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LT3548B - Novel esters, method for the preparation thereof and pharmaceutical composition - Google Patents

Novel esters, method for the preparation thereof and pharmaceutical composition Download PDF

Info

Publication number
LT3548B
LT3548B LTIP603A LTIP603A LT3548B LT 3548 B LT3548 B LT 3548B LT IP603 A LTIP603 A LT IP603A LT IP603 A LTIP603 A LT IP603A LT 3548 B LT3548 B LT 3548B
Authority
LT
Lithuania
Prior art keywords
estramastine
compounds
general formula
hydrogen
methylaminoacetate
Prior art date
Application number
LTIP603A
Other languages
English (en)
Lithuanian (lt)
Inventor
Bertil Hansen
Per Olov Gunnarsson
Rene Mollberg
Sven-Aake Johansson
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Publication of LTIP603A publication Critical patent/LTIP603A/xx
Publication of LT3548B publication Critical patent/LT3548B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/46—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LTIP603A 1988-06-28 1993-06-02 Novel esters, method for the preparation thereof and pharmaceutical composition LT3548B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8802402A SE8802402D0 (sv) 1988-06-28 1988-06-28 Novel esters

Publications (2)

Publication Number Publication Date
LTIP603A LTIP603A (en) 1995-01-31
LT3548B true LT3548B (en) 1995-11-27

Family

ID=20372746

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP603A LT3548B (en) 1988-06-28 1993-06-02 Novel esters, method for the preparation thereof and pharmaceutical composition

Country Status (25)

Country Link
US (1) US5036062A (pt)
EP (1) EP0351561B1 (pt)
JP (1) JP2563587B2 (pt)
KR (1) KR910000607A (pt)
CN (1) CN1031060C (pt)
AT (1) ATE96446T1 (pt)
CA (1) CA1317587C (pt)
DD (1) DD284026A5 (pt)
DE (1) DE68910211T2 (pt)
DK (1) DK318989A (pt)
ES (1) ES2059626T3 (pt)
FI (1) FI92707C (pt)
HU (1) HU203766B (pt)
IE (1) IE62462B1 (pt)
IL (1) IL90724A0 (pt)
LT (1) LT3548B (pt)
LV (1) LV10235B (pt)
MD (1) MD940402A (pt)
NO (1) NO172939C (pt)
NZ (1) NZ229649A (pt)
PH (1) PH30437A (pt)
PT (1) PT90986B (pt)
RU (1) RU2036929C1 (pt)
SE (1) SE8802402D0 (pt)
ZA (1) ZA894716B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5209926A (en) * 1990-06-12 1993-05-11 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5256408A (en) * 1990-06-12 1993-10-26 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5252319A (en) * 1990-06-12 1993-10-12 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
JP2520074B2 (ja) * 1992-06-11 1996-07-31 呉羽化学工業株式会社 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤
JPH07101977A (ja) * 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
FR2717690B1 (fr) * 1994-03-24 1996-04-26 Roussel Uclaf Application de stéroïdes aromatiques 3 substitués par un aminoalcoxy substitué à l'obtention d'un médicament pour contrôler la stérilité, notamment masculine.
GB9419153D0 (en) * 1994-09-22 1994-11-09 Erba Carlo Spa Estramustine formulations with improved pharmaceutical properties
US20030108764A1 (en) * 2001-12-04 2003-06-12 Neill John Thomas Method for improving bonding of circuit board substrates to metal surfaces and the articles formed thereby
CN101463295B (zh) * 2008-11-28 2011-08-17 江苏海迅实业集团股份有限公司 半导体工业用清洗剂
PE20160655A1 (es) 2013-07-11 2016-07-08 Evestra Inc Profarmacos de formacion de compuestos
EP3697421B1 (en) 2017-10-19 2024-04-17 Evestra, Inc. Longer-acting progestin prodrug contraceptives
CN112979744B (zh) * 2021-02-18 2022-02-15 齐齐哈尔医学院 具有抗肿瘤活性的薯蓣皂苷元拼合氮芥衍生物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB962797A (en) 1959-11-14 1964-07-01 Hoechst Ag Steroid-21-amino-acid esters and process for their manufacture
US3299104A (en) 1963-04-09 1967-01-17 Leo Ab Certain steroid nu-bis-(haloethyl)-carbamates
EP0104746A1 (en) 1982-08-30 1984-04-04 The Upjohn Company 21-Hydroxycorticosteroid esters, and compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4615835A (en) * 1983-11-17 1986-10-07 Stiftung Deutsches Krebsforschungs Zentrum Steroid esters of N-(2-halogenethyl)-N-nitroso-carbamoylamino and acids and peptides therefore, as well as method for preparing them
JPS617292A (ja) * 1984-06-20 1986-01-13 Japan Atom Energy Res Inst 制癌剤を結合させたエストラサイト系化合物を製造する方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB962797A (en) 1959-11-14 1964-07-01 Hoechst Ag Steroid-21-amino-acid esters and process for their manufacture
US3299104A (en) 1963-04-09 1967-01-17 Leo Ab Certain steroid nu-bis-(haloethyl)-carbamates
EP0104746A1 (en) 1982-08-30 1984-04-04 The Upjohn Company 21-Hydroxycorticosteroid esters, and compositions containing them

Also Published As

Publication number Publication date
DE68910211T2 (de) 1994-05-11
PT90986B (pt) 1994-11-30
LV10235A (lv) 1994-10-20
US5036062A (en) 1991-07-30
NO892672D0 (no) 1989-06-27
KR910000607A (ko) 1991-01-29
LTIP603A (en) 1995-01-31
FI92707B (fi) 1994-09-15
JP2563587B2 (ja) 1996-12-11
JPH0253795A (ja) 1990-02-22
NO172939B (no) 1993-06-21
FI92707C (fi) 1994-12-27
AU3668289A (en) 1990-01-04
SE8802402D0 (sv) 1988-06-28
NZ229649A (en) 1991-12-23
IE62462B1 (en) 1995-02-08
HU203766B (en) 1991-09-30
NO172939C (no) 1993-09-29
EP0351561B1 (en) 1993-10-27
ATE96446T1 (de) 1993-11-15
ZA894716B (en) 1990-03-28
PH30437A (en) 1997-05-09
FI893130A0 (fi) 1989-06-27
MD940402A (ro) 1996-01-31
DE68910211D1 (de) 1993-12-02
EP0351561A1 (en) 1990-01-24
CA1317587C (en) 1993-05-11
IL90724A0 (en) 1990-01-18
PT90986A (pt) 1989-12-29
CN1045792A (zh) 1990-10-03
AU607621B2 (en) 1991-03-07
FI893130A (fi) 1989-12-29
ES2059626T3 (es) 1994-11-16
IE891908L (en) 1989-12-28
NO892672L (no) 1989-12-29
HUT52521A (en) 1990-07-28
LV10235B (en) 1995-04-20
DK318989D0 (da) 1989-06-27
DD284026A5 (de) 1990-10-31
DK318989A (da) 1989-12-29
CN1031060C (zh) 1996-02-21
RU2036929C1 (ru) 1995-06-09

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Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19970602