AU AU69786/81A patent/AU6978681A/en not_active Abandoned
- 1981-04-24 IE IE925/81A patent/IE51197B1/en unknown
- 1981-04-24 OA OA57388A patent/OA06797A/xx unknown
- 1981-04-27 MA MA19337A patent/MA19131A1/fr unknown
- 1981-04-27 FI FI811314A patent/FI811314L/fi not_active Application Discontinuation
- 1981-04-27 RO RO104130A patent/RO82032B/ro unknown
- 1981-04-27 US US06/257,939 patent/US4452812A/en not_active Expired - Fee Related
- 1981-04-28 DK DK188481A patent/DK188481A/da not_active Application Discontinuation
- 1981-04-28 LU LU83325A patent/LU83325A1/fr unknown
- 1981-04-28 PL PL1981230896A patent/PL128539B1/pl unknown
- 1981-04-28 GB GB8113116A patent/GB2077720B/en not_active Expired
- 1981-04-28 NO NO811449A patent/NO811449L/no unknown
- 1981-04-28 PT PT72941A patent/PT72941B/pt unknown
- 1981-04-29 CA CA000376517A patent/CA1171425A/en not_active Expired
- 1981-04-29 DD DD81229603A patent/DD158777A5/de unknown
- 1981-04-29 ES ES502411A patent/ES8203324A1/es not_active Expired
- 1981-04-29 AT AT0191981A patent/AT372072B/de not_active IP Right Cessation
- 1981-04-30 JP JP56066119A patent/JPS595599B2/ja not_active Expired
- 1981-06-15 JO JO19811176A patent/JO1176B1/en active
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