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KR950703976A - 아시클로비르 유사 화합물과 2′-비닐 치환 뉴클레오시드 유사체를 함유하는 바이러스 감염 치료용 조성물(Compositions Containing Acyclovir-Like Compounds and 2′-Vinyl substituted Nucleoside Analogs for the Treatment of Viral Infections) - Google Patents

아시클로비르 유사 화합물과 2′-비닐 치환 뉴클레오시드 유사체를 함유하는 바이러스 감염 치료용 조성물(Compositions Containing Acyclovir-Like Compounds and 2′-Vinyl substituted Nucleoside Analogs for the Treatment of Viral Infections)

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Publication number
KR950703976A
KR950703976A KR1019950702242A KR19950702242A KR950703976A KR 950703976 A KR950703976 A KR 950703976A KR 1019950702242 A KR1019950702242 A KR 1019950702242A KR 19950702242 A KR19950702242 A KR 19950702242A KR 950703976 A KR950703976 A KR 950703976A
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South Korea
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use according
acyclovir
viral infection
group
infection
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KR1019950702242A
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KR100297568B1 (ko
Inventor
사이 피. 순카라
제임스 알. 맥카티
Original Assignee
게리 디. 스트리트
메렐 다우 파마슈티칼스 인크
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Publication of KR950703976A publication Critical patent/KR950703976A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

본 발명은 항바이러스제로서의 유효량의 아시클로비르 유사 화합물을 병합 치료로서 항바이러스제로서의 유효량의 2′-비닐 치환 뉴클레오시드 유사체와 함께 환자에게 투여하는 것으로 이루어진, 바이러스 감염으로 고통받는 환자를 치료하는 방법에 관한 것이다.

Description

아시클로비르 유사 화합물과 2′-비닐 치환 뉴클레오시드 유사체를 함유하는 바이러스 감염 치료용 조성물(Compositions Containing Acyclovir-Like Compounds and 2′-Vinyl substituted Nucleoside Analogs for the Treatment of Viral Infections)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 바이러스 감염 치료를 위한 약제의 제조에 있어서, 하기 식의 화합물 또는 이의 약제학적으로 허용가능한 염의 항바이러스제로서의 유효량과의 병합 치료로서의 아시클로비르 유사 화합물의 용도
    상기식에서, V는 옥시, 메틸렌 또는 티오이며, X1및 X2는 각각 독립적으로 수소 또는 할로겐이며 B는 하기 식의 라디칼이다.
    상기식에서, Y1은 질소, CH기, CC1기, CBr기 또는 CNH2기이고, Y2및 Y3는 각각 독립적으로 질소 또는 CH기이며, Y4는 수소, C1-C4알킬, C1-C4알콕시 또는 할로겐이고, Y5는 아미노 또는 C1-C4알콜시이며, Z는 수소, 할로겐 또는 NH2이다.
  2. 제1항에 있어서, 아시클로비르는 유사 화합물은 아시클로비르인 것을 특징으로 하는 용도.
  3. 제2항에 있어서, 아시클로비르는 2′-데옥시-2′-플로우로메틸리덴시티딘과 함께 투여되는 것을 특징으로 하는 용도.
  4. 제2항에 있어서, 아시클로비르는 (E)-2′-데옥시-2′-플로우로메틸리덴시티딘과 함께 투여되는 것을 특징으로 하는 용도.
  5. 제2항에 있어서, 아시클로비르는 2′-데옥시-′-메틸리멘시티딘과 함께 투여되는 것을 특징으로 하는 용도.
  6. 제2항에 있어서, 바이러스 감염은 헤르페르 바이러스 감염인 것을 특징으로 하는 용도.
  7. 제2항에 있어서, 바이러스 감염은 헤르페르 심플렉스 바이러스 감염인 것을 특징으로 하는 용도.
  8. 제2항에 있어서, 바이러스 감염은 바리셀라 조스터 바이러스 감염인 것을 특징으로 하는 용도.
  9. 제2항에 있어서, 바이러스 감염은 시토메갈로 바이러스 감염인 것을 특징으로 하는 용도.
  10. 제2항에 있어서, 바이러스 감염은 엡스타인-바르 바이러스 감염인 것을 특징으로 하는 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950702242A 1992-12-03 1993-11-03 아시클로비르유사화합물과2'-비닐치환뉴클레오시드유사체를함유하는바이러스감염치료용조성물 Expired - Fee Related KR100297568B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98475792A 1992-12-03 1992-12-03
US07/984757 1992-12-03
PCT/US1993/010649 WO1994012188A1 (en) 1992-12-03 1993-11-03 Compositions containing acyclovir-like compounds and 2'-vinyl substituted nucleoside analogs for the treatment of viral infections

