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KR970042523A - Biphenyl derivative, preparation method thereof and pharmaceutical composition containing same - Google Patents

Biphenyl derivative, preparation method thereof and pharmaceutical composition containing same Download PDF

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Publication number
KR970042523A
KR970042523A KR1019950072319A KR19950072319A KR970042523A KR 970042523 A KR970042523 A KR 970042523A KR 1019950072319 A KR1019950072319 A KR 1019950072319A KR 19950072319 A KR19950072319 A KR 19950072319A KR 970042523 A KR970042523 A KR 970042523A
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KR
South Korea
Prior art keywords
pyridinyl
phenyl
alkyl
pharmaceutical composition
compound
Prior art date
Application number
KR1019950072319A
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Korean (ko)
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KR0181212B1 (en
Inventor
고동현
박성용
김종훈
이건호
정성목
안양수
Original Assignee
손경식
제일제당 주식회사
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Publication date
Application filed by 손경식, 제일제당 주식회사 filed Critical 손경식
Priority to KR1019950072319A priority Critical patent/KR0181212B1/en
Publication of KR970042523A publication Critical patent/KR970042523A/en
Application granted granted Critical
Publication of KR0181212B1 publication Critical patent/KR0181212B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. 청구범위에 기재되어 있는 발명이 속하는 기술분야 유기화합물 및 약학1. Organic compounds and pharmaceuticals in the technical field to which the invention described in the claims belong

2. 그 발명이 해결하고자 하는 기술분야 개선된 안지오텐신 Ⅱ길항제의 개발2. Development of an angiotensin II antagonist improved in the technical field to be solved by the present invention

3. 그 기술적 과제의 해결방법의 요지 하기 일반식(Ⅰ)로 표시되는 화합물(여기서, R1은 C1내지 C6알킬 이고, R2는 페닐, 피리디닐, 테트라졸릴 또는 이미다졸릴이고, 여기에서, 페닐 및 피니디닐은 비치환되거나, 할로겐원자, C1내지 C4알킬, 하이드록실 또는 C1내지 C4알콕시로 단일 치환 또는 다중치환될 수 있으며, 또한 피리디닐은 N-옥사이드를 포함한다);3. Summary of the technical problem The compound represented by the following general formula (I), wherein R 1 is C 1 to C 6 alkyl, R 2 is phenyl, pyridinyl, tetrazolyl or imidazolyl, Wherein phenyl and fininidinyl may be unsubstituted or mono-substituted or polysubstituted with halogen atoms, C 1 to C 4 alkyl, hydroxyl or C 1 to C 4 alkoxy, and pyridinyl also includes N-oxides do);

4. 발명의 중요한 용도 ; 중추신경계 질환 및 심장질환계 질환의 치료제4. Important uses of the invention; Treatment of diseases of the central nervous system and heart diseases

Description

비페닐 유도체, 이의 제조방법 및 이를 함유한 약제학적 조성물Biphenyl derivative, preparation method thereof and pharmaceutical composition containing same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

하기 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염:A compound of formula (I) or a pharmaceutically acceptable salt thereof: 상기식에서, R1은 C1내지 C6알킬이고, R2는 페닐, 피리디닐, 테트라졸릴 또는 이미다졸릴이고, 여기서, 페닐 및 피니디닐은 비치환되거나, 할로겐원자, C1내지 C4알킬, 하이드록실 또는 C1내지 C4알콕시로 단일 치환 또는 다중 치환될 수 있으며, 또한 피리디닐은 N-옥사이드를 포함한다.Wherein R 1 is C 1 to C 6 alkyl, R 2 is phenyl, pyridinyl, tetrazolyl or imidazolyl, wherein phenyl and pininidinyl are unsubstituted or halogen atom, C 1 to C 4 alkyl , Mono- or polysubstituted by hydroxyl or C 1 to C 4 alkoxy, pyridinyl also includes N-oxides. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키고 알킬화시켜 일반식(Ⅰ)의 화합물을 제조하는 방법Process for preparing compound of formula (I) by reacting and alkylating a compound of formula (II) with a compound of formula (III) 상기식에서, R1은 C1내지 C6알킬 이고, R2는 페닐, 피리디닐, 테트라졸릴 또는 이미다졸릴이고, 여기서, 페닐 및 피니디닐은 비치환되거나, 할로겐원자, C1내지 C4알킬, 하이드록실 또는 C1내지 C4알콕시로 단일 치환 또는 다중 치환될 수 있으며, 또한 피리디닐은 N-옥사이드를 포함한다.Wherein R 1 is C 1 to C 6 alkyl, R 2 is phenyl, pyridinyl, tetrazolyl or imidazolyl, wherein phenyl and fininidinyl are unsubstituted, halogen atom, C 1 to C 4 alkyl , Mono- or polysubstituted by hydroxyl or C 1 to C 4 alkoxy, pyridinyl also includes N-oxides. 제1항에 따른 화합물과 약제학적으로 허용되는 담체가 혼합되어 안지오텐신 Ⅱ의 작용에 의한 질병을 치료하는데 사용하는 약제학적 조성물A pharmaceutical composition for use in treating a disease caused by the action of angiotensin II by mixing the compound according to claim 1 with a pharmaceutically acceptable carrier.
KR1019950072319A 1995-12-21 1995-12-21 Biphenyl Derivatives and Methods for Making the Same KR0181212B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950072319A KR0181212B1 (en) 1995-12-21 1995-12-21 Biphenyl Derivatives and Methods for Making the Same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950072319A KR0181212B1 (en) 1995-12-21 1995-12-21 Biphenyl Derivatives and Methods for Making the Same

Publications (2)

Publication Number Publication Date
KR970042523A true KR970042523A (en) 1997-07-24
KR0181212B1 KR0181212B1 (en) 1999-03-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950072319A KR0181212B1 (en) 1995-12-21 1995-12-21 Biphenyl Derivatives and Methods for Making the Same

Country Status (1)

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KR (1) KR0181212B1 (en)

Also Published As

Publication number Publication date
KR0181212B1 (en) 1999-03-20

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