[go: up one dir, main page]

LTIP263A - Process for the preparing a concentrate of blood coagulation factor vii-von willebrand factor complex from total plasma - Google Patents

Process for the preparing a concentrate of blood coagulation factor vii-von willebrand factor complex from total plasma

Info

Publication number
LTIP263A
LTIP263A LTIP263A LTIP263A LTIP263A LT IP263 A LTIP263 A LT IP263A LT IP263 A LTIP263 A LT IP263A LT IP263 A LTIP263 A LT IP263A LT IP263 A LTIP263 A LT IP263A
Authority
LT
Lithuania
Prior art keywords
concentrate
von willebrand
complex
preparing
blood coagulation
Prior art date
Application number
LTIP263A
Inventor
Miryana Burnouf
Thierry Burnouf
Original Assignee
Centre Regional De Transfusion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Regional De Transfusion filed Critical Centre Regional De Transfusion
Publication of LTIP263A publication Critical patent/LTIP263A/en
Publication of LT3418B publication Critical patent/LT3418B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

The invention relates to a process for the preparation of a concentrate of factor VIII-von Willebrand factor complex having high specific activity from whole plasma (not cryoprecipitate). The process comprises a prepurification by a double treatment with barium chloride and aluminium hydroxide. The process then comprises a purification by chromatography on an anion exchange resin of the DEAE-Fractogel type. The process comprises a step of viral inactivation by a solvent/detergent treatment. The process also enables fibrinogen, albumin, immunoglobulins, antithrombin III, fibronectin and prothrombin complex to be recovered from the same plasma. The various concentrates obtained by the process of the invention are intended, in particular, for therapeutic use.
LTIP263A 1989-09-05 1992-12-29 Process for the preparing a concentrate of blood coagulation factor vii-von willebrand factor complex from total plasma LT3418B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8911567A FR2651437A1 (en) 1989-09-05 1989-09-05 PROCESS FOR PREPARING A CONCENTRATE OF THE VON WILLEBRAND FACTOR VIII-FACTOR COMPLEX OF BLOOD COAGULATION FROM TOTAL PLASMA.

Publications (2)

Publication Number Publication Date
LTIP263A true LTIP263A (en) 1994-10-25
LT3418B LT3418B (en) 1995-09-25

Family

ID=9385124

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP263A LT3418B (en) 1989-09-05 1992-12-29 Process for the preparing a concentrate of blood coagulation factor vii-von willebrand factor complex from total plasma

Country Status (24)

