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LT4053128T - 5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui - Google Patents

5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui

Info

Publication number
LT4053128T
LT4053128T LTEP22152688.2T LT22152688T LT4053128T LT 4053128 T LT4053128 T LT 4053128T LT 22152688 T LT22152688 T LT 22152688T LT 4053128 T LT4053128 T LT 4053128T
Authority
LT
Lithuania
Prior art keywords
pyrazolo
difluorophenyl
pyrazol
pyrrolidin
treating cancer
Prior art date
Application number
LTEP22152688.2T
Other languages
English (en)
Inventor
Kollol Pal
Stephane Ciblat
Vincent Albert
Nicolas BRUNEAU-LATOUR
Jonathan BOUDREAULT
Original Assignee
Biohaven Therapeutics Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohaven Therapeutics Ltd. filed Critical Biohaven Therapeutics Ltd.
Publication of LT4053128T publication Critical patent/LT4053128T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTEP22152688.2T 2017-12-15 2018-12-12 5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui LT4053128T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762599490P 2017-12-15 2017-12-15

Publications (1)

Publication Number Publication Date
LT4053128T true LT4053128T (lt) 2024-11-25

Family

ID=65139120

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP22152688.2T LT4053128T (lt) 2017-12-15 2018-12-12 5-(2-(2,5-difluorfenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazolo[1,5-a] pirimidino dariniai ir giminingi junginiai, kaip trk kinazės inhibitoriai vėžio gydymui
LTEPPCT/US2018/065187T LT3724191T (lt) 2017-12-15 2018-12-12 5-(2-(2,5-difluorofenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazol[1,5-a]pirimidino dariniai ir susiję junginiai kaip trk kinazės inhibitoriai, skirti vėžiui gydyti

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2018/065187T LT3724191T (lt) 2017-12-15 2018-12-12 5-(2-(2,5-difluorofenil)pirolidin-1-il)-3-(1h-pirazol-1-il)pirazol[1,5-a]pirimidino dariniai ir susiję junginiai kaip trk kinazės inhibitoriai, skirti vėžiui gydyti

Country Status (27)

Country Link
US (4) US11230546B2 (lt)
EP (2) EP3724191B9 (lt)
JP (1) JP7321183B2 (lt)
KR (1) KR102738182B1 (lt)
CN (1) CN111819179B (lt)
AU (1) AU2018383571B2 (lt)
BR (1) BR112020011775A2 (lt)
CA (1) CA3084814A1 (lt)
DK (2) DK4053128T3 (lt)
EA (1) EA202091475A1 (lt)
ES (2) ES2908773T3 (lt)
FI (1) FI4053128T3 (lt)
HR (2) HRP20241426T1 (lt)
HU (2) HUE069285T2 (lt)
IL (1) IL275059B2 (lt)
LT (2) LT4053128T (lt)
MX (1) MX2020006293A (lt)
PL (2) PL4053128T3 (lt)
PT (2) PT4053128T (lt)
RS (1) RS66124B1 (lt)
SA (1) SA520412192B1 (lt)
SG (1) SG11202005237SA (lt)
SI (2) SI3724191T1 (lt)
SM (1) SMT202400435T1 (lt)
TW (1) TWI848925B (lt)
WO (1) WO2019118584A1 (lt)
ZA (2) ZA202003483B (lt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL275059B2 (en) 2017-12-15 2023-11-01 Pyramid Biosciences Inc 5-(2-(5,2-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-1-yl)pyrazolo[5,1-A]pyrimidine derivatives and related compounds as TRK kinase inhibitors for cancer therapy
GB201813791D0 (en) * 2018-08-23 2018-10-10 Benevolental Bio Ltd Organic compounds
AU2020242735B2 (en) * 2019-03-19 2022-12-01 Central China Normal University Pyrazolopyrimidine compound, pharmaceutical composition, and application therefor
CN111718350B (zh) * 2019-03-19 2021-04-13 华中师范大学 吡唑取代的吡唑并嘧啶化合物和药物组合物及其应用
CN111848626B (zh) * 2019-04-30 2021-11-30 江苏柯菲平医药股份有限公司 Trk激酶抑制剂及其用途
CN112979654B (zh) * 2019-12-16 2024-03-19 赛诺哈勃药业（成都）有限公司 杂芳基稠环化合物、其制备方法及应用
JP2023522841A (ja) * 2020-04-15 2023-06-01 ピラミッド バイオサイエンシズ インコーポレイテッド チロシン受容体キナーゼ阻害剤を調製する方法
CN114437077B (zh) * 2020-11-04 2024-01-30 浙江同源康医药股份有限公司 用作激酶抑制剂的化合物及其应用
CN114437075A (zh) * 2020-11-03 2022-05-06 上海瑶琪生物科技有限公司 用作ntrk激酶抑制剂的化合物及其应用
KR102541026B1 (ko) * 2020-11-11 2023-06-12 주식회사 한독 Trk 억제제 화합물의 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102056927B (zh) * 2008-05-13 2014-06-25 Irm责任有限公司 作为激酶抑制剂的稠合含氮杂环及其组合物
PT2725028T (pt) 2008-10-22 2016-08-31 Array Biopharma Inc Compostos de pirazolo[1,5-]pirimidina substituídos como intermediários na síntese de inibidores de cinase trk
RU2539568C2 (ru) 2008-10-31 2015-01-20 Дженентек, Инк. Пиразолопиримидиновые соединения-ингибиторы jak и способы
WO2010118207A1 (en) * 2009-04-09 2010-10-14 Schering Corporation Pyrazolo [1, 5-a] pyrimidine derivatives as mtor inhibitors
WO2012034095A1 (en) * 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
WO2012125668A1 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
NZ630721A (en) 2012-03-09 2016-12-23 Lexicon Pharmaceuticals Inc Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
US20140288043A1 (en) * 2013-03-19 2014-09-25 Genentech, Inc. Pyrazolopyridine compounds
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
FR3029769A1 (fr) * 2014-12-10 2016-06-17 Tornier Sa Kit pour une prothese d'epaule
EP3233863B1 (en) * 2014-12-15 2024-04-10 CMG Pharmaceutical Co., Ltd. Fused ring heteroaryl compounds and their use as trk inhibitors
TWI770525B (zh) 2014-12-30 2022-07-11 美商瓦洛健康公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
JP6475084B2 (ja) 2015-05-21 2019-02-27 臼井国際産業株式会社 トルクセンサ用シャフトの製造設備およびその製造方法
IL275059B2 (en) 2017-12-15 2023-11-01 Pyramid Biosciences Inc 5-(2-(5,2-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-1-yl)pyrazolo[5,1-A]pyrimidine derivatives and related compounds as TRK kinase inhibitors for cancer therapy
JP2023522841A (ja) 2020-04-15 2023-06-01 ピラミッド バイオサイエンシズ インコーポレイテッド チロシン受容体キナーゼ阻害剤を調製する方法

