KR940014789A - Recovery of L (L) -phenylalanine - Google Patents
Recovery of L (L) -phenylalanine Download PDFInfo
- Publication number
- KR940014789A KR940014789A KR1019920024330A KR920024330A KR940014789A KR 940014789 A KR940014789 A KR 940014789A KR 1019920024330 A KR1019920024330 A KR 1019920024330A KR 920024330 A KR920024330 A KR 920024330A KR 940014789 A KR940014789 A KR 940014789A
- Authority
- KR
- South Korea
- Prior art keywords
- phenylalanine
- fermentation broth
- sulfate
- yield
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 title claims abstract 19
- 238000011084 recovery Methods 0.000 title claims 2
- KLRWOUZEYNJFEP-QRPNPIFTSA-N (2s)-2-amino-3-phenylpropanoic acid;sulfuric acid Chemical compound OS(O)(=O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 KLRWOUZEYNJFEP-QRPNPIFTSA-N 0.000 claims abstract description 3
- 229960005190 phenylalanine Drugs 0.000 claims abstract 9
- 238000000034 method Methods 0.000 claims abstract 6
- 238000000855 fermentation Methods 0.000 claims abstract 4
- 230000004151 fermentation Effects 0.000 claims abstract 4
- 239000003960 organic solvent Substances 0.000 claims abstract 4
- 239000003513 alkali Substances 0.000 claims abstract 2
- 239000003957 anion exchange resin Substances 0.000 claims abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 abstract 4
- -1 L-phenylalanine sulfate compound Chemical class 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
본 발명은 여러 불순물들을 포함하고 있는 L-페닐알라닌 발효액으로부터 고순도로 L-페닐알라닌을 회수하는 방법에 관한 것이다. 본 발명의 방법에 따르면, 균체를 막 분리한 후 L-페닐알라닌을 L-페닐알라닌 황산염으로 하여 1차 결정을 회수함으로서 결정순도 및 수율을 향상시키고, 유기용매를 첨가하여 결정수율을 향상시키면서 불순물 누적을 방지하여 현장공정 적용이 가능하도록 하였다.The present invention relates to a method for recovering L-phenylalanine with high purity from L-phenylalanine fermentation broth containing various impurities. According to the method of the present invention, after purifying the cells, the primary crystals are recovered by using L-phenylalanine as L-phenylalanine sulfate, thereby improving crystal purity and yield, and adding organic solvents to improve crystal yield while improving the crystal yield. It was possible to apply the field process by preventing it.
L-페닐알라닌 황산염 화합물에서 L-페닐알라닌을 해리하기 위해서는 음이온 교환수지를 사용하여 황산이온을 제거하거나, 알카리로 중화하면 L-페닐알라닌을 쉽게 얻을 수 있다.In order to dissociate L-phenylalanine from the L-phenylalanine sulfate compound, L-phenylalanine can be easily obtained by removing sulfate ions using an anion exchange resin or neutralizing with alkali.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
제1도는 L-페닐알라닌 황산염의 용해도를 나타낸 것이다.1 shows the solubility of L-phenylalanine sulfate.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019920024330A KR940014789A (en) | 1992-12-15 | 1992-12-15 | Recovery of L (L) -phenylalanine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019920024330A KR940014789A (en) | 1992-12-15 | 1992-12-15 | Recovery of L (L) -phenylalanine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR940014789A true KR940014789A (en) | 1994-07-19 |
Family
ID=67215333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920024330A Withdrawn KR940014789A (en) | 1992-12-15 | 1992-12-15 | Recovery of L (L) -phenylalanine |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR940014789A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010002083A (en) * | 1999-06-11 | 2001-01-05 | 고두모 | A method for producing α-L-aspartyl-L-phenylalanine methylester |
| KR100285236B1 (en) * | 1999-01-18 | 2001-03-15 | 김효근 | Separation and Purification Methods for Phenylalanine by Electrodialysis |
-
1992
- 1992-12-15 KR KR1019920024330A patent/KR940014789A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100285236B1 (en) * | 1999-01-18 | 2001-03-15 | 김효근 | Separation and Purification Methods for Phenylalanine by Electrodialysis |
| KR20010002083A (en) * | 1999-06-11 | 2001-01-05 | 고두모 | A method for producing α-L-aspartyl-L-phenylalanine methylester |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19921215 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |