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LT3918B - 2,4- and 2,5- substituted pyridin-n-oxides, methods for the production thereof, pharmaceutical compositions and preparation the same - Google Patents

2,4- and 2,5- substituted pyridin-n-oxides, methods for the production thereof, pharmaceutical compositions and preparation the same Download PDF

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Publication number
LT3918B
LT3918B LTIP1464A LTIP1464A LT3918B LT 3918 B LT3918 B LT 3918B LT IP1464 A LTIP1464 A LT IP1464A LT IP1464 A LTIP1464 A LT IP1464A LT 3918 B LT3918 B LT 3918B
Authority
LT
Lithuania
Prior art keywords
same
different
alkyl
formula
phenyl
Prior art date
Application number
LTIP1464A
Other languages
English (en)
Lithuanian (lt)
Inventor
Ekkehard Baader
Martin Bickel
Volkmar Guenzler-Pukall
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of LTIP1464A publication Critical patent/LTIP1464A/xx
Publication of LT3918B publication Critical patent/LT3918B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
LTIP1464A 1990-06-28 1993-11-12 2,4- and 2,5- substituted pyridin-n-oxides, methods for the production thereof, pharmaceutical compositions and preparation the same LT3918B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4020570A DE4020570A1 (de) 1990-06-28 1990-06-28 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung

Publications (2)

Publication Number Publication Date
LTIP1464A LTIP1464A (en) 1995-05-25
LT3918B true LT3918B (en) 1996-04-25

Family

ID=6409247

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1464A LT3918B (en) 1990-06-28 1993-11-12 2,4- and 2,5- substituted pyridin-n-oxides, methods for the production thereof, pharmaceutical compositions and preparation the same

Country Status (27)

Country Link
EP (1) EP0463592B1 (no)
JP (1) JPH0832687B2 (no)
KR (1) KR920000724A (no)
CN (1) CN1038585C (no)
AT (1) ATE110059T1 (no)
AU (1) AU636990B2 (no)
BR (1) BR9102699A (no)
CA (1) CA2045868A1 (no)
CZ (1) CZ283782B6 (no)
DE (2) DE4020570A1 (no)
DK (1) DK0463592T3 (no)
EG (1) EG19851A (no)
ES (1) ES2061118T3 (no)
FI (1) FI101070B (no)
HR (1) HRP940701B1 (no)
HU (1) HU214627B (no)
IE (1) IE65300B1 (no)
IL (1) IL98629A (no)
LT (1) LT3918B (no)
MA (1) MA22191A1 (no)
MX (1) MX26415A (no)
MY (1) MY107573A (no)
NO (1) NO178026C (no)
NZ (1) NZ238701A (no)
PT (1) PT98108B (no)
YU (1) YU113391A (no)
ZA (1) ZA914958B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
TW222585B (no) * 1992-09-11 1994-04-21 Hoechst Ag
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19624704A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalkansäureamide
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
FR2766187B1 (fr) 1997-07-17 2000-06-02 Rhone Poulenc Rorer Sa Derives de pyrazine, leur preparation et les medicaments les contenant
DE19756261A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756212A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
DOP2002000332A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
WO2002064571A1 (en) 2001-02-14 2002-08-22 Warner-Lambert Company Llc Pyrimidine matrix metalloproteinase inhibitors
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
JP4164028B2 (ja) 2001-10-12 2008-10-08 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アルキンマトリックスメタロプロテイナーゼ阻害剤
DE10160357A1 (de) * 2001-12-08 2003-06-18 Aventis Pharma Gmbh Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen
US6933298B2 (en) 2001-12-08 2005-08-23 Aventis Pharma Deutschland Gmbh Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5328175A (en) 1976-08-27 1978-03-16 Chugai Pharmaceut Co Ltd Pyridine derivatives and their preparation
DE3432094A1 (de) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
DE3703962A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703959A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703963A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3826471A1 (de) 1988-08-04 1990-02-22 Hoechst Ag Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden
DE3924093A1 (de) 1989-07-20 1991-02-07 Hoechst Ag N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
DE4001002A1 (de) 1990-01-16 1991-07-18 Hoechst Ag Pyridin-2,4-und 2,5-dicarbonsaeuredi-(nitroxyalkyl)amide, verfahren zu ihrer herstellung sowie deren verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5623987B2 (no) * 1972-02-04 1981-06-03
JPS57109792A (en) * 1980-12-26 1982-07-08 Banyu Pharmaceut Co Ltd Penicillin derivative and salt thereof
JP2512924B2 (ja) * 1987-01-21 1996-07-03 萬有製薬株式会社 育毛剤
JP2600786B2 (ja) * 1988-04-12 1997-04-16 萬有製薬株式会社 育毛剤

