KR950700304A - 5ht4-수용체 길항질로서 축합 인돌 유도체(condensed indole derivatives as 5ht4-receptor antagonists) - Google Patents

5ht4-수용체 길항질로서 축합 인돌 유도체(condensed indole derivatives as 5ht4-receptor antagonists)

Info

Publication number: KR950700304A
Authority: KR; South Korea
Prior art keywords: receptor; indole derivatives; condensed indole; receptor antagonist; receptor antagonists
Prior art date: 1992-03-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

KR1019940703167A

Other languages

English (en)

Other versions

KR100282730B1 (ko

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-12

Filing date

1994-09-10

Publication date

1995-01-16

1992-03-12 Priority claimed from GB929205428A external-priority patent/GB9205428D0/en

1992-09-05 Priority claimed from GB929218846A external-priority patent/GB9218846D0/en

1992-12-29 Priority claimed from GB929227045A external-priority patent/GB9227045D0/en

1993-03-10 Application filed filed Critical

1995-01-16 Publication of KR950700304A publication Critical patent/KR950700304A/ko

2001-02-15 Application granted granted Critical

2001-02-15 Publication of KR100282730B1 publication Critical patent/KR100282730B1/ko

2013-03-10 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

KR1019940703167A 1992-03-12 1993-03-10 5ht4-수용체 길항질로서 축합 인돌 유도체(condensed indole derivatives as 5ht4-receptor antagonists) Expired - Fee Related KR100282730B1 (ko)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
GB929205428A GB9205428D0 (en)	1992-03-12	1992-03-12	Pharmaceuticals
GB9205428.7		1992-03-12
GB9218846.5		1992-09-05
GB929218846A GB9218846D0 (en)	1992-09-05	1992-09-05	Pharmaceuticals
GB9227045.3		1992-12-29
GB929227045A GB9227045D0 (en)	1992-12-29	1992-12-29	Pharmaceuticals
PCT/GB1993/000506 WO1993018036A1 (en)	1992-03-12	1993-03-10	Condensed indole derivatives as 5ht4-receptor antagonists

Publications (2)

Publication Number	Publication Date
KR950700304A true KR950700304A (ko)	1995-01-16
KR100282730B1 KR100282730B1 (ko)	2001-02-15

Family

ID=27266092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019940703167A Expired - Fee Related KR100282730B1 (ko)	1992-03-12	1993-03-10	5ht4-수용체 길항질로서 축합 인돌 유도체(condensed indole derivatives as 5ht4-receptor antagonists)

Country Status (29)