Country Link
US (1) US5679776A (en)
EP (1) EP0416983B1 (en)
AT (1) ATE91896T1 (en)
AU (1) AU627618B2 (en)
BR (1) BR9004626A (en)
CA (1) CA2024667C (en)
CZ (1) CZ277939B6 (en)
DD (1) DD298110A5 (en)
DE (1) DE69002427T2 (en)
DK (1) DK0416983T3 (en)
ES (1) ES2057475T3 (en)
FI (1) FI95654C (en)
FR (1) FR2651437A1 (en)
HR (1) HRP920768B1 (en)
HU (1) HU206378B (en)
LT (1) LT3418B (en)
LV (1) LV10053B (en)
NO (1) NO178716C (en)
PL (1) PL164754B1 (en)
RU (1) RU2025129C1 (en)
SI (1) SI9012034B (en)
SK (1) SK431290A3 (en)
UA (1) UA26847C2 (en)
YU (1) YU48356B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3904354A1 (en) * 1989-02-14 1990-08-16 Behringwerke Ag PASTEURIZED, PURIFIED OF WILLEBRAND FACTOR CONCENTRATE AND METHOD FOR THE PRODUCTION THEREOF
ATE90875T1 (en) * 1989-05-24 1993-07-15 Miles Inc GEL FILTRATION OF HEAT-TREATED FACTOR VIII.
AT403991B (en) * 1990-04-04 1998-07-27 Atomic Austria Gmbh ALPINSCHI
AT403992B (en) * 1991-02-22 1998-07-27 Head Sport Ag SKI
DE4204694C3 (en) * 1992-02-01 1995-10-12 Octapharma Ag Method for obtaining highly pure, virus-inactivated factor VIII by means of anion exchange chromatography
IT1256622B (en) * 1992-12-04 1995-12-12 Sclavo Spa PROCESS FOR THE EXTRACTION OF THE FACTOR VIII-FACTOR VON WILLEBRAND (FVIII: C-FVW) FROM TOTAL HUMAN PLASMA.
DE4430205A1 (en) * 1994-08-26 1996-02-29 Behringwerke Ag Compositions suitable as antidotes for blood anticoagulants and their use
DE4435485C1 (en) * 1994-10-04 1996-03-21 Immuno Ag Process for obtaining high-purity von Willebrand factor
AT403764B (en) 1996-03-15 1998-05-25 Immuno Ag STABLE FACTOR VIII / VWF COMPLEX
AT403765B (en) 1996-04-12 1998-05-25 Immuno Ag METHOD FOR PRODUCING A PREPARATION CONTAINING A HIGHLY CLEANED COMPLEX
AT406373B (en) 1997-02-27 2000-04-25 Immuno Ag METHOD FOR CLEANING FACTOR VIII / VWF COMPLEX BY CATION EXCHANGER CHROMATOGRAPHY
EP1029546A1 (en) * 1997-11-05 2000-08-23 Yoshitomi Pharmaceutical Industries, Ltd. Heparin cofactor ii preparations and process for producing the same
DK0937735T3 (en) * 1998-02-11 2003-06-02 Zlb Bioplasma Ag Method for Removing Causal Agent / Causal Agents for Transferable Spongiform Encephalopathies from Protein Solutions
ATE365052T1 (en) 1999-02-22 2007-07-15 Univ Connecticut NEW ALBUMINE-FREE FACTOR VIII FORMULATIONS
DE19937218A1 (en) 1999-08-06 2001-02-08 Aventis Behring Gmbh Process for the pure presentation of the protease activating the blood coagulation factor VII, its proenzyme or a mixture of both proteins by means of affinity chromatography
ES2229931B1 (en) * 2003-10-03 2006-01-16 Grifols, S.A. BILOGICALLY STABLE LIQUID COMPOSITION OF FVIII, FVW OR HUMAN FVIII / FVW COMPLEX.
FR2874216B1 (en) * 2004-08-16 2006-11-03 Lab Francais Du Fractionnement PROCESS FOR THE PREPARATION OF A VON WILLEBRAND FACTOR CONCENTRATE (FVW) BY CHROMATOGRAPHIC AND CONCENTRATED FVW SO LIKELY TO BE OBTAINED
ES2706296T3 (en) 2008-11-07 2019-03-28 Univ Connecticut Formulations of Factor VIII
WO2013083858A1 (en) 2012-04-24 2013-06-13 Novo Nordisk A/S Compounds suitable for treatment of haemophilia
EP3066119B1 (en) * 2013-11-08 2018-08-01 CSL Limited New method to concentrate von willebrand factor or complexes thereof
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
CN104231073B (en) * 2014-09-25 2017-01-25 广东双林生物制药有限公司 Preparation method of human coagulation factor VIII
CN105315365A (en) * 2015-11-17 2016-02-10 上海洲跃生物科技有限公司 Preparation method for human antithrombin III