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5328175A (en) 1976-08-27 1978-03-16 Chugai Pharmaceut Co Ltd Pyridine derivatives and their preparation
DE3432094A1 (de) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
DE3703962A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703959A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703963A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3826471A1 (de) 1988-08-04 1990-02-22 Hoechst Ag Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden
DE3924093A1 (de) 1989-07-20 1991-02-07 Hoechst Ag N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
DE4001002A1 (de) 1990-01-16 1991-07-18 Hoechst Ag Pyridin-2,4-und 2,5-dicarbonsaeuredi-(nitroxyalkyl)amide, verfahren zu ihrer herstellung sowie deren verwendung

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
E. LNDSBERG: "Pyridine and its Derivatives, part 2", pages: 93
EIJI. OCHIAI: "RECENT JAPANESE WORK ON THE CHEMISTRY OF PYRIDINE 1-OXIDE AND RELATED COMPOUNDS", J. ORG. CHEM., 1953, pages 534, XP055088740, DOI: doi:10.1021/jo01133a010
HOOPER NM, TURNER AJ: "Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism", BIOCHEM J., 1987, pages 625 - 633
KARI MAJAMAA ET AL.: "The 2-oxoglutarate binding site of prolyl 4-hydroxylase", EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, pages 239 - 245
KELLEY J, NEWMAN RA, EVANS JN: "Bleomycin-induced pulmonary fibrosis in the rat. Prevention with an inhibitor of collagen synthesis", J LAB CLIN MED., 1980, pages 954, XP009178343
KIVIRIKKO KI, LAITINEN O, PROCKOP DJ.: "Modifications of a specific assay for hydroxyproline in urine", ANAL BIOCHEM., 1967, pages 249, XP024826742, DOI: doi:10.1016/0003-2697(67)90160-1
ROVILLER C.: "The liver, Experimental Toxic Injury of the Liver", pages: 335 - 476

Also Published As

Publication number Publication date
HUT59104A (en) 1992-04-28
FI913118A (fi) 1991-12-29
DK0463592T3 (da) 1994-12-19
CN1057649A (zh) 1992-01-08
MA22191A1 (fr) 1991-12-31
ES2061118T3 (es) 1994-12-01
JPH0832687B2 (ja) 1996-03-29
FI101070B (fi) 1998-04-15
IL98629A0 (en) 1992-07-15
NO178026C (no) 1996-01-10
KR920000724A (ko) 1992-01-29
AU636990B2 (en) 1993-05-13
NO912541D0 (no) 1991-06-27
MY107573A (en) 1996-04-30
NO178026B (no) 1995-10-02
CZ283782B6 (cs) 1998-06-17
BR9102699A (pt) 1992-02-04
EG19851A (en) 1996-10-31
IL98629A (en) 1996-05-14
EP0463592B1 (de) 1994-08-17
HU214627B (hu) 1998-04-28
HRP940701A2 (en) 1997-02-28
AU7935691A (en) 1992-01-02
YU113391A (sh) 1995-10-03
HU912158D0 (en) 1991-12-30
LTIP1464A (en) 1995-05-25
FI913118A0 (fi) 1991-06-26
IE912253A1 (en) 1992-01-01
CN1038585C (zh) 1998-06-03
DE4020570A1 (de) 1992-01-02
EP0463592A1 (de) 1992-01-02
JPH04230264A (ja) 1992-08-19
ATE110059T1 (de) 1994-09-15
NZ238701A (en) 1994-06-27
CS195991A3 (en) 1992-02-19
IE65300B1 (en) 1995-10-18
HRP940701B1 (en) 1999-08-31
MX26415A (es) 1993-05-01
PT98108B (pt) 1998-12-31
NO912541L (no) 1991-12-30
DE59102547D1 (de) 1994-09-22
ZA914958B (en) 1992-03-25
CA2045868A1 (en) 1991-12-29
PT98108A (pt) 1993-06-30

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Effective date: 20011112