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LT2001045A - Compositions and use thereof for downmodulating the immune response to therapeutic proteins - Google Patents

Compositions and use thereof for downmodulating the immune response to therapeutic proteins

Info

Publication number
LT2001045A
LT2001045A LT2001045A LT2001045A LT2001045A LT 2001045 A LT2001045 A LT 2001045A LT 2001045 A LT2001045 A LT 2001045A LT 2001045 A LT2001045 A LT 2001045A LT 2001045 A LT2001045 A LT 2001045A
Authority
LT
Lithuania
Prior art keywords
therapeutic proteins
compositions
downmodulating
immune response
agents
Prior art date
Application number
LT2001045A
Other languages
Lithuanian (lt)
Other versions
LT4920B (en
Inventor
Jiahua Qian
Leon W. Hoyer
Mary Collins
Gary S. Gray
Original Assignee
Genetics Institute,Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute,Inc. filed Critical Genetics Institute,Inc.
Publication of LT2001045A publication Critical patent/LT2001045A/en
Publication of LT4920B publication Critical patent/LT4920B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to compositions for treating a hemostatic disorder using agents which promote hemostasis and agents which inhibit a costimulatory signal in a T cell are provided. The instant compositions enable the treatment of hemostatic disorders using foreign therapeutic proteins, while downmodulating immune responses to the therapeutic proteins.
LT2001045A 1998-09-21 2001-04-20 Compositions and use thereof for downmodulating the immune response to therapeutic proteins LT4920B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15817898A 1998-09-21 1998-09-21

Publications (2)

Publication Number Publication Date
LT2001045A true LT2001045A (en) 2002-01-25
LT4920B LT4920B (en) 2002-06-25

Family

ID=22566971

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2001045A LT4920B (en) 1998-09-21 2001-04-20 Compositions and use thereof for downmodulating the immune response to therapeutic proteins

Country Status (21)

Country Link
EP (1) EP1115423A1 (en)
JP (1) JP2002526455A (en)
KR (1) KR20010085830A (en)
CN (1) CN1331602A (en)
AU (1) AU761206B2 (en)
BR (1) BR9913991A (en)
CA (1) CA2343916A1 (en)
CZ (1) CZ20011021A3 (en)
EA (1) EA005236B1 (en)
HK (1) HK1039059A1 (en)
HU (1) HUP0103960A3 (en)
IL (1) IL142069A0 (en)
LT (1) LT4920B (en)
LV (1) LV12768B (en)
MX (1) MXPA01002898A (en)
NO (1) NO20011412L (en)
NZ (1) NZ511034A (en)
PL (1) PL346796A1 (en)
SI (1) SI20626A (en)
WO (1) WO2000016801A1 (en)
ZA (1) ZA200103156B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5397703A (en) 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
EP1289552B1 (en) * 2000-05-19 2006-03-29 The Center for Blood Research, INC. Methods for treating hemostatic disorders by soluble p-selectin
EP1636579A4 (en) * 2003-06-10 2011-10-05 Smiths Detection Inc Sensor arrangement
GB201508024D0 (en) * 2015-05-11 2015-06-24 Haemostatix Ltd Haemostatic compositions

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171569A (en) 1985-03-15 1992-12-15 National Research Development Corporation Factor IX preparations uncontaminated by plasma components or pox virus
ATE72838T1 (en) 1985-04-12 1992-03-15 Genetics Inst NEW PROCOAGULATION PROTEINS.
US5422260A (en) 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US4994371A (en) 1987-08-28 1991-02-19 Davie Earl W DNA preparation of Christmas factor and use of DNA sequences
FR2657884B1 (en) 1990-02-05 1994-09-02 Tm Innovation PROCESS FOR THE PREPARATION OF HUMAN FACTOR VIII AND FACTOR VIII ANALOGS.
US5661008A (en) 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US5770197A (en) 1991-06-27 1998-06-23 Bristol-Myers Squibb Company Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
EP0606217B2 (en) 1991-06-27 2008-12-03 Bristol-Myers Squibb Company Ctl4a receptor, fusion proteins containing it and uses thereof
WO1993009804A1 (en) 1991-11-18 1993-05-27 The Scripps Research Institute Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation
US5744446A (en) 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
US5663060A (en) 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5364771A (en) 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
EP0776217A1 (en) * 1994-08-19 1997-06-04 Novo Nordisk A/S A method of treating a patient with a biologically active compound
EP0804076A4 (en) * 1994-10-19 1998-10-21 Genetic Therapy Inc Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
DE69713499T3 (en) * 1996-03-20 2010-05-06 Bristol-Myers Squibb Co., Seattle PROCEDURE FOR INHIBITING THE IMMUNE REACTION BY BLOCKING THE GP39 / CD40 AND CTLA4 / CD28 / B7 ROUTES AND COMPOSITION TO THEIR USE
KR20000070035A (en) * 1997-01-10 2000-11-25 아스트루 마이클 제이 Methods Of Therapeutic Administration of Anti-CD40L Compounds
KR100567998B1 (en) * 1997-06-20 2006-04-07 바이오겐 아이덱 엠에이 인코포레이티드 CD154 blockade therapy for therapeutic protein inhibitor syndrome
US8099877B2 (en) 2009-11-06 2012-01-24 Hexagon Metrology Ab Enhanced position detection for a CMM

Also Published As

Publication number Publication date
IL142069A0 (en) 2002-03-10
NO20011412L (en) 2001-05-16
HUP0103960A3 (en) 2003-09-29
LV12768B (en) 2002-06-20
EA200100385A1 (en) 2001-10-22
MXPA01002898A (en) 2002-06-04
BR9913991A (en) 2001-07-03
AU761206B2 (en) 2003-05-29
WO2000016801A1 (en) 2000-03-30
NO20011412D0 (en) 2001-03-20
CZ20011021A3 (en) 2001-10-17
JP2002526455A (en) 2002-08-20
CN1331602A (en) 2002-01-16
KR20010085830A (en) 2001-09-07
LV12768A (en) 2001-12-20
CA2343916A1 (en) 2000-03-30
NZ511034A (en) 2004-03-26
AU6057899A (en) 2000-04-10
EA005236B1 (en) 2004-12-30
LT4920B (en) 2002-06-25
WO2000016801A9 (en) 2000-10-26
ZA200103156B (en) 2002-07-18
EP1115423A1 (en) 2001-07-18
HUP0103960A2 (en) 2002-02-28
PL346796A1 (en) 2002-02-25
SI20626A (en) 2002-02-28
HK1039059A1 (en) 2002-04-12

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Legal Events

Date Code Title Description
PD9A Change of patent owner

Owner name: AMERICAN RED CROSS, US

Free format text: FORMEROWNER: GENETICS INSTITUTE, LLC, US

Effective date: 20031223

MM9A Lapsed patents

Effective date: 20050921