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LT3768674T - Aminopirimidino dariniai kaip ctps1 inhibitoriai - Google Patents

Aminopirimidino dariniai kaip ctps1 inhibitoriai

Info

Publication number
LT3768674T
LT3768674T LTEPPCT/EP2019/057320T LTEP2019057320T LT3768674T LT 3768674 T LT3768674 T LT 3768674T LT EP2019057320 T LTEP2019057320 T LT EP2019057320T LT 3768674 T LT3768674 T LT 3768674T
Authority
LT
Lithuania
Prior art keywords
aminopyrimidine derivatives
ctps1 inhibitors
ctps1
inhibitors
aminopyrimidine
Prior art date
Application number
LTEPPCT/EP2019/057320T
Other languages
English (en)
Inventor
Abdul Quddus
Andrew Novak
David Cousin
Emma BLACKHAM
Geraint Jones
Joseph WRIGGLESWORTH
Lorna Duffy
Louise BIRCH
Pascal George
Saleh Ahmed
Original Assignee
Step Pharma S.A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP18163772.9A external-priority patent/EP3543232A1/en
Priority claimed from EP18175823.6A external-priority patent/EP3578551A1/en
Application filed by Step Pharma S.A.S. filed Critical Step Pharma S.A.S.
Priority claimed from PCT/EP2019/057320 external-priority patent/WO2019180244A1/en
Publication of LT3768674T publication Critical patent/LT3768674T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/76Nitrogen atoms to which a second hetero atom is attached
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTEPPCT/EP2019/057320T 2018-03-23 2019-03-22 Aminopirimidino dariniai kaip ctps1 inhibitoriai LT3768674T (lt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP18163772.9A EP3543232A1 (en) 2018-03-23 2018-03-23 Aminopyrimidine derivatives as ctps1 inhibitors
EP18175823.6A EP3578551A1 (en) 2018-06-04 2018-06-04 Sulfonamide derivatives
EP18202136 2018-10-23
PCT/EP2018/086617 WO2019179652A1 (en) 2018-03-23 2018-12-21 Aminopyrimidine derivatives as ctps1 inhibitors
PCT/EP2019/057320 WO2019180244A1 (en) 2018-03-23 2019-03-22 Aminopyrimidine derivatives as ctps1 inhibitors

Publications (1)

Publication Number Publication Date
LT3768674T true LT3768674T (lt) 2024-04-25

Family

ID=64949297

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2019/057320T LT3768674T (lt) 2018-03-23 2019-03-22 Aminopirimidino dariniai kaip ctps1 inhibitoriai

Country Status (22)

