LT3196194T - Pirimidino dariniai, tinkami naudoti kaip selektyvūs jak3 ir (arba) jak1 inhibitoriai - Google Patents
Pirimidino dariniai, tinkami naudoti kaip selektyvūs jak3 ir (arba) jak1 inhibitoriaiInfo
- Publication number
- LT3196194T LT3196194T LTEP15842179.2T LT15842179T LT3196194T LT 3196194 T LT3196194 T LT 3196194T LT 15842179 T LT15842179 T LT 15842179T LT 3196194 T LT3196194 T LT 3196194T
- Authority
- LT
- Lithuania
- Prior art keywords
- jak1
- jak3
- pyrimidine derivatives
- selective inhibitors
- derivatives suitable
- Prior art date
Links
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 title 1
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 title 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 title 1
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410471468.9A CN105399685B (zh) | 2014-09-16 | 2014-09-16 | 作为选择性jak3和/或jak1激酶抑制剂的芳杂环化合物的制备方法及其应用 |
PCT/CN2015/089499 WO2016041472A1 (zh) | 2014-09-16 | 2015-09-14 | 作为选择性jak3和/或jak1激酶抑制剂的芳杂环化合物的制备方法及其应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
LT3196194T true LT3196194T (lt) | 2019-10-10 |
Family
ID=55465491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP15842179.2T LT3196194T (lt) | 2014-09-16 | 2015-09-14 | Pirimidino dariniai, tinkami naudoti kaip selektyvūs jak3 ir (arba) jak1 inhibitoriai |
Country Status (23)
Country | Link |
---|---|
US (1) | US10011571B2 (lt) |
EP (1) | EP3196194B1 (lt) |
JP (1) | JP6516305B2 (lt) |
KR (1) | KR101971887B1 (lt) |
CN (1) | CN105399685B (lt) |
AU (1) | AU2015317937B2 (lt) |
BR (1) | BR112017005113B1 (lt) |
CA (1) | CA2982881C (lt) |
CY (1) | CY1122423T1 (lt) |
DK (1) | DK3196194T3 (lt) |
ES (1) | ES2754403T3 (lt) |
HK (1) | HK1220975A1 (lt) |
HR (1) | HRP20191734T1 (lt) |
HU (1) | HUE045899T2 (lt) |
LT (1) | LT3196194T (lt) |
PL (1) | PL3196194T3 (lt) |
PT (1) | PT3196194T (lt) |
RS (1) | RS59467B1 (lt) |
RU (1) | RU2671195C2 (lt) |
SI (1) | SI3196194T1 (lt) |
SM (1) | SMT201900605T1 (lt) |
TW (1) | TWI570109B (lt) |
WO (1) | WO2016041472A1 (lt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3983081A1 (en) | 2019-06-17 | 2022-04-20 | Deciphera Pharmaceuticals, LLC | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
CA3146693A1 (en) * | 2019-08-02 | 2021-02-11 | Amgen Inc. | Kif18a inhibitors |
US20220387430A1 (en) * | 2019-11-08 | 2022-12-08 | Shenzhen Chipscreen Biosciences, Co., Ltd. | Use of compound in preventing or treating graft versus host disease |
CA3162886A1 (en) * | 2019-11-26 | 2021-06-03 | Shenzhen Chipscreen Biosciences Co., Ltd. | Composition containing aromatic heterocyclic compound in amorphous form, and preparation method therefor and use thereof |
CN111297866B (zh) * | 2020-03-09 | 2021-04-02 | 深圳微芯生物科技股份有限公司 | 一种包含jak3/jak1/tbk1抑制剂和甲氨蝶呤的药物组合物及其用途 |
CN117136059A (zh) * | 2021-04-22 | 2023-11-28 | 深圳微芯生物科技股份有限公司 | 包含jak3/jak1/tbk1选择性抑制剂的药物组合物及其医药用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2502970A1 (en) | 2002-11-28 | 2004-06-10 | Schering Aktiengesellschaft | Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
CN101421250A (zh) * | 2006-01-30 | 2009-04-29 | 埃克塞里艾克西斯公司 | 作为jak-2调节剂的4-芳基-2-氨基-嘧啶或4-芳基-2-氨基烷基-嘧啶及包含它们的药物组合物 |
DE602007012363D1 (de) * | 2006-10-19 | 2011-03-17 | Rigel Pharmaceuticals Inc | 2,4-pyridimediamon-derivate als hemmer von jak-kinasen zur behandlung von autoimmunerkrankungen |
WO2008092199A1 (en) * | 2007-01-31 | 2008-08-07 | Cytopia Research Pty Ltd | Thiopyrimidine-based compounds and uses thereof |
US8338439B2 (en) * | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
EP3549934A1 (en) * | 2008-06-27 | 2019-10-09 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
DE102009001438A1 (de) * | 2009-03-10 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Carbonylamino-substituierte Anilino-Pyrimidinderivate als Tyk-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
