[go: up one dir, main page]

KR950702416A - 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine) - Google Patents

돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine) Download PDF

Info

Publication number
KR950702416A
KR950702416A KR1019950700058A KR19950700058A KR950702416A KR 950702416 A KR950702416 A KR 950702416A KR 1019950700058 A KR1019950700058 A KR 1019950700058A KR 19950700058 A KR19950700058 A KR 19950700058A KR 950702416 A KR950702416 A KR 950702416A
Authority
KR
South Korea
Prior art keywords
benzimidazole
article
compound
sulfinyl
manufacture
Prior art date
Application number
KR1019950700058A
Other languages
English (en)
Inventor
클리프튼 오거스터스 베일
프란시스 캐서린 부오노모
캐롤 린 맥러플린
빌리 대일 비니야드
Original Assignee
제임스 클리프튼 보올딩
몬산토 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제임스 클리프튼 보올딩, 몬산토 캄파니 filed Critical 제임스 클리프튼 보올딩
Publication of KR950702416A publication Critical patent/KR950702416A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 헤테로시클일알킬(술피닐 또는 티오)벤즈이미다졸 및 [벤즈이미다졸일(술피닐 또는 티오)알킬]아닐린으로 부터 선택된 벤즈이미다졸 화합물을 돼지에게 투여함으로써 외생 소마토트로핀이 투여되고 있는 돼지의 위궤양의 완화에 관한 것이다.

Description

돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 헤테로 시클일알킬(술피닐 또는 티오)벤즈이미다졸과 [벤즈이미다졸일(술피닐 또는 티오)알킬]아닐린으로 부터 선택된 벤즈이미다졸 화합물을 돼지의 위궤양의 완화시키는데 효과적인 양으로 돼지에게 투여함을 포함하는 외생, 소마토트로핀이 투여된 돼지의 위궤양을 완화시키는 방법.
  2. 제1항에 있어서, 벤즈이미다졸 화합물은 2-[2-피리딜메틸(술피닐 또는 티오)]벤즈이미다졸인 방법.
  3. 제2항에 있어서, 벤즈이미다졸 화합물은 2-[2-피리딜메틸티오]벤즈이미다졸인 방법.
  4. 제2항에 있어서, 벤즈이미다졸 화합물은 2-[2-피리딜메틸술피닐]벤즈이미다졸인 방법.
  5. 제2항에 있어서, 벤즈이미다졸 화합물은 5-메톡시-2-[(4-메톡시-3, 5-디메틸-2-피리딜)메틸술피닐]벤즈이미다졸인 방법.
  6. 제1항에 있어서, 벤즈이미다졸 화합물은 소마토트로핀과 동시에 주사에 의해 투여되는 것인 방법.
  7. 헤테로시클일알킬(술피닐 또는 티오) 벤즈이미다졸과 [벤즈이미다졸인(술피닐 또는 티오)알킬]아닐린으로 부터 선택된 벤즈이미다졸 화합물과 포르신 소마토트로핀을 포함하는 제조물품; 여기서 상기 제조물품은 돼지의 성장속도, 사료에서 고기로의 전환효율, 살코기 또는 돈유 생산을 증가시키는 데 유효한 양과 속도로 소마토트로핀을 또한 돼지의 위궤양을 완화시키는데 유효한 양과 속도로 벤즈이미다졸 화합물을 돼지의 순환계 내로 지속적 방출을 초래하는 데 적합한 형태로 소마토트로핀과 벤즈이미다졸 화합물을 동시에 돼지내에로 주사하는 데 유용한 것이다.
  8. 제7항에 있어서, 벤즈이미다졸 화합물은 2-[2-피리딜메틸(술피닐 또는 티오)]벤즈이미다졸인 제조물품.
  9. 제8항에 있어서, 벤즈이미다졸 화합물은 2-[2-피리딜메틸티오]벤즈이미다졸인 제조물품.
  10. 제8항에 있어서, 벤즈이미다졸 화합물은 2-[2-피리딜메틸 술피닐]벤즈이미다졸인 제조물품.
  11. 제8항에 있어서, 벤즈이미다졸 화합물은 5-메톡시-2-[(4-메톡시-3, 5-디메틸-2-피리딜)메틸술피닐]벤즈이미다졸인 제조물품.
  12. 제8항에 있어서, 상기 지속적 방출을 초래하기 위해 소마토트로핀의 고체 펠렛과 벤즈 이미다졸 화합물의 고체 펠렛의 돼지내에로의 동시 주사에 유용한 제조물품.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950700058A 1992-07-08 1993-06-14 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine) KR950702416A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91086392A 1992-07-08 1992-07-08
US910,863 1992-07-08
PCT/US1993/005692 WO1994001107A1 (en) 1992-07-08 1993-06-14 Benzimidazoles for alleviating stomach ulcers in swine