Country	Link
EP (2)	EP0630376B1 (ko)
JP (1)	JP2831467B2 (ko)
KR (1)	KR100282730B1 (ko)
CN (2)	CN1043893C (ko)
AP (1)	AP401A (ko)
AT (2)	ATE266033T1 (ko)
AU (1)	AU671102B2 (ko)
CA (1)	CA2131797C (ko)
CY (1)	CY2510B1 (ko)
CZ (1)	CZ286194B6 (ko)
DE (2)	DE69333504T2 (ko)
DK (2)	DK0630376T3 (ko)
ES (2)	ES2219813T3 (ko)
FI (1)	FI107158B (ko)
GR (1)	GR3030668T3 (ko)
HU (1)	HU219121B (ko)
IL (1)	IL105003A (ko)
MA (1)	MA22819A1 (ko)
MX (1)	MX9301348A (ko)
MY (1)	MY110110A (ko)
NO (1)	NO303638B1 (ko)
NZ (1)	NZ249565A (ko)
PT (1)	PT884319E (ko)
RU (1)	RU2104279C1 (ko)
SG (1)	SG50693A1 (ko)
SI (1)	SI9300114B (ko)
SK (1)	SK281423B6 (ko)
UA (1)	UA41311C2 (ko)
WO (1)	WO1993018036A1 (ko)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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US5852014A (en) *	1992-03-12	1998-12-22	Smithkline Beecham P.L.C.	Condensed indole derivatives as 5HT4 -receptor antagonists
GB9316195D0 (en) *	1993-08-05	1993-09-22	Smithkline Beecham Plc	Pharmaceuticals
US5998409A (en) *	1992-03-12	1999-12-07	Smithkline Beecham Plc	Condensed indole derivatives as 5HT4 -receptor antagonists
MX9305947A (es) *	1992-09-29	1994-06-30	Smithkline Beecham Plc	Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
WO1994008965A1 (en) *	1992-10-16	1994-04-28	Smithkline Beecham Plc	N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
NZ257545A (en) *	1992-11-05	1997-01-29	Smithkline Beecham Plc	Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
FR2699921B1 (fr) *	1992-12-30	1995-02-10	Synthelabo	Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) *	1993-02-19	1993-04-07	Smithkline Beecham Plc	Pharmaceuticals
GB9310582D0 (en) *	1993-05-22	1993-07-07	Smithkline Beecham Plc	Pharmaceuticals
GB9312348D0 (en) *	1993-06-16	1993-07-28	Smithkline Beecham Plc	Pharmaceuticals
KR100219922B1 (ko) *	1996-05-16	1999-09-01	이서봉	신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
WO1998000422A1 (en) *	1996-07-02	1998-01-08	Sang Sup Jew	Oxirane carboxylic acid derivative and its manufacturing method
CA2263480C (en) *	1996-08-16	2007-03-06	Smithkline Beecham P.L.C.	Process for the preparation of n-[(1-nbutyl-4-piperidyl)methyl] -3,4-dihydro -2h-[1,3] oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
US6100397A (en) *	1996-08-16	2000-08-08	Smithkline Beecham Plc	Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
GB9618967D0 (en) *	1996-09-11	1996-10-23	Smithkline Beecham Plc	Pharmaceuticals
GB9725933D0 (en) *	1997-12-05	1998-02-04	Smithkline Beecham Plc	Pharmaceuticals
US6277870B1 (en) *	1998-05-04	2001-08-21	Astra Ab	Use
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US20020091271A1 (en)	1998-07-16	2002-07-11	Smithkline Beecham Plc	Process for the preparation of an indole derivative
GB9819035D0 (en) *	1998-09-01	1998-10-28	Cerebrus Res Ltd	Chemical compounds VII
BRPI9913542B8 (pt) *	1998-09-10	2021-05-25	Hoffmann La Roche	derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos
GB9820294D0 (en) *	1998-09-17	1998-11-11	Smithkline Beecham Plc	Pharmaceuticals
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
AU2005203196B9 (en) *	2000-08-07	2009-04-09	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782863C (en) *	2000-08-07	2006-08-31	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782870C (en) *	2000-08-07	2007-03-15	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
US20050032866A1 (en) *	2000-08-07	2005-02-10	Bonhomme Mireille Marguerite Jeanne	The use of 5ht4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
NZ535261A (en) *	2000-08-08	2004-12-24	Smithkline Beecham P	A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
EP1313481B1 (en) *	2000-08-08	2007-09-26	Smithkline Beecham Plc	Pharmaceutical composition comprising condensed indole compound
AU2003202058B2 (en) *	2002-02-14	2009-05-28	Glaxo Group Limited	Pharmaceutical composition comprising N- ((1-N-butyl-4-piperidinyl) methyl)-3, 4-dihydro-2H- (1, 3) oxazino (3, 2-a) indole-10-carboxamide or salt and process therefor comprising dry granulation
AU2003213092A1 (en)	2002-02-15	2003-09-09	Smithkline Beecham Corporation	Syntheses of quinazolinones
MXPA04011074A (es)	2002-05-09	2005-06-08	Cytokinetics Inc	Compuestos de pirimidinona, composiciones y metodos.
WO2003097053A1 (en)	2002-05-09	2003-11-27	Cytokinetics, Inc.	Compounds, compositions, and methods
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
JP2005536475A (ja)	2002-05-23	2005-12-02	サイトキネティクス・インコーポレーテッド	化合物、組成物、および方法
AU2003236527A1 (en)	2002-06-14	2003-12-31	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1537089A4 (en)	2002-07-23	2008-04-16	Cytokinetics Inc	CONNECTIONS, COMPOSITIONS AND PROCEDURES
AU2003277079A1 (en)	2002-09-30	2004-05-04	Cytokinetics, Inc.	Compounds, compositions, and methods
ITMI20031468A1 (it)	2003-07-18	2005-01-19	Acraf	Farmaco ativo nel dolore neuropatico
ITMI20031467A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco attivo nel dolore neuropatico
JP2007513154A (ja)	2003-12-08	2007-05-24	サイトキネティクス・インコーポレーテッド	化合物、組成物及び方法
DK1701951T3 (da)	2003-12-23	2010-06-07	Serodus As	Modulatorer af perifere 5-HT receptorer
JP4612301B2 (ja) *	2003-12-26	2011-01-12	広栄化学工業株式会社	１−アルキル−４−アミノメチルピペリジンの製造法
JP4912320B2 (ja) *	2004-12-07	2012-04-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	置換された四環式テトラヒドロピラン、ピロリジンおよびテトラヒドロチオフェン誘導体
RU2320662C1 (ru) *	2006-08-24	2008-03-27	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ ПИРРОЛО[4,3-b]ИНДОЛЫ, КОМБИНАТОРНАЯ И ФОКУСИРОВАННАЯ БИБЛИОТЕКИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EP2173724B1 (en)	2007-06-22	2012-12-05	ArQule, Inc.	Quinazolinone compounds and methods of use thereof
GB0905641D0 (en) *	2009-04-01	2009-05-13	Serodus As	Compounds
WO2021116487A1 (en)	2019-12-13	2021-06-17	Som Innovation Biotech, S.A.	Compounds for use in the treatment of niemann-pick c disease
WO2025077825A1 (en) *	2023-10-13	2025-04-17	Fauna Bio Incorporated	Methods and compositions for treating cardio-pulmonary disorders