Also Published As

Publication number Publication date
IL275059B1 (en) 2023-07-01
WO2019118584A1 (en) 2019-06-20
RS66124B1 (sr) 2024-11-29
HUE059313T2 (hu) 2022-11-28
EA202091475A1 (ru) 2020-09-09
EP3724191B1 (en) 2022-01-26
EP3724191A1 (en) 2020-10-21
JP2021506954A (ja) 2021-02-22
DK4053128T3 (da) 2024-10-21
FI4053128T3 (fi) 2024-10-25
HRP20241426T1 (hr) 2024-12-20
PL4053128T3 (pl) 2025-01-27
DK3724191T3 (da) 2022-03-14
US20230124248A1 (en) 2023-04-20
US20220235055A1 (en) 2022-07-28
PL3724191T3 (pl) 2022-04-25
EP3724191B9 (en) 2022-05-18
LT3724191T (lt) 2022-04-25
CN111819179A (zh) 2020-10-23
CA3084814A1 (en) 2019-06-20
EP4053128B8 (en) 2024-10-02
PT4053128T (pt) 2024-10-15
TW201936194A (zh) 2019-09-16
KR20200099557A (ko) 2020-08-24
ES2992993T3 (en) 2024-12-20
ZA202205900B (en) 2023-11-29
ZA202003483B (en) 2023-01-25
HUE069285T2 (hu) 2025-02-28
IL275059B2 (en) 2023-11-01
TWI848925B (zh) 2024-07-21
CN111819179B (zh) 2023-09-01
ES2908773T3 (es) 2022-05-03
PT3724191T (pt) 2022-03-07
AU2018383571B2 (en) 2023-09-21
EP4053128A1 (en) 2022-09-07
US20240246976A1 (en) 2024-07-25
MX2020006293A (es) 2020-12-03
HRP20220464T1 (hr) 2022-05-27
US11230546B2 (en) 2022-01-25
SI3724191T1 (sl) 2022-06-30
IL275059A (en) 2020-07-30
EP4053128B1 (en) 2024-08-21
US20210094956A1 (en) 2021-04-01
SI4053128T1 (sl) 2025-03-31
AU2018383571A1 (en) 2020-06-18
JP7321183B2 (ja) 2023-08-04
SA520412192B1 (ar) 2022-08-11
US11739096B2 (en) 2023-08-29
SMT202400435T1 (it) 2025-01-14
BR112020011775A2 (pt) 2020-11-17
SG11202005237SA (en) 2020-07-29
KR102738182B1 (ko) 2024-12-03

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