Country Link
US (1) US20210024507A1 (lt)
EP (1) EP3768674B1 (lt)
JP (2) JP7428692B2 (lt)
KR (1) KR102735169B1 (lt)
CN (1) CN111868051B (lt)
AU (1) AU2018413791B2 (lt)
BR (1) BR112020018701A2 (lt)
CA (1) CA3093050A1 (lt)
DK (1) DK3768674T3 (lt)
EA (1) EA202092263A1 (lt)
ES (1) ES2974445T3 (lt)
FI (1) FI3768674T3 (lt)
HR (1) HRP20240375T8 (lt)
HU (1) HUE066693T2 (lt)
IL (1) IL277455B2 (lt)
LT (1) LT3768674T (lt)
MX (1) MX2020009887A (lt)
PH (1) PH12020500655A1 (lt)
PL (1) PL3768674T3 (lt)
SG (1) SG11202103238XA (lt)
SI (1) SI3768674T1 (lt)
WO (1) WO2019179652A1 (lt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3717459A1 (en) 2017-11-30 2020-10-07 Step Pharma S.A.S. Compounds
EP3717465A1 (en) 2017-11-30 2020-10-07 Step Pharma S.A.S. Compounds
WO2020083975A1 (en) * 2018-10-23 2020-04-30 Step Pharma S.A.S. Aminopyrimidine/pyrazine derivatives as ctps1 inhibitors
WO2020245665A1 (en) 2019-06-04 2020-12-10 Step Pharma S.A.S. N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl) butanamide derivatives and related compounds as human ctps1 inhibitors for the treatment of proliferative diseases
US20220324837A1 (en) * 2019-06-04 2022-10-13 Step Pharma S.A.S. N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2H-pyran-4-carboxamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases
US20230020663A1 (en) 2019-09-20 2023-01-19 Step Pharma S.A.S. Sulfonamide inhibitors as ctps1 inhibitors
WO2021053402A2 (en) 2019-09-20 2021-03-25 Step Pharma S.A.S. Compounds
JP2023546996A (ja) * 2020-10-23 2023-11-08 ニンバス クロソー, インコーポレイテッド Ctps1阻害剤およびその使用
WO2023166080A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination treatments comprising a ctps1 inhibitor and a wee1 inhibitor
WO2023166077A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination of a ctps1 inhibitor and a atr inhibitor in cancer therapy
WO2023166078A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination treatments comprising a ctps1 inhibitor and a chek1 inhibitor
EP4486347A1 (en) 2022-03-01 2025-01-08 Step Pharma S.A.S. Combinations of ctps1 and bcl2 inhibitors for cancer
WO2024133721A1 (en) 2022-12-21 2024-06-27 Step Pharma S.A.S. Combinations of ctps1 inhibitor with iap inhibitor for use in the treatment of cancer
WO2024133730A1 (en) 2022-12-21 2024-06-27 Step Pharma S.A.S. Ctps1 inhibitors for use in the treatment of ctps2 deficient cancer
CN118359588A (zh) * 2023-01-19 2024-07-19 杭州英创医药科技有限公司 作为ctps1抑制剂的化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR056871A1 (es) * 2005-10-04 2007-10-31 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
KR100928203B1 (ko) * 2007-12-10 2009-11-25 한국전자통신연구원 실리콘 바이오 센서 및 그의 제조 방법
AU2008335709A1 (en) * 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
KR101097312B1 (ko) * 2009-08-10 2011-12-23 삼성모바일디스플레이주식회사 유기 발광 소자
JP2016523818A (ja) * 2013-04-18 2016-08-12 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル それを必要とする被験体におけるt細胞増殖を阻害するための方法及び医薬組成物(ctps1阻害剤、例えばノルロイシン)
GB201322333D0 (en) * 2013-12-17 2014-01-29 Agency Science Tech & Res WNT pathway modulators
WO2015170435A1 (ja) * 2014-05-09 2015-11-12 パナソニック インテレクチュアル プロパティ コーポレーション オブ アメリカ 端末、基地局、送信方法及び受信方法
WO2016016370A1 (en) * 2014-07-31 2016-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Flt3 receptor antagonists

Also Published As

Publication number Publication date
HRP20240375T1 (hr) 2024-06-07
PH12020500655A1 (en) 2021-06-21
JP2021518436A (ja) 2021-08-02
IL277455B2 (en) 2024-05-01
JP7428692B2 (ja) 2024-02-06
EA202092263A1 (ru) 2021-01-15
SG11202103238XA (en) 2021-04-29
ES2974445T3 (es) 2024-06-27
FI3768674T3 (fi) 2024-04-02
BR112020018701A2 (pt) 2020-12-29
HUE066693T2 (hu) 2024-08-28
MX2020009887A (es) 2020-10-12
EP3768674A1 (en) 2021-01-27
SI3768674T1 (sl) 2024-05-31
DK3768674T3 (da) 2024-02-19
HRP20240375T8 (hr) 2024-06-21
AU2018413791B2 (en) 2023-05-18
IL277455A (en) 2020-11-30
WO2019179652A1 (en) 2019-09-26
US20210024507A1 (en) 2021-01-28
AU2018413791A1 (en) 2020-09-17
CN111868051B (zh) 2024-04-09
KR20200135463A (ko) 2020-12-02
KR102735169B1 (ko) 2024-11-26
EP3768674B1 (en) 2024-01-03
PL3768674T3 (pl) 2024-04-29
IL277455B1 (en) 2024-01-01
JP2024020222A (ja) 2024-02-14
CA3093050A1 (en) 2019-09-26
CN111868051A (zh) 2020-10-30

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