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DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung
AU622330B2 (en) *	1989-06-23	1992-04-02	Takeda Chemical Industries Ltd.	Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
CA2030051C (en) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Indole derivatives
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists
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US5206382A (en) *	1991-06-27	1993-04-27	Fidia Georgetown Institute For The Neurosciences	Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders

1993
- 1993-03-10 AT AT98114130T patent/ATE266033T1/de active
- 1993-03-10 IL IL10500393A patent/IL105003A/en not_active IP Right Cessation
- 1993-03-10 DE DE69333504T patent/DE69333504T2/de not_active Expired - Lifetime
- 1993-03-10 ES ES98114130T patent/ES2219813T3/es not_active Expired - Lifetime
- 1993-03-10 AU AU36448/93A patent/AU671102B2/en not_active Expired
- 1993-03-10 JP JP5515490A patent/JP2831467B2/ja not_active Expired - Lifetime
- 1993-03-10 CZ CZ19942210A patent/CZ286194B6/cs not_active IP Right Cessation
- 1993-03-10 MA MA23113A patent/MA22819A1/fr unknown
- 1993-03-10 HU HU9402601A patent/HU219121B/hu unknown
- 1993-03-10 MY MYPI93000436A patent/MY110110A/en unknown
- 1993-03-10 SI SI9300114A patent/SI9300114B/sl active Search and Examination
- 1993-03-10 DK DK93905561T patent/DK0630376T3/da active
- 1993-03-10 RU RU94040864A patent/RU2104279C1/ru not_active IP Right Cessation
- 1993-03-10 WO PCT/GB1993/000506 patent/WO1993018036A1/en active IP Right Grant
- 1993-03-10 NZ NZ249565A patent/NZ249565A/en not_active IP Right Cessation
- 1993-03-10 PT PT98114130T patent/PT884319E/pt unknown
- 1993-03-10 DK DK98114130T patent/DK0884319T3/da active
- 1993-03-10 ES ES93905561T patent/ES2132223T3/es not_active Expired - Lifetime
- 1993-03-10 DE DE69325167T patent/DE69325167T2/de not_active Expired - Lifetime
- 1993-03-10 AT AT93905561T patent/ATE180785T1/de active
- 1993-03-10 SK SK1078-94A patent/SK281423B6/sk not_active IP Right Cessation
- 1993-03-10 KR KR1019940703167A patent/KR100282730B1/ko not_active Expired - Fee Related
- 1993-03-10 AP APAP/P/1993/000494A patent/AP401A/en active
- 1993-03-10 EP EP93905561A patent/EP0630376B1/en not_active Expired - Lifetime
- 1993-03-10 CA CA2131797A patent/CA2131797C/en not_active Expired - Fee Related
- 1993-03-10 UA UA94095780A patent/UA41311C2/uk unknown
- 1993-03-10 EP EP98114130A patent/EP0884319B1/en not_active Expired - Lifetime
- 1993-03-10 SG SG1996008846A patent/SG50693A1/en unknown
- 1993-03-11 MX MX9301348A patent/MX9301348A/es not_active IP Right Cessation
- 1993-03-11 CN CN93102648A patent/CN1043893C/zh not_active Expired - Fee Related
- 1993-05-22 CN CN93107234A patent/CN1085083A/zh active Pending
1994
- 1994-09-09 NO NO943348A patent/NO303638B1/no not_active IP Right Cessation
- 1994-09-12 FI FI944204A patent/FI107158B/fi not_active IP Right Cessation
1999
- 1999-06-30 GR GR990401755T patent/GR3030668T3/el unknown
2005
- 2005-04-12 CY CY0500021A patent/CY2510B1/xx unknown

Also Published As

Publication number	Publication date
HU219121B (hu)	2001-02-28
AU671102B2 (en)	1996-08-15
HU9402601D0 (en)	1994-12-28
ES2132223T3 (es)	1999-08-16
WO1993018036A1 (en)	1993-09-16
RU2104279C1 (ru)	1998-02-10
AP401A (en)	1995-08-29
CY2510B1 (en)	2005-12-23
MX9301348A (es)	1993-09-01
PT884319E (pt)	2004-09-30
SI9300114B (sl)	2006-08-31
CN1078471A (zh)	1993-11-17
CA2131797C (en)	2010-05-18
SG50693A1 (en)	1998-07-20
KR100282730B1 (ko)	2001-02-15
CA2131797A1 (en)	1993-09-16
NO303638B1 (no)	1998-08-10
FI944204A0 (fi)	1994-09-12
MY110110A (en)	1998-01-27
ATE180785T1 (de)	1999-06-15
EP0884319A2 (en)	1998-12-16
AP9300494A0 (en)	1993-04-30
ES2219813T3 (es)	2004-12-01
CZ221094A3 (en)	1995-09-13
IL105003A (en)	1996-09-12
NZ249565A (en)	1997-07-27
JPH07504433A (ja)	1995-05-18
CZ286194B6 (cs)	2000-02-16
JP2831467B2 (ja)	1998-12-02
DK0884319T3 (da)	2004-08-30
EP0884319B1 (en)	2004-05-06
AU3644893A (en)	1993-10-05
RU94040864A (ru)	1996-07-20
SK281423B6 (sk)	2001-03-12
DE69325167T2 (de)	2000-01-20
IL105003A0 (en)	1993-07-08
EP0630376B1 (en)	1999-06-02
HK1012352A1 (en)	1999-07-30
CN1043893C (zh)	1999-06-30
CN1085083A (zh)	1994-04-13
DE69333504T2 (de)	2005-05-12
UA41311C2 (uk)	2001-09-17
NO943348D0 (no)	1994-09-09
HUT71121A (en)	1995-11-28
NO943348L (no)	1994-11-09
EP0630376A1 (en)	1994-12-28
SI9300114A (sl)	1993-12-31
MA22819A1 (fr)	1993-10-01
FI107158B (fi)	2001-06-15
FI944204L (fi)	1994-09-12
DE69333504D1 (de)	2004-06-09
SK107894A3 (en)	1995-04-12
ATE266033T1 (de)	2004-05-15
DE69325167D1 (de)	1999-07-08
DK0630376T3 (da)	1999-06-23
GR3030668T3 (en)	1999-10-29
EP0884319A3 (en)	1999-02-10