Publications (1)

Publication Number Publication Date
KR950702416A true KR950702416A (ko) 1995-07-29

Family

ID=25429425

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019950700058A KR0144793B1 (ko) 1992-07-08 1993-06-14 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸
KR1019950700058A KR950702416A (ko) 1992-07-08 1993-06-14 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019950700058A KR0144793B1 (ko) 1992-07-08 1993-06-14 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸

Country Status (13)

Country Link
US (1) US5389664A (ko)
EP (1) EP0649305A1 (ko)
KR (2) KR0144793B1 (ko)
CN (1) CN1082922A (ko)
BR (1) BR9306702A (ko)
CA (1) CA2138787A1 (ko)
HU (1) HUT71885A (ko)
IL (1) IL106279A0 (ko)
MX (1) MX9304087A (ko)
PL (1) PL307026A1 (ko)
RU (1) RU95105442A (ko)
WO (1) WO1994001107A1 (ko)
ZA (1) ZA934892B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509192B1 (en) * 1992-02-24 2003-01-21 Coulter International Corp. Quality control method
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
PL214224B1 (pl) * 2001-01-30 2013-07-31 Lauridsen Group Doustna forma koncentratu nie - hiperimmunizowanych nie-specyficznych immunoglobulin oraz suplement diety
US20030190314A1 (en) * 2001-01-30 2003-10-09 The Lauridsen Group Methods and compositions of treatment for modulating the immune system of animals
PL211753B1 (pl) * 2001-01-30 2012-06-29 Lauridsen Group Zastosowanie koncentratu antygenowo nie-specyficznych immunoglobulin pochodzących z krwi zwierząt i kompozycja farmaceutyczna zawierająca immunoglobuliny
US20030103962A1 (en) * 2001-10-09 2003-06-05 Campbell Joy M. Methods and compositions for modulating the immune system of animals
US6653137B2 (en) 2001-12-03 2003-11-25 Streck Laboratories Inc. Hematology reference control
US6723563B2 (en) 2001-12-03 2004-04-20 Streck Laboratories Inc. Hematology reference control
KR102049881B1 (ko) 2018-07-16 2019-11-28 충북대학교 산학협력단 파인애플박 및 페퍼민트 에센셜 오일을 유효성분으로 포함하는 돼지의 위궤양 개선 또는 예방용 사료첨가제 조성물

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (ko) * 1968-10-21 1971-06-03
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (ko) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
KR890000387B1 (ko) * 1984-09-24 1989-03-16 디 엎존 캄파니 2-(피리딜알켄술 피닐)벤즈 이미드아졸류의 n-치환 유도체의 제조방법
US4861868A (en) * 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
AU5768886A (en) * 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
CA1327010C (en) * 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
US5215974A (en) * 1986-11-21 1993-06-01 Aktiebolaget Hassle Certain pyridyl[(methylthio- or methyl sulfinyl)-2 benzimidazol-2-yl]N-methyl phosphonates useful for treating gastric-acid secretion related diseases
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
EP0382489B1 (en) * 1989-02-10 1994-11-17 Takeda Chemical Industries, Ltd. Use of benzimidazole derivatives as antibacterial agents
JP2524420B2 (ja) * 1990-05-16 1996-08-14 明治製菓株式会社 ピペリジン誘導体及びそれらを有効成分とする抗潰瘍剤

