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KR950018051A - Fusion protein fused with thymosin-alpha and other cytokines - Google Patents

Fusion protein fused with thymosin-alpha and other cytokines Download PDF

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Publication number
KR950018051A
KR950018051A KR1019930029130A KR930029130A KR950018051A KR 950018051 A KR950018051 A KR 950018051A KR 1019930029130 A KR1019930029130 A KR 1019930029130A KR 930029130 A KR930029130 A KR 930029130A KR 950018051 A KR950018051 A KR 950018051A
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KR
South Korea
Prior art keywords
alpha
fusion protein
thymosin
cytokines
fused
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Granted
Application number
KR1019930029130A
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Korean (ko)
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KR100274186B1 (en
Inventor
정지영
정혜신
이영미
박순재
Original Assignee
최근선
주식회사 럭키
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Priority to KR1019930029130A priority Critical patent/KR100274186B1/en
Publication of KR950018051A publication Critical patent/KR950018051A/en
Application granted granted Critical
Publication of KR100274186B1 publication Critical patent/KR100274186B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 싸이모신-알파와 다른 싸이토킨이 그 생리활성을 유지하는 형태로 융합된 융합 단백질을 제공하며 이는 두가지 단백질의 생리 활성효과를 동시에 나타내는 잇점이 있다.The present invention provides a fusion protein in which thymosin-alpha and other cytokines are fused in a form that maintains their physiological activity, which has the advantage of simultaneously exhibiting the physiological activity of the two proteins.

Description

싸이모신-알파와 다른 싸이토킨이 융합된 융합 단백질Fusion protein fused with thymosin-alpha and other cytokines

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

싸이모신-알파와 다른 싸이토킨이 각각의 활성을 유지하는 형태로 융합된 융합 단백질.A fusion protein in which thymosin-alpha and other cytokines are fused in a form that maintains their respective activity. 제1항에 있어서, 싸이모신-알파와 다른 싸이토킨을 화학적 교차 결합으로 융합시킴을 특징으로 하는 융합 단백질.4. The fusion protein of claim 1, wherein the fusion protein is fused by chemical crosslinking of thymosin-alpha and other cytokines. 제1항에 있어서, 다른 싸이토킨이 인터페론-알파인 융합 단백질.The fusion protein of claim 1, wherein the other cytokine is interferon-alpha. 제3항에 있어서, 인터페론-알파를 부분산화형으로 만들어서 융합시킨 융합 단백질.4. The fusion protein of claim 3, wherein the interferon-alpha is partially oxidized and fused. 제4항에 있어서, 부분산화형은 천연형 인터페론-알파에 0.1~0.2mM 다이티오 트레이롤을 처리하여 20~200분간 반응시켜 만들어짐을 특징으로 하는 융합 단백질.The fusion protein according to claim 4, wherein the partial oxidation type is made by reacting the natural interferon-alpha with 0.1-0.2 mM dithio trollol for 20 to 200 minutes. 제3항에 있어서, 싸이모신-알파와 인터페론-알파가 동일 몰비로 결합된 융합단백질.4. The fusion protein of claim 3, wherein thymosin-alpha and interferon-alpha are bound in the same molar ratio. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930029130A 1993-12-22 1993-12-22 Fusion protein consisting of thymosin-alpha and other cytokine Expired - Fee Related KR100274186B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930029130A KR100274186B1 (en) 1993-12-22 1993-12-22 Fusion protein consisting of thymosin-alpha and other cytokine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930029130A KR100274186B1 (en) 1993-12-22 1993-12-22 Fusion protein consisting of thymosin-alpha and other cytokine

Publications (2)

Publication Number Publication Date
KR950018051A true KR950018051A (en) 1995-07-22
KR100274186B1 KR100274186B1 (en) 2000-12-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930029130A Expired - Fee Related KR100274186B1 (en) 1993-12-22 1993-12-22 Fusion protein consisting of thymosin-alpha and other cytokine

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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators

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KR100274186B1 (en) 2000-12-15

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