Publication	Publication Date	Title
KR950700304A (ko)	1995-01-16	5ht4-수용체 길항질로서 축합 인돌 유도체(condensed indole derivatives as 5ht4-receptor antagonists)
FI903331A7 (fi)	1991-01-04	Angiotensiini-II-antagonisteina käyttökelpoisia substituoituja kinatsolinoneja
DE69232003D1 (de)	2001-09-20	Benzanilidderivate als 5-HT1D-Antagonisten
FI944734A7 (fi)	1994-10-07	Kinoliinijohdannaiset leukotrieeniantagonisteina
FI933810L (fi)	1994-03-04	Reseptorantagonister av exiterbara aminosyror
DE69207351D1 (de)	1996-02-15	Fibrinogen-Rezeptor-Antagoniste
FI934894A7 (fi)	1993-11-05	Fibrinogeenireseptorin antagonisteja
FI960840A7 (fi)	1996-02-23	Indolijohdannaisia tromboksaani-A2-antagonisteina
FI943247L (fi)	1994-07-07	Piperatsiinijohdannaisia 5-HT-reseptoriantagonisteina
DK0569013T3 (da)	1996-09-16	Quinolinforbindelser som angiotensin II antagonister
FI961628A7 (fi)	1996-04-12	Indolijohdannaisia NMDA-antagonisteina
FI950089A7 (fi)	1995-03-07	Dioksosyklobuteenijohdannaiset angiotensiini-II-antagonisteina
FI943941L (fi)	1994-10-26	CCK-reseptoriantagonisteina käyttökelpoiset bentsodiatsepiinijohdannaiset
DE69703242D1 (de)	2000-11-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
FI951798A7 (fi)	1995-04-13	Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
FI943807L (fi)	1994-10-24	Pyratsolopyrimidiinijohdannaisia angiotensiini II:n reseptoreiden vastavaikuttajina
DE69717449D1 (de)	2003-01-09	Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
FI943513L (fi)	1994-07-26	Kolekystokiniiniantagonisteina käyttökelpoisia 3-fenyyliureidoatsepin-2-oneja ja -bentsatsepin-2-oneja
FI943359L (fi)	1995-01-16	Atsasykliset-heterosykliset yhdisteet angiotensiini II reseptoriantagonisteina
ATE208764T1 (de)	2001-11-15	Isazole derivate als fibrinogen-rezeptor- antagonisten
KR950700297A (ko)	1995-01-16	5-HT3-수용체 길항제로서의 2,6-메타노-2H-퀴놀리진 유도체(2,6-Methano-2H-quinolizin derivative as 5-HT3-receptor antagonist)
FI941118A0 (fi)	1994-03-09	Bentsyyli-imidatsopyridiinijohdannainen angiotensiini II reseptoriantagonistina
KR950700884A (ko)	1995-02-20	루코트리엔 길항제로서의 퀴놀린 유도체(Quinoline derivatives as leukotriene antagonists)
FI941117A0 (fi)	1994-03-09	Bentsyyli-imidatsopyridiinijohdannaiset angiotensiini II reseptoriantagonisteina
ZA937507B (en)	1994-07-22	Heterocyclic condensed benzoic acid derivatives as 5-HT4 receptor antagonists

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