KR930017582A - 수퍼옥사이드 디스무타제 안정화 조성물 - Google Patents
수퍼옥사이드 디스무타제 안정화 조성물 Download PDFInfo
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- KR930017582A KR930017582A KR1019920003013A KR920003013A KR930017582A KR 930017582 A KR930017582 A KR 930017582A KR 1019920003013 A KR1019920003013 A KR 1019920003013A KR 920003013 A KR920003013 A KR 920003013A KR 930017582 A KR930017582 A KR 930017582A
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Abstract
본 발명은 수퍼옥사이드 디스무타제와 약학적으로 허용되는 아미노산, 당류, 단백질류, 고분자화합물류 및 계면활성제류중에서 선택된 1종 이상의 물질을 조합시킴으로써 수퍼옥사이드 디스무타제를 안정화시킨 조성물을 제공하는 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따른 글리신에 의한 수퍼옥사이드 디스무타제의 안정화 효과를 도시한 그래프이고, 제2도는 본 발명에 따른 만니톨에 의한 수퍼옥사이드 디스무타제의 안정화 효과를 도시한 그래프이며, 제3도는 본 발명에 따른 덱스트란에 의한 수퍼옥사이드 디스무타제의 안정화 효과를 도시한 그래프이다.
Claims (14)
- 수퍼옥사이드 디스무타제 와 약리학적으로 허용되는 아미노산, 당류, 단백질류, 고분자화합물류 및 계면활성게류 중에서 선택된 1종 이상의 물질을 포함하는 수퍼옥사이드 디스무타제 안정화 조성물.
- 제1항에 있어서, 상기 수퍼옥사이드 디스무타제가 인가 Cu,Zu-수퍼옥사이드 디스무타제인 조성물.
- 제1항에 있어서, 상기 아미노산이 글리신, 알라닌, 로이신, 트레오닌, 트립토판, 리신, 히드록시리신, 히스티딘, 알기닌, 시스테인 및 메티오닌 중에서 선택된 1종이상의 물질인 조성물.
- 제1항 또는 제3항에 있어서, 상기 아미노산을 5내지 50mg/ml의 농도로 포함하는 조성물.
- 제1항에 있어서, 상기 당류가 글리세린, 에리트리톨, 아라비톨, 크실리톨, 솔비톨, 만니톨, 글루쿠론산, 이두론론산, 뉴라민산, 갈락투론산, 글루콘산, 만누론산, 케토글루콜산, 케토갈락톤산, 케토구론산, 히아루론산 황산 콘드로이틴 및 그의 염, 헤파린, 인슐린, 키틴 및 그의 유도체, 댁스티린, 5,000 내지 150,000의 평균 분자량을 갖는 데스트란, 알긴산 및 그의 염, 및 10,000 내지 200,000의 평균 분자량을 갖는 히드록시에틸 스타치 중에서 선택된 1종 이상의 물질인 조성물.
- 제1항 또는 5항에 있어서, 상기 당류를 3내지 50mg/ml의 농도로 포함하는 조성물.
- 제1항에 있어서, 상기 단백질류가 인간 혈청 알부민, 간 혈청 글로불린, 젤라틴, 평균 분자량 7,000 내지 100,000인 산처리 젤라틴, 평균 분자량이 7,000 내지 100,000인 알칼리 처리 젤라틴 및 콜라겐 중에서 선택된 1종 이상의 물질인 조성물.
- 제1항 또는 7항에 있어서, 상기 단백질류를 2내지 50mg/ml의 농도로 포함하는 조성물.
- 제1항에 있어서, 상기 고분자화합물류가 히드록시프로필 셀루로우스, 히드록시 메틸 셀루로오스, 분자량 300 내지 6,000의 폴리에틸렌글리콜, 분자량 20,000 내지 100,000의 폴리비닐알코올, 및 분자량 20,000 내지 100,000의 폴리비닐피로리돈 중에서 선택된 1종 이상의 물질인 조성물.
- 제1항 또는 9항에 있어서, 상기 고분자 화합물류를 2내지 100mg/ml의 농도로 포함하는 조성물.
- 제1항에 있어서, 상기 계면 활성제류가 솔비탄 지방족산 에스테르, 글리세린 지방족산 에스테르, 폴리글리세린 지방족산 에스테르, 폴리 옥시에틸렌솔비탄 지방족산 에스테르, 폴리옥시에틸렌솔비를 지방족산 에스테르, 폴리에틸렌글리세린 지방족산 에스테르, 폴리에틸렌 글리콜 지방족산 에스테르, 폴리옥시에틸렌 알칼 에테르, 폴리옥시에틸렌 폴리옥시프로필렌 알킬 체테르, 폴리 옥시에틸렌 알켈 페닐 에테르, 폴리옥시에틸화 캐스터오일, 경화된 폴리옥시에틸화 캐스터오일, 폴리옥시에틸화 밀납유도체, 폴리옥시에틸렌 라놀린 유도체 및 폴리옥시에틸렌 지방족산 아미드, 탄소수 10내지 18의 알킬기를 갖는 알킬황산염, 폴리옥시에틸렌 알칼 에테르 황산염, 알킬술포숙시네이트 에스테르 염, 레시틴, 글리세로 포스포리피드 및 스핀고포스포리피드 중에서 선택된 1종 이상의 물질인 조성물.
- 제1항에 있어서, 상기 계면활성제류를 0.0001 내지 20%의 농도로 포함하는 조성물.
- 제1항에 있어서, 아황상 환원제 및 항산화제중에서 선택된 1종 이상의 물질을 추가로 함유하는 조성물.
- 제1항에 있어서, 카탈라아제를 추가로 함유하는 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019920003013A KR930017582A (ko) | 1992-02-26 | 1992-02-26 | 수퍼옥사이드 디스무타제 안정화 조성물 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019920003013A KR930017582A (ko) | 1992-02-26 | 1992-02-26 | 수퍼옥사이드 디스무타제 안정화 조성물 |
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| Publication Number | Publication Date |
|---|---|
| KR930017582A true KR930017582A (ko) | 1993-09-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920003013A Ceased KR930017582A (ko) | 1992-02-26 | 1992-02-26 | 수퍼옥사이드 디스무타제 안정화 조성물 |
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| Country | Link |
|---|---|
| KR (1) | KR930017582A (ko) |
-
1992
- 1992-02-26 KR KR1019920003013A patent/KR930017582A/ko not_active Ceased
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