CN101906076B (zh) * | 2009-06-04 | 2013-03-13 | 深圳微芯生物科技有限责任公司 | 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用 |
CN103073508B (zh) * | 2011-10-25 | 2016-06-01 | 北京大学深圳研究生院 | 激酶抑制剂及治疗相关疾病的方法 |
CN104109127B (zh) * | 2013-04-19 | 2019-11-05 | 北京大学深圳研究生院 | 激酶抑制剂及治疗相关疾病的方法 |
-
2014
- 2014-09-16 CN CN201410471468.9A patent/CN105399685B/zh active Active
-
2015
- 2015-09-14 PT PT158421792T patent/PT3196194T/pt unknown
- 2015-09-14 PL PL15842179T patent/PL3196194T3/pl unknown
- 2015-09-14 SI SI201530965T patent/SI3196194T1/sl unknown
- 2015-09-14 AU AU2015317937A patent/AU2015317937B2/en active Active
- 2015-09-14 SM SM20190605T patent/SMT201900605T1/it unknown
- 2015-09-14 US US15/510,758 patent/US10011571B2/en active Active
- 2015-09-14 RU RU2017112299A patent/RU2671195C2/ru active
- 2015-09-14 WO PCT/CN2015/089499 patent/WO2016041472A1/zh active Application Filing
- 2015-09-14 JP JP2017533675A patent/JP6516305B2/ja active Active
- 2015-09-14 BR BR112017005113-3A patent/BR112017005113B1/pt active IP Right Grant
- 2015-09-14 HU HUE15842179A patent/HUE045899T2/hu unknown
- 2015-09-14 KR KR1020177009942A patent/KR101971887B1/ko active IP Right Grant
- 2015-09-14 EP EP15842179.2A patent/EP3196194B1/en active Active
- 2015-09-14 DK DK15842179T patent/DK3196194T3/da active
- 2015-09-14 LT LTEP15842179.2T patent/LT3196194T/lt unknown
- 2015-09-14 RS RSP20191336 patent/RS59467B1/sr unknown
- 2015-09-14 CA CA2982881A patent/CA2982881C/en active Active
- 2015-09-14 ES ES15842179T patent/ES2754403T3/es active Active
- 2015-09-15 TW TW104130419A patent/TWI570109B/zh active
-
2016
- 2016-08-01 HK HK16109126.0A patent/HK1220975A1/zh unknown
-
2019
- 2019-09-25 HR HRP20191734 patent/HRP20191734T1/hr unknown
- 2019-10-25 CY CY20191101116T patent/CY1122423T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL286428A (en) | Disubstituted heterocyclyl derivatives as inhibitors of cyclin-dependent kinases | |
IL247949A0 (en) | New histories of pyrazolopyrimidines and their use as malt1 inhibitors | |
LT3461821T (lt) | Indolo karboksamido junginiai, naudotini kaip kinazės inhibitoriai | |
LT3121175T (lt) | 1,3-benzodioksazolo dariniai, kaip ezh1 ir (arba) ezh2 inhibitoriai | |
PL3218378T3 (pl) | Pochodne 6-amino-7-bicyklo-7-deazapuryny jako inhibitory kinaz białkowych | |
DK3183254T3 (da) | Nye spiro[3h-indol-3,2 ?-pyrrolidin]-2(1h)-one forbindelser og derivater som mdm2-p53 inhibitorer | |
DK3356345T3 (da) | Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer | |
HK1246667A1 (zh) | 作為jak抑制劑的2-(吡唑並吡啶-3-基)嘧啶衍生物 | |
PL3092227T3 (pl) | Bicykliczne pochodne heterocykliczne jako inhibitory bromodomeny | |
DK3227297T3 (da) | 4,6-substitueret-pyrazolo[1,5-a]pyraziner som janus kinase-inhibitorer | |
ZA201708568B (en) | Pyrimidine derivatives as btk inhibitors and uses thereof | |
LT3196194T (lt) | Pirimidino dariniai, tinkami naudoti kaip selektyvūs jak3 ir (arba) jak1 inhibitoriai | |
IL304547A (en) | 3-substituted benzamide derivatives as kinase inhibitors | |
ZA201808014B (en) | Adenine derivatives as protein kinase inhibitors | |
DK3310784T3 (da) | Tricykliske forbindelser og deres anvendelse som phosphodiesterasehæmmere | |
LT3113778T (lt) | Piridazino dariniai, skirti naudoti ataksinio sutrikimo profilaktikai arba gydymui | |
PL3200786T3 (pl) | Zastosowanie pochodnych pirydylowych o skondensowanym układzie bicyklicznym jako inhibitorów fgfr4 | |
HK1252767A1 (zh) | 作為eaat3抑制劑的吡唑-吡啶衍生物 | |
BR112017018183A2 (pt) | derivados de pirimidina como inibidores de quinase e suas aplicações terapêuticas. | |
IL258690A (en) | Pyridone derivatives and their use as kinase inhibitors | |
PT3484875T (pt) | Derivados de pirazolilaminobenzimidazol como inibidores de jak | |
TH1501005718A (th) | อนุพันธ์ 6-(5-ไฮดรอกซี-1เอช-ไพราซอล-1-อิล)นิโคตินเอไมด์และการใช้เป็นสารยับยั้ง phd |