Publications (2)

Publication Number Publication Date
KR950703976A true KR950703976A (ko) 1995-11-17
KR100297568B1 KR100297568B1 (ko) 2001-11-14

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KR1019950702242A Expired - Fee Related KR100297568B1 (ko) 1992-12-03 1993-11-03 아시클로비르유사화합물과2'-비닐치환뉴클레오시드유사체를함유하는바이러스감염치료용조성물

Country Status (17)

Country Link
EP (1) EP0671918B1 (ko)
JP (1) JPH08503942A (ko)
KR (1) KR100297568B1 (ko)
AT (1) ATE153533T1 (ko)
AU (1) AU678789B2 (ko)
CA (1) CA2150671C (ko)
DE (1) DE69311135T2 (ko)
DK (1) DK0671918T3 (ko)
ES (1) ES2105599T3 (ko)
GR (1) GR3024289T3 (ko)
HU (1) HUT72604A (ko)
IL (1) IL107818A (ko)
MX (1) MX9307639A (ko)
NO (1) NO952212L (ko)
NZ (1) NZ258015A (ko)
WO (1) WO1994012188A1 (ko)
ZA (1) ZA938915B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001638A1 (en) * 1994-07-11 1996-01-25 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
DE10343365A1 (de) * 2003-09-17 2005-04-14 Biosphings Ag Pharmazeutische Formulierungen von Xanthogenaten und Hemmstoffen der viralen Nukleinsäurereplikation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002723A1 (en) * 1982-02-12 1983-08-18 Smith, Kendall, O. Anti-viral compositions
IT1170232B (it) * 1983-10-31 1987-06-03 Anna Gioia Stendardi Composizioni terapeutiche ad attivita' antivirale
JPH0232093A (ja) * 1988-06-08 1990-02-01 Merrell Dow Pharmaceut Inc 抗レトロウィルスジフルオロ化ヌクレオシド類
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
EP0468119A1 (en) * 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
EP0477871A3 (en) * 1990-09-28 1992-12-02 Nippon Kayaku Kabushiki Kaisha Antiviral composition, containing guanine derivatives

Also Published As

Publication number Publication date
HU9501627D0 (en) 1995-08-28
NO952212D0 (no) 1995-06-02
HUT72604A (en) 1996-05-28
ES2105599T3 (es) 1997-10-16
DE69311135T2 (de) 1997-09-25
AU5549594A (en) 1994-06-22
NO952212L (no) 1995-06-02
KR100297568B1 (ko) 2001-11-14
IL107818A (en) 2000-01-31
CA2150671C (en) 2000-12-26
CA2150671A1 (en) 1994-06-09
GR3024289T3 (en) 1997-10-31
EP0671918A1 (en) 1995-09-20
JPH08503942A (ja) 1996-04-30
AU678789B2 (en) 1997-06-12
WO1994012188A1 (en) 1994-06-09
DE69311135D1 (de) 1997-07-03
ATE153533T1 (de) 1997-06-15
DK0671918T3 (da) 1997-06-16
IL107818A0 (en) 1994-04-12
NZ258015A (en) 1997-01-29
ZA938915B (en) 1994-08-02
MX9307639A (es) 1994-06-30
EP0671918B1 (en) 1997-05-28

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