KR960022427A - 2-(4'치환 아릴)프로피온산의 새로운 제조방법 - Google Patents
2-(4'치환 아릴)프로피온산의 새로운 제조방법 Download PDFInfo
- Publication number
- KR960022427A KR960022427A KR1019940036086A KR19940036086A KR960022427A KR 960022427 A KR960022427 A KR 960022427A KR 1019940036086 A KR1019940036086 A KR 1019940036086A KR 19940036086 A KR19940036086 A KR 19940036086A KR 960022427 A KR960022427 A KR 960022427A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- propionic acid
- substituted aryl
- group
- Prior art date
Links
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title claims abstract 8
- 235000019260 propionic acid Nutrition 0.000 title claims abstract 4
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 title claims abstract 4
- 125000003107 substituted aryl group Chemical group 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 239000003054 catalyst Substances 0.000 claims abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 238000006114 decarboxylation reaction Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- NWKYZYGOSPOKDY-UHFFFAOYSA-N n,n-dimethylformamide;pyridine Chemical compound CN(C)C=O.C1=CC=NC=C1 NWKYZYGOSPOKDY-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (2)
- 소듐에독사이드 또는 수듐메톡사이드의 염기성 촉매존재하, 20∼60℃에서 일반식 (Ⅱ) 화합물과 일반식 (Ⅲ) 화합물을 축합시키고, 가수분해시켜 일반식 (Ⅳ)의 화합물을 제조한 후, 이를 산호-탈카르복실화 반응시킴을 특징으로 하는 일반식 (Ⅰ)의 2-(4'-치환 아릴)프로피온산의 제조방법.식 중, R은 수고, 탄소수 1-4의 알킬기 또는 메톡시기이며, R'는 수소, 메틸기 또는 에틸기이다.
- 제1항에 일반식 (Ⅱ)의 일반식 (Ⅲ)의 화합물을 반응시킬 때, 염기성 촉매 대신에 디메틸포름아미드 피리딘, 피페리딘 또는 그 혼합용액의 염기성 용매하에서 90∼120℃에서 반응시킴을 특징으로 하는 일반식 (Ⅰ)의 2-(4'치환 아릴)프로피온산의 제조방법.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019940036086A KR100343230B1 (ko) | 1994-12-22 | 1994-12-22 | 2-(4'-치환아릴)프로피온산의새로운제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019940036086A KR100343230B1 (ko) | 1994-12-22 | 1994-12-22 | 2-(4'-치환아릴)프로피온산의새로운제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR960022427A true KR960022427A (ko) | 1996-07-18 |
| KR100343230B1 KR100343230B1 (ko) | 2002-12-11 |
Family
ID=37488372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940036086A KR100343230B1 (ko) | 1994-12-22 | 1994-12-22 | 2-(4'-치환아릴)프로피온산의새로운제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR100343230B1 (ko) |
-
1994
- 1994-12-22 KR KR1019940036086A patent/KR100343230B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100343230B1 (ko) | 2002-12-11 |
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