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KR960041370A - 프라바스타틴(Pravastatin) 전구체의 제조방법 - Google Patents

프라바스타틴(Pravastatin) 전구체의 제조방법 Download PDF

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Publication number
KR960041370A
KR960041370A KR1019960033248A KR19960033248A KR960041370A KR 960041370 A KR960041370 A KR 960041370A KR 1019960033248 A KR1019960033248 A KR 1019960033248A KR 19960033248 A KR19960033248 A KR 19960033248A KR 960041370 A KR960041370 A KR 960041370A
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South Korea
Prior art keywords
producing
pravastatin precursor
precursor
microorganism
derivative
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KR1019960033248A
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English (en)
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KR100186706B1 (ko
Inventor
정계종
이주경
박주웅
서동진
이상춘
Original Assignee
김종인
영진약품공업 주식회사
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Priority to KR1019960033248A priority Critical patent/KR100186706B1/ko
Publication of KR960041370A publication Critical patent/KR960041370A/ko
Application granted granted Critical
Publication of KR100186706B1 publication Critical patent/KR100186706B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 프라바스타틴(Pravastatin) 전구체의 제조방법에 관한 것으로서, 토양으로부터 프라바스타틴 전구체의 생산능을 갖는 신균주를 분리하고 이를 호기적 배양하여 고지혈증 치료제로 유용한 프라바스타틴 전구체인 ML-236B의 락톤형, 염형, 산형 및 그의 에스테르 유도체를 고농도로 제조하는 방법에 관한 것이다.

Description

프라바스타틴(Pravastatin) 전구체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따른 프라바스타틴 전구체의 적외선 스펙트럼을 나타낸 것이고, 제2도는 본 발명에 따른 프라바스타틴 전구체의13C-NMR 스펙트럼을 나타낸 것이다.

Claims (3)

  1. 미생물을 배양하여 프라바스타틴 전구체 및 그 유도체를 제조함에 있어서, 상기 미생물로서 신균주 글리오클라디움속(Gliocladium sp.) YJ-9515(기탁번호 : KCTC 0252BP)를 호기적 배양하여서 제조하는 것을 특징으로 하는 다음 화학식 1의 프라바스타틴 전구체 및 그 유도체의 제조방법.
  2. 제1항에 있어서, 상기 호기적 배양은 본 배지 배양성분 중의 탄소원으로 락토오즈를 사용하여 수행하는 것을 특징으로 하는 제조방법.
  3. 신균주 글리오클라디움속(Gliocladium sp.) YJ-9515(기탁번호 : KCTC 0252BP).
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019960033248A 1996-08-09 1996-08-09 프라바스타틴 나트륨의 제조방법 KR100186706B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960033248A KR100186706B1 (ko) 1996-08-09 1996-08-09 프라바스타틴 나트륨의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960033248A KR100186706B1 (ko) 1996-08-09 1996-08-09 프라바스타틴 나트륨의 제조방법

Publications (2)

Publication Number Publication Date
KR960041370A true KR960041370A (ko) 1996-12-19
KR100186706B1 KR100186706B1 (ko) 1999-04-01

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ID=19469231

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960033248A KR100186706B1 (ko) 1996-08-09 1996-08-09 프라바스타틴 나트륨의 제조방법

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KR (1) KR100186706B1 (ko)

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KR100186706B1 (ko) 1999-04-01

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