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803115A (en) * 1972-05-17 1974-04-09 Baxter Laboratories Inc Stabilization of ahf using heparin
ES471858A1 (en) * 1977-07-25 1979-02-01 Monsanto Co Non-activating polyelectrolytes and their use in a method for separation of blood coagulation factors.
US4386068A (en) * 1980-02-26 1983-05-31 Cutter Laboratories, Inc. Antihemophilic factor concentrate and method for preparation
US4359463A (en) * 1980-11-26 1982-11-16 Rock Gail A Stabilization of Factor VIII activity in whole blood or blood plasma
US4435318A (en) * 1981-05-22 1984-03-06 Ionics, Incorporated Electrodialysis preparation of purified AHF concentrate
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
US4952675A (en) * 1985-02-01 1990-08-28 New York University Method for purifying antihemophilic factor
FR2632309B1 (en) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine PROCESS FOR THE CHROMATOGRAPHIC PURIFICATION OF PROTEINS, PARTICULARLY FACTOR VIII, AND THE PRODUCTS OBTAINED

Also Published As

Publication number Publication date
DK0416983T3 (en) 1993-10-04
AU627618B2 (en) 1992-08-27
EP0416983A1 (en) 1991-03-13
FI904381A0 (en) 1990-09-05
PL286746A1 (en) 1991-05-06
SI9012034B (en) 1999-12-31
FR2651437A1 (en) 1991-03-08
AU6221890A (en) 1992-03-12
EP0416983B1 (en) 1993-07-28
CA2024667A1 (en) 1991-03-06
LV10053A (en) 1994-05-10
HUT56858A (en) 1991-10-28
DE69002427D1 (en) 1993-09-02
ES2057475T3 (en) 1994-10-16
HRP920768B1 (en) 1998-12-31
NO903865D0 (en) 1990-09-05
FI95654C (en) 1996-03-11
LT3418B (en) 1995-09-25
DE69002427T2 (en) 1993-12-23
YU203490A (en) 1993-05-28
FI95654B (en) 1995-11-30
LV10053B (en) 1995-02-20
RU2025129C1 (en) 1994-12-30
HU206378B (en) 1992-10-28
CZ277939B6 (en) 1993-06-16
BR9004626A (en) 1992-03-24
HU905797D0 (en) 1991-03-28
PL164754B1 (en) 1994-10-31
CA2024667C (en) 2001-07-31
FR2651437B1 (en) 1994-08-19
SK279367B6 (en) 1998-10-07
CZ431290A3 (en) 1993-01-13
YU48356B (en) 1998-07-10
DD298110A5 (en) 1992-02-06
NO903865L (en) 1991-03-06
UA26847C2 (en) 1999-12-29
SK431290A3 (en) 1998-10-07
US5679776A (en) 1997-10-21
SI9012034A (en) 1997-10-31
NO178716B (en) 1996-02-12
ATE91896T1 (en) 1993-08-15
HRP920768A2 (en) 1995-02-28
NO178716C (en) 1996-05-22

Similar Documents

Publication Publication Date Title
AU627618B2 (en) Process for preparing a concentrate of blood coagulation factor v111-von willebrand factor complex from total plasma
UA11061A (en) Method for separating proteins of blood
US5378365A (en) Process for the isolation of highly purified factors IX, X and II from prothrombin complex or human plasma
AU638969B2 (en) Pasteurized, purified von willebrand factor concentrate and a process for the preparation thereof
EP0168234A3 (en) Purification process for hepatitis surface antigen and product thereof
AU633925B2 (en) Process for the preparation of purified albumin solutions
ATE36861T1 (en) PRODUCTION OF BLOOD COAGLING FACTOR VIII:C.
AU6487286A (en) Antihemophilic factor by cold precipitation
ES2053684T3 (en) PROCEDURE TO PREPARE A HIGHLY PURE, NON-INFECTIOUS ANTIHEMOPHILIC FACTOR THROUGH CHROMATOGRAPHY.
ES2055875T3 (en) MANUFACTURING PROCEDURE OF THE ANTIHEMOPHILIC FACTOR (FVIIIC) WITH A VERY HIGH PURITY.
EP0151482A3 (en) Heat defribinogenation of ahf preparation
DE3170868D1 (en) Process for the preparation of highly purified antihemophilic factor

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20091229