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KR950032082A - Composition for preventing or treating aldehyde disorders containing amino acids - Google Patents

Composition for preventing or treating aldehyde disorders containing amino acids Download PDF

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KR950032082A
KR950032082A KR1019940033990A KR19940033990A KR950032082A KR 950032082 A KR950032082 A KR 950032082A KR 1019940033990 A KR1019940033990 A KR 1019940033990A KR 19940033990 A KR19940033990 A KR 19940033990A KR 950032082 A KR950032082 A KR 950032082A
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histidine
aldehyde
composition
mixture
glutamine
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KR1019940033990A
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Korean (ko)
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KR0162674B1 (en
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박상철
한재갑
강흔수
이현정
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유영학
주식회사 미 원
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

본 발명은 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 새로운 용도를 제공한다. 본 발명에 따르면 이들 아미노산은 아세트알데히드를 비롯한 포름알데히드 또는 프로피온알데히드 등의 탄소수 1 내지 5의 저급 알데히드류를 효과적으로 제거할 수 있다.The present invention provides new uses of asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives or salts thereof. According to the present invention, these amino acids can effectively remove lower aldehydes having 1 to 5 carbon atoms such as formaldehyde or propionaldehyde including acetaldehyde.

따라서, 본 발명은 상기 아미노산들을 이용하여 생체내에서 여러가지 독성의 큰 요인이 되는 알데히드를 효과적으로 제거하는 방법, 알데히드에 기인한 여러 장해를 예방 또는 치료하기 위한 조성물, 알데히드를 포함하고 있거나 알데히드를 발생할 수 있는 화학적 제품에의 첨가방법을 제공하며, 이러한 아미노산들이 정상적으로 체내에 존재하는 아미노산들임을 감안할 때 그 안전성, 안정성 및 효율성이 높을 것이며, 그 응용의 범위 또한 매우 클 것으로 예측된다.Accordingly, the present invention provides a method for effectively removing aldehydes, which are a major cause of various toxicity in vivo using the amino acids, a composition for preventing or treating various disorders caused by aldehydes, including aldehydes or generating aldehydes. It provides a method of addition to a chemical product, and considering that these amino acids are amino acids normally present in the body, their safety, stability and efficiency will be high, and the scope of their application is also expected to be very large.

Description

아미노산을 함유한 알데히드성 장해를 예방 또는 치료하기 위한 조성물Composition for preventing or treating aldehyde disorders containing amino acids

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 pH7.4의 완충액내에서 포름알데히드를 각종 아미노산과 반응시킨 경우 시간 경과에 따른 포름알데히드의 양의 변화를 보여주는 그래프이다. 제2도는 pH7.4의 완충액내에서 아세트알데히드를 각종 아미노산과 반응시킨 경우 시간 경과에 따른 아세트알데히드의 양의 변화를 보여주는 그래프이다. 제3도는 pH7.4의 완충액내에서 프로피온알데히드를 각종 아미노산과 반응시킨 경우 시간 경과에 따른 프로피온알데히드의 양의 변화를 보여주는 그래프이다.FIG. 1 is a graph showing the change in the amount of formaldehyde over time when formaldehyde is reacted with various amino acids in a buffer of pH 7.4. 2 is a graph showing the change of the amount of acetaldehyde over time when acetaldehyde is reacted with various amino acids in a buffer of pH 7.4. 3 is a graph showing the change in the amount of propionaldehyde over time when propionaldehyde is reacted with various amino acids in a buffer of pH 7.4.

Claims (23)

