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KR970706234A - 3, 4-디하이드록시-5-니트로벤즈알데히드의 신규 제조방법 - Google Patents

3, 4-디하이드록시-5-니트로벤즈알데히드의 신규 제조방법

Info

Publication number
KR970706234A
KR970706234A KR1019970701878A KR19970701878A KR970706234A KR 970706234 A KR970706234 A KR 970706234A KR 1019970701878 A KR1019970701878 A KR 1019970701878A KR 19970701878 A KR19970701878 A KR 19970701878A KR 970706234 A KR970706234 A KR 970706234A
Authority
KR
South Korea
Prior art keywords
nitrobenzaldehyde
zinc chloride
pct
ethoxy
hydroxy
Prior art date
Application number
KR1019970701878A
Other languages
English (en)
Other versions
KR100368163B1 (ko
Inventor
벡스트룀 레이조 요하네스
Original Assignee
카우코 쿠르켈라, 라이자 멘틸레
오리온-위티모 오위
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 카우코 쿠르켈라, 라이자 멘틸레, 오리온-위티모 오위 filed Critical 카우코 쿠르켈라, 라이자 멘틸레
Publication of KR970706234A publication Critical patent/KR970706234A/ko
Application granted granted Critical
Publication of KR100368163B1 publication Critical patent/KR100368163B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/16—Separation; Purification; Stabilisation; Use of additives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

본 발명은 염화아연, 물 및 염화수소로 이루어진 시약과 3-에폭시-4-하이드록시-5-니트로벤즈알데히드와의 반응에 의해 3,4-디하이드록시-5-니트로벤즈알데히드를 제조하는 방법을 제공한다.

Description

3,4-디하이드록시-5-니트로벤즈알데히드의 신규 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 3-에톡시-4-하이드록시-5-니트로벤즈알데히드를 염화아연, 물 및 염화수소로 이루어진 시약과 반응시키는 것을 특징으로 하는 3,4-디하이드록시-5-니트로벤즈알데히드를 제조하는 방법
  2. 제1항에 있어서, 염화아연의 양이 3-에톡시-4-하이드록시-5-니트로벤즈알데히드 1㎏당 1.5-25㎏인 것을 특징으로 하는 방법
  3. 제2항에 있어서, 염화아연의 양이 3-에톡시-4-하이드록시-5-니트로벤즈알데히드 1㎏당 2.5-4㎏인 것을 특징으로 하는 방법
  4. 제1항에 있어서, 상기 염산의 양이 염화아연 1㎏당 0.17-0.6L인 것을 특징으로 하는 방법
  5. 제4항에 있어서, 상기 염산의 양이 염화아연 1㎏당 0.22-0.4L인 것을 특징으로 하는 방법
  6. 제1항에 있어서, 상기 염산의 농도가 10-38%인 것을 특징으로 하는 방법
  7. 제6항에 있어서, 상기 염산의 농도가 20-40%인 것을 특징으로 하는 방법
  8. 제1항에 있어서, 상기 온도가 70-130℃인 것을 특징으로 하는 방법
  9. 제8항에 있어서, 상기 온도가 80-110℃인 것을 특징으로 하는 방법
  10. 제1항에 있어서, 조생성물(crude product) 을 톨루엔으로부터 더 결정화되는 것을 특징으로 하는 방법
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970701878A 1994-09-23 1995-05-22 3,4-디하이드록시-5-니트로벤즈알데히드의신규제조방법 KR100368163B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9419274.7 1994-09-23
GB9419274A GB9419274D0 (en) 1994-09-23 1994-09-23 New method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde

Publications (2)

Publication Number Publication Date
KR970706234A true KR970706234A (ko) 1997-11-03
KR100368163B1 KR100368163B1 (ko) 2003-03-26

Family

ID=10761838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970701878A KR100368163B1 (ko) 1994-09-23 1995-05-22 3,4-디하이드록시-5-니트로벤즈알데히드의신규제조방법

Country Status (28)