Also Published As

Publication number Publication date
PL307026A1 (en) 1995-05-02
RU95105442A (ru) 1997-02-20
HUT71885A (en) 1996-02-28
US5389664A (en) 1995-02-14
MX9304087A (es) 1994-01-31
IL106279A0 (en) 1993-11-15
HU9500047D0 (en) 1995-03-28
KR0144793B1 (ko) 1998-07-15
CN1082922A (zh) 1994-03-02
WO1994001107A1 (en) 1994-01-20
ZA934892B (en) 1995-01-13
EP0649305A1 (en) 1995-04-26
CA2138787A1 (en) 1994-01-20
BR9306702A (pt) 1998-12-08

Similar Documents

Publication Publication Date Title
KR950702416A (ko) 돼지에서 위궤양을 완화시키기 위한 벤즈이미다졸(Benzimidazoles for alloviating stomach ulcers in swine)
AR093609A2 (es) Compuesto amorfo de benzimidazol, composicion farmaceutica que lo comprende y metodo para tratar o prevenir la ulcera gastrica
DK0736039T3 (da) Forbindelser med væksthormon-frigivende egenskaber
RU95105587A (ru) Оптически чистые соединения пиридинилметил сульфинил-1н-бензимидазола, их соли, способы получения, фармкомпозиция, способ лечения
AR245718A1 (es) Procedimiento para preparar un compuesto de imidazo (4,5-b)-piridina
KR920002586A (ko) 신규 인돌 유도체
DE3486238D1 (de) rCRF und ähnliche Verbindungen.
KR890009875A (ko) 신규 화합물
TR199802554T2 (xx) Yeni bile�ikler
DK0533824T3 (da) Piperidylsubstituerede indoler
CO5150192A1 (es) Nuevos antagonistas de la lhrh que contienen componentes de aminoacido n-metilados con propiedades mejoradas de solubilidad
FI902292A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten aryylitiatsolyylimetyyli-imidatsolien valmistamiseksi
ATE110379T1 (de) Therapeutisch aktive substituierte benzimidazole und verfahren zu ihrer herstellung.
ES2023609A6 (es) Procedimiento para la obtencion del 2-(((3-metil -4-(2,2,2-trifluoroetoxi) -2-piridinil) metilisulfinil) -1h-bemzimidazol.
CO5251424A1 (es) Oxazinquinolonas utiles en el tratamiento de infecciones virales
DK0544760T3 (da) Farmaceutiske præparater indeholdende 5-difluormethoxy-2- (3,4-dimethoxy-2-pyridyl)methylsulfinyl benzimidazol og at anti-helicobactermiddel til behandling af gastrointestinale lidelser
KR900016154A (ko) 티오우라실 유도체, 이를 함유하는 약학적 조성물 및 이의 제조방법
MY115949A (en) Treatment of h. pylori infections
DK0676199T3 (da) Anvendelse af trovafloxacin eller derivater deraf til fremstilling af et medikament til behandling af H. pylori-infektione
ATE56213T1 (de) Substituierte carbonsaeureamide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
ES8702368A1 (es) Procedimiento para la obtencion de un compuesto derivado de imidazol
NO942378L (no) Anvendelse av arylindolderivater for behandling av psykoser
CO5390078A1 (es) Derivados anticonvulsivantes utiles en el tratamiento de desordenes de estres post traumaticos
JPS6456616A (en) Antiulcer agent
FR2592650A1 (fr) Nouvelles phenyl-naphtyridines fonctionnalisees en position-3, leur procede de preparation, medicaments les contenant, notamment anti-ulceres.

Legal Events

Date Code Title Description
A201 Request for examination
PA0105 International application

Patent event date: 19950107

Patent event code: PA01051R01D

Comment text: International Patent Application

PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19950107

Comment text: Request for Examination of Application

PG1501 Laying open of application
E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19980123

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19980423

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19980423

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20010419

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20020417

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20030414

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20040413

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20040413

Start annual number: 7

End annual number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

Termination category: Default of registration fee

Termination date: 20060410