아스파라긴(asparagine), 글루타민(glutamine), 호모시스테인(homocyshine), 시스테인(cysteine), 히스티딘(histidine), 히스티딘 유도체, 또는 그의 염의 단독 또는 그들의 혼합물을 알데히드와 접촉시킴을 특징으로 하는 알데히드를 제거하는 방법.A method for removing aldehydes characterized by contacting asparagine, glutamine, homocyshine, cysteine, histidine, histidine derivatives, or a salt thereof alone or in a mixture thereof with aldehydes. 제1항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물을 알데히드와 직접 접촉시켜 알데히드를 직접 제거함을 특징으로 하는 방법.The method according to claim 1, characterized in that asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivative or only one or a mixture thereof is directly contacted with an aldehyde to directly remove the aldehyde. 제1항에 있어서, 알데히드는 포름알데히드(formaldehyde), 아세트알데히드 (acetaldehyde), 또는 프로피온알데히드(propionaldehyde)등의 저급 알데히드임을 특징으로 하는 방법.The method of claim 1, wherein the aldehyde is lower aldehyde, such as formaldehyde, acetaldehyde, or propionaldehyde. 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물을 유효성분으로 하고, 섭취가능한 고형 또는 액체 부형제를 함유함을 특징으로 하는 알데히드성 장해를 예방 또는 치료하기 위한 조성물.A composition for preventing or treating aldehyde disorders, comprising asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives or salts thereof alone or as a mixture thereof as an active ingredient and containing ingestible solid or liquid excipients. 제4항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물을 0.001-100중량%를 함유함을 특징으로 하는 조성물.5. A composition according to claim 4, comprising 0.001-100% by weight of asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives, or a mixture thereof or a mixture thereof. 제4항에 있어서, 알데히드성 장해는 알데히드가 초래하는 생체의 조직손상 또는 기능 저하임을 특징으로 하는 조성물.5. A composition according to claim 4, wherein the aldehyde disorder is tissue damage or deterioration of the body caused by the aldehyde. 제4항에 있어서, 알데히드는 포름알데히드, 아세트알데히드 또는 프로피온알데히드 등의 저급 알데히드임을 특징으로 하는 조성물.The composition according to claim 4, wherein the aldehyde is a lower aldehyde such as formaldehyde, acetaldehyde or propionaldehyde. 제4항에 있어서, 부형제는 채소류 추출액, 관실류 추출액, 아미노산, 소금, 당류, 유기산 또는 비타민으로 구성된 군에서 선택된 1종 또는 2종 이상임을 특징으로 하는 조성물.The composition according to claim 4, wherein the excipient is one or two or more selected from the group consisting of vegetable extracts, tubular extracts, amino acids, salts, sugars, organic acids or vitamins. 제8항에 있어서, 채소류는 아스파라거스, 콩나물 또는 숙주나물이고, 과실류는 복숭아, 배, 사과 또는 무화과 열매임을 특징으로 하는 조성물.The composition according to claim 8, wherein the vegetables are asparagus, bean sprouts or bean sprouts, and the fruits are peaches, pears, apples or fig fruits. 제8항에 있어서, 아미노산은 L-아스파테이트, 글루탐산, 루신, 발린, 이소루이신으로 구성된 군에서 선택된 1종 또는 2종 이상임을 특징으로 하는 조성물.The composition of claim 8, wherein the amino acid is one or two or more selected from the group consisting of L-aspartate, glutamic acid, leucine, valine, and isoleucine. 제8항에 있어서, 당류는 과당, 설탕, 올리고당, 아스파탐 및 스테비오사이드로 구성된 군에서 선택된 1종 또는 2종 이상임을 특징으로 하는 조성물.The composition according to claim 8, wherein the sugar is one or two or more selected from the group consisting of fructose, sugar, oligosaccharide, aspartame and stevioside. 제8항에 있어서, 유기산은 구연산, 사과산, 호박산 및 주석산으로 구성된 군에서 선택된 1종 또는 2종 이상임을 특징으로 하는 조성물.The composition of claim 8, wherein the organic acid is one or two or more selected from the group consisting of citric acid, malic acid, succinic acid and tartaric acid. 제4항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물 0.0.1-10중량% 및 섭취가능한 액체 성분을 함유함을 특징으로 하는 조성물.5. A composition according to claim 4, containing 0.0.1-10% by weight of asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives or salts alone or mixtures thereof and ingestible liquid components. 제4항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물 0,01-10중량% 함유하는 정맥주사용 제제임을 특징으로 하는 조성물.The composition according to claim 4, which is an intravenous preparation containing 0,01-10% by weight of asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives or salts thereof alone or in a mixture thereof. 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물을 알데히드 제거에 유효한 양으로 함유함을 특징으로 하는 알데히드 제거를 위한 조성물.A composition for aldehyde removal, comprising asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives, or a mixture thereof or a mixture thereof in an amount effective for aldehyde removal. 제15항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물을 0.001-100중량%의 양으로 함유함을 특징으로 하는 조성물.The composition according to claim 15, which contains asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives or a salt thereof alone or in a mixture thereof in an amount of 0.001-100% by weight. 제15항에 있어서, 알데히드는 포롬알데히드, 아세트알데히드 또는 프로피온알데히드 등의 저급 알데히드임을 특징으로 하는 조성물.The composition according to claim 15, wherein the aldehyde is a lower aldehyde such as formaldehyde, acetaldehyde or propionaldehyde. 제16항에 있어서, 맥주, 막걸리, 소주, 위스키, 포도주, 과일주, 및 민속주로 구성된 주류군에서 선택된 1종에 첨가함을 특징으로 하는 조성물.17. The composition of claim 16, wherein the composition is added to one selected from the group of liquors consisting of beer, rice wine, shochu, whiskey, wine, fruit wine, and folk wine. 제15항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물의 농도가 0.001-5중량%롤 되도록 우유 발효식품, 젓갈류, 장류 및 김치류로 구성된 발효식품군에서 선택된 1종에 첨가함을 특징으로 하는 조성물.16. The fermented food group according to claim 15, wherein the concentration of asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives or salts thereof alone or in a mixture thereof is 0.001-5% by weight. The composition characterized in that the addition to one selected. 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물을 알데히드성 화학적 변화의 방지에 유효한 양으로 함유함을 특징으로 하는 알데히드성 화학적 변화를 방지하기 위한 조성물.A composition for preventing aldehyde chemical changes, characterized in that it contains asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives, or a mixture thereof or a mixture thereof in an amount effective to prevent aldehyde chemical changes. 제20항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물의 농도가 0.001-5중량%로 되도록 화장품에 첨가함을 특징으로 하는 조성물.The composition according to claim 20, wherein the composition is added to the cosmetic so that the concentration of asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivatives or salts thereof alone or in a mixture thereof is 0.001-5% by weight. 제20항에 있어서, 아스파라긴, 글루타민, 호모시스테인, 시스테인, 히스티딘, 히스티딘 유도체 또는 그의 염의 단독 또는 그들의 혼합물의 농도가 0.001-5중량%로 되도록 알데히드를 함유하거나 알데히드가 발생할 수 있는 화학제품에 첨가함을 특징으로 하는 조성물.21. The method according to claim 20, which is added to a chemical containing aldehyde or capable of generating aldehyde such that the concentration of asparagine, glutamine, homocysteine, cysteine, histidine, histidine derivative or its salt alone or in a mixture thereof is 0.001-5% by weight. Characterized in that the composition. 제20항에 있어서, 알데히드는 포름알데히드, 아세트알데히드 또는 프로피온알데히드 등의 저급 알데히드임을 특징으로 하는 조성물.The composition of claim 20, wherein the aldehyde is a lower aldehyde such as formaldehyde, acetaldehyde or propionaldehyde. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임,※ Note: The disclosure is based on the initial application.
KR1019940033990A 1994-05-03 1994-12-13 Composition for preventing or treating aldehyde disorders containing amino acids Expired - Fee Related KR0162674B1 (en)

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