Country Link
US (1) US5710343A (ko)
EP (1) EP0782559B1 (ko)
JP (1) JP3717933B2 (ko)
KR (1) KR100368163B1 (ko)
CN (1) CN1064673C (ko)
AT (1) ATE175660T1 (ko)
AU (1) AU684672B2 (ko)
BG (1) BG61912B1 (ko)
BR (1) BR9508852A (ko)
CA (1) CA2200227C (ko)
CZ (1) CZ288684B6 (ko)
DE (1) DE69507309T2 (ko)
DK (1) DK0782559T3 (ko)
ES (1) ES2127552T3 (ko)
GB (1) GB9419274D0 (ko)
GR (1) GR3029815T3 (ko)
HU (1) HU224821B1 (ko)
IL (1) IL115122A (ko)
LV (1) LV11831B (ko)
MX (1) MX9702064A (ko)
NO (1) NO306670B1 (ko)
NZ (1) NZ292187A (ko)
PL (1) PL180016B1 (ko)
RO (1) RO119540B1 (ko)
RU (1) RU2130449C1 (ko)
SI (1) SI9520102A (ko)
SK (1) SK281789B6 (ko)
WO (1) WO1996009274A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419274D0 (en) * 1994-09-23 1994-11-09 Orion Yhtymae Oy New method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
EP2124947B1 (en) * 2007-01-31 2017-07-19 BIAL - Portela & Ca., S.A. Dosage regimen for comt inhibitors
EP2251323B1 (en) 2009-05-14 2014-04-23 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Method for the purification of entacapone
CN102633646B (zh) * 2012-04-10 2014-06-04 中国海洋大学 一种新的5-硝基水杨醛制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO107714C (ko) * 1961-06-21
FR1330382A (fr) * 1961-06-21 1963-06-21 Monsanto Chemicals Procédé de clivage des éthers d'alcoyle o-hydroxyphényle et de préparation simultanée de composés 1-alkyl-2,3-dihydroxyphényliques
US4213920A (en) * 1977-07-06 1980-07-22 Ciba-Geigy Corporation Process for the production of substituted benzaldehydes
DK175069B1 (da) * 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
DE4012008A1 (de) * 1990-04-13 1991-10-17 Bayer Ag Verfahren zur herstellung von o-hydroxy-benzaldehyden
GB9113431D0 (en) * 1991-06-20 1991-08-07 Orion Yhytma Oy Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
SG45426A1 (en) * 1991-12-12 1998-01-16 Roussel Uclaf Novel cephalosporins substituted in the 7-position by a benzylamino radical processes for their preparation and their use as medicaments
GB9419274D0 (en) * 1994-09-23 1994-11-09 Orion Yhtymae Oy New method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde

Also Published As

Publication number Publication date
SK37897A3 (en) 1997-11-05
DE69507309D1 (de) 1999-02-25
KR100368163B1 (ko) 2003-03-26
AU3390195A (en) 1996-04-09
DE69507309T2 (de) 1999-07-15
US5710343A (en) 1998-01-20
DK0782559T3 (da) 1999-08-30
ATE175660T1 (de) 1999-01-15
IL115122A0 (en) 1995-12-08
LV11831B (en) 1997-12-20
BG101309A (en) 1997-10-31
HUT77441A (hu) 1998-04-28
PL319348A1 (en) 1997-08-04
LV11831A (lv) 1997-08-20
NO306670B1 (no) 1999-12-06
CA2200227C (en) 2005-09-13
IL115122A (en) 1999-07-14
CN1164852A (zh) 1997-11-12
NO971325D0 (no) 1997-03-21
AU684672B2 (en) 1997-12-18
HU224821B1 (en) 2006-02-28
BG61912B1 (bg) 1998-09-30
CZ288684B6 (cs) 2001-08-15
RU2130449C1 (ru) 1999-05-20
SI9520102A (en) 1997-08-31
CA2200227A1 (en) 1996-03-28
EP0782559B1 (en) 1999-01-13
BR9508852A (pt) 1999-05-04
CN1064673C (zh) 2001-04-18
EP0782559A1 (en) 1997-07-09
PL180016B1 (en) 2000-11-30
NO971325L (no) 1997-03-21
SK281789B6 (sk) 2001-08-06
CZ80097A3 (cs) 1998-03-18
RO119540B1 (ro) 2004-12-30
ES2127552T3 (es) 1999-04-16
GR3029815T3 (en) 1999-06-30
NZ292187A (en) 1997-12-19
JP3717933B2 (ja) 2005-11-16
MX9702064A (es) 1997-10-31
JPH10505849A (ja) 1998-06-09
GB9419274D0 (en) 1994-11-09
WO1996009274A1 (en) 1996-03-28

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